Summary
The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.
AVX54678.1
JCVISYN3A_0239
Uncharacterized protein.
M. mycoides homolog: Q6MTW6.
TIGRfam Classification: 1=Unknown.
Category: Nonessential.
Statistics
Total GO Annotation: 6
Unique PROST Go: 0
Unique BLAST Go: 0
Unique Foldseek Go: 0
Total Homologs: 89
Unique PROST Homologs: 2
Unique BLAST Homologs: 0
Unique Foldseek Homologs: 0
Structures and Sequence Alignment
The best structural homolog that predicted by 2. PF was
Q71Z73
(Septation ring formation regulator EzrA) with a FATCAT P-Value: 1.07e-14 and RMSD of 3.34 angstrom. The sequence alignment identity is 20.7%.
Structural alignment shown in left. Query protein AVX54678.1 colored as red in alignment, homolog Q71Z73 colored as blue.
Query protein AVX54678.1 is also shown in right top, homolog Q71Z73 showed in right bottom. They are colored based on secondary structures.
AVX54678.1 MWFELMLIITKLSETKAINIVFLTIFLLAFFCSLFTIFKLYVYRNTLKKLHFTFLN-I-EKTLK---HPLANRLVRMQFI-VTNSNNQNLSKAL-EIWKI 93 Q71Z73 MYY--ML----------IGFIIVVIAVIG--AG-------YI----LKRKHYQRINELEEKKIKLRERPVIDELSKVKKLKLTGQ-----TEALFESWRS 70 AVX54678.1 KYNQIYNVELDILIKQTKEHF-DLNSYSKKILFRVLSIK-NFYRT-RKLYKTSKAIYQKVNLMYSETQQVTNIEFLLRDYRIILQNHIND-----LFDIV 185 Q71Z73 SWDEI----------ETR-LFPDL----EEVL---LEAEMN---TDR--YK-----FR------SATHAENDIEQML----VVIEKQM-DQILGGLKELL 131 AVX54678.1 FKEQEN-NELNIDKKIINNYQESIFKKMIVCEYYIKIGNFKEAF----SKLNLLSNNVIEYIKFLD--DHYKITKFL-----EFNGILDSKLQEIKNKV- 272 Q71Z73 ISEEKNAKESRATKE---KFAE--LRREVLTRGF-KLG---ETLPYIETKLSELSESLNSYDSLTDQGDHLEAREIVIVVQKEMQ-VIEAQMERIPSLLH 221 AVX54678.1 QLD--VNQKNNQL-IKYQINLLEQ-QFIDQKQAVEKLLFHGKNNQAFLIIETLIKNIQNLDVILKYDQQILSLFETNVKNIRT-ILLSFNTELLKTE-EL 366 Q71Z73 ETDTILPEEMTKLRAGYE-EMVRKGYYLAQ-MELDKEISRMKNQ-----IDKMKKNVINLDL----DE-----AEQGVEELHNEIDLFYDT--LEHEAEA 303 AVX54678.1 INF---NNN-----L--NNDISD-IKIQFDQLKTSFNNITTEFD-KEYQKISS-------NFIQFNSLIVD-YVNY--IRNVL--IDIKKHYTQLIDIKT 442 Q71Z73 RHFVKENHSPTSDKLQRQNAVSDALAEQITEVKQTYH--VAEDDLAVYLKTSAKLSEAKENFEQLTALIASGEIAYSAAQDTLKEID-----AALITI-S 395 AVX54678.1 LLKNK---SL-VLR-D-LETKYDNIKTLLFLSQAII---KKYEKVINWSVYKEL--INNKFL-I-------INFIYKNLE---LEANTFTNDY-----DA 515 Q71Z73 AEQDKFAEELRSLRKDELEAR-DDAER---MRRAIITLDRKMER-------ERLPGLPEEYLSLREHMGESINALEKRLEEKPLNMKAVSQDWRIAEED- 483 AVX54678.1 LLVLNNQLDNQIEQVEQLHLNIEQVVVIYKIAQQIIIYIAKN--LA--YISNNNAFEEILTKFKEKNHKKVINLAIHLIRKNQL---------------- 595 Q71Z73 LTHLTEKAE---EMMENVRL-VEHVIQ-Y--ANR---YRLRNKELADELVQAENHF------YNDYQYKKALEIAVTALEK--VETGAFKKVEKAYESKV 565 AVX54678.1 ------ 595 Q71Z73 SVDDIE 571
Go Annotations
1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.
| Source | GO | Description |
|---|---|---|
| 2. PF | GO:0000918 | division septum site selection |
| 2. PF | GO:0000917 | division septum assembly |
| 2. PF | GO:0005940 | septin ring |
| 2. PF | GO:0000921 | septin ring assembly |
| 2. PF | GO:0016021 | integral component of membrane |
| 2. PF | GO:0005886 | plasma membrane |
Uniprot GO Annotations
| GO | Description |
|---|---|
| GO:0016020 | membrane |
| GO:0016021 | integral component of membrane |
Homologs
1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.
| Source | Homolog | Description | Fatcat Pvalue | PROST Evalue | BLAST Evalue | Foldseek TMScore |
|---|---|---|---|---|---|---|
| 2. PF | Q1JML7 | Septation ring formation regulator EzrA | 1.75e-12 | 2.08e-19 | NA | 0.403 |
| 2. PF | A2RFE5 | Septation ring formation regulator EzrA | 1.51e-12 | 7.27e-19 | NA | 0.3905 |
| 2. PF | Q8EPB2 | Septation ring formation regulator EzrA | 4.07e-12 | 2.01e-23 | NA | 0.3555 |
| 2. PF | Q04L94 | Septation ring formation regulator EzrA | 1.55e-12 | 1.73e-24 | NA | 0.3516 |
| 2. PF | Q1JHQ8 | Septation ring formation regulator EzrA | 1.42e-12 | 4.87e-19 | NA | 0.3832 |
| 2. PF | Q8DTQ3 | Septation ring formation regulator EzrA | 6.48e-13 | 3.51e-25 | NA | 0.3912 |
| 2. PF | Q88UX2 | Septation ring formation regulator EzrA | 7.62e-12 | 1.29e-27 | NA | 0.38 |
| 2. PF | Q8CNW5 | Septation ring formation regulator EzrA | 4.74e-14 | 1.12e-18 | NA | 0.3891 |
| 2. PF | B7JS25 | Septation ring formation regulator EzrA | 4.22e-14 | 1.75e-15 | NA | 0.3706 |
| 2. PF | A2RNU8 | Septation ring formation regulator EzrA | 5.57e-12 | 1.11e-15 | NA | 0.352 |
| 2. PF | A4IRU1 | Septation ring formation regulator EzrA | 1.57e-12 | 8.46e-16 | NA | 0.3699 |
| 2. PF | A9VKG1 | Septation ring formation regulator EzrA | 7.87e-14 | 7.79e-14 | NA | 0.3935 |
| 2. PF | B5E3I9 | Septation ring formation regulator EzrA | 1.46e-12 | 1.73e-24 | NA | 0.3465 |
| 2. PF | Q8E0U6 | Septation ring formation regulator EzrA | 2.48e-12 | 1.30e-17 | NA | 0.3872 |
| 2. PF | Q5HNI8 | Septation ring formation regulator EzrA | 4.02e-13 | 1.92e-18 | NA | 0.3954 |
| 2. PF | A8FG97 | Septation ring formation regulator EzrA | 1.45e-13 | 5.80e-23 | NA | 0.3813 |
| 2. PF | A4VWI6 | Septation ring formation regulator EzrA | 2.23e-13 | 3.89e-14 | NA | 0.3823 |
| 2. PF | B4U2B4 | Septation ring formation regulator EzrA | 3.29e-13 | 1.12e-19 | NA | 0.3687 |
| 2. PF | C1C6F1 | Septation ring formation regulator EzrA | 2.76e-13 | 1.73e-24 | NA | 0.3621 |
| 2. PF | C1CDG4 | Septation ring formation regulator EzrA | 8.52e-13 | 1.64e-24 | NA | 0.3537 |
| 2. PF | C5D695 | Septation ring formation regulator EzrA | 9.94e-13 | 5.16e-18 | NA | 0.4038 |
| 2. PF | Q8NW47 | Septation ring formation regulator EzrA | 1.16e-13 | 4.23e-21 | NA | 0.3655 |
| 2. PF | Q65G47 | Septation ring formation regulator EzrA | 3.27e-12 | 7.09e-22 | NA | 0.3902 |
| 2. PF | B8DHE7 | Septation ring formation regulator EzrA | 3.40e-14 | 4.64e-19 | NA | 0.3639 |
| 2. PF | B5XKM5 | Septation ring formation regulator EzrA | 1.27e-13 | 2.08e-19 | NA | 0.3953 |
| 2. PF | Q71Z73 | Septation ring formation regulator EzrA | 1.07e-14 | 2.89e-18 | NA | 0.3749 |
| 2. PF | P0DA99 | Septation ring formation regulator EzrA | 3.30e-13 | 2.08e-19 | NA | 0.3709 |
| 2. PF | B7IK49 | Septation ring formation regulator EzrA | 5.61e-14 | 3.01e-14 | NA | 0.3577 |
| 2. PF | C1KVP1 | Septation ring formation regulator EzrA | 2.45e-14 | 2.89e-18 | NA | 0.3681 |
| 2. PF | Q8Y6T8 | Septation ring formation regulator EzrA | 2.53e-14 | 1.86e-18 | NA | 0.3658 |
| 2. PF | Q5HF56 | Septation ring formation regulator EzrA | 3.26e-13 | 4.23e-21 | NA | 0.3807 |
| 2. PF | A6QHQ1 | Septation ring formation regulator EzrA | 2.30e-13 | 4.23e-21 | NA | 0.3771 |
| 2. PF | Q1J7I7 | Septation ring formation regulator EzrA | 3.10e-12 | 3.01e-19 | NA | 0.3919 |
| 2. PF | B7HSI6 | Septation ring formation regulator EzrA | 5.09e-13 | 4.36e-14 | NA | 0.3726 |
| 2. PF | B8ZNG7 | Septation ring formation regulator EzrA | 4.03e-12 | 1.64e-24 | NA | 0.3567 |
| 2. PF | A8Z2N4 | Septation ring formation regulator EzrA | 2.22e-13 | 4.23e-21 | NA | 0.3696 |
| 2. PF | C1EUZ7 | Septation ring formation regulator EzrA | 5.22e-14 | 1.75e-15 | NA | 0.364 |
| 2. PF | Q817A9 | Septation ring formation regulator EzrA | 1.18e-12 | 7.55e-15 | NA | 0.3748 |
| 2. PF | C1CS76 | Septation ring formation regulator EzrA | 4.17e-11 | 1.73e-24 | NA | 0.3232 |
| 2. PF | Q3K2B6 | Septation ring formation regulator EzrA | 3.94e-14 | 1.30e-17 | NA | 0.3865 |
| 2. PF | Q8P1M3 | Septation ring formation regulator EzrA | 1.57e-12 | 7.27e-19 | NA | 0.3875 |
| 2. PF | C3PBB5 | Septation ring formation regulator EzrA | 4.81e-14 | 1.75e-15 | NA | 0.3807 |
| 2. PF | C0M6K2 | Septation ring formation regulator EzrA | 1.26e-13 | 1.10e-19 | NA | 0.3927 |
| 2. PF | P47637 | Uncharacterized protein MG397 | 5.22e-12 | 4.36e-30 | NA | 0.414 |
| 2. PF | Q9A0K9 | Septation ring formation regulator EzrA | 1.85e-12 | 5.05e-20 | NA | 0.3791 |
| 2. PF | A4W2T8 | Septation ring formation regulator EzrA | 1.80e-13 | 1.13e-14 | NA | 0.3806 |
| 2. PF | O34894 | Septation ring formation regulator EzrA | 1.70e-13 | 1.09e-20 | NA | 0.3713 |
| 2. PF | Q1JCP0 | Septation ring formation regulator EzrA | 1.75e-12 | 2.08e-19 | NA | 0.3952 |
| 2. PF | B7H705 | Septation ring formation regulator EzrA | 6.69e-13 | 1.39e-14 | NA | 0.3639 |
| 2. PF | A0AJ43 | Septation ring formation regulator EzrA | 2.32e-14 | 1.53e-19 | NA | 0.372 |
| 2. PF | Q6HCM8 | Septation ring formation regulator EzrA | 1.05e-12 | 1.22e-14 | NA | 0.3565 |
| 2. PF | Q8E6G4 | Septation ring formation regulator EzrA | 1.94e-13 | 1.30e-17 | NA | 0.3824 |
| 2. PF | A7Z7N6 | Septation ring formation regulator EzrA | 1.51e-13 | 3.06e-19 | NA | 0.3956 |
| 2. PF | C3L9V6 | Septation ring formation regulator EzrA | 9.03e-13 | 1.75e-15 | NA | 0.3575 |
| 2. PF | A6U2I4 | Septation ring formation regulator EzrA | 2.38e-13 | 4.23e-21 | NA | 0.3643 |
| 2. PF | C1CJQ4 | Septation ring formation regulator EzrA | 1.71e-12 | 1.73e-24 | NA | 0.3476 |
| 2. PF | Q838R5 | Septation ring formation regulator EzrA | 5.33e-12 | 1.63e-23 | NA | 0.3416 |
| 2. PF | Q2FG20 | Septation ring formation regulator EzrA | 2.79e-13 | 4.23e-21 | NA | 0.3931 |
| 2. PF | A0RJP1 | Septation ring formation regulator EzrA | 5.18e-14 | 1.75e-15 | NA | 0.3651 |
| 2. PF | A7GTT0 | Septation ring formation regulator EzrA | 5.40e-14 | 2.15e-15 | NA | 0.3659 |
| 2. PF | B9DRR4 | Septation ring formation regulator EzrA | 2.53e-12 | 6.33e-17 | NA | 0.3744 |
| 2. PF | B9J153 | Septation ring formation regulator EzrA | 6.73e-14 | 4.36e-14 | NA | 0.3697 |
| 2. PF | Q633E6 | Septation ring formation regulator EzrA | 3.92e-13 | 1.75e-15 | NA | 0.3681 |
| 2. PF | B1IAY5 | Septation ring formation regulator EzrA | 1.87e-12 | 1.73e-24 | NA | 0.3461 |
| 2. PF | Q5KW53 | Septation ring formation regulator EzrA | 6.44e-13 | 1.05e-21 | NA | 0.3357 |
| 2. PF | A5ITP0 | Septation ring formation regulator EzrA | 2.01e-13 | 4.23e-21 | NA | 0.3802 |
| 2. PF | Q92BB4 | Septation ring formation regulator EzrA | 4.41e-14 | 2.07e-18 | NA | 0.3668 |
| 2. PF | Q6G8L0 | Septation ring formation regulator EzrA | 2.57e-13 | 4.23e-21 | NA | 0.3756 |
| 2. PF | Q48UF9 | Septation ring formation regulator EzrA | 2.01e-12 | 2.08e-19 | NA | 0.3686 |
| 2. PF | Q97RK0 | Septation ring formation regulator EzrA | 1.95e-12 | 3.11e-24 | NA | 0.3445 |
| 2. PF | Q50333 | Uncharacterized protein MG397 homolog | 6.67e-14 | 1.81e-26 | NA | 0.3651 |
| 2. PF | Q6GFZ0 | Septation ring formation regulator EzrA | 2.29e-13 | 1.39e-21 | NA | 0.3651 |
| 2. PF | Q9K802 | Septation ring formation regulator EzrA | 3.24e-13 | 2.87e-22 | NA | 0.4191 |
| 2. PF | P0DA98 | Septation ring formation regulator EzrA | 5.51e-14 | 2.08e-19 | NA | 0.389 |
| 2. PF | A7X3E7 | Septation ring formation regulator EzrA | 6.96e-14 | 3.19e-20 | NA | 0.372 |
| 2. PF | C0MH92 | Septation ring formation regulator EzrA | 1.36e-13 | 1.10e-19 | NA | 0.3908 |
| 2. PF | P64003 | Septation ring formation regulator EzrA | 2.10e-13 | 3.19e-20 | NA | 0.3655 |
| 2. PF | Q72Z83 | Septation ring formation regulator EzrA | 4.92e-13 | 6.04e-14 | NA | 0.3728 |
| 2. PF | A3CMA0 | Septation ring formation regulator EzrA | 1.06e-12 | 4.58e-20 | NA | 0.373 |
| 2. PF | P64002 | Septation ring formation regulator EzrA | 2.02e-13 | 3.19e-20 | NA | 0.3688 |
| 2. PF | Q81KT8 | Septation ring formation regulator EzrA | 8.24e-13 | 1.75e-15 | NA | 0.3655 |
| 2. PF | Q8DQE5 | Septation ring formation regulator EzrA | 1.71e-12 | 1.73e-24 | NA | 0.3501 |
| 2. PF | Q5XD04 | Septation ring formation regulator EzrA | 1.55e-12 | 7.27e-19 | NA | 0.3746 |
| 2. PF | A8AY51 | Septation ring formation regulator EzrA | 2.77e-13 | 7.13e-24 | NA | 0.402 |
| 2. PF | Q2YTH2 | Septation ring formation regulator EzrA | 2.04e-13 | 4.23e-21 | NA | 0.3646 |
| 2. PF | Q02VY0 | Septation ring formation regulator EzrA | 1.06e-11 | 4.07e-16 | NA | 0.3554 |
| 2. PF | Q9CDR6 | Septation ring formation regulator EzrA | 1.40e-12 | 1.48e-16 | NA | 0.3344 |
| 5. P | B2WBQ6 | MICOS complex subunit MIC60 | 4.12e-03 | 3.89e-02 | NA | NA |
| 5. P | Q2FXK8 | Septation ring formation regulator EzrA | 2.18e-13 | 2.69e-21 | NA | NA |