Summary
The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.
AVX54674.1
JCVISYN3A_0233
Phosphoenolpyruvate--protein phosphotransferase.
M. mycoides homolog: Q6MTX2.
TIGRfam Classification: 4=Probable.
Category: Essential.
Statistics
Total GO Annotation: 27
Unique PROST Go: 0
Unique BLAST Go: 7
Unique Foldseek Go: 1
Total Homologs: 116
Unique PROST Homologs: 0
Unique BLAST Homologs: 23
Unique Foldseek Homologs: 13
Structures and Sequence Alignment
The best structural homolog that predicted by 1. PBF was
P43922
(Phosphoenolpyruvate-protein phosphotransferase) with a FATCAT P-Value: 0 and RMSD of 2.31 angstrom. The sequence alignment identity is 47.3%.
Structural alignment shown in left. Query protein AVX54674.1 colored as red in alignment, homolog P43922 colored as blue.
Query protein AVX54674.1 is also shown in right top, homolog P43922 showed in right bottom. They are colored based on secondary structures.
AVX54674.1 MSKQIKGIAASDGISLAKALVIKE--IKLDVQKQLIDD-VDQQIAKLEQAINQTITDLKKIQKITLEKLGEEKAAIFDAHQDIANDPAIKEEVVQLIKTE 97 P43922 M---ISGILASPGIAFGKALVLKEEKIVLDTQK-ITDDQIDAEVARFYEGRNAAVEQLNSIRERALISLGEEKAAIFEGHLMILEDEELEEEILDYLRSN 96 AVX54674.1 KVNAEYALF-IVSNNYFEMFSQLEDPYFKERSADIKDVSSRIISHILGLEIHDLSTIDKEVIIISDDLTPSQTAQLD-KKFVKGFLTNVGGRTSHAAIMA 195 P43922 KVNAGVAASKILDQQVT-MLSEIDDEYLKERAGDIRDIANRLVKNILGMYIVDLGDIQEESILVAYDLTPSETAQLNLEKVL-GVVTDIGGRTSHTSIMA 194 AVX54674.1 RSLEIPAILGLKNITELVKTDDLIALDGSSGIVELDLN------DNDIKNYQTKVKQYLELKDQLKKFKDKPSLTKD--KIKKLIEANIGSTNDIQSVLD 287 P43922 RSLELPAIVGTNKVTKLVNTGDYLILDAINN--QVYINPTASQID-ELKALEAKIS---EEKAELAKLKDLPAITLDGHKV-DVV-ANIGTIRDCDGAER 286 AVX54674.1 SGAEGIGLFRTEFLYMNNDHFPTEEEQFEAYKKVVSQID-HLVVFRTLDIGGDKKLSYFKFDEEMNPFLGYRAIRFTLDRKDIFKDQIRALLRASAFGKL 386 P43922 NGAEGIGLYRTEFLFMDREQLPTEEEQFIAYKQVVEAMNGRLTVIRTMDIGGDKELSYLDLPKEMNPFLGWRAIRIALDRREILNAQLRAVLRASAFGKL 386 AVX54674.1 GIMFPMIATIDEFKQAKAFVEECKLELDKENIKYDKQVQIGMMVEIPSAAILADQF-AKYADFFSIGTNDLIQYSFASDRMNQNVSYLYQPLNPSLLRLI 485 P43922 AVMFPMIISVEEIRELKAVIETLKAELREEGRLFDNNIQVGVMVETPSAAVNA-KFLAKEVDFFSIGTNDLTQYTLAVDRGNEFISHLYNPMHPSVLGLI 485 AVX54674.1 QLTISGAHKHNKWVGMCGEMAGDSKALPILLGLDLDAFSMSATSVLKARSLMSKIESIKAKELANKALECQTSQQVNDLVEEF-LKN-LD 573 P43922 KQVIDASHAEGKWTGMCGELAGDERATLLLLGMGLDEFSMSAISVPRIKKLIRNVNFQDAKVLADTALQKPTAAEIDQLIEEFLLENSLN 575
Go Annotations
1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.
Source | GO | Description |
---|---|---|
1. PBF | GO:0008965 | phosphoenolpyruvate-protein phosphotransferase activity |
1. PBF | GO:0008982 | protein-N(PI)-phosphohistidine-sugar phosphotransferase activity |
1. PBF | GO:0009401 | phosphoenolpyruvate-dependent sugar phosphotransferase system |
1. PBF | GO:0005737 | cytoplasm |
1. PBF | GO:0046872 | metal ion binding |
1. PBF | GO:0016301 | kinase activity |
3. BF | GO:0004743 | pyruvate kinase activity |
3. BF | GO:0008986 | pyruvate, water dikinase activity |
3. BF | GO:0030955 | potassium ion binding |
3. BF | GO:0019563 | glycerol catabolic process |
3. BF | GO:0050242 | pyruvate, phosphate dikinase activity |
3. BF | GO:0016874 | ligase activity |
3. BF | GO:0005524 | ATP binding |
3. BF | GO:0006090 | pyruvate metabolic process |
3. BF | GO:0017000 | antibiotic biosynthetic process |
3. BF | GO:0006094 | gluconeogenesis |
3. BF | GO:0047324 | phosphoenolpyruvate-glycerone phosphotransferase activity |
4. PB | GO:0019197 | phosphoenolpyruvate-dependent sugar phosphotransferase complex |
4. PB | GO:0010243 | response to organonitrogen compound |
6. F | GO:0000287 | magnesium ion binding |
7. B | GO:0016772 | transferase activity, transferring phosphorus-containing groups |
7. B | GO:0016310 | phosphorylation |
7. B | GO:0043042 | amino acid adenylylation by nonribosomal peptide synthase |
7. B | GO:0008460 | dTDP-glucose 4,6-dehydratase activity |
7. B | GO:0015979 | photosynthesis |
7. B | GO:0009507 | chloroplast |
7. B | GO:0009403 | toxin biosynthetic process |
Uniprot GO Annotations
GO | Description |
---|---|
GO:0008965 | phosphoenolpyruvate-protein phosphotransferase activity |
GO:0016772 | transferase activity, transferring phosphorus-containing groups |
GO:0016740 | transferase activity |
GO:0016310 | phosphorylation |
GO:0009401 | phosphoenolpyruvate-dependent sugar phosphotransferase system |
GO:0008643 | carbohydrate transport |
GO:0005737 | cytoplasm |
GO:0003824 | catalytic activity |
GO:0046872 | metal ion binding |
GO:0016301 | kinase activity |
Homologs
1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.
Source | Homolog | Description | Fatcat Pvalue | PROST Evalue | BLAST Evalue | Foldseek TMScore |
---|---|---|---|---|---|---|
1. PBF | O31149 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 6.82e-100 | 0.0 | 0.8208 |
1. PBF | P47668 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 7.32e-96 | 0.0 | 0.8988 |
1. PBF | Q8KA50 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 1.83e-95 | 1.22e-161 | 0.8902 |
1. PBF | O07126 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 7.73e-97 | 0.0 | 0.8436 |
1. PBF | Q931U2 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 2.20e-95 | 0.0 | 0.8452 |
1. PBF | P42014 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 2.21e-92 | 0.0 | 0.9198 |
1. PBF | Q9Z9E3 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 8.26e-65 | 7.09e-71 | 0.6439 |
1. PBF | P0A249 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 2.46e-97 | 2.86e-169 | 0.889 |
1. PBF | P45595 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 6.71e-98 | 0.0 | 0.9105 |
1. PBF | P0A250 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 2.46e-97 | 2.86e-169 | 0.9044 |
1. PBF | Q5HH01 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 6.09e-96 | 0.0 | 0.8504 |
1. PBF | Q84F83 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 8.85e-95 | 0.0 | 0.9688 |
1. PBF | Q8NX83 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 4.06e-96 | 0.0 | 0.8489 |
1. PBF | Q9PK57 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 9.98e-64 | 7.28e-63 | 0.6898 |
1. PBF | D4GYE2 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 6.70e-78 | 3.09e-117 | 0.8708 |
1. PBF | Q9KZP1 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 2.19e-71 | 8.56e-91 | 0.7525 |
1. PBF | P30299 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 2.85e-97 | 0.0 | 0.8295 |
1. PBF | P43922 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 3.03e-96 | 2.86e-178 | 0.938 |
1. PBF | Q8CT19 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 2.46e-94 | 0.0 | 0.8593 |
1. PBF | P23536 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 4.96e-85 | 2.60e-112 | 0.8834 |
1. PBF | P51183 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 6.09e-96 | 0.0 | 0.8506 |
1. PBF | Q9K8D3 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 3.67e-94 | 0.0 | 0.8886 |
1. PBF | P08838 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 2.28e-95 | 0.0 | 0.9196 |
1. PBF | Q6GI01 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 3.30e-97 | 0.0 | 0.8567 |
1. PBF | P37178 | Phosphoenolpyruvate-dependent phosphotransferase system | 0.00e+00 | 5.69e-05 | 3.08e-93 | 0.8658 |
1. PBF | Q6GAD0 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 4.06e-96 | 0.0 | 0.8498 |
1. PBF | O51508 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 4.92e-94 | 4.44e-136 | 0.8967 |
1. PBF | O69251 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 2.81e-96 | 0.0 | 0.91 |
1. PBF | O84340 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 3.66e-63 | 4.60e-66 | 0.6065 |
1. PBF | Q5HQ85 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 2.46e-94 | 0.0 | 0.8611 |
1. PBF | Q83QP3 | Multiphosphoryl transfer protein | 0.00e+00 | 1.79e-03 | 3.44e-104 | 0.7626 |
1. PBF | Q9CJ82 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 2.53e-99 | 0.0 | 0.8979 |
1. PBF | Q99V14 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 4.37e-96 | 0.0 | 0.847 |
1. PBF | Q9ZAD8 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 2.53e-99 | 0.0 | 0.9053 |
1. PBF | Q9WXK9 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 6.14e-95 | 0.0 | 0.9254 |
1. PBF | P23530 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 1.07e-99 | 0.0 | 0.8529 |
1. PBF | O83018 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 1.29e-92 | 0.0 | 0.9379 |
1. PBF | Q9WXI6 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 2.81e-96 | 2.82e-160 | 0.8738 |
1. PBF | Q92D19 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 1.39e-99 | 0.0 | 0.8141 |
1. PBF | Q8XBQ8 | Multiphosphoryl transfer protein | 0.00e+00 | 1.14e-03 | 8.97e-104 | 0.7628 |
1. PBF | P75168 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 1.65e-94 | 0.0 | 0.8768 |
1. PBF | Q8FFD8 | Multiphosphoryl transfer protein | 0.00e+00 | 2.43e-03 | 4.14e-105 | 0.7786 |
1. PBF | P45617 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 1.23e-133 | 0.0 | 0.9865 |
1. PBF | P23533 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 1.65e-94 | 0.0 | 0.9107 |
1. PBF | Q89B04 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 1.16e-90 | 1.01e-159 | 0.8765 |
3. BF | O29548 | Probable phosphoenolpyruvate synthase | 2.11e-07 | NA | 5.29e-45 | 0.495 |
3. BF | P80885 | Pyruvate kinase | 8.89e-03 | NA | 0.004 | 0.3909 |
3. BF | P37213 | Pyruvate, phosphate dikinase | 9.56e-07 | NA | 5.37e-21 | 0.4593 |
3. BF | Q9YEC5 | Phosphoenolpyruvate synthase | 2.38e-07 | NA | 3.70e-29 | 0.6093 |
3. BF | P0DN88 | PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaM | 8.50e-10 | NA | 1.09e-08 | 0.8441 |
3. BF | Q5W252 | Prodigiosin synthesizing transferase PigC | 2.61e-01 | NA | 1.16e-05 | 0.4161 |
3. BF | Q9V2H7 | Probable phosphoenolpyruvate synthase | 9.58e-07 | NA | 4.14e-45 | 0.4875 |
3. BF | Q55905 | Phosphoenolpyruvate synthase | 7.17e-07 | NA | 7.75e-26 | 0.5265 |
3. BF | O67899 | Phosphoenolpyruvate synthase | 1.04e-06 | NA | 1.40e-18 | 0.5891 |
3. BF | P56070 | Phosphoenolpyruvate synthase | 1.10e-06 | NA | 9.82e-28 | 0.5061 |
3. BF | Q5W269 | Prodigiosin synthesizing transferase PigC | 2.31e-01 | NA | 8.80e-06 | 0.4186 |
3. BF | Q9ZMV4 | Phosphoenolpyruvate synthase | 1.19e-07 | NA | 1.97e-28 | 0.5166 |
3. BF | Q9K0I2 | Phosphoenolpyruvate synthase | 5.72e-06 | NA | 5.45e-31 | 0.55 |
3. BF | Q02KR1 | Phosphoenolpyruvate synthase | 7.77e-07 | NA | 5.92e-28 | 0.5561 |
3. BF | Q42910 | Pyruvate, phosphate dikinase, chloroplastic | 9.52e-07 | NA | 1.03e-23 | 0.4574 |
3. BF | P42850 | Phosphoenolpyruvate synthase | 6.92e-09 | NA | 4.37e-46 | 0.5661 |
3. BF | P51181 | Pyruvate kinase | 1.01e-02 | NA | 0.002 | 0.4324 |
3. BF | P46893 | Probable phosphoenolpyruvate synthase | 2.57e-08 | NA | 1.61e-34 | 0.4921 |
3. BF | A0A0H3H456 | PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaM | 7.99e-12 | NA | 1.87e-16 | 0.8765 |
3. BF | O27190 | Probable phosphoenolpyruvate synthase | 4.66e-06 | NA | 7.17e-27 | 0.3774 |
3. BF | P51182 | Pyruvate kinase | 2.81e-03 | NA | 4.56e-05 | 0.4059 |
3. BF | P23388 | Multiphosphoryl transfer protein | 0.00e+00 | NA | 1.08e-117 | 0.805 |
3. BF | O57830 | Probable phosphoenolpyruvate synthase | 4.07e-07 | NA | 6.79e-46 | 0.4915 |
3. BF | Q39734 | Pyruvate, phosphate dikinase, chloroplastic | 9.49e-07 | NA | 3.27e-30 | 0.4579 |
3. BF | D4GL26 | PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaM | 7.68e-12 | NA | 8.91e-22 | 0.8433 |
3. BF | O34796 | Uncharacterized phosphotransferase YvkC | 6.51e-02 | NA | 3.40e-07 | 0.3991 |
3. BF | Q02499 | Pyruvate kinase | 7.98e-03 | NA | 0.002 | 0.4062 |
3. BF | O34309 | Putative phosphoenolpyruvate synthase | 2.25e-01 | NA | 1.75e-06 | 0.3009 |
3. BF | O83026 | Phosphoenolpyruvate synthase | 1.09e-08 | NA | 6.63e-21 | 0.5231 |
3. BF | Q39735 | Pyruvate, phosphate dikinase, chloroplastic | 8.53e-07 | NA | 3.60e-28 | 0.4574 |
3. BF | P45597 | Multiphosphoryl transfer protein | 0.00e+00 | NA | 2.41e-99 | 0.8301 |
4. PB | P32670 | Multiphosphoryl transfer protein 2 | 0.00e+00 | 1.69e-02 | 1.97e-109 | NA |
4. PB | P77439 | Multiphosphoryl transfer protein 1 | 0.00e+00 | 9.94e-04 | 1.59e-104 | NA |
4. PB | P08839 | Phosphoenolpyruvate-protein phosphotransferase | 0.00e+00 | 4.96e-99 | 3.75e-170 | NA |
4. PB | P37177 | Phosphoenolpyruvate-dependent phosphotransferase system | 0.00e+00 | 5.63e-05 | 3.01e-93 | NA |
6. F | Q2YTE3 | Pyruvate kinase | 2.96e-03 | NA | NA | 0.383 |
6. F | Q99TG5 | Pyruvate kinase | 2.98e-03 | NA | NA | 0.3996 |
6. F | Q7A0N4 | Pyruvate kinase | 2.98e-03 | NA | NA | 0.3996 |
6. F | Q5HNK7 | Pyruvate kinase | 3.01e-03 | NA | NA | 0.4195 |
6. F | Q4L739 | Pyruvate kinase | 2.78e-03 | NA | NA | 0.4156 |
6. F | P34038 | Pyruvate kinase | 1.60e-02 | NA | NA | 0.421 |
6. F | Q5HF76 | Pyruvate kinase | 2.97e-03 | NA | NA | 0.3996 |
6. F | Q8CS69 | Pyruvate kinase | 4.32e-03 | NA | NA | 0.4386 |
6. F | Q6GG09 | Pyruvate kinase | 4.59e-03 | NA | NA | 0.4061 |
6. F | Q7A559 | Pyruvate kinase | 2.95e-03 | NA | NA | 0.3996 |
6. F | Q6G8M9 | Pyruvate kinase | 2.96e-03 | NA | NA | 0.4095 |
6. F | Q2FG40 | Pyruvate kinase | 2.96e-03 | NA | NA | 0.3999 |
6. F | P73534 | Pyruvate kinase 2 | 3.94e-03 | NA | NA | 0.4453 |
7. B | Q9ZD55 | Pyruvate, phosphate dikinase | 4.64e-07 | NA | 2.56e-26 | NA |
7. B | P22983 | Pyruvate, phosphate dikinase | 3.30e-07 | NA | 3.57e-24 | NA |
7. B | Q75KR1 | Pyruvate, phosphate dikinase 2 | 4.33e-07 | NA | 1.52e-25 | NA |
7. B | P51776 | Pyruvate, phosphate dikinase | 8.03e-07 | NA | 3.42e-21 | NA |
7. B | Q42736 | Pyruvate, phosphate dikinase, chloroplastic | 8.79e-07 | NA | 4.00e-29 | NA |
7. B | P23538 | Phosphoenolpyruvate synthase | 5.43e-07 | NA | 7.71e-32 | NA |
7. B | P9WIH5 | Uncharacterized protein Rv2047c | 5.74e-02 | NA | 0.039 | NA |
7. B | P37349 | PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaM | 8.38e-11 | NA | 1.56e-16 | NA |
7. B | Q1RH78 | Pyruvate, phosphate dikinase | 1.54e-07 | NA | 8.14e-28 | NA |
7. B | P9WIH4 | Uncharacterized protein MT2107 | 2.91e-01 | NA | 0.039 | NA |
7. B | Q59754 | Pyruvate, phosphate dikinase | 1.04e-06 | NA | 2.72e-25 | NA |
7. B | O83728 | Pyruvate, phosphate dikinase | 6.79e-07 | NA | 4.50e-20 | NA |
7. B | Q0VZ70 | Chondramide synthase cmdD | NA | NA | 6.76e-05 | NA |
7. B | O23404 | Pyruvate, phosphate dikinase 1, chloroplastic | 1.24e-06 | NA | 6.11e-24 | NA |
7. B | Q57962 | Probable phosphoenolpyruvate synthase | 1.13e-04 | NA | 5.61e-36 | NA |
7. B | P22221 | Pyruvate, phosphate dikinase, chloroplastic | 8.59e-07 | NA | 4.08e-28 | NA |
7. B | P11155 | Pyruvate, phosphate dikinase 1, chloroplastic | 8.53e-07 | NA | 7.53e-24 | NA |
7. B | Q68WP2 | Pyruvate, phosphate dikinase | 1.27e-07 | NA | 1.48e-24 | NA |
7. B | P65685 | Uncharacterized protein Mb2073c | 5.78e-02 | NA | 0.039 | NA |
7. B | Q4ULI7 | Pyruvate, phosphate dikinase | 9.98e-08 | NA | 2.21e-26 | NA |
7. B | Q92HI8 | Pyruvate, phosphate dikinase | 5.20e-07 | NA | 1.27e-24 | NA |
7. B | Q6AVA8 | Pyruvate, phosphate dikinase 1, chloroplastic | 1.22e-06 | NA | 1.17e-22 | NA |
7. B | Q42368 | Pyruvate, phosphate dikinase 2 | 4.15e-07 | NA | 7.49e-26 | NA |