Summary
The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.
AVX54721.1
JCVISYN3A_0326
Uncharacterized protein.
M. mycoides homolog: Q6MTL9.
TIGRfam Classification: 1=Unknown.
Category: Nonessential.
Statistics
Total GO Annotation: 16
Unique PROST Go: 16
Unique BLAST Go: 0
Unique Foldseek Go: 0
Total Homologs: 19
Unique PROST Homologs: 19
Unique BLAST Homologs: 0
Unique Foldseek Homologs: 0
Structures and Sequence Alignment
The best structural homolog that predicted by 5. P was
B0CN28
(3-methyl-L-tyrosine peroxygenase) with a FATCAT P-Value: 0.00294 and RMSD of 3.69 angstrom. The sequence alignment identity is 16.9%.
Structural alignment shown in left. Query protein AVX54721.1 colored as red in alignment, homolog B0CN28 colored as blue.
Query protein AVX54721.1 is also shown in right top, homolog B0CN28 showed in right bottom. They are colored based on secondary structures.
AVX54721.1 ----------------------------MTEYELITTKLNEL-IKMS-RKKE----LSQ-DQLFDICIYL--TNVIDDVLLKKN---LKDD----LINQ- 55 B0CN28 MTAPADTVHPAGQPDYVAQVATVPFRLGRPE-ELPGT-LDELRAAVSARAGEAVRGLNRPGARTDLAALLAATERTRAALAPVGAGPVGDDPSESEANRD 98 AVX54721.1 NDQFYYLLY-LLKT---LLAILFTRNAFFNFD-IFNKLNPVLLFYIKQ--SL-D---HQF---YD-------DP---KKNYLLENS-----ELH--SLTS 124 B0CN28 ND----LAFGIVRTRGPVAELL--------VDAALAALAGILEVAVDRGSDLEDAAWQRFIGGFDALLGWLADPHSAPRPATVPGAGPAGPPVHQDAL-R 185 AVX54721.1 MYL---YVFSIFNKLIKKINYLNLKYNLKPNLNEYKRSSFINDF--TNLSYAFFKT--RGTQ----Y----RSEQF---FK--LV------K----HSWI 194 B0CN28 RWVRGHHVFMV---L---AQGCAL---ATACLRD---SAARGDLPGAEASAAAAEALMRGCQGALLYAGDANREQYNEQIRPTLMPPVAPPKMSGLH-W- 271 AVX54721.1 FNH-LL--EIKTNLDNSDYL-VN-----LVF--ELECLF---IIICRIFIQITLDFKTNYEINKLLEIN-STNL-------------------------- 253 B0CN28 RDHEVLIKELAGSRDAWEWLSAQGSERPATFRAALAETYDSHIGVCGHFVG---D-----QSPSLLAAQGSTRSAVGVIGQFRKIRLSALPEQPATQQGE 363 AVX54721.1 -- 253 B0CN28 PS 365
Go Annotations
1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.
| Source | GO | Description |
|---|---|---|
| 5. P | GO:0099617 | matrix side of mitochondrial inner membrane |
| 5. P | GO:0000002 | mitochondrial genome maintenance |
| 5. P | GO:0031314 | extrinsic component of mitochondrial inner membrane |
| 5. P | GO:0017000 | antibiotic biosynthetic process |
| 5. P | GO:0039679 | viral occlusion body |
| 5. P | GO:0032259 | methylation |
| 5. P | GO:0070402 | NADPH binding |
| 5. P | GO:0006231 | dTMP biosynthetic process |
| 5. P | GO:0050797 | thymidylate synthase (FAD) activity |
| 5. P | GO:0005739 | mitochondrion |
| 5. P | GO:0019013 | viral nucleocapsid |
| 5. P | GO:0006235 | dTTP biosynthetic process |
| 5. P | GO:0097745 | mitochondrial tRNA 5'-end processing |
| 5. P | GO:0050660 | flavin adenine dinucleotide binding |
| 5. P | GO:0019029 | helical viral capsid |
| 5. P | GO:0004799 | thymidylate synthase activity |
Uniprot GO Annotations
| GO | Description |
|---|---|
| GO:0016020 | membrane |
| GO:0016021 | integral component of membrane |
Homologs
1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.
| Source | Homolog | Description | Fatcat Pvalue | PROST Evalue | BLAST Evalue | Foldseek TMScore |
|---|---|---|---|---|---|---|
| 5. P | Q751B5 | Ubiquinone biosynthesis protein COQ4, mitochondrial | 2.39e-02 | 2.31e-02 | NA | NA |
| 5. P | O86840 | Flavin-dependent thymidylate synthase | 5.56e-02 | 1.47e-04 | NA | NA |
| 5. P | P47086 | Uncharacterized protein YJR011C | 7.05e-04 | 9.47e-03 | NA | NA |
| 5. P | C7GQR4 | Genetic interactor of prohibitin 5, mitochondrial | 1.65e-02 | 9.47e-03 | NA | NA |
| 5. P | C8ZD61 | Genetic interactor of prohibitin 5, mitochondrial | 9.79e-03 | 9.47e-03 | NA | NA |
| 5. P | Q65111 | Nucleoprotein | NA | 1.31e-02 | NA | NA |
| 5. P | P33859 | Protein C1 | NA | 1.66e-04 | NA | NA |
| 5. P | Q12393 | Genetic interactor of prohibitin 5, mitochondrial | 9.67e-03 | 1.49e-02 | NA | NA |
| 5. P | Q4VPH8 | Uncharacterized protein VP7-1 | NA | 2.44e-02 | NA | NA |
| 5. P | P22026 | Non-structural protein NS-S | NA | 2.33e-03 | NA | NA |
| 5. P | Q82K86 | Flavin-dependent thymidylate synthase | 5.13e-02 | 2.14e-04 | NA | NA |
| 5. P | P21036 | Protein C1 | NA | 1.67e-03 | NA | NA |
| 5. P | A7A0Z5 | Genetic interactor of prohibitin 5, mitochondrial | 1.18e-02 | 1.25e-02 | NA | NA |
| 5. P | Q9P799 | Uncharacterized protein P35G2.04c | 3.85e-04 | 2.37e-04 | NA | NA |
| 5. P | O18559 | Granulin | NA | 2.96e-02 | NA | NA |
| 5. P | P17368 | Protein C1 | NA | 1.52e-02 | NA | NA |
| 5. P | B0CN28 | 3-methyl-L-tyrosine peroxygenase | 2.94e-03 | 7.78e-03 | NA | NA |
| 5. P | A8F7Q7 | Flavin-dependent thymidylate synthase | 8.44e-02 | 6.69e-03 | NA | NA |
| 5. P | B3LT59 | Genetic interactor of prohibitin 5, mitochondrial | 9.54e-03 | 9.47e-03 | NA | NA |