Summary
The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.
AVX54575.1
JCVISYN3A_0007
DNA gyrase subunit A.
M. mycoides homolog: Q6MUM1.
TIGRfam Classification: 5=Equivalog.
Category: Essential.
Statistics
Total GO Annotation: 76
Unique PROST Go: 8
Unique BLAST Go: 25
Unique Foldseek Go: 0
Total Homologs: 275
Unique PROST Homologs: 112
Unique BLAST Homologs: 25
Unique Foldseek Homologs: 0
Structures and Sequence Alignment
The best structural homolog that predicted by 1. PBF was
Q9Z8R4
(DNA gyrase subunit A) with a FATCAT P-Value: 0 and RMSD of 2.12 angstrom. The sequence alignment identity is 35.9%.
Structural alignment shown in left. Query protein AVX54575.1 colored as red in alignment, homolog Q9Z8R4 colored as blue.
Query protein AVX54575.1 is also shown in right top, homolog Q9Z8R4 showed in right bottom. They are colored based on secondary structures.
AVX54575.1 MNNENNNNDSLNENQDHYHGKISPIDISTEVRKDFLEYAMSVIVSRALPDLKDGLKPVHRRIIYAMNDLGITSDKPHKKSARIVGEVIGKYHPHGDSAVY 100 Q9Z8R4 -----------MFNKDEI---IVPKNLEEEMKESYLRYSMSVIISRALPDIRDGLKPSQRRVLYAMKQLSLSPGAKHRKCAKICGDTSGDYHPHGESVIY 86 AVX54575.1 ETMVRMAQEFSYRYPLIDGHGNFGSIDGDGAAAMRYTEARLAKISNYLIKDIDMDTVPFIDNYDASEREPAYLTGYLPNLLVNGTMGIAVGMATSIPPHN 200 Q9Z8R4 PTLVRMAQNWAMRYPLVDGQGNFGSIDGDPPAAMRYTEARLTHSAMYLMEDLDKDTVDIVPNYDETKHEPVVFPSKFPNLLCNGSSGIAVGMATNIPPHN 186 AVX54575.1 LKEVVSAINAYIDNNDITIDEILNDHIL-GPDFPTGALMTNGSK-MREGYKTGRGSVIIRAKIDFEENK-KH-DRFVVTEIPYQTNKAKIIEKIAELVKD 296 Q9Z8R4 LGELIEATLLLLANPQASVDEILQ--VMPGPDFPTGGIIC-GSEGIRSTYTTGRGKIKVRARLHVEENEDKHRESIIITEMPYNVNKSRLIEQIANLVNE 283 AVX54575.1 KTIEGIFDIRDESNYEGIRIIIELKKDANPDVVLSKLYKYTALQSSFSINLLTLNNNLPVLLDLKTIIKNYVEFQISVIIKRSIFEKNKL-TKRYHILEA 395 Q9Z8R4 KTLAGISDVRDESDKDGIRVVLEIKKGESSEIIINRLYKFTDVQVTFGANMLALDKNLPRTMSIHRMISAWIRHRKEVIRRRTRYELNKAET-RAHVLEG 382 AVX54575.1 LHI-ALDNVDDVINIIKNSKTSEEAKVQLTNKYNFDEEQNKAILDMRLQRLVGLERDKITLEMTNIKERLTYL-DVLINTKEE---QDNVLKNQLNEI-- 488 Q9Z8R4 -YLKALSCLDALVKTIRESGNKEHAKERIIESFGFTEPQALAILELRLYQLTGLEAEKIQKEYEELLNKIAYYKQVL---SDEGLVKD-IIRNELQDLLK 477 AVX54575.1 ADKFGDNRRTEL-IDEELINIED-EELIPDLKWMILLSQEGYIRRINP-DEFRIQKRGGRGVSVNAEPSDPIDIATM--G----KA------KDWVLFFT 573 Q9Z8R4 HHKVA--RRTTIEFDAD--DIRDIEDIITNESVIITISGDDYVKRM-PVKVFKEQRRGGHGVT-------GFD---MKKGAGFLKAVYSAFTKDYLLIFT 562 AVX54575.1 NSGKVYRTKLYNIRSYSRTARGLPIVNFLNDLTSEDKITAILPLRNNKEKFNYLTFV-TQKGMIKRTKISEFENINRNGKKAINLRDNDQLVSV-FATTG 671 Q9Z8R4 NFGQCYWLKVWQLPEGERRAKGKPIINFLEGIRPGEELAAILNIK-NFDNAGFL-FLATKRGVVKKVSLDAFSNPRKKGIRALEIDEGDELIAACHIVSD 660 AVX54575.1 QDTVFIANESGKVIRIKESVVNPQSRVGGGVKALKLE-DDDVVVGA-ISSFKLTH---ITTVSNKGLFKKTPIDDYRISGRNGKGIKVMNLNQRTGKFKA 766 Q9Z8R4 EEKVMLFTHLGMAVRFPHEKVRPMGRTARGVRGVSLKNEEDKVVSCQI----VTENQSVLIVCDQGFGKRSLVEDFRETNRGGVGVRSILINERNGN--- 753 AVX54575.1 IIGA-RETD----LIMIISSDGNLIKTKVSNIPSLSRNASGVKAIRLTDNQEINAITLEYRKHGL---ENED-----FEED-------- 834 Q9Z8R4 VLGAIPVTDHDSILLM--SSQGQAIRINMQDVRVMGRSTQGVRLVHLKEGDAL--VSME--K--LSSNENDDEVLSGSEEECSDTVSLR 834
Go Annotations
1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.
| Source | GO | Description |
|---|---|---|
| 1. PBF | GO:0006261 | DNA-dependent DNA replication |
| 1. PBF | GO:0003677 | DNA binding |
| 1. PBF | GO:0034335 | DNA negative supercoiling activity |
| 1. PBF | GO:0003918 | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| 1. PBF | GO:0019897 | extrinsic component of plasma membrane |
| 1. PBF | GO:0005886 | plasma membrane |
| 1. PBF | GO:0005524 | ATP binding |
| 1. PBF | GO:0005694 | chromosome |
| 1. PBF | GO:0046677 | response to antibiotic |
| 1. PBF | GO:0006265 | DNA topological change |
| 1. PBF | GO:0009340 | DNA topoisomerase IV complex |
| 1. PBF | GO:0007059 | chromosome segregation |
| 1. PBF | GO:0009330 | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex |
| 2. PF | GO:0005737 | cytoplasm |
| 3. BF | GO:0034506 | chromosome, centromeric core domain |
| 3. BF | GO:0016539 | intein-mediated protein splicing |
| 3. BF | GO:0000793 | condensed chromosome |
| 3. BF | GO:0020023 | kinetoplast |
| 3. BF | GO:0000019 | regulation of mitotic recombination |
| 3. BF | GO:1905463 | negative regulation of DNA duplex unwinding |
| 3. BF | GO:1990904 | ribonucleoprotein complex |
| 3. BF | GO:0035327 | |
| 3. BF | GO:0006266 | DNA ligation |
| 3. BF | GO:0009303 | rRNA transcription |
| 3. BF | GO:0097046 | replication fork progression beyond termination site |
| 3. BF | GO:0003916 | DNA topoisomerase activity |
| 3. BF | GO:0045870 | positive regulation of single stranded viral RNA replication via double stranded DNA intermediate |
| 3. BF | GO:0000795 | synaptonemal complex |
| 3. BF | GO:0006271 | DNA strand elongation involved in DNA replication |
| 3. BF | GO:0008301 | DNA binding, bending |
| 3. BF | GO:0007076 | mitotic chromosome condensation |
| 3. BF | GO:0042752 | regulation of circadian rhythm |
| 3. BF | GO:0000819 | sister chromatid segregation |
| 3. BF | GO:0031055 | chromatin remodeling at centromere |
| 3. BF | GO:0000712 | resolution of meiotic recombination intermediates |
| 3. BF | GO:0030263 | apoptotic chromosome condensation |
| 3. BF | GO:0097047 | DNA replication termination region |
| 3. BF | GO:0048511 | rhythmic process |
| 3. BF | GO:0040016 | embryonic cleavage |
| 3. BF | GO:0004519 | endonuclease activity |
| 3. BF | GO:0006333 | chromatin assembly or disassembly |
| 3. BF | GO:0051306 | mitotic sister chromatid separation |
| 4. PB | GO:0030541 | plasmid partitioning |
| 5. P | GO:0008270 | zinc ion binding |
| 5. P | GO:1904628 | cellular response to phorbol 13-acetate 12-myristate |
| 5. P | GO:0006419 | alanyl-tRNA aminoacylation |
| 5. P | GO:0016597 | amino acid binding |
| 5. P | GO:0004813 | alanine-tRNA ligase activity |
| 5. P | GO:0005634 | nucleus |
| 5. P | GO:0000049 | tRNA binding |
| 5. P | GO:0008349 | MAP kinase kinase kinase kinase activity |
| 7. B | GO:0008094 | ATP-dependent activity, acting on DNA |
| 7. B | GO:0003682 | chromatin binding |
| 7. B | GO:0000228 | nuclear chromosome |
| 7. B | GO:0019899 | enzyme binding |
| 7. B | GO:0000182 | rDNA binding |
| 7. B | GO:0006974 | cellular response to DNA damage stimulus |
| 7. B | GO:0042826 | histone deacetylase binding |
| 7. B | GO:0043130 | ubiquitin binding |
| 7. B | GO:0046982 | protein heterodimerization activity |
| 7. B | GO:0043065 | positive regulation of apoptotic process |
| 7. B | GO:0071107 | response to parathyroid hormone |
| 7. B | GO:0007143 | female meiotic nuclear division |
| 7. B | GO:0021707 | cerebellar granule cell differentiation |
| 7. B | GO:0008623 | CHRAC |
| 7. B | GO:0000070 | mitotic sister chromatid segregation |
| 7. B | GO:0000775 | chromosome, centromeric region |
| 7. B | GO:0005080 | protein kinase C binding |
| 7. B | GO:0051309 | female meiosis chromosome separation |
| 7. B | GO:0007060 | male meiosis chromosome segregation |
| 7. B | GO:0003696 | satellite DNA binding |
| 7. B | GO:0005730 | nucleolus |
| 7. B | GO:0006314 | intron homing |
| 7. B | GO:0008022 | protein C-terminus binding |
| 7. B | GO:0002244 | hematopoietic progenitor cell differentiation |
| 7. B | GO:0030900 | forebrain development |
Uniprot GO Annotations
| GO | Description |
|---|---|
| GO:0003677 | DNA binding |
| GO:0003918 | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| GO:0016853 | isomerase activity |
| GO:0005524 | ATP binding |
| GO:0006265 | DNA topological change |
| GO:0006259 | DNA metabolic process |
| GO:0003916 | DNA topoisomerase activity |
Homologs
1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.
| Source | Homolog | Description | Fatcat Pvalue | PROST Evalue | BLAST Evalue | Foldseek TMScore |
|---|---|---|---|---|---|---|
| 1. PBF | P05653 | DNA gyrase subunit A | 0.00e+00 | 1.23e-94 | 0.0 | 0.7023 |
| 1. PBF | Q92JH0 | DNA topoisomerase 4 subunit A | 0.00e+00 | 4.36e-62 | 3.40e-130 | 0.6573 |
| 1. PBF | Q5HK04 | DNA gyrase subunit A | 0.00e+00 | 5.95e-46 | 0.0 | 0.7162 |
| 1. PBF | Q932M0 | DNA gyrase subunit A | 0.00e+00 | 6.60e-49 | 0.0 | 0.7154 |
| 1. PBF | D8K235 | DNA gyrase subunit A | 0.00e+00 | 3.70e-86 | 0.0 | 0.8799 |
| 1. PBF | Q1RID9 | DNA gyrase subunit A | 0.00e+00 | 2.34e-69 | 0.0 | 0.5825 |
| 1. PBF | Q9PKK4 | DNA gyrase subunit A | 0.00e+00 | 3.52e-78 | 0.0 | 0.7054 |
| 1. PBF | P47719 | DNA gyrase subunit A | 0.00e+00 | 4.75e-79 | 0.0 | 0.8493 |
| 1. PBF | P72524 | DNA gyrase subunit A | 0.00e+00 | 8.09e-81 | 0.0 | 0.7264 |
| 1. PBF | P0C1U9 | DNA topoisomerase 4 subunit A | 0.00e+00 | 1.11e-82 | 7.74e-139 | 0.7014 |
| 1. PBF | Q8K9W2 | DNA gyrase subunit A | 0.00e+00 | 5.88e-74 | 0.0 | 0.6728 |
| 1. PBF | Q6GKT9 | DNA gyrase subunit A | 0.00e+00 | 1.47e-51 | 0.0 | 0.7118 |
| 1. PBF | Q9PR63 | DNA gyrase subunit A | 0.00e+00 | 2.07e-95 | 0.0 | 0.8224 |
| 1. PBF | P43702 | DNA topoisomerase 4 subunit A | 0.00e+00 | 1.34e-63 | 2.14e-120 | 0.727 |
| 1. PBF | Q931S2 | DNA topoisomerase 4 subunit A | 0.00e+00 | 2.16e-83 | 1.13e-139 | 0.7032 |
| 1. PBF | Q9ZE79 | DNA topoisomerase 4 subunit A | 0.00e+00 | 3.24e-58 | 1.06e-123 | 0.6803 |
| 1. PBF | O51396 | DNA gyrase subunit A | 0.00e+00 | 1.07e-86 | 1.30e-180 | 0.611 |
| 1. PBF | Q5HPI5 | DNA topoisomerase 4 subunit A | 0.00e+00 | 7.78e-80 | 4.40e-144 | 0.7169 |
| 1. PBF | O33926 | DNA gyrase subunit A | 0.00e+00 | 1.95e-86 | 0.0 | 0.9198 |
| 1. PBF | C1CVF4 | DNA gyrase subunit A | 0.00e+00 | 7.06e-83 | 0.0 | 0.8805 |
| 1. PBF | Q5XCJ9 | DNA topoisomerase 4 subunit A | 0.00e+00 | 8.25e-71 | 1.23e-142 | 0.6195 |
| 1. PBF | P48354 | DNA gyrase subunit A | 0.00e+00 | 7.73e-91 | 0.0 | 0.6805 |
| 1. PBF | Q8P1B3 | DNA topoisomerase 4 subunit A | 0.00e+00 | 8.52e-71 | 6.28e-145 | 0.6204 |
| 1. PBF | Q59556 | DNA gyrase subunit A | 0.00e+00 | 8.02e-87 | 0.0 | 0.6985 |
| 1. PBF | P35885 | DNA gyrase subunit A | 0.00e+00 | 1.79e-72 | 0.0 | 0.7094 |
| 1. PBF | Q5XC58 | DNA gyrase subunit A | 0.00e+00 | 2.75e-87 | 0.0 | 0.7362 |
| 1. PBF | P47446 | DNA topoisomerase 4 subunit A | 0.00e+00 | 1.52e-55 | 5.49e-114 | 0.657 |
| 1. PBF | Q5YLB5 | DNA gyrase subunit A, chloroplastic/mitochondrial | 0.00e+00 | 2.64e-34 | 0.0 | 0.8637 |
| 1. PBF | P21557 | DNA gyrase subunit A | 0.00e+00 | 3.52e-78 | 0.0 | 0.6757 |
| 1. PBF | P9WG46 | DNA gyrase subunit A | 0.00e+00 | 1.42e-85 | 0.0 | 0.7404 |
| 1. PBF | Q9L7Q5 | DNA gyrase subunit A | 0.00e+00 | 7.21e-87 | 0.0 | 0.722 |
| 1. PBF | Q99XG5 | DNA gyrase subunit A | 0.00e+00 | 1.05e-48 | 0.0 | 0.716 |
| 1. PBF | O84192 | DNA gyrase subunit A | 0.00e+00 | 4.31e-78 | 0.0 | 0.6577 |
| 1. PBF | P0AFI3 | DNA topoisomerase 4 subunit A | 0.00e+00 | 3.77e-69 | 7.11e-125 | 0.8 |
| 1. PBF | Q9ZLD9 | DNA gyrase subunit A | 0.00e+00 | 1.80e-91 | 0.0 | 0.6977 |
| 1. PBF | C5CHA8 | DNA gyrase subunit A | 0.00e+00 | 8.11e-84 | 0.0 | 0.7173 |
| 1. PBF | P48369 | DNA gyrase subunit A | 0.00e+00 | 3.52e-59 | 0.0 | 0.9263 |
| 1. PBF | P41513 | DNA gyrase subunit A | 0.00e+00 | 1.63e-71 | 0.0 | 0.6379 |
| 1. PBF | Q0BST5 | DNA gyrase subunit A | 0.00e+00 | 3.07e-63 | 0.0 | 0.8348 |
| 1. PBF | Q6GD84 | DNA gyrase subunit A | 0.00e+00 | 1.78e-49 | 0.0 | 0.7082 |
| 1. PBF | P48371 | DNA gyrase subunit A | 0.00e+00 | 6.58e-71 | 0.0 | 0.7861 |
| 1. PBF | P41080 | DNA gyrase subunit A | 0.00e+00 | 5.64e-68 | 0.0 | 0.6205 |
| 1. PBF | Q2FKQ0 | DNA gyrase subunit A | 0.00e+00 | 4.66e-50 | 0.0 | 0.7175 |
| 1. PBF | P0AFI4 | DNA topoisomerase 4 subunit A | 0.00e+00 | 3.77e-69 | 7.11e-125 | 0.7859 |
| 1. PBF | Q93KF4 | DNA topoisomerase 4 subunit A | 0.00e+00 | 6.25e-85 | 1.58e-140 | 0.6838 |
| 1. PBF | Q8P116 | DNA gyrase subunit A | 0.00e+00 | 1.61e-87 | 0.0 | 0.7195 |
| 1. PBF | P48372 | DNA gyrase subunit A | 0.00e+00 | 1.62e-45 | 0.0 | 0.8485 |
| 1. PBF | P94605 | DNA gyrase subunit A | 0.00e+00 | 3.43e-85 | 0.0 | 0.6847 |
| 1. PBF | Q5HG64 | DNA topoisomerase 4 subunit A | 0.00e+00 | 9.88e-85 | 3.49e-141 | 0.7051 |
| 1. PBF | Q59749 | DNA topoisomerase 4 subunit A | 0.00e+00 | 1.53e-60 | 2.05e-124 | 0.7841 |
| 1. PBF | C0R046 | DNA gyrase subunit A | 0.00e+00 | 7.33e-90 | 0.0 | 0.7861 |
| 1. PBF | P0DG03 | DNA gyrase subunit A | 0.00e+00 | 7.74e-87 | 0.0 | 0.7832 |
| 1. PBF | Q68XG2 | DNA gyrase subunit A | 0.00e+00 | 3.85e-68 | 0.0 | 0.8365 |
| 1. PBF | P57277 | DNA gyrase subunit A | 0.00e+00 | 3.05e-79 | 0.0 | 0.6725 |
| 1. PBF | P26973 | DNA topoisomerase 4 subunit A | 0.00e+00 | 4.13e-70 | 4.50e-120 | 0.7297 |
| 1. PBF | O50628 | DNA gyrase subunit A | 0.00e+00 | 3.07e-87 | 0.0 | 0.6941 |
| 1. PBF | Q9L7Q4 | DNA topoisomerase 4 subunit A | 0.00e+00 | 5.01e-70 | 5.15e-143 | 0.6186 |
| 1. PBF | P14829 | DNA gyrase subunit A | 0.00e+00 | 1.37e-67 | 0.0 | 0.6393 |
| 1. PBF | Q1RGX8 | DNA topoisomerase 4 subunit A | 0.00e+00 | 1.34e-61 | 1.58e-135 | 0.6609 |
| 1. PBF | B2S0D7 | DNA gyrase subunit A | 0.00e+00 | 3.31e-85 | 0.0 | 0.5897 |
| 1. PBF | Q6GH50 | DNA topoisomerase 4 subunit A | 0.00e+00 | 9.87e-82 | 1.36e-140 | 0.7137 |
| 1. PBF | Q9Z8R4 | DNA gyrase subunit A | 0.00e+00 | 7.32e-75 | 0.0 | 0.5902 |
| 1. PBF | Q8NWU8 | DNA topoisomerase 4 subunit A | 0.00e+00 | 2.30e-84 | 7.50e-141 | 0.7072 |
| 1. PBF | A0QPN1 | Topoisomerase subunit TopoM | 0.00e+00 | 1.23e-37 | 4.80e-76 | 0.651 |
| 1. PBF | P47235 | DNA gyrase subunit A | 0.00e+00 | 4.31e-78 | 0.0 | 0.6409 |
| 1. PBF | P0AES5 | DNA gyrase subunit A | 0.00e+00 | 1.14e-73 | 0.0 | 0.8407 |
| 1. PBF | Q4UKM1 | DNA gyrase subunit A | 0.00e+00 | 2.05e-69 | 0.0 | 0.6412 |
| 1. PBF | Q1MQ89 | DNA gyrase subunit A | 0.00e+00 | 5.24e-85 | 0.0 | 0.7673 |
| 1. PBF | C5C7X9 | DNA gyrase subunit A | 0.00e+00 | 1.40e-69 | 0.0 | 0.7298 |
| 1. PBF | P0DG07 | DNA topoisomerase 4 subunit A | 0.00e+00 | 6.70e-69 | 5.35e-142 | 0.6202 |
| 1. PBF | Q4UNA0 | DNA topoisomerase 4 subunit A | 0.00e+00 | 1.05e-61 | 3.75e-131 | 0.6575 |
| 1. PBF | Q5SIL4 | DNA gyrase subunit A | 0.00e+00 | 6.87e-89 | 0.0 | 0.9133 |
| 1. PBF | P0C0R0 | DNA gyrase subunit A | 0.00e+00 | 9.31e-46 | 0.0 | 0.7139 |
| 1. PBF | P37411 | DNA gyrase subunit A | 0.00e+00 | 5.03e-69 | 0.0 | 0.6448 |
| 1. PBF | Q8CSN8 | DNA topoisomerase 4 subunit A | 0.00e+00 | 5.72e-80 | 1.90e-144 | 0.7133 |
| 1. PBF | Q03470 | DNA gyrase subunit A | 0.00e+00 | 2.19e-73 | 0.0 | 0.6591 |
| 1. PBF | P35810 | DNA gyrase subunit A | 0.00e+00 | 1.06e-58 | 0.0 | 0.6743 |
| 1. PBF | P48374 | DNA topoisomerase 4 subunit A | 0.00e+00 | 1.04e-60 | 1.13e-112 | 0.6904 |
| 1. PBF | Q45066 | DNA topoisomerase 4 subunit A | 0.00e+00 | 3.15e-79 | 1.61e-147 | 0.6809 |
| 1. PBF | O83051 | DNA gyrase subunit A | 0.00e+00 | 3.72e-89 | 0.0 | 0.6672 |
| 1. PBF | D5ECW5 | DNA gyrase subunit A | 0.00e+00 | 2.41e-92 | 0.0 | 0.6699 |
| 1. PBF | Q89AS3 | DNA gyrase subunit A | 0.00e+00 | 7.23e-82 | 0.0 | 0.6703 |
| 1. PBF | P20831 | DNA gyrase subunit A | 0.00e+00 | 1.30e-48 | 0.0 | 0.6915 |
| 1. PBF | Q5HJZ0 | DNA gyrase subunit A | 0.00e+00 | 1.69e-49 | 0.0 | 0.712 |
| 1. PBF | P0DG06 | DNA topoisomerase 4 subunit A | 0.00e+00 | 1.22e-70 | 5.79e-143 | 0.6183 |
| 1. PBF | P72525 | DNA topoisomerase 4 subunit A | 0.00e+00 | 6.93e-65 | 1.80e-143 | 0.6088 |
| 1. PBF | Q9HUK1 | DNA topoisomerase 4 subunit A | 0.00e+00 | 2.92e-67 | 3.43e-125 | 0.6787 |
| 1. PBF | O51066 | DNA topoisomerase 4 subunit A | 0.00e+00 | 5.48e-21 | 2.68e-45 | 0.6838 |
| 1. PBF | P48370 | DNA gyrase subunit A | 0.00e+00 | 3.70e-93 | 0.0 | 0.6859 |
| 1. PBF | Q8DPM2 | DNA gyrase subunit A | 0.00e+00 | 6.36e-81 | 0.0 | 0.7352 |
| 1. PBF | P0DG02 | DNA gyrase subunit A | 0.00e+00 | 7.74e-87 | 0.0 | 0.8052 |
| 1. PBF | B0S912 | DNA gyrase subunit A | 0.00e+00 | 1.54e-95 | 0.0 | 0.7043 |
| 1. PBF | P22446 | DNA gyrase subunit A | 0.00e+00 | 1.03e-85 | 0.0 | 0.848 |
| 1. PBF | A1SCM2 | DNA gyrase subunit A | 0.00e+00 | 1.11e-48 | 0.0 | 0.821 |
| 1. PBF | P47250 | DNA gyrase subunit A | 0.00e+00 | 3.04e-84 | 0.0 | 0.8769 |
| 1. PBF | P43700 | DNA gyrase subunit A | 0.00e+00 | 3.99e-77 | 0.0 | 0.6615 |
| 1. PBF | Q68XU1 | DNA topoisomerase 4 subunit A | 0.00e+00 | 1.21e-60 | 6.05e-130 | 0.7051 |
| 1. PBF | Q92IZ6 | DNA gyrase subunit A | 0.00e+00 | 4.70e-70 | 0.0 | 0.8661 |
| 1. PBF | A0A0G2Q9F8 | DNA gyrase subunit A | 0.00e+00 | 1.11e-85 | 0.0 | 0.6978 |
| 1. PBF | Q18GY3 | DNA gyrase subunit A | 0.00e+00 | 1.58e-71 | 0.0 | 0.7264 |
| 1. PBF | P75352 | DNA topoisomerase 4 subunit A | 0.00e+00 | 2.41e-58 | 2.35e-120 | 0.6294 |
| 1. PBF | O54478 | DNA topoisomerase 4 subunit A | 0.00e+00 | 4.89e-58 | 5.70e-114 | 0.6639 |
| 1. PBF | Q8NKW8 | DNA gyrase subunit A | 0.00e+00 | 1.78e-49 | 0.0 | 0.7144 |
| 1. PBF | P73077 | DNA topoisomerase 4 subunit A | 0.00e+00 | 1.43e-42 | 2.12e-150 | 0.6236 |
| 1. PBF | Q57532 | DNA gyrase subunit A | 1.75e-14 | 2.66e-08 | 4.71e-140 | 0.7549 |
| 1. PBF | Q6G9K4 | DNA topoisomerase 4 subunit A | 0.00e+00 | 2.09e-85 | 5.17e-141 | 0.7066 |
| 1. PBF | O67108 | Type 2 topoisomerase subunit A | 0.00e+00 | 1.84e-72 | 1.79e-162 | 0.6225 |
| 1. PBF | B3PN30 | DNA gyrase subunit A | 0.00e+00 | 8.70e-73 | 0.0 | 0.7099 |
| 1. PBF | Q55738 | DNA gyrase subunit A | 0.00e+00 | 1.07e-83 | 0.0 | 0.9245 |
| 3. BF | Q49608 | DNA gyrase subunit A (Fragment) | 7.65e-02 | NA | 1.65e-17 | 0.1887 |
| 3. BF | Q64399 | DNA topoisomerase 2-beta | 1.02e-05 | NA | 1.36e-18 | 0.6633 |
| 3. BF | O93794 | DNA topoisomerase 2 | 1.57e-05 | NA | 6.19e-16 | 0.708 |
| 3. BF | P12531 | DNA topoisomerase 2 | 2.72e-06 | NA | 2.22e-16 | 0.7047 |
| 3. BF | P87078 | DNA topoisomerase 2 | 3.52e-05 | NA | 7.56e-18 | 0.7161 |
| 3. BF | P72065 | DNA gyrase subunit A (Fragment) | 3.00e-01 | NA | 4.28e-20 | 0.388 |
| 3. BF | P41515 | DNA topoisomerase 2-alpha | 1.51e-06 | NA | 3.38e-16 | 0.6595 |
| 3. BF | O42131 | DNA topoisomerase 2-beta | 1.46e-06 | NA | 7.20e-19 | 0.6243 |
| 3. BF | Q49166 | DNA gyrase subunit A (Fragment) | 2.01e-01 | NA | 2.52e-19 | 0.1398 |
| 3. BF | O46374 | DNA topoisomerase 2-alpha | 5.33e-06 | NA | 2.66e-15 | 0.6992 |
| 3. BF | P27570 | DNA topoisomerase 2 | 3.62e-06 | NA | 3.47e-17 | 0.8015 |
| 3. BF | Q49467 | DNA gyrase subunit A (Fragment) | 1.30e-01 | NA | 1.74e-19 | 0.1745 |
| 3. BF | Q9Y8G8 | DNA topoisomerase 2 | 2.53e-06 | NA | 7.08e-13 | 0.7622 |
| 3. BF | P30190 | DNA topoisomerase 2 | 4.22e-07 | NA | 9.03e-15 | 0.7233 |
| 3. BF | O16140 | DNA topoisomerase 2 | 1.83e-06 | NA | 1.84e-12 | 0.708 |
| 3. BF | P0C0Q9 | DNA gyrase subunit A (Fragment) | 9.14e-04 | NA | 7.92e-38 | 0.9289 |
| 3. BF | P34030 | DNA gyrase subunit A (Fragment) | 0.00e+00 | NA | 5.99e-102 | 0.9839 |
| 3. BF | P41001 | DNA topoisomerase 2 | 5.54e-07 | NA | 3.06e-23 | 0.7373 |
| 3. BF | O24308 | DNA topoisomerase 2 | 1.26e-04 | NA | 1.35e-10 | 0.7196 |
| 3. BF | O68891 | DNA topoisomerase 4 subunit A (Fragment) | 4.90e-08 | NA | 9.03e-42 | 0.9585 |
| 3. BF | O42130 | DNA topoisomerase 2-alpha | 8.93e-08 | NA | 2.52e-16 | 0.7397 |
| 3. BF | Q01879 | DNA topoisomerase 2 | 1.74e-05 | NA | 2.05e-14 | 0.6723 |
| 4. PB | Q2G2Q0 | DNA gyrase subunit A | 0.00e+00 | 1.78e-49 | 0.0 | NA |
| 4. PB | P0AFI2 | DNA topoisomerase 4 subunit A | 0.00e+00 | 3.77e-69 | 7.11e-125 | NA |
| 4. PB | Q2FYS4 | DNA topoisomerase 4 subunit A | 0.00e+00 | 9.88e-85 | 3.49e-141 | NA |
| 4. PB | P0AES4 | DNA gyrase subunit A | 0.00e+00 | 1.14e-73 | 0.0 | NA |
| 4. PB | Q9CAF6 | DNA gyrase subunit A, chloroplastic/mitochondrial | 0.00e+00 | 6.89e-31 | 0.0 | NA |
| 4. PB | P9WG47 | DNA gyrase subunit A | 0.00e+00 | 1.32e-85 | 0.0 | NA |
| 4. PB | Q7XZF7 | Probable DNA gyrase subunit A, chloroplastic/mitochondrial | 0.00e+00 | 6.12e-37 | 0.0 | NA |
| 5. P | A8FSV6 | Alanine--tRNA ligase | 3.79e-01 | 1.32e-02 | NA | NA |
| 5. P | B0BNS8 | Alanine--tRNA ligase | 3.28e-01 | 4.08e-02 | NA | NA |
| 5. P | Q48G25 | Alanine--tRNA ligase | 3.25e-01 | 1.44e-02 | NA | NA |
| 5. P | A4YXQ6 | Alanine--tRNA ligase | 3.40e-01 | 4.15e-02 | NA | NA |
| 5. P | Q98NQ5 | Alanine--tRNA ligase | 3.04e-01 | 2.95e-02 | NA | NA |
| 5. P | A9W5Y4 | Alanine--tRNA ligase | 2.49e-01 | 4.88e-02 | NA | NA |
| 5. P | Q7WHL6 | Alanine--tRNA ligase | 5.30e-01 | 4.97e-02 | NA | NA |
| 5. P | A5CRZ5 | Alanine--tRNA ligase | 3.31e-01 | 1.22e-02 | NA | NA |
| 5. P | A3N018 | Alanine--tRNA ligase | 3.25e-01 | 4.40e-02 | NA | NA |
| 5. P | A3PLJ1 | Alanine--tRNA ligase | 3.02e-01 | 3.01e-02 | NA | NA |
| 5. P | Q2ITM9 | Alanine--tRNA ligase | 2.84e-01 | 3.81e-02 | NA | NA |
| 5. P | A7MYT5 | Alanine--tRNA ligase | 1.98e-01 | 2.50e-02 | NA | NA |
| 5. P | P67008 | Alanine--tRNA ligase | 2.88e-01 | 1.48e-02 | NA | NA |
| 5. P | A0KPG1 | Alanine--tRNA ligase | 3.51e-01 | 4.44e-02 | NA | NA |
| 5. P | P61706 | Alanine--tRNA ligase | 2.84e-01 | 4.08e-02 | NA | NA |
| 5. P | Q0HL60 | Alanine--tRNA ligase | 4.14e-01 | 2.50e-02 | NA | NA |
| 5. P | Q5P7Q3 | Alanine--tRNA ligase | 4.46e-01 | 3.01e-02 | NA | NA |
| 5. P | Q5E7G5 | Alanine--tRNA ligase | 2.83e-01 | 3.37e-02 | NA | NA |
| 5. P | Q01XA0 | Alanine--tRNA ligase | 3.59e-01 | 3.37e-02 | NA | NA |
| 5. P | A2SI90 | Alanine--tRNA ligase | 4.85e-01 | 2.98e-02 | NA | NA |
| 5. P | A9AC16 | Alanine--tRNA ligase | 4.61e-01 | 4.44e-02 | NA | NA |
| 5. P | Q57CU0 | Alanine--tRNA ligase | 3.06e-01 | 1.48e-02 | NA | NA |
| 5. P | Q9I553 | Alanine--tRNA ligase | 3.71e-01 | 1.06e-02 | NA | NA |
| 5. P | Q21L68 | Alanine--tRNA ligase | 3.72e-01 | 1.89e-02 | NA | NA |
| 5. P | B0TK15 | Alanine--tRNA ligase | 3.50e-01 | 1.28e-02 | NA | NA |
| 5. P | B1JCG9 | Alanine--tRNA ligase | 3.67e-01 | 2.65e-02 | NA | NA |
| 5. P | Q0BYM3 | Alanine--tRNA ligase | 3.79e-01 | 4.79e-02 | NA | NA |
| 5. P | Q02I63 | Alanine--tRNA ligase | 4.27e-01 | 1.48e-02 | NA | NA |
| 5. P | Q6D1T0 | Alanine--tRNA ligase | 4.17e-01 | 4.92e-02 | NA | NA |
| 5. P | B0CGZ9 | Alanine--tRNA ligase | 2.87e-01 | 1.48e-02 | NA | NA |
| 5. P | Q11IW3 | Alanine--tRNA ligase | 2.70e-01 | 5.60e-03 | NA | NA |
| 5. P | A9IK31 | Alanine--tRNA ligase | 4.80e-01 | 2.73e-02 | NA | NA |
| 5. P | Q3J0R1 | Alanine--tRNA ligase | 3.12e-01 | 2.73e-02 | NA | NA |
| 5. P | Q9RNN8 | Alanine--tRNA ligase | 4.20e-01 | 3.03e-02 | NA | NA |
| 5. P | B1ZC90 | Alanine--tRNA ligase | 2.74e-01 | 3.40e-02 | NA | NA |
| 5. P | A8ZY67 | Alanine--tRNA ligase | 4.74e-01 | 4.57e-02 | NA | NA |
| 5. P | A5W0D9 | Alanine--tRNA ligase | 3.61e-01 | 1.89e-02 | NA | NA |
| 5. P | A5FXC2 | Alanine--tRNA ligase | 3.59e-01 | 3.06e-02 | NA | NA |
| 5. P | Q7MHR6 | Alanine--tRNA ligase | 2.99e-01 | 3.64e-02 | NA | NA |
| 5. P | A4VJB3 | Alanine--tRNA ligase | 3.87e-01 | 8.04e-03 | NA | NA |
| 5. P | A6VA71 | Alanine--tRNA ligase | 3.71e-01 | 1.10e-02 | NA | NA |
| 5. P | B1KPS5 | Alanine--tRNA ligase | 3.86e-01 | 2.01e-02 | NA | NA |
| 5. P | Q4QM86 | Alanine--tRNA ligase | 4.56e-01 | 4.40e-02 | NA | NA |
| 5. P | A5VQX4 | Alanine--tRNA ligase | 2.95e-01 | 1.84e-02 | NA | NA |
| 5. P | Q085Z9 | Alanine--tRNA ligase | 3.97e-01 | 2.43e-02 | NA | NA |
| 5. P | Q885J0 | Alanine--tRNA ligase | 3.05e-01 | 3.74e-02 | NA | NA |
| 5. P | A6VKD6 | Alanine--tRNA ligase | 3.72e-01 | 1.15e-02 | NA | NA |
| 5. P | A7HH87 | Alanine--tRNA ligase | 3.04e-01 | 4.88e-02 | NA | NA |
| 5. P | Q2RQI0 | Alanine--tRNA ligase | 2.88e-01 | 9.42e-03 | NA | NA |
| 5. P | A1S4E9 | Alanine--tRNA ligase | 4.12e-01 | 6.78e-03 | NA | NA |
| 5. P | Q07R87 | Alanine--tRNA ligase | 2.87e-01 | 2.36e-02 | NA | NA |
| 5. P | A3D783 | Alanine--tRNA ligase | 4.01e-01 | 2.06e-02 | NA | NA |
| 5. P | A4Y931 | Alanine--tRNA ligase | 4.04e-01 | 3.67e-02 | NA | NA |
| 5. P | A8H1T6 | Alanine--tRNA ligase | 3.55e-01 | 8.62e-03 | NA | NA |
| 5. P | Q2YRU8 | Alanine--tRNA ligase | 2.97e-01 | 1.48e-02 | NA | NA |
| 5. P | Q1I6Z8 | Alanine--tRNA ligase | 3.31e-01 | 1.97e-02 | NA | NA |
| 5. P | A9M5L7 | Alanine--tRNA ligase | 3.15e-01 | 1.48e-02 | NA | NA |
| 5. P | Q12PX7 | Alanine--tRNA ligase | 4.07e-01 | 1.08e-02 | NA | NA |
| 5. P | A1SJC7 | Alanine--tRNA ligase | 3.44e-01 | 4.97e-02 | NA | NA |
| 5. P | Q7VXE1 | Alanine--tRNA ligase | 4.76e-01 | 3.67e-02 | NA | NA |
| 5. P | Q39HB7 | Alanine--tRNA ligase | 4.16e-01 | 4.57e-02 | NA | NA |
| 5. P | Q1BX19 | Alanine--tRNA ligase | 3.68e-01 | 3.03e-02 | NA | NA |
| 5. P | Q8UE87 | Alanine--tRNA ligase | 3.26e-01 | 3.57e-02 | NA | NA |
| 5. P | Q2KY72 | Alanine--tRNA ligase | 4.67e-01 | 3.40e-02 | NA | NA |
| 5. P | A0LLA3 | Alanine--tRNA ligase | 3.28e-01 | 4.91e-03 | NA | NA |
| 5. P | Q5YTJ9 | Alanine--tRNA ligase | 2.54e-01 | 1.72e-02 | NA | NA |
| 5. P | A4XWE2 | Alanine--tRNA ligase | 4.14e-01 | 3.54e-02 | NA | NA |
| 5. P | Q8EBS1 | Alanine--tRNA ligase | 4.08e-01 | 2.04e-02 | NA | NA |
| 5. P | A6X0E9 | Alanine--tRNA ligase | 3.30e-01 | 2.89e-02 | NA | NA |
| 5. P | B0REK2 | Alanine--tRNA ligase | 3.16e-01 | 1.08e-02 | NA | NA |
| 5. P | A1T001 | Alanine--tRNA ligase | 5.04e-01 | 1.75e-02 | NA | NA |
| 5. P | Q4ZQI4 | Alanine--tRNA ligase | 3.48e-01 | 1.78e-02 | NA | NA |
| 5. P | B0KR43 | Alanine--tRNA ligase | 3.62e-01 | 1.68e-02 | NA | NA |
| 5. P | A6WR16 | Alanine--tRNA ligase | 3.81e-01 | 1.02e-02 | NA | NA |
| 5. P | A5UDR0 | Alanine--tRNA ligase | 4.45e-01 | 4.74e-02 | NA | NA |
| 5. P | P67009 | Alanine--tRNA ligase | 2.76e-01 | 1.48e-02 | NA | NA |
| 5. P | A8ICW8 | Alanine--tRNA ligase | 3.74e-01 | 1.00e-02 | NA | NA |
| 5. P | Q0BSD5 | Alanine--tRNA ligase | 3.29e-01 | 3.78e-02 | NA | NA |
| 5. P | A4WV47 | Alanine--tRNA ligase | 3.07e-01 | 2.10e-02 | NA | NA |
| 5. P | Q0HXF8 | Alanine--tRNA ligase | 4.07e-01 | 3.54e-02 | NA | NA |
| 5. P | A5V3L0 | Alanine--tRNA ligase | 2.77e-01 | 1.47e-02 | NA | NA |
| 5. P | A7IMR0 | Alanine--tRNA ligase | 3.18e-01 | 3.28e-02 | NA | NA |
| 5. P | A0L3J9 | Alanine--tRNA ligase | 2.59e-01 | 3.64e-02 | NA | NA |
| 5. P | A9NCN7 | Alanine--tRNA ligase | 3.48e-01 | 4.57e-02 | NA | NA |
| 5. P | Q3SLA9 | Alanine--tRNA ligase | 4.46e-01 | 3.41e-03 | NA | NA |
| 5. P | Q7VLK0 | Alanine--tRNA ligase | 2.90e-01 | 3.47e-02 | NA | NA |
| 5. P | Q88EI8 | Alanine--tRNA ligase | 3.64e-01 | 1.68e-02 | NA | NA |
| 5. P | A0KU94 | Alanine--tRNA ligase | 3.78e-01 | 1.97e-02 | NA | NA |
| 5. P | Q47AU8 | Alanine--tRNA ligase | 4.20e-01 | 4.44e-02 | NA | NA |
| 5. P | A1RHG5 | Alanine--tRNA ligase | 3.77e-01 | 3.67e-02 | NA | NA |
| 5. P | Q13AB9 | Alanine--tRNA ligase | 2.37e-01 | 3.64e-02 | NA | NA |
| 5. P | P70218 | Mitogen-activated protein kinase kinase kinase kinase 1 | 8.31e-01 | 2.55e-02 | NA | NA |
| 5. P | B0UTE1 | Alanine--tRNA ligase | 6.90e-01 | 4.83e-02 | NA | NA |
| 5. P | Q218Q3 | Alanine--tRNA ligase | 2.82e-01 | 1.89e-02 | NA | NA |
| 5. P | A9WSC4 | Alanine--tRNA ligase | 3.48e-01 | 4.57e-02 | NA | NA |
| 5. P | A9KG28 | Alanine--tRNA ligase | 3.38e-01 | 4.57e-02 | NA | NA |
| 5. P | B1K026 | Alanine--tRNA ligase | 3.91e-01 | 3.60e-02 | NA | NA |
| 5. P | A0K6N4 | Alanine--tRNA ligase | 2.96e-01 | 2.95e-02 | NA | NA |
| 5. P | Q1RKG2 | Alanine--tRNA ligase | 3.19e-01 | 3.64e-02 | NA | NA |
| 5. P | A5UHW6 | Alanine--tRNA ligase | 4.46e-01 | 4.52e-02 | NA | NA |
| 5. P | Q83CQ6 | Alanine--tRNA ligase | 4.42e-01 | 4.57e-02 | NA | NA |
| 5. P | A3QC89 | Alanine--tRNA ligase | 3.98e-01 | 7.88e-03 | NA | NA |
| 5. P | Q1AWA6 | Alanine--tRNA ligase | 3.30e-01 | 3.92e-02 | NA | NA |
| 5. P | B0UGC4 | Alanine--tRNA ligase | 3.21e-01 | 4.97e-02 | NA | NA |
| 5. P | Q3ST43 | Alanine--tRNA ligase | 3.44e-01 | 4.79e-02 | NA | NA |
| 5. P | Q8DC49 | Alanine--tRNA ligase | 3.39e-01 | 3.67e-02 | NA | NA |
| 5. P | A9KYF8 | Alanine--tRNA ligase | 4.08e-01 | 2.13e-02 | NA | NA |
| 5. P | Q4K843 | Alanine--tRNA ligase | 3.52e-01 | 3.50e-02 | NA | NA |
| 5. P | A1W7D0 | Alanine--tRNA ligase | 3.66e-01 | 4.40e-02 | NA | NA |
| 5. P | Q89I89 | Alanine--tRNA ligase | 3.18e-01 | 4.61e-02 | NA | NA |
| 5. P | Q7W6N4 | Alanine--tRNA ligase | 5.20e-01 | 4.36e-02 | NA | NA |
| 5. P | A5EML9 | Alanine--tRNA ligase | 2.64e-01 | 4.08e-02 | NA | NA |
| 7. B | P34534 | Putative DNA topoisomerase 2, mitochondrial | 1.55e-12 | NA | 1.03e-16 | NA |
| 7. B | Q00942 | DNA topoisomerase 2 | NA | NA | 4.76e-09 | NA |
| 7. B | Q9QSK1 | DNA topoisomerase 2 | NA | NA | 5.56e-14 | NA |
| 7. B | P08096 | DNA topoisomerase 2 | 1.48e-06 | NA | 8.58e-14 | NA |
| 7. B | Q64511 | DNA topoisomerase 2-beta | 3.82e-06 | NA | 2.88e-18 | NA |
| 7. B | P07065 | DNA topoisomerase medium subunit | NA | NA | 9.86e-27 | NA |
| 7. B | P15348 | DNA topoisomerase 2 | 2.12e-06 | NA | 6.70e-12 | NA |
| 7. B | P0C9C2 | DNA topoisomerase 2 | NA | NA | 8.80e-11 | NA |
| 7. B | P41516 | DNA topoisomerase 2-alpha | 2.06e-05 | NA | 3.11e-16 | NA |
| 7. B | Q23670 | DNA topoisomerase 2 top-2 | 1.60e-05 | NA | 3.67e-15 | NA |
| 7. B | O33149 | DNA gyrase subunit A (Fragment) | 1.97e-01 | NA | 2.09e-12 | NA |
| 7. B | Q01320 | DNA topoisomerase 2-alpha | 8.98e-08 | NA | 3.98e-16 | NA |
| 7. B | P34203 | DNA topoisomerase 2 | NA | NA | 2.88e-09 | NA |
| 7. B | P11388 | DNA topoisomerase 2-alpha | 1.79e-06 | NA | 2.40e-15 | NA |
| 7. B | P0C9C0 | DNA topoisomerase 2 | NA | NA | 3.68e-10 | NA |
| 7. B | O61078 | DNA topoisomerase 2 | NA | NA | 8.27e-17 | NA |
| 7. B | Q02880 | DNA topoisomerase 2-beta | 5.35e-05 | NA | 1.49e-18 | NA |
| 7. B | G5ECQ8 | DNA topoisomerase-like protein cin-4 | 3.77e-07 | NA | 2.35e-15 | NA |
| 7. B | P06786 | DNA topoisomerase 2 | 1.72e-05 | NA | 2.00e-15 | NA |
| 7. B | Q55BP5 | Probable DNA topoisomerase 2 | 3.52e-06 | NA | 2.30e-15 | NA |
| 7. B | Q5UQE6 | DNA topoisomerase 2 | NA | NA | 1.83e-15 | NA |
| 7. B | P0C9C1 | DNA topoisomerase 2 | NA | NA | 3.43e-10 | NA |
| 7. B | P30182 | DNA topoisomerase 2 | 7.97e-08 | NA | 2.20e-13 | NA |
| 7. B | Q196X4 | DNA topoisomerase 2 | NA | NA | 5.07e-14 | NA |
| 7. B | P90520 | DNA topoisomerase 2, mitochondrial | 1.29e-08 | NA | 9.13e-18 | NA |