Summary

The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.

AVX54674.1
JCVISYN3A_0233

Phosphoenolpyruvate--protein phosphotransferase.
M. mycoides homolog: Q6MTX2.
TIGRfam Classification: 4=Probable.
Category: Essential.

Statistics

Total GO Annotation: 27
Unique PROST Go: 0
Unique BLAST Go: 7
Unique Foldseek Go: 1

Total Homologs: 116
Unique PROST Homologs: 0
Unique BLAST Homologs: 23
Unique Foldseek Homologs: 13

Literature

Danchin and Fang [1]: NA
Yang and Tsui [2]: NA
Antczak et al. [3]: ptsP; Phosphoenolpyruvate-protein phosphotransferase
Zhang et al. [4]: GO:0008965|phosphoenolpyruvate-protein phosphotransferase activity
Bianchi et al. [5]: NA

Structures and Sequence Alignment

The best structural homolog that predicted by 1. PBF was P43922 (Phosphoenolpyruvate-protein phosphotransferase) with a FATCAT P-Value: 0 and RMSD of 2.31 angstrom. The sequence alignment identity is 47.3%.
Structural alignment shown in left. Query protein AVX54674.1 colored as red in alignment, homolog P43922 colored as blue. Query protein AVX54674.1 is also shown in right top, homolog P43922 showed in right bottom. They are colored based on secondary structures.

  AVX54674.1 MSKQIKGIAASDGISLAKALVIKE--IKLDVQKQLIDD-VDQQIAKLEQAINQTITDLKKIQKITLEKLGEEKAAIFDAHQDIANDPAIKEEVVQLIKTE 97
      P43922 M---ISGILASPGIAFGKALVLKEEKIVLDTQK-ITDDQIDAEVARFYEGRNAAVEQLNSIRERALISLGEEKAAIFEGHLMILEDEELEEEILDYLRSN 96

  AVX54674.1 KVNAEYALF-IVSNNYFEMFSQLEDPYFKERSADIKDVSSRIISHILGLEIHDLSTIDKEVIIISDDLTPSQTAQLD-KKFVKGFLTNVGGRTSHAAIMA 195
      P43922 KVNAGVAASKILDQQVT-MLSEIDDEYLKERAGDIRDIANRLVKNILGMYIVDLGDIQEESILVAYDLTPSETAQLNLEKVL-GVVTDIGGRTSHTSIMA 194

  AVX54674.1 RSLEIPAILGLKNITELVKTDDLIALDGSSGIVELDLN------DNDIKNYQTKVKQYLELKDQLKKFKDKPSLTKD--KIKKLIEANIGSTNDIQSVLD 287
      P43922 RSLELPAIVGTNKVTKLVNTGDYLILDAINN--QVYINPTASQID-ELKALEAKIS---EEKAELAKLKDLPAITLDGHKV-DVV-ANIGTIRDCDGAER 286

  AVX54674.1 SGAEGIGLFRTEFLYMNNDHFPTEEEQFEAYKKVVSQID-HLVVFRTLDIGGDKKLSYFKFDEEMNPFLGYRAIRFTLDRKDIFKDQIRALLRASAFGKL 386
      P43922 NGAEGIGLYRTEFLFMDREQLPTEEEQFIAYKQVVEAMNGRLTVIRTMDIGGDKELSYLDLPKEMNPFLGWRAIRIALDRREILNAQLRAVLRASAFGKL 386

  AVX54674.1 GIMFPMIATIDEFKQAKAFVEECKLELDKENIKYDKQVQIGMMVEIPSAAILADQF-AKYADFFSIGTNDLIQYSFASDRMNQNVSYLYQPLNPSLLRLI 485
      P43922 AVMFPMIISVEEIRELKAVIETLKAELREEGRLFDNNIQVGVMVETPSAAVNA-KFLAKEVDFFSIGTNDLTQYTLAVDRGNEFISHLYNPMHPSVLGLI 485

  AVX54674.1 QLTISGAHKHNKWVGMCGEMAGDSKALPILLGLDLDAFSMSATSVLKARSLMSKIESIKAKELANKALECQTSQQVNDLVEEF-LKN-LD 573
      P43922 KQVIDASHAEGKWTGMCGELAGDERATLLLLGMGLDEFSMSAISVPRIKKLIRNVNFQDAKVLADTALQKPTAAEIDQLIEEFLLENSLN 575

Go Annotations

1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.

Source GO Description
1. PBF GO:0008965 phosphoenolpyruvate-protein phosphotransferase activity
1. PBF GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
1. PBF GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system
1. PBF GO:0005737 cytoplasm
1. PBF GO:0046872 metal ion binding
1. PBF GO:0016301 kinase activity
3. BF GO:0004743 pyruvate kinase activity
3. BF GO:0008986 pyruvate, water dikinase activity
3. BF GO:0030955 potassium ion binding
3. BF GO:0019563 glycerol catabolic process
3. BF GO:0050242 pyruvate, phosphate dikinase activity
3. BF GO:0016874 ligase activity
3. BF GO:0005524 ATP binding
3. BF GO:0006090 pyruvate metabolic process
3. BF GO:0017000 antibiotic biosynthetic process
3. BF GO:0006094 gluconeogenesis
3. BF GO:0047324 phosphoenolpyruvate-glycerone phosphotransferase activity
4. PB GO:0019197 phosphoenolpyruvate-dependent sugar phosphotransferase complex
4. PB GO:0010243 response to organonitrogen compound
6. F GO:0000287 magnesium ion binding
7. B GO:0016772 transferase activity, transferring phosphorus-containing groups
7. B GO:0016310 phosphorylation
7. B GO:0043042 amino acid adenylylation by nonribosomal peptide synthase
7. B GO:0008460 dTDP-glucose 4,6-dehydratase activity
7. B GO:0015979 photosynthesis
7. B GO:0009507 chloroplast
7. B GO:0009403 toxin biosynthetic process

Uniprot GO Annotations

GO Description
GO:0008965 phosphoenolpyruvate-protein phosphotransferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016740 transferase activity
GO:0016310 phosphorylation
GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system
GO:0008643 carbohydrate transport
GO:0005737 cytoplasm
GO:0003824 catalytic activity
GO:0046872 metal ion binding
GO:0016301 kinase activity

Homologs

1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.

Source Homolog Description Fatcat Pvalue PROST Evalue BLAST Evalue Foldseek TMScore
1. PBF O31149 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 6.82e-100 0.0 0.8208
1. PBF P47668 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 7.32e-96 0.0 0.8988
1. PBF Q8KA50 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 1.83e-95 1.22e-161 0.8902
1. PBF O07126 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 7.73e-97 0.0 0.8436
1. PBF Q931U2 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 2.20e-95 0.0 0.8452
1. PBF P42014 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 2.21e-92 0.0 0.9198
1. PBF Q9Z9E3 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 8.26e-65 7.09e-71 0.6439
1. PBF P0A249 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 2.46e-97 2.86e-169 0.889
1. PBF P45595 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 6.71e-98 0.0 0.9105
1. PBF P0A250 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 2.46e-97 2.86e-169 0.9044
1. PBF Q5HH01 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 6.09e-96 0.0 0.8504
1. PBF Q84F83 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 8.85e-95 0.0 0.9688
1. PBF Q8NX83 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 4.06e-96 0.0 0.8489
1. PBF Q9PK57 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 9.98e-64 7.28e-63 0.6898
1. PBF D4GYE2 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 6.70e-78 3.09e-117 0.8708
1. PBF Q9KZP1 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 2.19e-71 8.56e-91 0.7525
1. PBF P30299 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 2.85e-97 0.0 0.8295
1. PBF P43922 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 3.03e-96 2.86e-178 0.938
1. PBF Q8CT19 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 2.46e-94 0.0 0.8593
1. PBF P23536 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 4.96e-85 2.60e-112 0.8834
1. PBF P51183 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 6.09e-96 0.0 0.8506
1. PBF Q9K8D3 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 3.67e-94 0.0 0.8886
1. PBF P08838 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 2.28e-95 0.0 0.9196
1. PBF Q6GI01 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 3.30e-97 0.0 0.8567
1. PBF P37178 Phosphoenolpyruvate-dependent phosphotransferase system 0.00e+00 5.69e-05 3.08e-93 0.8658
1. PBF Q6GAD0 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 4.06e-96 0.0 0.8498
1. PBF O51508 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 4.92e-94 4.44e-136 0.8967
1. PBF O69251 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 2.81e-96 0.0 0.91
1. PBF O84340 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 3.66e-63 4.60e-66 0.6065
1. PBF Q5HQ85 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 2.46e-94 0.0 0.8611
1. PBF Q83QP3 Multiphosphoryl transfer protein 0.00e+00 1.79e-03 3.44e-104 0.7626
1. PBF Q9CJ82 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 2.53e-99 0.0 0.8979
1. PBF Q99V14 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 4.37e-96 0.0 0.847
1. PBF Q9ZAD8 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 2.53e-99 0.0 0.9053
1. PBF Q9WXK9 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 6.14e-95 0.0 0.9254
1. PBF P23530 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 1.07e-99 0.0 0.8529
1. PBF O83018 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 1.29e-92 0.0 0.9379
1. PBF Q9WXI6 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 2.81e-96 2.82e-160 0.8738
1. PBF Q92D19 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 1.39e-99 0.0 0.8141
1. PBF Q8XBQ8 Multiphosphoryl transfer protein 0.00e+00 1.14e-03 8.97e-104 0.7628
1. PBF P75168 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 1.65e-94 0.0 0.8768
1. PBF Q8FFD8 Multiphosphoryl transfer protein 0.00e+00 2.43e-03 4.14e-105 0.7786
1. PBF P45617 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 1.23e-133 0.0 0.9865
1. PBF P23533 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 1.65e-94 0.0 0.9107
1. PBF Q89B04 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 1.16e-90 1.01e-159 0.8765
3. BF O29548 Probable phosphoenolpyruvate synthase 2.11e-07 NA 5.29e-45 0.495
3. BF P80885 Pyruvate kinase 8.89e-03 NA 0.004 0.3909
3. BF P37213 Pyruvate, phosphate dikinase 9.56e-07 NA 5.37e-21 0.4593
3. BF Q9YEC5 Phosphoenolpyruvate synthase 2.38e-07 NA 3.70e-29 0.6093
3. BF P0DN88 PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaM 8.50e-10 NA 1.09e-08 0.8441
3. BF Q5W252 Prodigiosin synthesizing transferase PigC 2.61e-01 NA 1.16e-05 0.4161
3. BF Q9V2H7 Probable phosphoenolpyruvate synthase 9.58e-07 NA 4.14e-45 0.4875
3. BF Q55905 Phosphoenolpyruvate synthase 7.17e-07 NA 7.75e-26 0.5265
3. BF O67899 Phosphoenolpyruvate synthase 1.04e-06 NA 1.40e-18 0.5891
3. BF P56070 Phosphoenolpyruvate synthase 1.10e-06 NA 9.82e-28 0.5061
3. BF Q5W269 Prodigiosin synthesizing transferase PigC 2.31e-01 NA 8.80e-06 0.4186
3. BF Q9ZMV4 Phosphoenolpyruvate synthase 1.19e-07 NA 1.97e-28 0.5166
3. BF Q9K0I2 Phosphoenolpyruvate synthase 5.72e-06 NA 5.45e-31 0.55
3. BF Q02KR1 Phosphoenolpyruvate synthase 7.77e-07 NA 5.92e-28 0.5561
3. BF Q42910 Pyruvate, phosphate dikinase, chloroplastic 9.52e-07 NA 1.03e-23 0.4574
3. BF P42850 Phosphoenolpyruvate synthase 6.92e-09 NA 4.37e-46 0.5661
3. BF P51181 Pyruvate kinase 1.01e-02 NA 0.002 0.4324
3. BF P46893 Probable phosphoenolpyruvate synthase 2.57e-08 NA 1.61e-34 0.4921
3. BF A0A0H3H456 PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaM 7.99e-12 NA 1.87e-16 0.8765
3. BF O27190 Probable phosphoenolpyruvate synthase 4.66e-06 NA 7.17e-27 0.3774
3. BF P51182 Pyruvate kinase 2.81e-03 NA 4.56e-05 0.4059
3. BF P23388 Multiphosphoryl transfer protein 0.00e+00 NA 1.08e-117 0.805
3. BF O57830 Probable phosphoenolpyruvate synthase 4.07e-07 NA 6.79e-46 0.4915
3. BF Q39734 Pyruvate, phosphate dikinase, chloroplastic 9.49e-07 NA 3.27e-30 0.4579
3. BF D4GL26 PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaM 7.68e-12 NA 8.91e-22 0.8433
3. BF O34796 Uncharacterized phosphotransferase YvkC 6.51e-02 NA 3.40e-07 0.3991
3. BF Q02499 Pyruvate kinase 7.98e-03 NA 0.002 0.4062
3. BF O34309 Putative phosphoenolpyruvate synthase 2.25e-01 NA 1.75e-06 0.3009
3. BF O83026 Phosphoenolpyruvate synthase 1.09e-08 NA 6.63e-21 0.5231
3. BF Q39735 Pyruvate, phosphate dikinase, chloroplastic 8.53e-07 NA 3.60e-28 0.4574
3. BF P45597 Multiphosphoryl transfer protein 0.00e+00 NA 2.41e-99 0.8301
4. PB P32670 Multiphosphoryl transfer protein 2 0.00e+00 1.69e-02 1.97e-109 NA
4. PB P77439 Multiphosphoryl transfer protein 1 0.00e+00 9.94e-04 1.59e-104 NA
4. PB P08839 Phosphoenolpyruvate-protein phosphotransferase 0.00e+00 4.96e-99 3.75e-170 NA
4. PB P37177 Phosphoenolpyruvate-dependent phosphotransferase system 0.00e+00 5.63e-05 3.01e-93 NA
6. F Q2YTE3 Pyruvate kinase 2.96e-03 NA NA 0.383
6. F Q99TG5 Pyruvate kinase 2.98e-03 NA NA 0.3996
6. F Q7A0N4 Pyruvate kinase 2.98e-03 NA NA 0.3996
6. F Q5HNK7 Pyruvate kinase 3.01e-03 NA NA 0.4195
6. F Q4L739 Pyruvate kinase 2.78e-03 NA NA 0.4156
6. F P34038 Pyruvate kinase 1.60e-02 NA NA 0.421
6. F Q5HF76 Pyruvate kinase 2.97e-03 NA NA 0.3996
6. F Q8CS69 Pyruvate kinase 4.32e-03 NA NA 0.4386
6. F Q6GG09 Pyruvate kinase 4.59e-03 NA NA 0.4061
6. F Q7A559 Pyruvate kinase 2.95e-03 NA NA 0.3996
6. F Q6G8M9 Pyruvate kinase 2.96e-03 NA NA 0.4095
6. F Q2FG40 Pyruvate kinase 2.96e-03 NA NA 0.3999
6. F P73534 Pyruvate kinase 2 3.94e-03 NA NA 0.4453
7. B Q9ZD55 Pyruvate, phosphate dikinase 4.64e-07 NA 2.56e-26 NA
7. B P22983 Pyruvate, phosphate dikinase 3.30e-07 NA 3.57e-24 NA
7. B Q75KR1 Pyruvate, phosphate dikinase 2 4.33e-07 NA 1.52e-25 NA
7. B P51776 Pyruvate, phosphate dikinase 8.03e-07 NA 3.42e-21 NA
7. B Q42736 Pyruvate, phosphate dikinase, chloroplastic 8.79e-07 NA 4.00e-29 NA
7. B P23538 Phosphoenolpyruvate synthase 5.43e-07 NA 7.71e-32 NA
7. B P9WIH5 Uncharacterized protein Rv2047c 5.74e-02 NA 0.039 NA
7. B P37349 PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaM 8.38e-11 NA 1.56e-16 NA
7. B Q1RH78 Pyruvate, phosphate dikinase 1.54e-07 NA 8.14e-28 NA
7. B P9WIH4 Uncharacterized protein MT2107 2.91e-01 NA 0.039 NA
7. B Q59754 Pyruvate, phosphate dikinase 1.04e-06 NA 2.72e-25 NA
7. B O83728 Pyruvate, phosphate dikinase 6.79e-07 NA 4.50e-20 NA
7. B Q0VZ70 Chondramide synthase cmdD NA NA 6.76e-05 NA
7. B O23404 Pyruvate, phosphate dikinase 1, chloroplastic 1.24e-06 NA 6.11e-24 NA
7. B Q57962 Probable phosphoenolpyruvate synthase 1.13e-04 NA 5.61e-36 NA
7. B P22221 Pyruvate, phosphate dikinase, chloroplastic 8.59e-07 NA 4.08e-28 NA
7. B P11155 Pyruvate, phosphate dikinase 1, chloroplastic 8.53e-07 NA 7.53e-24 NA
7. B Q68WP2 Pyruvate, phosphate dikinase 1.27e-07 NA 1.48e-24 NA
7. B P65685 Uncharacterized protein Mb2073c 5.78e-02 NA 0.039 NA
7. B Q4ULI7 Pyruvate, phosphate dikinase 9.98e-08 NA 2.21e-26 NA
7. B Q92HI8 Pyruvate, phosphate dikinase 5.20e-07 NA 1.27e-24 NA
7. B Q6AVA8 Pyruvate, phosphate dikinase 1, chloroplastic 1.22e-06 NA 1.17e-22 NA
7. B Q42368 Pyruvate, phosphate dikinase 2 4.15e-07 NA 7.49e-26 NA