Summary
The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.
AVX54589.1
JCVISYN3A_0034
Uncharacterized efflux ABC transporter permease.
M. mycoides homolog: Q6MUJ8.
TIGRfam Classification: 2=Generic.
Category: Nonessential.
Statistics
Total GO Annotation: 12
Unique PROST Go: 0
Unique BLAST Go: 0
Unique Foldseek Go: 9
Total Homologs: 52
Unique PROST Homologs: 2
Unique BLAST Homologs: 0
Unique Foldseek Homologs: 48
Structures and Sequence Alignment
The best structural homolog that predicted by 6. F was
Q4L8L8
(Putative hemin transport system permease protein HrtB) with a FATCAT P-Value: 0.00715 and RMSD of 3.01 angstrom. The sequence alignment identity is 6.8%.
Structural alignment shown in left. Query protein AVX54589.1 colored as red in alignment, homolog Q4L8L8 colored as blue.
Query protein AVX54589.1 is also shown in right top, homolog Q4L8L8 showed in right bottom. They are colored based on secondary structures.
AVX54589.1 MKNLYLMLKQGVKWILKFKLQLIVIVVLTFIASSILTISFTTNKRLSSAYDQVVNNQKSPKFDSTYQITVGSKAKPEKGDPLFIPIFDFVDKQYTGFKDE 100 Q4L8L8 ---------------------------------------------------------------------------------------------------- 0 AVX54589.1 GYDNFNLAFNDIYKNKDLLTITTSSQEFKDAWAKKKEVFEYKENLDDIKQLSKEQEQFDFAINDVFFNTMAELLSKNDPAIKNTVIGRYTLSNPNWYKHF 200 Q4L8L8 ---------------------------------------------------------------------------------------------------- 0 AVX54589.1 YDKEKNIKSNWSEFIKDKQKIENLKKSNPDDLKTYFYSYYAFESLSQYFFKTIQTFLQNKDSELAQQSNNNKNEAHKYFYEFLFGKYFDNNKASYKEDYI 300 Q4L8L8 ---------------------------------------------------------------------------------------------------- 0 AVX54589.1 ANNNNLYTLTFDSTVSSSEFEKMNFLISSENKEQNSQDQNFFNELVKKGFKGILRPLQITYQNFGDQV-DIKNVVQYSETQELRGFVSNSNI-YSQNVKE 398 Q4L8L8 ----------------------MN-LAWKEIK--------FYR------FRYTLIML-IIFL-LGSMVLFISGLAQ--------G-LARENISYLNN--- 49 AVX54589.1 LP-EIFKNNSFVDILAMNADPFANIGEKS-VNFYTSKTNDLETTVASDFPITAAFLTHHKLTALANG-YDLYIRPETIFNDPITKKTFRIVDITNKDFTN 495 Q4L8L8 MPAEHY-------IVEDNKEP--KL-ESSQLN--QSQQNKIEK------------IIHENATQM--GTQTLKINQQD--QDVITLNTPK--HLTPK---- 115 AVX54589.1 YIILDGQTPSSASEITISKQFAKANKIQIGDRLTL-G---NAKGLIVTGYAVDT-YSFFPTSDPNVPLPKSDSGGLIYADFATINQILGDGNSATGNDQT 590 Q4L8L8 --LVSGNYPKKQNEIAISEKLT-GNDLKVGDTVTFKGHHHNYK---ISGIMNESMY-----SHSSMILMNKEA-------FKSLNK------------QV 185 AVX54589.1 STFNFFL--IKKNN--SL-NIKNVFFDHFSVANR--IRDNILAKQKGTEIQTFYQEYEFSNSWYSLNWTLYQKIAFWYSLATFLTASLIALVSALAVFVG 683 Q4L8L8 STF-YPVDKINKDNKESLKQIKGI-----KVVNEKALTDNIAS----------YQAEQM-----PLN--LM--I---ISL--FV---ITAIV--LSAFFY 250 AVX54589.1 VIKSIQANSK--QIGILKANGASSATISWSYVSYAVILVFIAIPLGWMAGTMLQVPFVAIFKDYFSFKTN--VLIYDWLAPLISIIIFGVLIGVFSFLVA 779 Q4L8L8 VM-TIQ---KIPQIGILKAIG-----IKTKHLLTALLLQII---LTTMVGVILAFSVILILNAFMPV-TMPFYLSYSQV--LLMIVVF-LIVGLIGALLS 334 AVX54589.1 LFHIK--K--PVLDIIKSSKKWSKPKITDWLHKRIFKKPRFATLLMLKLTESGKKPFSLLLVLVFVGTLFVSAGVAIPSVTKYAKDNYFKKVNYDNQYEI 875 Q4L8L8 -F-IKVLKVDP-IEAIGGME-------------------------------------------------------------------------------- 351 AVX54589.1 YNSLSNSPLGKDVFNFWNGHEQIDNTYKEVKDPSGTINYYEDPNSYTLSNQNSSVLPQLIYKINTNKNNDSNNAEILTPYKSIIKEYLKTGVSNLYKNLL 975 Q4L8L8 ---------------------------------------------------------------------------------------------------- 351 AVX54589.1 DWASYQISISNGKSISIGTIEQLYAYILNDADLNERFKNDIDKVKETNNVTQPLTQFVGELLKTIFKDKVQTTGEWKEKILNLILGYSPSFIKSYLTSES 1075 Q4L8L8 ---------------------------------------------------------------------------------------------------- 351 AVX54589.1 RRAQFSFGWQKQTIIPQKDQLATIFKPKSNNIETNYSILGLDKNQQTYKLSDKQKNQLFLSNNQVQKLYQIINNPYDKNQNDDIYLNNIKVYDHKTNTLT 1175 Q4L8L8 ---------------------------------------------------------------------------------------------------- 351 AVX54589.1 IPTIVNKNLNYKLNKFGDNIISNLSANNIQLSYKTRNNDFNVLPKQAWIYDDSDYLKTEYVNKHTKWEDQPIQIINNKNNSSSYGYEVVENDNEKYYYLN 1275 Q4L8L8 ---------------------------------------------------------------------------------------------------- 351 AVX54589.1 PYNLDVNKFTQRQVIDIWSNNSNSSLVAKQHENIVDESPLFGDFVINNNGQITKSFIRPYYQLRNLLLFVPITNQVSWEDFALYASGWSESAEHGLDIKR 1375 Q4L8L8 ---------------------------------------------------------------------------------------------------- 351 AVX54589.1 VISDLDKTDDHTRNYKYPAIKKLNASLVPQSVKNGWQSVIKDLKSDTAYLAIRPYDFSIQQEKWANNHYEYFILDNSTKKILGVNPPSADKSIPNILLNS 1475 Q4L8L8 ---------------------------------------------------------------------------------------------------- 351 AVX54589.1 VPHFYRRAVGKRKSIPAILKLQDKNVSYVNKDLKIKLQKVDDIDIYGKAYALVDSDLANMLYGFDISRSTNYDYRPFDTSKIIKKGELFNTYKTTNWLKV 1575 Q4L8L8 ---------------------------------------------------------------------------------------------------- 351 AVX54589.1 NNKDPWKQAFISQKDTFSYSPHYYYNTIFSNSSEPLIITSSVSLISEQRLGIAILDLMNLSDYKAGIVDVDFTFETKQLLNQIAKTAIYIAIIIITAIML 1675 Q4L8L8 ---------------------------------------------------------------------------------------------------- 351 AVX54589.1 CASLLIMLITDIYISQYKSFMIMLRSMGYTNTQVMFYTLGIATIFSLLISFITTIIVFSSTSIIDKVFSANGFSIPINVYWVSVVFCILLILVSFFTSLW 1775 Q4L8L8 ---------------------------------------------------------------------------------------------------- 351 AVX54589.1 VSTKRVRNAEPSTMLSEVDE 1795 Q4L8L8 -------------------- 351
Go Annotations
1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.
| Source | GO | Description |
|---|---|---|
| 1. PBF | GO:0022857 | transmembrane transporter activity |
| 4. PB | GO:0005886 | plasma membrane |
| 4. PB | GO:0016021 | integral component of membrane |
| 6. F | GO:0015562 | efflux transmembrane transporter activity |
| 6. F | GO:0005887 | integral component of plasma membrane |
| 6. F | GO:2001070 | starch binding |
| 6. F | GO:0005524 | ATP binding |
| 6. F | GO:0008559 | ABC-type xenobiotic transporter activity |
| 6. F | GO:0042908 | xenobiotic transport |
| 6. F | GO:0046677 | response to antibiotic |
| 6. F | GO:1990961 | xenobiotic detoxification by transmembrane export across the plasma membrane |
| 6. F | GO:0015893 |
Uniprot GO Annotations
| GO | Description |
|---|---|
| GO:0005886 | plasma membrane |
| GO:0016020 | membrane |
| GO:0016021 | integral component of membrane |
Homologs
1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.
| Source | Homolog | Description | Fatcat Pvalue | PROST Evalue | BLAST Evalue | Foldseek TMScore |
|---|---|---|---|---|---|---|
| 1. PBF | P75613 | Uncharacterized ABC transporter permease MG064 homolog | 1.95e-06 | 4.24e-09 | 1.16e-04 | 0.4725 |
| 1. PBF | P47310 | Uncharacterized ABC transporter permease MG064 | 4.24e-06 | 2.12e-12 | 1.17e-04 | 0.4706 |
| 5. P | O53900 | Uncharacterized ABC transporter permease protein Rv0987 | 1.17e-02 | 2.42e-02 | NA | NA |
| 5. P | P77504 | Uncharacterized ABC transporter permease YbbP | 7.85e-03 | 3.77e-02 | NA | NA |
| 6. F | Q2EHL8 | Macrolide export ATP-binding/permease protein MacB | 7.62e-02 | NA | NA | 0.25 |
| 6. F | P0C2H3 | Macrolide export ATP-binding/permease protein MacB 2 | 8.73e-02 | NA | NA | 0.4422 |
| 6. F | A0L0V9 | Macrolide export ATP-binding/permease protein MacB | 1.80e-01 | NA | NA | 0.45 |
| 6. F | Q2KVS6 | Macrolide export ATP-binding/permease protein MacB | 1.61e-01 | NA | NA | 0.3993 |
| 6. F | Q6MPX9 | Macrolide export ATP-binding/permease protein MacB | 6.83e-02 | NA | NA | 0.4159 |
| 6. F | Q884D4 | Macrolide export ATP-binding/permease protein MacB 1 | 8.41e-02 | NA | NA | 0.4129 |
| 6. F | Q0C1N8 | Macrolide export ATP-binding/permease protein MacB | 1.40e-01 | NA | NA | 0.3769 |
| 6. F | A1BE50 | Macrolide export ATP-binding/permease protein MacB | 1.06e-01 | NA | NA | 0.3219 |
| 6. F | Q87JM4 | Macrolide export ATP-binding/permease protein MacB | 9.54e-02 | NA | NA | 0.4454 |
| 6. F | Q88F88 | Macrolide export ATP-binding/permease protein MacB | 9.34e-02 | NA | NA | 0.3955 |
| 6. F | Q6F813 | Macrolide export ATP-binding/permease protein MacB | 5.26e-02 | NA | NA | 0.3271 |
| 6. F | P94412 | Uncharacterized ABC transporter permease YclI | 2.60e-02 | NA | NA | 0.3206 |
| 6. F | Q7M8U0 | Macrolide export ATP-binding/permease protein MacB | 1.13e-01 | NA | NA | 0.3839 |
| 6. F | A1BCE9 | Macrolide export ATP-binding/permease protein MacB 3 | 1.78e-02 | NA | NA | 0.4181 |
| 6. F | Q2NSZ1 | Macrolide export ATP-binding/permease protein MacB | 8.37e-02 | NA | NA | 0.3979 |
| 6. F | O34741 | Bacitracin export permease protein BceB | 1.65e-02 | NA | NA | 0.3605 |
| 6. F | Q8EIL8 | Macrolide export ATP-binding/permease protein MacB | 9.55e-02 | NA | NA | 0.4555 |
| 6. F | Q6D8T5 | Macrolide export ATP-binding/permease protein MacB | 6.98e-02 | NA | NA | 0.4339 |
| 6. F | Q7CHI2 | Macrolide export ATP-binding/permease protein MacB 1 | 9.06e-02 | NA | NA | 0.4627 |
| 6. F | A1K323 | Macrolide export ATP-binding/permease protein MacB | 1.10e-01 | NA | NA | 0.3888 |
| 6. F | Q5HVG3 | Macrolide export ATP-binding/permease protein MacB | 1.84e-01 | NA | NA | 0.4152 |
| 6. F | Q668L6 | Macrolide export ATP-binding/permease protein MacB 2 | 5.15e-02 | NA | NA | 0.428 |
| 6. F | Q7VMF9 | Macrolide export ATP-binding/permease protein MacB | 7.32e-02 | NA | NA | 0.3933 |
| 6. F | Q8UKE4 | Macrolide export ATP-binding/permease protein MacB | 9.15e-02 | NA | NA | 0.4254 |
| 6. F | Q5P6D5 | Macrolide export ATP-binding/permease protein MacB | 1.38e-01 | NA | NA | 0.4048 |
| 6. F | P0C2H2 | Macrolide export ATP-binding/permease protein MacB | 1.43e-01 | NA | NA | 0.4537 |
| 6. F | Q3JGG7 | Macrolide export ATP-binding/permease protein MacB | 6.52e-02 | NA | NA | 0.4381 |
| 6. F | A0RP01 | Macrolide export ATP-binding/permease protein MacB | 1.17e-01 | NA | NA | 0.3342 |
| 6. F | Q4ZT65 | Macrolide export ATP-binding/permease protein MacB 2 | 7.53e-02 | NA | NA | 0.4245 |
| 6. F | Q3ATR5 | Macrolide export ATP-binding/permease protein MacB | 6.93e-02 | NA | NA | 0.4405 |
| 6. F | Q1QDA8 | Macrolide export ATP-binding/permease protein MacB | 7.30e-02 | NA | NA | 0.4647 |
| 6. F | Q9K0N7 | Macrolide export ATP-binding/permease protein MacB | 6.95e-02 | NA | NA | 0.4306 |
| 6. F | Q6FYL0 | Macrolide export ATP-binding/permease protein MacB | 7.43e-02 | NA | NA | 0.4262 |
| 6. F | Q1C5W7 | Macrolide export ATP-binding/permease protein MacB 2 | 5.21e-02 | NA | NA | 0.4324 |
| 6. F | Q4FU75 | Macrolide export ATP-binding/permease protein MacB | 8.26e-02 | NA | NA | 0.47 |
| 6. F | A0KGB3 | Macrolide export ATP-binding/permease protein MacB 1 | 1.84e-01 | NA | NA | 0.3809 |
| 6. F | Q5HLN3 | Putative hemin transport system permease protein HrtB | 1.17e-02 | NA | NA | 0.444 |
| 6. F | A1VYW8 | Macrolide export ATP-binding/permease protein MacB | 9.98e-02 | NA | NA | 0.4224 |
| 6. F | A1RG29 | Macrolide export ATP-binding/permease protein MacB | 1.84e-01 | NA | NA | 0.4561 |
| 6. F | A1B677 | Macrolide export ATP-binding/permease protein MacB 1/2 | 9.43e-02 | NA | NA | 0.4419 |
| 6. F | Q5MK06 | Macrolide export ATP-binding/permease protein MacB | 5.94e-02 | NA | NA | 0.4367 |
| 6. F | Q0PAR0 | Macrolide export ATP-binding/permease protein MacB | 1.24e-01 | NA | NA | 0.3845 |
| 6. F | Q4L8L8 | Putative hemin transport system permease protein HrtB | 7.15e-03 | NA | NA | 0.4332 |
| 6. F | Q9JVR5 | Macrolide export ATP-binding/permease protein MacB | 7.36e-02 | NA | NA | 0.4317 |
| 6. F | O31712 | Uncharacterized ABC transporter permease YknZ | 2.75e-02 | NA | NA | 0.3749 |
| 6. F | Q89NX6 | Macrolide export ATP-binding/permease protein MacB | 5.47e-02 | NA | NA | 0.4153 |
| 6. F | Q6G1V5 | Macrolide export ATP-binding/permease protein MacB | 9.28e-02 | NA | NA | 0.4184 |
| 6. F | Q1CJW8 | Macrolide export ATP-binding/permease protein MacB 1 | 7.94e-02 | NA | NA | 0.4262 |