Summary
The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.
AVX54613.1
JCVISYN3A_0097
Uncharacterized 5'-3' exonuclease.
M. mycoides homolog: Q6MUE1.
TIGRfam Classification: 2=Generic.
Category: Quasiessential.
Statistics
Total GO Annotation: 51
Unique PROST Go: 9
Unique BLAST Go: 1
Unique Foldseek Go: 3
Total Homologs: 352
Unique PROST Homologs: 37
Unique BLAST Homologs: 2
Unique Foldseek Homologs: 15
Literature
Danchin and Fang [1]: proofreading 5'3'-exonuclease|exonuclease activity associated to PolA; the 5'-3' exonuclease activity encoded by either polA or ypcP xni was required for the growth of B. subtilis and E. coli; essential domain
Yang and Tsui [2]: DNA polymerase I, 5' 3' exonuclease
Antczak et al. [3]: 5'-3' exonuclease
Zhang et al. [4]: GO:0017108|5'-flap endonuclease activity
Bianchi et al. [5]: 5'-3' exonuclease (fenA/yycJ-like)
Structures and Sequence Alignment
The best structural homolog that predicted by 1. PBF was
Q1CFD3
(Flap endonuclease Xni) with a FATCAT P-Value: 0 and RMSD of 2.12 angstrom. The sequence alignment identity is 21.8%.
Structural alignment shown in left. Query protein AVX54613.1 colored as red in alignment, homolog Q1CFD3 colored as blue.
Query protein AVX54613.1 is also shown in right top, homolog Q1CFD3 showed in right bottom. They are colored based on secondary structures.
AVX54613.1 MITNETKPILLIDGYHLLHKGYYGTLKRTIVSKNKDGI-VINAIYSFVANILKFVQSDRYHSVIVAFDFDE--NCWRKELYSEYKAKRKPTPID-LVPQL 96 Q1CFD3 MQIH----LLIVDALNLI---------RRIHAVQ--GSPCVKACQHALQQLIQ--HSQPSHAVAV-FDEDDRSDSWRHQCLPDYKAGRSPMP-DNLQQEM 81 AVX54613.1 QIARDFLTSANIS-WYEKYNYEGDDVIGS-ICRIANKLGYDVCILTNDKDIY-QLVNNKTSIITNISKKE---KTKIIKPQQVYEHF--LCQPNQVADIK 188 Q1CFD3 PLIRQAFNELGVACWHSPGN-EADDLAATLVVKVAG-AGHQVTIVSTDKG-YCQL------LAPNIQIRDYFQKRWLDMP-FVKQEFGVL--PRQLPDYW 169 AVX54613.1 AILGDQSDNIKGVKYIKRKQAENLINKYENVENILAHINELNEPLKTIISENKQLIIDNKKITKILTNVKL-GRINFKPTKITYYGLIRFLKEQEMYAFI 287 Q1CFD3 GLAGISSSKIPGVAGVGAKTATLLLQQADTLEVLYQNLESIPEKWRKKLQQHQQMAFTCKQIATLKTDLLLSGNLQ----------QLR-LKK------- 251 AVX54613.1 KPIRRYLDRTNKNLKK 303 Q1CFD3 ---------------- 251
Go Annotations
1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.
| Source | GO | Description |
|---|---|---|
| 1. PBF | GO:0003677 | DNA binding |
| 1. PBF | GO:0030955 | potassium ion binding |
| 1. PBF | GO:0004527 | exonuclease activity |
| 1. PBF | GO:0006281 | DNA repair |
| 1. PBF | GO:0008409 | 5'-3' exonuclease activity |
| 1. PBF | GO:0017108 | 5'-flap endonuclease activity |
| 1. PBF | GO:0005737 | cytoplasm |
| 1. PBF | GO:0000287 | magnesium ion binding |
| 1. PBF | GO:0033567 | DNA replication, Okazaki fragment processing |
| 2. PF | GO:0003723 | RNA binding |
| 2. PF | GO:0006286 | obsolete base-excision repair, base-free sugar-phosphate removal |
| 2. PF | GO:0043137 | DNA replication, removal of RNA primer |
| 2. PF | GO:0006284 | base-excision repair |
| 2. PF | GO:0070914 | UV-damage excision repair |
| 2. PF | GO:0007534 | gene conversion at mating-type locus |
| 2. PF | GO:0035753 | maintenance of DNA trinucleotide repeats |
| 2. PF | GO:0004523 | RNA-DNA hybrid ribonuclease activity |
| 2. PF | GO:0005739 | mitochondrion |
| 2. PF | GO:0046872 | metal ion binding |
| 2. PF | GO:0045876 | positive regulation of sister chromatid cohesion |
| 2. PF | GO:0035861 | site of double-strand break |
| 2. PF | GO:0051908 | double-stranded DNA 5'-3' exodeoxyribonuclease activity |
| 2. PF | GO:0005730 | nucleolus |
| 2. PF | GO:0006303 | double-strand break repair via nonhomologous end joining |
| 2. PF | GO:0006260 | DNA replication |
| 2. PF | GO:0045145 | single-stranded DNA 5'-3' exodeoxyribonuclease activity |
| 2. PF | GO:0006309 | apoptotic DNA fragmentation |
| 2. PF | GO:0005654 | nucleoplasm |
| 3. BF | GO:0006261 | DNA-dependent DNA replication |
| 3. BF | GO:0006302 | double-strand break repair |
| 3. BF | GO:0008408 | 3'-5' exonuclease activity |
| 3. BF | GO:0003887 | DNA-directed DNA polymerase activity |
| 3. BF | GO:0001882 | nucleoside binding |
| 4. PB | GO:0035312 | 5'-3' exodeoxyribonuclease activity |
| 4. PB | GO:1990238 | double-stranded DNA endodeoxyribonuclease activity |
| 4. PB | GO:0004529 | exodeoxyribonuclease activity |
| 4. PB | GO:0019034 | viral replication complex |
| 4. PB | GO:0019086 | late viral transcription |
| 5. P | GO:0099015 | degradation of host chromosome by virus |
| 5. P | GO:0032201 | telomere maintenance via semi-conservative replication |
| 5. P | GO:0090305 | nucleic acid phosphodiester bond hydrolysis |
| 5. P | GO:0007613 | memory |
| 5. P | GO:0048256 | flap endonuclease activity |
| 5. P | GO:0008309 | double-stranded DNA exodeoxyribonuclease activity |
| 5. P | GO:0000781 | chromosome, telomeric region |
| 5. P | GO:0004519 | endonuclease activity |
| 5. P | GO:0030145 | manganese ion binding |
| 6. F | GO:0008270 | zinc ion binding |
| 6. F | GO:0035061 | interchromatin granule |
| 6. F | GO:0008311 | double-stranded DNA 3'-5' exodeoxyribonuclease activity |
| 7. B | GO:0005886 | plasma membrane |
Uniprot GO Annotations
| GO | Description |
|---|---|
| GO:0016740 | transferase activity |
| GO:0016779 | nucleotidyltransferase activity |
| GO:0003677 | DNA binding |
| GO:0016788 | hydrolase activity, acting on ester bonds |
| GO:0090305 | nucleic acid phosphodiester bond hydrolysis |
| GO:0004527 | exonuclease activity |
| GO:0017108 | 5'-flap endonuclease activity |
| GO:0090304 | nucleic acid metabolic process |
| GO:0003887 | DNA-directed DNA polymerase activity |
| GO:0071897 | DNA biosynthetic process |
| GO:0003824 | catalytic activity |
| GO:0033567 | DNA replication, Okazaki fragment processing |
Homologs
1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.
| Source | Homolog | Description | Fatcat Pvalue | PROST Evalue | BLAST Evalue | Foldseek TMScore |
|---|---|---|---|---|---|---|
| 1. PBF | B5RDV0 | Flap endonuclease Xni | 0.00e+00 | 2.39e-31 | 8.55e-16 | 0.8559 |
| 1. PBF | B6I6J6 | Flap endonuclease Xni | 0.00e+00 | 6.74e-32 | 7.14e-13 | 0.8513 |
| 1. PBF | Q98PK2 | 5'-3' exonuclease | 0.00e+00 | 3.83e-61 | 2.35e-27 | 0.8326 |
| 1. PBF | A1JP96 | Flap endonuclease Xni | 0.00e+00 | 1.07e-30 | 8.06e-12 | 0.8669 |
| 1. PBF | B7MLB9 | Flap endonuclease Xni | 0.00e+00 | 1.53e-31 | 9.84e-13 | 0.8522 |
| 1. PBF | A1SYB8 | Flap endonuclease Xni | 0.00e+00 | 4.88e-35 | 7.68e-15 | 0.8357 |
| 1. PBF | Q3ICC5 | Flap endonuclease Xni | 0.00e+00 | 3.42e-30 | 1.49e-16 | 0.8687 |
| 1. PBF | B5QWQ6 | Flap endonuclease Xni | 0.00e+00 | 2.39e-31 | 8.55e-16 | 0.8534 |
| 1. PBF | P57506 | 5'-3' exonuclease | 0.00e+00 | 1.58e-61 | 3.79e-26 | 0.8172 |
| 1. PBF | B1XDK7 | Flap endonuclease Xni | 0.00e+00 | 6.74e-32 | 7.14e-13 | 0.858 |
| 1. PBF | Q2NRJ8 | Flap endonuclease Xni | 0.00e+00 | 6.47e-32 | 1.69e-15 | 0.9014 |
| 1. PBF | Q7N8Q9 | Flap endonuclease Xni | 0.00e+00 | 5.24e-33 | 4.24e-15 | 0.8731 |
| 1. PBF | A3QGM4 | Flap endonuclease Xni | 0.00e+00 | 3.34e-31 | 9.24e-11 | 0.8487 |
| 1. PBF | A3D2C6 | Flap endonuclease Xni | 0.00e+00 | 7.82e-38 | 7.31e-15 | 0.8267 |
| 1. PBF | B7VJ90 | Flap endonuclease Xni | 0.00e+00 | 4.32e-33 | 1.69e-08 | 0.8327 |
| 1. PBF | P54161 | 5'-3' exonuclease | 0.00e+00 | 1.18e-65 | 3.05e-33 | 0.8668 |
| 1. PBF | A6WL18 | Flap endonuclease Xni | 0.00e+00 | 5.70e-39 | 1.42e-15 | 0.8235 |
| 1. PBF | B5F4R7 | Flap endonuclease Xni | 0.00e+00 | 2.88e-31 | 1.31e-15 | 0.8556 |
| 1. PBF | C6DAH2 | Flap endonuclease Xni | 0.00e+00 | 3.43e-38 | 1.24e-13 | 0.854 |
| 1. PBF | C0PXF9 | Flap endonuclease Xni | 0.00e+00 | 3.55e-31 | 6.45e-15 | 0.8555 |
| 1. PBF | A4Y4Y4 | Flap endonuclease Xni | 0.00e+00 | 1.48e-37 | 1.45e-13 | 0.8254 |
| 1. PBF | Q0TE61 | Flap endonuclease Xni | 0.00e+00 | 2.02e-31 | 1.08e-12 | 0.8507 |
| 1. PBF | Q667H8 | Flap endonuclease Xni | 0.00e+00 | 2.59e-31 | 1.62e-12 | 0.8703 |
| 1. PBF | P75403 | 5'-3' exonuclease | 0.00e+00 | 9.35e-59 | 1.12e-34 | 0.8733 |
| 1. PBF | B7MZ94 | Flap endonuclease Xni | 0.00e+00 | 1.53e-31 | 9.11e-13 | 0.8527 |
| 1. PBF | Q1CFD3 | Flap endonuclease Xni | 0.00e+00 | 3.27e-31 | 2.18e-12 | 0.869 |
| 1. PBF | Q83JW7 | Flap endonuclease Xni | 0.00e+00 | 6.89e-32 | 8.26e-13 | 0.8582 |
| 1. PBF | Q5PEL3 | Flap endonuclease Xni | 0.00e+00 | 1.50e-31 | 1.34e-15 | 0.8573 |
| 1. PBF | B5FTX5 | Flap endonuclease Xni | 0.00e+00 | 2.39e-31 | 8.55e-16 | 0.874 |
| 1. PBF | A7ZQP2 | Flap endonuclease Xni | 0.00e+00 | 6.74e-32 | 7.14e-13 | 0.8559 |
| 1. PBF | A7FFF8 | Flap endonuclease Xni | 0.00e+00 | 2.59e-31 | 1.62e-12 | 0.8702 |
| 1. PBF | B7LEX6 | Flap endonuclease Xni | 0.00e+00 | 6.74e-32 | 7.14e-13 | 0.8526 |
| 1. PBF | B2JZ46 | Flap endonuclease Xni | 0.00e+00 | 2.59e-31 | 1.62e-12 | 0.8702 |
| 1. PBF | A7MR03 | Flap endonuclease Xni | 0.00e+00 | 4.29e-30 | 5.51e-15 | 0.8908 |
| 1. PBF | B7LXL4 | Flap endonuclease Xni | 0.00e+00 | 6.74e-32 | 7.14e-13 | 0.8511 |
| 1. PBF | Q6D8F6 | Flap endonuclease Xni | 0.00e+00 | 1.71e-39 | 1.17e-14 | 0.8575 |
| 1. PBF | B8EAT2 | Flap endonuclease Xni | 0.00e+00 | 2.61e-38 | 2.24e-15 | 0.8155 |
| 1. PBF | Q7MN34 | Flap endonuclease Xni | 0.00e+00 | 4.75e-36 | 4.42e-12 | 0.8309 |
| 1. PBF | Q57KE5 | Flap endonuclease Xni | 0.00e+00 | 3.55e-31 | 6.45e-15 | 0.8575 |
| 1. PBF | A9KTM9 | Flap endonuclease Xni | 0.00e+00 | 1.14e-38 | 1.13e-15 | 0.8254 |
| 1. PBF | B8CS65 | Flap endonuclease Xni | 0.00e+00 | 1.12e-34 | 1.01e-11 | 0.8407 |
| 1. PBF | A8AP08 | Flap endonuclease Xni | 0.00e+00 | 6.20e-32 | 7.47e-14 | 0.8811 |
| 1. PBF | A4SQK3 | Flap endonuclease Xni | 0.00e+00 | 1.51e-37 | 2.07e-15 | 0.8377 |
| 1. PBF | B7LVW5 | Flap endonuclease Xni | 0.00e+00 | 5.07e-31 | 6.23e-13 | 0.8736 |
| 1. PBF | A1S8B8 | Flap endonuclease Xni | 0.00e+00 | 9.87e-31 | 1.56e-12 | 0.8538 |
| 1. PBF | B1JQE9 | Flap endonuclease Xni | 0.00e+00 | 2.59e-31 | 1.62e-12 | 0.8678 |
| 1. PBF | Q9KTK4 | Flap endonuclease Xni | 0.00e+00 | 4.22e-33 | 2.62e-09 | 0.8446 |
| 1. PBF | B5FAT7 | Flap endonuclease Xni | 0.00e+00 | 1.15e-39 | 9.33e-07 | 0.8208 |
| 1. PBF | B5BF27 | Flap endonuclease Xni | 0.00e+00 | 1.50e-31 | 1.34e-15 | 0.8561 |
| 1. PBF | A8A3T3 | Flap endonuclease Xni | 0.00e+00 | 6.74e-32 | 7.14e-13 | 0.8531 |
| 1. PBF | Q0T161 | Flap endonuclease Xni | 0.00e+00 | 6.89e-32 | 8.26e-13 | 0.8563 |
| 1. PBF | A1RLT6 | Flap endonuclease Xni | 0.00e+00 | 1.10e-37 | 1.39e-13 | 0.8224 |
| 1. PBF | B4TGM7 | Flap endonuclease Xni | 0.00e+00 | 2.88e-31 | 1.19e-15 | 0.8567 |
| 1. PBF | A9N2I4 | Flap endonuclease Xni | 0.00e+00 | 2.88e-31 | 1.31e-15 | 0.8574 |
| 1. PBF | P9WNU2 | 5'-3' exonuclease | 0.00e+00 | 8.50e-50 | 7.14e-17 | 0.7848 |
| 1. PBF | Q1R7P3 | Flap endonuclease Xni | 0.00e+00 | 1.53e-31 | 9.84e-13 | 0.8556 |
| 1. PBF | Q12L39 | Flap endonuclease Xni | 0.00e+00 | 2.53e-34 | 5.84e-17 | 0.8479 |
| 1. PBF | Q32CC0 | Flap endonuclease Xni | 0.00e+00 | 6.74e-32 | 7.14e-13 | 0.8511 |
| 1. PBF | Q89AD1 | 5'-3' exonuclease | 0.00e+00 | 3.32e-66 | 5.02e-20 | 0.856 |
| 1. PBF | O67550 | 5'-3' exonuclease | 0.00e+00 | 9.20e-62 | 5.91e-29 | 0.8694 |
| 1. PBF | A1AEY5 | Flap endonuclease Xni | 0.00e+00 | 1.53e-31 | 9.84e-13 | 0.856 |
| 1. PBF | Q87RT0 | Flap endonuclease Xni | 0.00e+00 | 5.21e-35 | 2.57e-10 | 0.8283 |
| 1. PBF | B0TPG7 | Flap endonuclease Xni | 0.00e+00 | 2.44e-31 | 2.04e-11 | 0.8577 |
| 1. PBF | Q47YA8 | Flap endonuclease Xni | 0.00e+00 | 4.73e-44 | 1.57e-12 | 0.7903 |
| 1. PBF | Q8Z433 | Flap endonuclease Xni | 0.00e+00 | 1.19e-31 | 1.10e-15 | 0.8583 |
| 1. PBF | A4TLA4 | Flap endonuclease Xni | 0.00e+00 | 3.27e-31 | 2.18e-12 | 0.8729 |
| 1. PBF | C4L9Z0 | Flap endonuclease Xni | 0.00e+00 | 2.84e-30 | 8.80e-13 | 0.8456 |
| 1. PBF | Q8X6R9 | Flap endonuclease Xni | 0.00e+00 | 6.74e-32 | 7.14e-13 | 0.8523 |
| 1. PBF | A0KZ94 | Flap endonuclease Xni | 0.00e+00 | 2.99e-33 | 1.41e-12 | 0.8271 |
| 1. PBF | A8H6V6 | Flap endonuclease Xni | 0.00e+00 | 2.19e-31 | 9.61e-11 | 0.8502 |
| 1. PBF | A0KHE3 | Flap endonuclease Xni | 0.00e+00 | 9.96e-33 | 2.84e-15 | 0.8501 |
| 1. PBF | Q8DFB4 | Flap endonuclease Xni | 0.00e+00 | 3.72e-36 | 3.20e-11 | 0.8377 |
| 1. PBF | Q0HGN0 | Flap endonuclease Xni | 0.00e+00 | 6.59e-34 | 5.59e-14 | 0.8225 |
| 1. PBF | B7NVU6 | Flap endonuclease Xni | 0.00e+00 | 9.86e-32 | 2.74e-11 | 0.85 |
| 1. PBF | B4T4W5 | Flap endonuclease Xni | 0.00e+00 | 4.71e-32 | 4.30e-15 | 0.8572 |
| 1. PBF | Q31XJ2 | Flap endonuclease Xni | 0.00e+00 | 6.74e-32 | 7.14e-13 | 0.8519 |
| 1. PBF | B6EGG3 | Flap endonuclease Xni | 0.00e+00 | 1.31e-34 | 1.32e-06 | 0.8316 |
| 1. PBF | Q9KAV6 | 5'-3' exonuclease | 0.00e+00 | 3.07e-69 | 1.45e-30 | 0.8418 |
| 1. PBF | A6TD79 | Flap endonuclease Xni | 0.00e+00 | 1.07e-30 | 3.83e-18 | 0.8801 |
| 1. PBF | B4TUJ1 | Flap endonuclease Xni | 0.00e+00 | 1.93e-31 | 1.89e-15 | 0.857 |
| 1. PBF | Q6LN06 | Flap endonuclease Xni | 0.00e+00 | 1.10e-34 | 2.59e-11 | 0.8777 |
| 1. PBF | B1KQX1 | Flap endonuclease Xni | 0.00e+00 | 5.24e-33 | 1.44e-14 | 0.8651 |
| 1. PBF | Q8ZMC9 | Flap endonuclease Xni | 0.00e+00 | 2.88e-31 | 1.31e-15 | 0.8559 |
| 1. PBF | Q9PQ75 | 5'-3' exonuclease | 0.00e+00 | 1.45e-61 | 1.08e-29 | 0.8463 |
| 1. PBF | B5XUZ0 | Flap endonuclease Xni | 0.00e+00 | 1.07e-30 | 3.83e-18 | 0.8787 |
| 1. PBF | A8GIF8 | Flap endonuclease Xni | 0.00e+00 | 1.19e-31 | 8.01e-14 | 0.8801 |
| 1. PBF | Q9RJ79 | 5'-3' exonuclease | 0.00e+00 | 1.61e-47 | 5.04e-19 | 0.8032 |
| 1. PBF | A7MYB8 | Flap endonuclease Xni | 0.00e+00 | 1.40e-34 | 1.28e-09 | 0.8083 |
| 1. PBF | Q5E7A7 | Flap endonuclease Xni | 0.00e+00 | 3.63e-36 | 6.73e-07 | 0.8143 |
| 1. PBF | C5BHA5 | Flap endonuclease Xni | 0.00e+00 | 1.10e-31 | 6.26e-15 | 0.8696 |
| 1. PBF | Q7CH07 | Flap endonuclease Xni | 0.00e+00 | 3.27e-31 | 2.18e-12 | 0.8694 |
| 1. PBF | Q49406 | 5'-3' exonuclease | 0.00e+00 | 3.98e-58 | 1.33e-28 | 0.8649 |
| 1. PBF | C4ZZV3 | Flap endonuclease Xni | 0.00e+00 | 6.74e-32 | 7.14e-13 | 0.8516 |
| 1. PBF | Q8EGP9 | Flap endonuclease Xni | 0.00e+00 | 1.83e-39 | 1.79e-12 | 0.814 |
| 1. PBF | B7UHL4 | Flap endonuclease Xni | 0.00e+00 | 1.24e-31 | 2.72e-13 | 0.8553 |
| 1. PBF | Q07ZE8 | Flap endonuclease Xni | 0.00e+00 | 1.97e-32 | 5.08e-15 | 0.855 |
| 1. PBF | B2TZD5 | Flap endonuclease Xni | 0.00e+00 | 6.74e-32 | 7.14e-13 | 0.8565 |
| 1. PBF | Q8K9D0 | 5'-3' exonuclease | 0.00e+00 | 9.55e-57 | 9.59e-25 | 0.8312 |
| 1. PBF | A8FYJ2 | Flap endonuclease Xni | 0.00e+00 | 4.67e-35 | 6.51e-12 | 0.792 |
| 1. PBF | Q8FEF2 | Flap endonuclease Xni | 0.00e+00 | 1.53e-31 | 9.84e-13 | 0.8525 |
| 1. PBF | Q1CAP8 | Flap endonuclease Xni | 0.00e+00 | 3.54e-14 | 9.60e-10 | 0.7972 |
| 1. PBF | A9R2J1 | Flap endonuclease Xni | 2.32e-13 | 3.17e-07 | 1.56e-08 | 0.7865 |
| 1. PBF | Q0HSY6 | Flap endonuclease Xni | 0.00e+00 | 6.59e-34 | 5.59e-14 | 0.8212 |
| 1. PBF | Q3YY58 | Flap endonuclease Xni | 0.00e+00 | 6.74e-32 | 7.14e-13 | 0.8575 |
| 1. PBF | B7N732 | Flap endonuclease Xni | 0.00e+00 | 3.34e-31 | 6.67e-13 | 0.8695 |
| 2. PF | Q5ZLN4 | Flap endonuclease 1 | 5.08e-06 | 5.46e-08 | NA | 0.5865 |
| 2. PF | Q976H6 | Flap endonuclease 1 | 5.47e-07 | 7.59e-27 | NA | 0.5664 |
| 2. PF | Q9HJD4 | Flap endonuclease 1 | 1.08e-08 | 2.52e-25 | NA | 0.5877 |
| 2. PF | Q178M1 | Flap endonuclease 1 | 1.68e-06 | 7.30e-10 | NA | 0.604 |
| 2. PF | Q76F73 | Flap endonuclease 1 | 5.80e-05 | 5.41e-05 | NA | 0.5016 |
| 2. PF | A0RU95 | Flap endonuclease 1 | 3.73e-07 | 1.54e-22 | NA | 0.6321 |
| 2. PF | O29975 | Flap endonuclease 1 | 2.38e-08 | 1.52e-21 | NA | 0.5635 |
| 2. PF | D1ZT73 | Flap endonuclease 1 | 3.67e-06 | 6.93e-10 | NA | 0.4934 |
| 2. PF | B8C6S5 | Flap endonuclease 1 | 8.80e-07 | 9.02e-10 | NA | 0.5023 |
| 2. PF | A0CYG2 | Flap endonuclease 1-2 | 6.57e-07 | 2.61e-07 | NA | 0.6092 |
| 2. PF | B4LM90 | Flap endonuclease 1 | 8.99e-06 | 6.65e-08 | NA | 0.6069 |
| 2. PF | P61942 | Flap endonuclease 1 | 1.07e-06 | 8.21e-25 | NA | 0.6015 |
| 2. PF | B2VTT3 | Flap endonuclease 1 | 5.54e-06 | 6.84e-10 | NA | 0.4862 |
| 2. PF | Q75DS8 | Flap endonuclease 1 | 4.05e-06 | 5.70e-09 | NA | 0.5011 |
| 2. PF | A8XL25 | Flap endonuclease 1 | 5.30e-06 | 2.98e-07 | NA | 0.6241 |
| 2. PF | Q5B9L6 | Flap endonuclease 1 | 6.30e-06 | 5.08e-09 | NA | 0.4963 |
| 2. PF | A8B672 | Flap endonuclease 1 | 4.06e-06 | 9.39e-14 | NA | 0.5488 |
| 2. PF | P70040 | Flap endonuclease 1-A | 5.78e-06 | 1.34e-09 | NA | 0.5919 |
| 2. PF | B4QIG6 | Flap endonuclease 1 | 1.66e-06 | 5.48e-09 | NA | 0.6007 |
| 2. PF | C4YLS2 | Flap endonuclease 1 | 1.09e-05 | 9.02e-10 | NA | 0.5543 |
| 2. PF | C5JVG7 | Flap endonuclease 1 | 1.25e-06 | 4.35e-09 | NA | 0.5031 |
| 2. PF | B9WLQ5 | Flap endonuclease 1 | 1.08e-05 | 4.24e-11 | NA | 0.5539 |
| 2. PF | C1BM18 | Flap endonuclease 1 | 1.12e-06 | 2.26e-08 | NA | 0.6199 |
| 2. PF | C8BKD0 | Flap endonuclease 1 | 5.82e-06 | 1.19e-07 | NA | 0.5813 |
| 2. PF | C7Z125 | Flap endonuclease 1 | 1.51e-06 | 2.73e-08 | NA | 0.493 |
| 2. PF | A3CWV2 | Flap endonuclease 1 | 5.06e-06 | 2.54e-17 | NA | 0.5669 |
| 2. PF | Q8TIY5 | Flap endonuclease 1 | 3.85e-07 | 1.80e-19 | NA | 0.5449 |
| 2. PF | B3LQY3 | Flap endonuclease 1 | 6.06e-06 | 1.36e-07 | NA | 0.4926 |
| 2. PF | Q4P1V1 | Flap endonuclease 1 | 5.74e-07 | 2.72e-11 | NA | 0.4919 |
| 2. PF | C9ZKW4 | Flap endonuclease 1 | 1.20e-05 | 3.91e-06 | NA | 0.6152 |
| 2. PF | C5GPA7 | Flap endonuclease 1 | 1.25e-06 | 4.35e-09 | NA | 0.5022 |
| 2. PF | B0DSN9 | Flap endonuclease 1-A | 2.45e-08 | 4.86e-11 | NA | 0.5498 |
| 2. PF | A8NQC2 | Flap endonuclease 1 | 2.13e-05 | 4.61e-05 | NA | 0.5007 |
| 2. PF | A0B9M7 | Flap endonuclease 1 | 2.81e-06 | 2.61e-28 | NA | 0.5913 |
| 2. PF | Q6CLH4 | Flap endonuclease 1 | 4.41e-06 | 1.93e-09 | NA | 0.4868 |
| 2. PF | Q2NFD4 | Flap endonuclease 1 | 6.22e-12 | 4.19e-21 | NA | 0.6134 |
| 2. PF | B5DUR8 | Flap endonuclease 1 | 1.84e-06 | 8.09e-08 | NA | 0.5926 |
| 2. PF | Q9HQ27 | Flap endonuclease 1 | 1.24e-06 | 4.22e-19 | NA | 0.5226 |
| 2. PF | B3NP61 | Flap endonuclease 1 | 1.73e-06 | 2.02e-08 | NA | 0.5865 |
| 2. PF | Q12UT1 | Flap endonuclease 1 | 5.63e-07 | 3.22e-19 | NA | 0.5779 |
| 2. PF | Q5V5T7 | Flap endonuclease 1 | 1.28e-07 | 5.68e-18 | NA | 0.5361 |
| 2. PF | A9VB27 | Flap endonuclease 1 | 2.47e-06 | 1.90e-08 | NA | 0.5928 |
| 2. PF | Q7Q323 | Flap endonuclease 1 | 1.47e-06 | 1.13e-10 | NA | 0.599 |
| 2. PF | A7TJ59 | Flap endonuclease 1 | 5.17e-06 | 4.95e-08 | NA | 0.6158 |
| 2. PF | Q8ZYN2 | Flap endonuclease 1 | 9.32e-09 | 3.62e-22 | NA | 0.6154 |
| 2. PF | A2SQC6 | Flap endonuclease 1 | 1.92e-06 | 1.16e-21 | NA | 0.5291 |
| 2. PF | B0R5F5 | Flap endonuclease 1 | 3.43e-07 | 4.22e-19 | NA | 0.5431 |
| 2. PF | A9A4B0 | Flap endonuclease 1 | 6.32e-09 | 5.97e-21 | NA | 0.6143 |
| 2. PF | A1RWY2 | Flap endonuclease 1 | 2.48e-08 | 1.18e-18 | NA | 0.5951 |
| 2. PF | C6HQJ2 | Flap endonuclease 1 | 1.34e-06 | 9.02e-08 | NA | 0.4985 |
| 2. PF | A1RSC7 | Flap endonuclease 1 | 1.57e-08 | 6.84e-17 | NA | 0.6053 |
| 2. PF | A5ABU3 | Flap endonuclease 1 | 8.55e-07 | 1.97e-08 | NA | 0.494 |
| 2. PF | B0EN90 | Flap endonuclease 1 | 8.01e-07 | 1.47e-10 | NA | 0.5996 |
| 2. PF | B0XZ33 | Flap endonuclease 1 | 3.90e-06 | 7.08e-09 | NA | 0.4977 |
| 2. PF | Q6L2I9 | Flap endonuclease 1 | 7.71e-12 | 2.62e-25 | NA | 0.5501 |
| 2. PF | Q46D63 | Flap endonuclease 1 | 1.91e-08 | 1.10e-20 | NA | 0.5564 |
| 2. PF | B3MDA3 | Flap endonuclease 1 | 1.77e-06 | 3.77e-08 | NA | 0.5946 |
| 2. PF | A4QS18 | Flap endonuclease 1 | 7.32e-06 | 4.30e-09 | NA | 0.4998 |
| 2. PF | C5YUK3 | Flap endonuclease 1-A | 5.12e-06 | 5.83e-10 | NA | 0.6093 |
| 2. PF | Q013G9 | Flap endonuclease 1 | 7.01e-06 | 6.82e-09 | NA | 0.6356 |
| 2. PF | B8AMS4 | Flap endonuclease 1-B | 5.81e-06 | 3.26e-03 | NA | 0.5809 |
| 2. PF | A5UL52 | Flap endonuclease 1 | 8.33e-08 | 2.51e-20 | NA | 0.4987 |
| 2. PF | C7GVJ8 | Flap endonuclease 1 | 6.03e-06 | 1.28e-07 | NA | 0.492 |
| 2. PF | B4P5U9 | Flap endonuclease 1 | 1.81e-06 | 1.48e-08 | NA | 0.5988 |
| 2. PF | A7RRJ0 | Flap endonuclease 1 | 5.51e-06 | 1.02e-08 | NA | 0.5936 |
| 2. PF | B3RVF0 | Flap endonuclease 1 | 1.43e-06 | 2.76e-08 | NA | 0.5764 |
| 2. PF | A4HFE4 | Flap endonuclease 1 | 1.38e-05 | 5.80e-07 | NA | 0.625 |
| 2. PF | A8J2Z9 | Flap endonuclease 1 | 6.43e-06 | 1.93e-06 | NA | 0.6354 |
| 2. PF | D3BN56 | Flap endonuclease 1 | 2.82e-06 | 5.85e-09 | NA | 0.6079 |
| 2. PF | C5DZA9 | Flap endonuclease 1 | 8.74e-07 | 2.60e-08 | NA | 0.5974 |
| 2. PF | B8AW67 | Flap endonuclease 1-A | 5.99e-06 | 4.83e-08 | NA | 0.6285 |
| 2. PF | B6QT52 | Flap endonuclease 1 | 9.27e-07 | 4.11e-08 | NA | 0.508 |
| 2. PF | P0CS61 | Flap endonuclease 1 | 2.96e-05 | 4.37e-05 | NA | 0.5315 |
| 2. PF | B4KNM1 | Flap endonuclease 1 | 2.44e-06 | 8.29e-08 | NA | 0.6466 |
| 2. PF | Q0CBS0 | Flap endonuclease 1 | 5.35e-06 | 7.64e-09 | NA | 0.4968 |
| 2. PF | Q4JAN1 | Flap endonuclease 1 | 1.45e-08 | 1.02e-25 | NA | 0.5455 |
| 2. PF | A8QCH0 | Flap endonuclease 1 | 9.81e-07 | 9.86e-09 | NA | 0.6049 |
| 2. PF | B8NV37 | Flap endonuclease 1 | 5.85e-06 | 3.37e-09 | NA | 0.4929 |
| 2. PF | A8AAC1 | Flap endonuclease 1 | 2.51e-12 | 6.44e-22 | NA | 0.5869 |
| 2. PF | B0E412 | Flap endonuclease 1-B | 4.02e-05 | 4.18e-03 | NA | 0.5295 |
| 2. PF | Q57WW6 | Flap endonuclease 1 | 2.26e-06 | 3.91e-06 | NA | 0.5997 |
| 2. PF | P70054 | Flap endonuclease 1-B | 1.42e-06 | 6.66e-10 | NA | 0.5958 |
| 2. PF | A1D8A4 | Flap endonuclease 1 | 3.91e-06 | 3.93e-09 | NA | 0.4978 |
| 2. PF | B4MR84 | Flap endonuclease 1 | 1.42e-06 | 4.64e-09 | NA | 0.5834 |
| 2. PF | A9U328 | Flap endonuclease 1-B | 5.82e-07 | 5.24e-14 | NA | 0.6165 |
| 2. PF | A3DMG2 | Flap endonuclease 1 | 1.20e-08 | 4.38e-26 | NA | 0.5591 |
| 2. PF | D2V434 | Flap endonuclease 1 | 4.54e-07 | 4.16e-07 | NA | 0.6221 |
| 2. PF | Q0W6I0 | Flap endonuclease 1 | 7.88e-07 | 2.81e-22 | NA | 0.5987 |
| 2. PF | Q4FYU7 | Flap endonuclease 1 | 2.96e-06 | 2.40e-06 | NA | 0.589 |
| 2. PF | B1L6R9 | Flap endonuclease 1 | 1.08e-11 | 2.74e-18 | NA | 0.5605 |
| 2. PF | C4M6G8 | Flap endonuclease 1 | 9.01e-07 | 3.33e-10 | NA | 0.6088 |
| 2. PF | O27670 | Flap endonuclease 1 | 9.04e-09 | 8.95e-21 | NA | 0.5805 |
| 2. PF | A9S0B8 | Flap endonuclease 1-A | 7.40e-06 | 2.31e-06 | NA | 0.5762 |
| 2. PF | Q6C116 | Flap endonuclease 1 | 7.50e-06 | 3.41e-09 | NA | 0.5748 |
| 2. PF | A2BMI0 | Flap endonuclease 1 | 1.29e-06 | 8.95e-21 | NA | 0.5975 |
| 2. PF | Q18HK0 | Flap endonuclease 1 | 3.73e-09 | 4.90e-18 | NA | 0.5293 |
| 2. PF | C1E3X9 | Flap endonuclease 1 | 6.56e-06 | 1.88e-09 | NA | 0.621 |
| 2. PF | A5E121 | Flap endonuclease 1 | 1.52e-05 | 1.51e-10 | NA | 0.5279 |
| 2. PF | B6HEM2 | Flap endonuclease 1 | 1.05e-06 | 3.17e-07 | NA | 0.4984 |
| 2. PF | C6A1U9 | Flap endonuclease 1 | 7.00e-08 | 4.66e-16 | NA | 0.5788 |
| 2. PF | Q5I4H3 | Flap endonuclease 1 | 5.21e-06 | 1.27e-07 | NA | 0.6158 |
| 2. PF | C5FZT5 | Flap endonuclease 1 | 1.24e-05 | 4.77e-08 | NA | 0.4795 |
| 2. PF | B9EMY6 | Flap endonuclease 1 | 4.81e-06 | 2.24e-07 | NA | 0.6204 |
| 2. PF | Q9V0P9 | Flap endonuclease 1 | 8.28e-08 | 7.18e-17 | NA | 0.562 |
| 2. PF | A4WNC4 | Flap endonuclease 1 | 1.14e-08 | 3.22e-19 | NA | 0.5897 |
| 2. PF | Q4WWJ1 | Flap endonuclease 1 | 3.97e-06 | 1.39e-08 | NA | 0.4969 |
| 2. PF | C5A639 | Flap endonuclease 1 | 1.02e-07 | 3.56e-19 | NA | 0.5664 |
| 2. PF | A0CXT3 | Flap endonuclease 1-1 | 4.17e-06 | 5.66e-08 | NA | 0.5768 |
| 2. PF | C4QZ20 | Flap endonuclease 1 | 4.81e-06 | 4.41e-09 | NA | 0.5567 |
| 2. PF | Q8TXU4 | Flap endonuclease 1 | 4.37e-07 | 8.77e-23 | NA | 0.6145 |
| 2. PF | A1CJ75 | Flap endonuclease 1 | 4.01e-06 | 5.28e-09 | NA | 0.4955 |
| 2. PF | B6YWX4 | Flap endonuclease 1 | 1.11e-07 | 4.16e-20 | NA | 0.5743 |
| 2. PF | B4J6M4 | Flap endonuclease 1 | 8.21e-06 | 6.39e-09 | NA | 0.5941 |
| 2. PF | D3TQJ5 | Flap endonuclease 1 | 1.37e-06 | 7.15e-08 | NA | 0.5891 |
| 2. PF | D0MY34 | Flap endonuclease 1 | 7.51e-07 | 2.67e-09 | NA | 0.6175 |
| 2. PF | A3MY15 | Flap endonuclease 1 | 1.62e-08 | 3.27e-19 | NA | 0.6403 |
| 2. PF | B8GIA0 | Flap endonuclease 1 | 1.27e-06 | 1.34e-20 | NA | 0.4859 |
| 2. PF | Q58DH8 | Flap endonuclease 1 | 5.89e-06 | 1.37e-08 | NA | 0.6236 |
| 2. PF | O93634 | Flap endonuclease 1 | 5.83e-08 | 1.64e-15 | NA | 0.5924 |
| 2. PF | C4JDR3 | Flap endonuclease 1 | 6.33e-06 | 5.74e-08 | NA | 0.4913 |
| 2. PF | C5DGG4 | Flap endonuclease 1 | 5.48e-06 | 2.18e-07 | NA | 0.5416 |
| 2. PF | B1H158 | Flap endonuclease 1 | 1.53e-06 | 1.24e-09 | NA | 0.5932 |
| 2. PF | B8MNF2 | Flap endonuclease 1 | 5.24e-06 | 4.24e-09 | NA | 0.5063 |
| 2. PF | A7UW97 | Flap endonuclease 1 | 5.18e-06 | 2.31e-09 | NA | 0.4941 |
| 2. PF | C4YBJ8 | Flap endonuclease 1 | 1.40e-05 | 1.90e-08 | NA | 0.6085 |
| 2. PF | A4VDN2 | Flap endonuclease 1 | 2.19e-06 | 1.88e-06 | NA | 0.6225 |
| 2. PF | A6QV55 | Flap endonuclease 1 | 5.25e-06 | 2.69e-08 | NA | 0.498 |
| 2. PF | A6ZZK4 | Flap endonuclease 1 | 6.18e-06 | 1.28e-07 | NA | 0.4912 |
| 2. PF | P0CS60 | Flap endonuclease 1 | 2.86e-05 | 4.37e-05 | NA | 0.5336 |
| 2. PF | B4HTA1 | Flap endonuclease 1 | 1.76e-06 | 5.48e-09 | NA | 0.5844 |
| 2. PF | Q8PYF6 | Flap endonuclease 1 | 6.49e-07 | 3.23e-18 | NA | 0.5773 |
| 2. PF | Q97B98 | Flap endonuclease 1 | 4.46e-07 | 1.34e-21 | NA | 0.6053 |
| 2. PF | A6UX46 | Flap endonuclease 1 | 5.68e-05 | 6.91e-23 | NA | 0.6205 |
| 2. PF | C3KJE6 | Flap endonuclease 1 | 5.61e-06 | 6.10e-08 | NA | 0.6334 |
| 2. PF | A7IA59 | Flap endonuclease 1 | 9.27e-07 | 4.66e-18 | NA | 0.5713 |
| 2. PF | Q2FNC9 | Flap endonuclease 1 | 9.90e-07 | 3.11e-19 | NA | 0.5932 |
| 2. PF | O50123 | Flap endonuclease 1 | 9.58e-08 | 9.34e-16 | NA | 0.5423 |
| 2. PF | B1YC46 | Flap endonuclease 1 | 1.46e-08 | 1.06e-16 | NA | 0.5889 |
| 2. PF | A8M9L3 | Flap endonuclease 1 | 2.70e-08 | 4.26e-22 | NA | 0.6075 |
| 2. PF | B6JYI7 | Flap endonuclease 1 | 7.35e-06 | 4.35e-10 | NA | 0.5858 |
| 2. PF | Q4R5U5 | Flap endonuclease 1 | 5.61e-06 | 2.35e-08 | NA | 0.5916 |
| 2. PF | A4S1G4 | Flap endonuclease 1 | 5.29e-06 | 6.64e-09 | NA | 0.5895 |
| 2. PF | A3M056 | Flap endonuclease 1 | 6.21e-06 | 3.81e-10 | NA | 0.5318 |
| 2. PF | Q6FM28 | Flap endonuclease 1 | 4.21e-06 | 7.64e-09 | NA | 0.6159 |
| 2. PF | B4GIM3 | Flap endonuclease 1 | 1.53e-06 | 6.98e-08 | NA | 0.6008 |
| 2. PF | C8ZC62 | Flap endonuclease 1 | 6.33e-06 | 1.28e-07 | NA | 0.4911 |
| 2. PF | Q5JGN0 | Flap endonuclease 1 | 4.34e-11 | 2.94e-20 | NA | 0.5525 |
| 2. PF | Q6BLF4 | Flap endonuclease 1 | 5.38e-06 | 4.72e-10 | NA | 0.5916 |
| 2. PF | Q3IPG8 | Flap endonuclease 1 | 2.74e-06 | 2.90e-19 | NA | 0.5652 |
| 2. PF | Q980U8 | Flap endonuclease 1 | 3.43e-06 | 6.74e-27 | NA | 0.5258 |
| 2. PF | B7XHS8 | Flap endonuclease 1 | 1.94e-06 | 1.40e-14 | NA | 0.5534 |
| 2. PF | Q0UZR3 | Flap endonuclease 1 | 1.25e-07 | 7.08e-09 | NA | 0.497 |
| 2. PF | C5M2X8 | Flap endonuclease 1 | 1.09e-06 | 1.17e-10 | NA | 0.5705 |
| 2. PF | A5DCF5 | Flap endonuclease 1 | 9.91e-07 | 6.02e-08 | NA | 0.5861 |
| 2. PF | C3ZBT0 | Flap endonuclease 1 | 2.07e-05 | 5.08e-09 | NA | 0.5832 |
| 2. PF | Q8SS91 | Flap endonuclease 1 | 2.25e-06 | 2.78e-12 | NA | 0.6016 |
| 2. PF | Q9YFY5 | Flap endonuclease 1 | 1.87e-08 | 9.73e-25 | NA | 0.5937 |
| 3. BF | P9WNU4 | DNA polymerase I | 3.08e-14 | NA | 4.91e-33 | 0.8093 |
| 3. BF | P74933 | DNA polymerase I | 4.37e-14 | NA | 7.31e-23 | 0.872 |
| 3. BF | Q04957 | DNA polymerase I | 9.66e-14 | NA | 1.24e-40 | 0.8478 |
| 3. BF | Q9RLA0 | DNA polymerase I | 6.29e-14 | NA | 4.53e-30 | 0.8422 |
| 3. BF | Q1RH76 | DNA polymerase I | 7.88e-15 | NA | 9.92e-34 | 0.8518 |
| 3. BF | Q9RLB6 | DNA polymerase I | 6.77e-15 | NA | 3.65e-32 | 0.8639 |
| 3. BF | P52026 | DNA polymerase I | 2.78e-13 | NA | 3.81e-37 | 0.8592 |
| 3. BF | P80194 | DNA polymerase I, thermostable | 1.58e-13 | NA | 4.19e-38 | 0.8237 |
| 3. BF | Q9F173 | DNA polymerase I | 2.13e-14 | NA | 3.96e-24 | 0.8481 |
| 3. BF | O52225 | DNA polymerase I, thermostable | 3.51e-13 | NA | 1.48e-36 | 0.8087 |
| 3. BF | Q92GB7 | DNA polymerase I | 3.66e-15 | NA | 3.16e-32 | 0.8621 |
| 3. BF | Q9HT80 | DNA polymerase I | 8.47e-13 | NA | 7.00e-15 | 0.8153 |
| 3. BF | P0A551 | DNA polymerase I | 3.56e-14 | NA | 4.91e-33 | 0.8183 |
| 3. BF | P19821 | DNA polymerase I, thermostable | 9.06e-14 | NA | 9.01e-40 | 0.8647 |
| 3. BF | P43741 | DNA polymerase I | 4.61e-12 | NA | 2.78e-22 | 0.8353 |
| 3. BF | P59200 | DNA polymerase I | 7.96e-14 | NA | 1.46e-33 | 0.8509 |
| 3. BF | Q59156 | DNA polymerase I | 9.33e-15 | NA | 2.69e-35 | 0.8721 |
| 3. BF | Q9S1G2 | DNA polymerase I | 5.62e-13 | NA | 3.10e-26 | 0.829 |
| 3. BF | Q9CDS1 | DNA polymerase I | 5.52e-14 | NA | 8.53e-31 | 0.8186 |
| 3. BF | P30313 | DNA polymerase I, thermostable | 1.13e-13 | NA | 6.29e-40 | 0.8321 |
| 3. BF | O08307 | DNA polymerase I | 5.08e-13 | NA | 1.11e-31 | 0.87 |
| 3. BF | P46835 | DNA polymerase I | 1.55e-13 | NA | 7.08e-31 | 0.8291 |
| 3. BF | P52028 | DNA polymerase I, thermostable | 1.13e-13 | NA | 7.46e-41 | 0.8261 |
| 3. BF | Q55971 | DNA polymerase I | 1.41e-13 | NA | 2.54e-29 | 0.8544 |
| 3. BF | O34996 | DNA polymerase I | 1.04e-13 | NA | 9.34e-41 | 0.8312 |
| 3. BF | O05949 | DNA polymerase I | 6.33e-15 | NA | 1.39e-31 | 0.8345 |
| 3. BF | Q9RAA9 | DNA polymerase I | 3.66e-15 | NA | 1.94e-33 | 0.876 |
| 3. BF | P59199 | DNA polymerase I | 9.91e-14 | NA | 1.01e-32 | 0.819 |
| 3. BF | O32801 | DNA polymerase I | 5.28e-14 | NA | 6.05e-31 | 0.8469 |
| 3. BF | O51498 | DNA polymerase I | 1.40e-14 | NA | 4.52e-23 | 0.8592 |
| 3. BF | P52027 | DNA polymerase I | 5.38e-13 | NA | 3.83e-28 | 0.8144 |
| 3. BF | Q9ZJE9 | DNA polymerase I | 1.68e-12 | NA | 4.19e-19 | 0.8137 |
| 3. BF | P56105 | DNA polymerase I | 2.26e-12 | NA | 1.56e-18 | 0.8115 |
| 4. PB | P38506 | Flap endonuclease Xni | 0.00e+00 | 6.74e-32 | 7.14e-13 | NA |
| 4. PB | P9WNU3 | 5'-3' exonuclease | 0.00e+00 | 9.93e-50 | 7.50e-17 | NA |
| 4. PB | P06229 | Flap endonuclease | NA | 4.51e-29 | 2.82e-07 | NA |
| 5. P | A4I2L4 | Flap endonuclease 1 | 1.49e-05 | 9.41e-06 | NA | NA |
| 5. P | Q12086 | DNA damage-inducible protein DIN7 | 2.32e-05 | 4.02e-02 | NA | NA |
| 5. P | B0UXL7 | Probable flap endonuclease 1 homolog | 2.71e-05 | 2.29e-10 | NA | NA |
| 5. P | P20321 | Exodeoxyribonuclease | NA | 1.45e-26 | NA | NA |
| 5. P | Q8PAV7 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 4.88e-02 | 4.93e-02 | NA | NA |
| 5. P | Q6TNU4 | Flap endonuclease 1 | 1.14e-06 | 1.74e-06 | NA | NA |
| 5. P | Q6UDJ0 | Virion host shutoff protein | NA | 2.73e-02 | NA | NA |
| 5. P | P0DSS5 | Putative nuclease G5 | NA | 6.01e-06 | NA | NA |
| 5. P | O65251 | Flap endonuclease 1 | 5.68e-06 | 1.22e-08 | NA | NA |
| 5. P | Q196Y4 | Probable RAD2-like endonuclease 076L | NA | 5.40e-07 | NA | NA |
| 5. P | Q9N3T2 | Flap endonuclease 1 | 1.26e-06 | 3.59e-08 | NA | NA |
| 5. P | C5WU23 | Flap endonuclease 1-B | 3.62e-05 | 2.84e-07 | NA | NA |
| 5. P | Q80HX0 | Putative nuclease G5 | NA | 3.82e-06 | NA | NA |
| 5. P | Q5A6K8 | Flap endonuclease 1 | 1.08e-05 | 1.00e-09 | NA | NA |
| 5. P | P39749 | Flap endonuclease 1 | 9.67e-06 | 1.35e-07 | NA | NA |
| 5. P | Q9SXQ6 | Flap endonuclease 1-A | 1.35e-06 | 4.21e-08 | NA | NA |
| 5. P | Q9J5A5 | Protein FPV117 | NA | 2.29e-06 | NA | NA |
| 5. P | C6TEX6 | Flap endonuclease 1 | 2.73e-06 | 1.83e-09 | NA | NA |
| 5. P | B4FHY0 | Flap endonuclease 1 | 4.74e-06 | 2.14e-09 | NA | NA |
| 5. P | Q58839 | Flap endonuclease 1 | 5.68e-07 | 9.61e-23 | NA | NA |
| 5. P | Q5UQW7 | Putative endonuclease L386 | NA | 3.78e-07 | NA | NA |
| 5. P | Q09708 | Uncharacterized protein C12G12.16c | 2.35e-03 | 6.58e-04 | NA | NA |
| 5. P | P0DSS6 | Putative nuclease G5 | NA | 6.01e-06 | NA | NA |
| 5. P | B7G7Y7 | Flap endonuclease 1 | 2.24e-06 | 3.77e-08 | NA | NA |
| 5. P | Q91FF5 | Probable RAD2-like endonuclease 369L | NA | 1.75e-10 | NA | NA |
| 5. P | P13319 | Ribonuclease H | NA | 2.28e-42 | NA | NA |
| 5. P | Q54NU0 | Flap endonuclease 1 | 3.02e-06 | 4.47e-10 | NA | NA |
| 5. P | Q6GZN0 | Putative RAD2-like endonuclease 095R | NA | 2.01e-15 | NA | NA |
| 5. P | P21026 | Putative nuclease G5 | NA | 7.61e-06 | NA | NA |
| 5. P | Q75LI2 | Flap endonuclease 1-B | 1.56e-06 | 3.26e-03 | NA | NA |
| 5. P | P26793 | Flap endonuclease 1 | 6.78e-06 | 1.28e-07 | NA | NA |
| 5. P | P00638 | Exonuclease | NA | 5.19e-24 | NA | NA |
| 5. P | P39750 | Flap endonuclease 1 | 6.17e-06 | 2.87e-08 | NA | NA |
| 5. P | Q4DKQ5 | Flap endonuclease 1 | 1.22e-05 | 7.00e-07 | NA | NA |
| 5. P | Q5XIP6 | Flap endonuclease 1 | 5.77e-06 | 2.00e-08 | NA | NA |
| 5. P | Q7K7A9 | Flap endonuclease 1 | 1.56e-06 | 6.00e-09 | NA | NA |
| 5. P | P39748 | Flap endonuclease 1 | 7.58e-07 | 1.51e-08 | NA | NA |
| 6. F | Q38C92 | Post-transcriptional regulator MKT1L | 1.37e-01 | NA | NA | 0.4328 |
| 6. F | Q29FC1 | Flap endonuclease GEN | 5.47e-04 | NA | NA | 0.5408 |
| 6. F | Q9GZ01 | Flap endonuclease 1 | 6.22e-05 | NA | NA | 0.596 |
| 6. F | B3L014 | Flap endonuclease 1 | 2.23e-05 | NA | NA | 0.5817 |
| 6. F | A7AX58 | Flap endonuclease 1 | 3.54e-06 | NA | NA | 0.6219 |
| 6. F | Q4UFP0 | Flap endonuclease 1 | 7.32e-10 | NA | NA | 0.6361 |
| 6. F | P0CL88 | 5'-3' exoribonuclease 2 | 1.35e-01 | NA | NA | 0.4503 |
| 6. F | Q4XXP8 | Flap endonuclease 1 | 6.11e-06 | NA | NA | 0.5044 |
| 6. F | Q4Z015 | Flap endonuclease 1 | 3.63e-06 | NA | NA | 0.6058 |
| 6. F | Q4N3S6 | Flap endonuclease 1 | 8.06e-11 | NA | NA | 0.6275 |
| 6. F | A3FPN7 | Flap endonuclease 1 | 5.47e-06 | NA | NA | 0.5888 |
| 6. F | A5KAL1 | Flap endonuclease 1 | 1.14e-04 | NA | NA | 0.6206 |
| 6. F | Q7RME3 | Flap endonuclease 1 | 2.84e-07 | NA | NA | 0.6195 |
| 6. F | Q587E3 | Post-transcriptional regulator MKT1 | 2.42e-02 | NA | NA | 0.3245 |
| 6. F | B6AFP1 | Flap endonuclease 1 | 4.82e-06 | NA | NA | 0.5851 |
| 7. B | P9WNU5 | DNA polymerase I | 5.04e-14 | NA | 4.91e-33 | NA |
| 7. B | P00582 | DNA polymerase I | 2.44e-14 | NA | 5.45e-24 | NA |