Summary

The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.

AVX54675.1
JCVISYN3A_0234

PTS glucose transporter subunit IIA.
M. mycoides homolog: Q6MTX1.
TIGRfam Classification: 4=Probable.
Category: Essential.

Statistics

Total GO Annotation: 30
Unique PROST Go: 7
Unique BLAST Go: 4
Unique Foldseek Go: 1

Total Homologs: 133
Unique PROST Homologs: 8
Unique BLAST Homologs: 5
Unique Foldseek Homologs: 43

Literature

Danchin and Fang [1]: NA
Yang and Tsui [2]: NA
Antczak et al. [3]: Phosphotransferase system, sugar-specific permease EIIA type 1
Zhang et al. [4]: GO:0043610|regulation of carbohydrate utilization
Bianchi et al. [5]: NA

Structures and Sequence Alignment

The best structural homolog that predicted by 1. PBF was Q8KA51 (PTS system glucose-specific EIIA component) with a FATCAT P-Value: 0 and RMSD of 1.33 angstrom. The sequence alignment identity is 34.8%.
Structural alignment shown in left. Query protein AVX54675.1 colored as red in alignment, homolog Q8KA51 colored as blue. Query protein AVX54675.1 is also shown in right top, homolog Q8KA51 showed in right bottom. They are colored based on secondary structures.

  AVX54675.1 M----WFFN-------KNLKVLAPCDGKIITLDEVEDDVFRERMLGDGFAIYPTSNDFHAPVS---GKLVTAFPTKHAFGIQTKNGVEILLHIGLDTVSL 86
      Q8KA51 MSFFSGFFNKKKSKYSKKIDILAPLSGDIINIEDVPDVVFSKKIVGDGIAINPTGNKILAPINGTIGKILNSM---HAFSIISEEGVELFVHFGIDTVKL 97

  AVX54675.1 DGNGFESYVIQD-QEVNAGDKLVTVDLQEVSKKVPSIKSPIIFTNNGGKTLEIVKMGEVKK--GDVVA---ILK---- 154
      Q8KA51 RGEGF-KQIAQDNQKVKIGDTIILFDLNLLKEKARSILTPVVISN-----IE--KFKNIEKSSGTIIAGKTIIMSLYN 167

Go Annotations

1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.

Source GO Description
1. PBF GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
1. PBF GO:0016301 kinase activity
1. PBF GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system
1. PBF GO:0046872 metal ion binding
2. PF GO:0004609 phosphatidylserine decarboxylase activity
3. BF GO:0015572 N-acetylglucosamine transmembrane transporter activity
3. BF GO:0015293 symporter activity
3. BF GO:0006814 sodium ion transport
3. BF GO:0016021 integral component of membrane
3. BF GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
3. BF GO:0090563 protein-phosphocysteine-sugar phosphotransferase activity
3. BF GO:0005886 plasma membrane
3. BF GO:0005355 glucose transmembrane transporter activity
3. BF GO:0090589 protein-phosphocysteine-trehalose phosphotransferase system transporter activity
3. BF GO:0015771 trehalose transport
3. BF GO:0034219 carbohydrate transmembrane transport
3. BF GO:0019866 organelle inner membrane
4. PB GO:0045912 negative regulation of carbohydrate metabolic process
5. P GO:0006226 dUMP biosynthetic process
5. P GO:0005737 cytoplasm
5. P GO:0006229 dUTP biosynthetic process
5. P GO:0008829 dCTP deaminase activity
5. P GO:0015949 nucleobase-containing small molecule interconversion
5. P GO:0033973 dCTP deaminase (dUMP-forming) activity
5. P GO:0000166 nucleotide binding
6. F GO:0006646 phosphatidylethanolamine biosynthetic process
7. B GO:0090587 protein-phosphocysteine-glucosamine phosphotransferase system transporter activity
7. B GO:0015764 N-acetylglucosamine transport
7. B GO:0090586 protein-phosphocysteine-N-acetylglucosamine phosphotransferase system transporter activity
7. B GO:0005887 integral component of plasma membrane

Uniprot GO Annotations

GO Description
GO:0016740 transferase activity
GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system
GO:0103111 D-glucosamine PTS permease activity

Homologs

1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.

Source Homolog Description Fatcat Pvalue PROST Evalue BLAST Evalue Foldseek TMScore
1. PBF Q9WXI7 PTS system glucose-specific EIIA component 0.00e+00 5.88e-49 4.01e-30 0.9277
1. PBF P60857 PTS system glucose-specific EIIA component 0.00e+00 6.55e-42 2.32e-35 0.9196
1. PBF Q8KA51 PTS system glucose-specific EIIA component 0.00e+00 4.60e-40 7.24e-27 0.9184
1. PBF P0A283 PTS system glucose-specific EIIA component 0.00e+00 2.70e-35 3.25e-28 0.9181
1. PBF Q44840 PTS system glucose-specific EIIA component 0.00e+00 6.29e-17 6.90e-30 0.8815
1. PBF Q5HPB5 PTS system glucose-specific EIIA component 0.00e+00 3.21e-39 3.31e-36 0.9175
1. PBF P45618 PTS system glucose-specific EIIA component 0.00e+00 3.19e-80 4.27e-101 0.9791
1. PBF Q8CP79 PTS system glucose-specific EIIA component 0.00e+00 3.21e-39 3.31e-36 0.9178
1. PBF P60856 PTS system glucose-specific EIIA component 0.00e+00 6.55e-42 2.32e-35 0.917
1. PBF Q9KCQ4 PTS system glucose-specific EIIA component 0.00e+00 8.05e-29 9.73e-34 0.9253
1. PBF Q93P61 PTS system glucose-specific EIIA component 0.00e+00 4.96e-43 9.71e-36 0.9161
1. PBF Q5HFZ9 PTS system glucose-specific EIIA component 0.00e+00 4.96e-43 9.71e-36 0.9083
1. PBF Q81JY0 PTS system glucose-specific EIIA component 0.00e+00 1.03e-38 1.99e-36 0.9164
1. PBF P50829 Putative phosphotransferase enzyme IIA component YpqE 0.00e+00 3.87e-42 6.02e-32 0.9254
1. PBF Q814U8 PTS system glucose-specific EIIA component 0.00e+00 8.56e-40 1.77e-36 0.9165
1. PBF Q8NWR1 PTS system glucose-specific EIIA component 0.00e+00 3.89e-43 4.59e-35 0.9167
1. PBF P0A284 PTS system glucose-specific EIIA component 0.00e+00 2.70e-35 3.25e-28 0.9168
1. PBF P69785 PTS system glucose-specific EIIA component 0.00e+00 3.24e-35 1.18e-28 0.9204
1. PBF Q89B05 PTS system glucose-specific EIIA component 0.00e+00 2.49e-35 2.16e-25 0.9207
1. PBF Q6G9D9 PTS system glucose-specific EIIA component 0.00e+00 3.89e-43 4.59e-35 0.9167
1. PBF P69784 PTS system glucose-specific EIIA component 0.00e+00 3.24e-35 1.18e-28 0.9206
1. PBF P45338 PTS system glucose-specific EIIA component 0.00e+00 4.15e-39 6.40e-28 0.9097
1. PBF Q8CZD5 PTS system glucose-specific EIIA component 0.00e+00 3.18e-46 1.83e-31 0.9203
1. PBF Q6GGY5 PTS system glucose-specific EIIA component 0.00e+00 7.73e-43 1.18e-35 0.9174
3. BF A6QDH3 PTS system glucose-specific EIICBA component 2.57e-09 NA 3.14e-29 0.9244
3. BF Q57071 PTS system glucose-specific EIICBA component 1.01e-11 NA 1.53e-34 0.9661
3. BF A7X6P1 PTS system glucoside-specific EIICBA component 1.12e-12 NA 5.43e-30 0.9569
3. BF A7WXI2 PTS system glucose-specific EIICBA component 2.90e-09 NA 2.30e-29 0.9222
3. BF Q8VRH0 PTS system glucose-specific EIICBA component 2.27e-13 NA 1.65e-35 0.9352
3. BF A8Z0F5 PTS system glucose-specific EIICBA component 7.80e-09 NA 3.14e-29 0.9188
3. BF Q45298 PTS system glucose-specific EIIBCA component 2.10e-10 NA 4.58e-22 0.8682
3. BF Q7A807 PTS system glucose-specific EIICBA component 6.66e-10 NA 2.30e-29 0.9367
3. BF A8Z3D6 PTS system glucoside-specific EIICBA component 1.71e-12 NA 1.20e-30 0.9353
3. BF Q2FDW8 PTS system glucoside-specific EIICBA component 6.18e-12 NA 1.20e-30 0.9624
3. BF P23936 Lactose permease 1.47e-11 NA 3.48e-20 0.9212
3. BF P26207 PTS system beta-glucoside-specific EIIBCA component 3.10e-13 NA 3.51e-21 0.9552
3. BF A6U4R9 PTS system glucoside-specific EIICBA component 1.65e-12 NA 9.58e-31 0.9566
3. BF Q4L945 PTS system glucose-specific EIICBA component 3.40e-11 NA 4.85e-32 0.9337
3. BF Q6GDR0 PTS system glucoside-specific EIICBA component 1.38e-12 NA 1.25e-30 0.9567
3. BF P35595 PTS system glucose-specific EIICBA component 5.58e-11 NA 7.30e-33 0.9296
3. BF Q9KF90 PTS system beta-glucoside-specific EIIBCA component 2.63e-10 NA 1.12e-28 0.9313
3. BF Q2YUZ1 PTS system glucose-specific EIICBA component 2.05e-09 NA 6.18e-30 0.926
3. BF Q5HL73 PTS system glucose-specific EIICBA component 1.87e-13 NA 1.65e-35 0.9498
3. BF A5IVW5 PTS system glucoside-specific EIICBA component 1.48e-12 NA 9.58e-31 0.9629
3. BF Q7CCJ4 PTS system glucose-specific EIICBA component 4.30e-13 NA 1.65e-35 0.9645
3. BF Q7A3G4 PTS system glucoside-specific EIICBA component 1.43e-12 NA 5.43e-30 0.932
3. BF P20166 PTS system glucose-specific EIICBA component 3.01e-09 NA 1.89e-33 0.9328
3. BF Q99R97 PTS system glucoside-specific EIICBA component 4.80e-11 NA 5.43e-30 0.9293
3. BF Q46072 PTS system mannose-specific EIIBCA component 4.93e-10 NA 2.67e-22 0.8618
3. BF Q8NUS2 PTS system glucoside-specific EIICBA component 4.09e-12 NA 1.20e-30 0.9571
3. BF P40739 PTS system beta-glucoside-specific EIIBCA component 4.56e-11 NA 2.58e-25 0.945
3. BF P22733 Lactose permease 3.35e-11 NA 1.85e-18 0.9141
3. BF P39816 Putative PTS system glucosamine-specific EIICBA component 1.18e-06 NA 8.07e-32 0.9546
3. BF Q2YWC1 PTS system glucoside-specific EIICBA component 6.91e-13 NA 2.64e-30 0.934
3. BF P75569 PTS system glucose-specific EIICBA component 2.65e-07 NA 2.49e-14 0.8953
3. BF P43470 PTS system sucrose-specific EIIBCA component 2.25e-11 NA 1.01e-18 0.9497
3. BF Q53922 PTS system glucoside-specific EIICBA component 1.40e-11 NA 1.29e-31 0.9533
3. BF Q6GKB7 PTS system glucose-specific EIICBA component 2.11e-08 NA 3.05e-29 0.9178
3. BF P42015 PTS system glucose-specific EIICBA component (Fragment) 0.00e+00 NA 7.29e-40 0.9441
3. BF Q4A0C4 PTS system glucose-specific EIICBA component 1.37e-13 NA 1.60e-30 0.9681
3. BF P47315 PTS system glucose-specific EIICBA component 1.04e-06 NA 6.59e-16 0.8952
3. BF P45604 PTS system N-acetylglucosamine-specific EIICBA component 7.01e-12 NA 9.24e-26 0.9166
3. BF Q2FK73 PTS system glucose-specific EIICBA component 7.64e-10 NA 3.14e-29 0.9284
3. BF Q6G6D6 PTS system glucoside-specific EIICBA component 4.26e-12 NA 1.20e-30 0.957
3. BF A6TXX3 PTS system glucose-specific EIICBA component 1.60e-09 NA 2.30e-29 0.926
3. BF A6QK27 PTS system glucoside-specific EIICBA component 1.58e-10 NA 1.20e-30 0.9625
3. BF Q5HD13 PTS system glucoside-specific EIICBA component 5.23e-11 NA 1.20e-30 0.9361
3. BF Q5HJI3 PTS system glucose-specific EIICBA component 3.22e-09 NA 3.14e-29 0.9243
3. BF P12655 PTS system sucrose-specific EIIBCA component 1.78e-11 NA 1.15e-24 0.9444
3. BF Q6GCT7 PTS system glucose-specific EIICBA component 7.01e-09 NA 3.14e-29 0.9204
3. BF P43466 Raffinose carrier protein 3.02e-09 NA 2.66e-19 0.89
3. BF Q8NYM1 PTS system glucose-specific EIICBA component 6.63e-09 NA 3.14e-29 0.9185
3. BF Q48624 Lactose permease 3.27e-08 NA 1.18e-14 0.8937
3. BF Q7WTB2 Lactose permease 5.25e-07 NA 1.08e-18 0.8525
3. BF A5IP58 PTS system glucose-specific EIICBA component 6.79e-11 NA 2.30e-29 0.9187
3. BF Q99X32 PTS system glucose-specific EIICBA component 4.61e-09 NA 2.30e-29 0.9203
4. PB P69783 PTS system glucose-specific EIIA component 0.00e+00 3.24e-35 1.18e-28 NA
5. P Q72W72 dCTP deaminase, dUMP-forming 7.95e-01 1.44e-02 NA NA
5. P Q04WA6 dCTP deaminase, dUMP-forming 7.80e-01 1.16e-02 NA NA
5. P Q58269 Uncharacterized protein MJ0859 2.24e-01 8.65e-04 NA NA
5. P Q04X69 dCTP deaminase, dUMP-forming 7.84e-01 1.16e-02 NA NA
5. P Q2NFH1 dCTP deaminase, dUMP-forming 7.81e-01 3.48e-02 NA NA
5. P B8DUY2 dCTP deaminase, dUMP-forming 7.87e-01 2.93e-02 NA NA
5. P Q58227 Putative archaetidylserine decarboxylase proenzyme 2.86e-06 7.82e-03 NA NA
5. P Q8F9W5 dCTP deaminase, dUMP-forming 7.77e-01 1.44e-02 NA NA
6. F Q3ST95 Phosphatidylserine decarboxylase proenzyme 1.75e-06 NA NA 0.5437
6. F B6JHT1 Phosphatidylserine decarboxylase proenzyme 1.21e-06 NA NA 0.5213
6. F Q9JZP0 Phosphatidylserine decarboxylase proenzyme 9.31e-06 NA NA 0.5558
6. F Q50967 Phosphatidylserine decarboxylase proenzyme 1.20e-05 NA NA 0.5178
6. F Q139C9 Phosphatidylserine decarboxylase proenzyme 2.52e-06 NA NA 0.5104
6. F Q1LPX5 Phosphatidylserine decarboxylase proenzyme 1.99e-06 NA NA 0.6044
6. F B3ESH0 Phosphatidylserine decarboxylase proenzyme 2.08e-06 NA NA 0.5766
6. F Q0SES0 Phosphatidylserine decarboxylase proenzyme 2.01e-06 NA NA 0.5912
6. F Q9X5E3 Phosphatidylserine decarboxylase proenzyme 3.58e-06 NA NA 0.5445
6. F Q89NP2 Phosphatidylserine decarboxylase proenzyme 2.83e-06 NA NA 0.5411
6. F Q2IUP7 Phosphatidylserine decarboxylase proenzyme 3.23e-06 NA NA 0.5249
6. F Q3SHE5 Phosphatidylserine decarboxylase proenzyme 1.42e-06 NA NA 0.5353
6. F Q3B2G7 Phosphatidylserine decarboxylase proenzyme 2.13e-06 NA NA 0.5694
6. F Q5NXP3 Phosphatidylserine decarboxylase proenzyme 1.16e-06 NA NA 0.5638
6. F A4F743 Phosphatidylserine decarboxylase proenzyme 4.91e-06 NA NA 0.5672
6. F A6LF25 Phosphatidylserine decarboxylase proenzyme 2.07e-06 NA NA 0.539
6. F A1UAG5 Phosphatidylserine decarboxylase proenzyme 3.20e-06 NA NA 0.6083
6. F Q984W0 Phosphatidylserine decarboxylase proenzyme 3.64e-06 NA NA 0.5088
6. F A3PU20 Phosphatidylserine decarboxylase proenzyme 3.21e-06 NA NA 0.602
6. F Q1QN82 Phosphatidylserine decarboxylase proenzyme 1.63e-06 NA NA 0.5501
6. F Q64YG8 Phosphatidylserine decarboxylase proenzyme 1.86e-06 NA NA 0.5648
6. F Q62IM1 Phosphatidylserine decarboxylase proenzyme 1.58e-06 NA NA 0.6026
6. F Q1MQ97 Phosphatidylserine decarboxylase proenzyme 6.52e-07 NA NA 0.5901
6. F Q1BEG9 Phosphatidylserine decarboxylase proenzyme 3.11e-06 NA NA 0.6064
6. F B2JDN8 Phosphatidylserine decarboxylase proenzyme 1.78e-06 NA NA 0.597
6. F Q5YNV8 Phosphatidylserine decarboxylase proenzyme 3.42e-06 NA NA 0.5959
6. F A9IRR6 Phosphatidylserine decarboxylase proenzyme 1.08e-05 NA NA 0.5309
6. F Q8A5K8 Phosphatidylserine decarboxylase proenzyme 2.05e-06 NA NA 0.5734
6. F A4YWZ6 Phosphatidylserine decarboxylase proenzyme 1.15e-06 NA NA 0.5479
6. F Q2SZP7 Phosphatidylserine decarboxylase proenzyme 1.67e-06 NA NA 0.6038
6. F Q473V4 Phosphatidylserine decarboxylase proenzyme 2.06e-06 NA NA 0.606
6. F Q4FMX4 Phosphatidylserine decarboxylase proenzyme 3.28e-06 NA NA 0.5273
6. F A7IPD6 Phosphatidylserine decarboxylase proenzyme 2.22e-06 NA NA 0.537
6. F A6L1J5 Phosphatidylserine decarboxylase proenzyme 5.54e-06 NA NA 0.5449
6. F Q142I5 Phosphatidylserine decarboxylase proenzyme 1.83e-06 NA NA 0.5895
6. F A4SXR2 Phosphatidylserine decarboxylase proenzyme 2.11e-06 NA NA 0.5877
6. F B2HQP4 Phosphatidylserine decarboxylase proenzyme 4.64e-06 NA NA 0.5492
6. F B4S5J9 Phosphatidylserine decarboxylase proenzyme 2.45e-06 NA NA 0.5434
6. F A9M4G3 Phosphatidylserine decarboxylase proenzyme 1.63e-05 NA NA 0.5481
6. F Q8RGF2 Phosphatidylserine decarboxylase proenzyme 5.18e-05 NA NA 0.5291
6. F B1YTR9 Phosphatidylserine decarboxylase proenzyme 1.40e-06 NA NA 0.5723
6. F B4E5N4 Phosphatidylserine decarboxylase proenzyme 1.48e-06 NA NA 0.6086
6. F C1B0C2 Phosphatidylserine decarboxylase proenzyme 2.22e-06 NA NA 0.5964
7. B Q2FV87 PTS system glucoside-specific EIICBA component 4.56e-12 NA 1.20e-30 NA
7. B P09323 PTS system N-acetylglucosamine-specific EIICBA component 5.32e-12 NA 6.04e-24 NA
7. B O32292 Putative phosphotransferase enzyme IIA component YyzE 2.57e-07 NA 3.64e-09 NA
7. B P08722 PTS system beta-glucoside-specific EIIBCA component 2.35e-10 NA 9.68e-25 NA
7. B Q2G1G8 PTS system glucose-specific EIICBA component 1.36e-09 NA 3.14e-29 NA