Summary

The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.

AVX54728.1
JCVISYN3A_0344

Inorganic diphosphatase.
M. mycoides homolog: Q6MTK0.
TIGRfam Classification: 4=Probable.
Category: Essential.

Statistics

Total GO Annotation: 24
Unique PROST Go: 0
Unique BLAST Go: 7
Unique Foldseek Go: 0

Total Homologs: 139
Unique PROST Homologs: 2
Unique BLAST Homologs: 8
Unique Foldseek Homologs: 0

Literature

Danchin and Fang [1]: NA
Yang and Tsui [2]: NA
Antczak et al. [3]: ppa; Inorganic pyrophosphatase
Zhang et al. [4]: GO:0004427|inorganic diphosphatase activity
Bianchi et al. [5]: NA

Structures and Sequence Alignment

The best structural homolog that predicted by 1. PBF was Q72MG4 (Inorganic pyrophosphatase) with a FATCAT P-Value: 0 and RMSD of 1.03 angstrom. The sequence alignment identity is 30.2%.
Structural alignment shown in left. Query protein AVX54728.1 colored as red in alignment, homolog Q72MG4 colored as blue. Query protein AVX54728.1 is also shown in right top, homolog Q72MG4 showed in right bottom. They are colored based on secondary structures.

  AVX54728.1 -----------MKN-NVISMVVEIPKGSSNKYEVDEKTKRIKLDRVLYGANFYPGEYGMIENTLDWDGDPLD--VIS------LCTYPTLPGVEVNVRIL 80
      Q72MG4 MVHPWHDISPGDQNPEIVNGVIEIKRGSRAKYEVDKEYGILKLDRVLYSSFYYPANYGFIPQSYCGDQDPLDILVLSQVELEPLC----L----VKAKVI 92

  AVX54728.1 GSIKMVDAGEVDTKLFGVFNDDPRFKEYKTLND---VPKHYRDEIENFFLQYKALQNKVVKI----NGWGTLEE--ALEELEECKTRFEEYKDRLAKGQK 171
      Q72MG4 GVMRMLDSGEEDDKIIAVAANDMSVNH---INDISELPPHFTLELKHFFEDYKKLENKTVVIEEFQN--AILARKIVLDSLELYKKTFPK-K-------- 178

  AVX54728.1 DEILAEWKEKGLGQA 186
      Q72MG4 --------------- 178

Go Annotations

1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.

Source GO Description
1. PBF GO:0004427 inorganic diphosphatase activity
1. PBF GO:0006793 phosphorus metabolic process
1. PBF GO:0006796 phosphate-containing compound metabolic process
1. PBF GO:0005829 cytosol
1. PBF GO:0071470 cellular response to osmotic stress
1. PBF GO:0005737 cytoplasm
1. PBF GO:0000287 magnesium ion binding
1. PBF GO:0071344 diphosphate metabolic process
1. PBF GO:0052386 cell wall thickening
1. PBF GO:0052546 cell wall pectin metabolic process
4. PB GO:2000904 regulation of starch metabolic process
4. PB GO:0030446 hyphal cell wall
4. PB GO:0005985 sucrose metabolic process
4. PB GO:0042546 cell wall biogenesis
4. PB GO:0044228 host cell surface
4. PB GO:0062040 fungal biofilm matrix
4. PB GO:0050355 triphosphatase activity
7. B GO:0051881 regulation of mitochondrial membrane potential
7. B GO:0035076 ecdysone receptor-mediated signaling pathway
7. B GO:0004722 protein serine/threonine phosphatase activity
7. B GO:0016589 NURF complex
7. B GO:0035206 regulation of hemocyte proliferation
7. B GO:0042766 nucleosome mobilization
7. B GO:0046686 response to cadmium ion

Uniprot GO Annotations

GO Description
GO:0004427 inorganic diphosphatase activity
GO:0016787 hydrolase activity
GO:0006796 phosphate-containing compound metabolic process
GO:0005737 cytoplasm
GO:0046872 metal ion binding
GO:0000287 magnesium ion binding

Homologs

1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.

Source Homolog Description Fatcat Pvalue PROST Evalue BLAST Evalue Foldseek TMScore
1. PBF Q87SW1 Inorganic pyrophosphatase 0.00e+00 4.40e-20 4.58e-26 0.9379
1. PBF Q949J1 Soluble inorganic pyrophosphatase 2 0.00e+00 1.25e-18 2.21e-32 0.9739
1. PBF P65749 Inorganic pyrophosphatase 0.00e+00 2.04e-21 5.99e-26 0.9339
1. PBF P65745 Inorganic pyrophosphatase 0.00e+00 4.17e-21 6.47e-23 0.936
1. PBF Q6ACP7 Inorganic pyrophosphatase 0.00e+00 2.52e-27 4.65e-45 0.9455
1. PBF Q4R543 Inorganic pyrophosphatase 5.95e-11 1.60e-12 3.83e-10 0.7604
1. PBF Q87WD6 Inorganic pyrophosphatase 2 0.00e+00 8.09e-29 7.87e-30 0.9296
1. PBF P65747 Inorganic pyrophosphatase 0.00e+00 1.15e-30 5.27e-36 0.9453
1. PBF O05724 Inorganic pyrophosphatase 0.00e+00 1.38e-27 5.15e-50 0.9692
1. PBF Q5JIY3 Inorganic pyrophosphatase 0.00e+00 3.57e-26 6.04e-43 0.9796
1. PBF P37980 Inorganic pyrophosphatase 5.12e-11 4.06e-12 2.15e-09 0.7267
1. PBF Q8PH18 Inorganic pyrophosphatase 0.00e+00 7.29e-24 2.29e-20 0.9366
1. PBF Q821T4 Inorganic pyrophosphatase 2.00e-15 6.67e-10 2.73e-15 0.7761
1. PBF Q9YBA5 Inorganic pyrophosphatase 0.00e+00 1.27e-21 9.86e-27 0.9336
1. PBF Q8DE89 Inorganic pyrophosphatase 0.00e+00 1.76e-20 2.15e-25 0.9265
1. PBF Q889M7 Inorganic pyrophosphatase 1 0.00e+00 8.38e-22 2.97e-26 0.9394
1. PBF O84777 Inorganic pyrophosphatase 0.00e+00 9.95e-10 1.93e-13 0.7859
1. PBF B0BAM7 Inorganic pyrophosphatase 0.00e+00 9.95e-10 1.93e-13 0.783
1. PBF Q8SR69 Inorganic pyrophosphatase 1.33e-15 3.87e-10 3.90e-05 0.78
1. PBF Q974Y8 Inorganic pyrophosphatase 0.00e+00 1.52e-24 2.15e-28 0.9509
1. PBF Q8FAG0 Inorganic pyrophosphatase 0.00e+00 2.06e-20 1.83e-25 0.9324
1. PBF P77992 Inorganic pyrophosphatase 0.00e+00 1.01e-21 1.39e-41 0.9784
1. PBF Q9K0G4 Inorganic pyrophosphatase 0.00e+00 8.41e-25 6.99e-26 0.9502
1. PBF P65748 Inorganic pyrophosphatase 0.00e+00 2.04e-21 5.99e-26 0.9335
1. PBF D4GT97 Inorganic pyrophosphatase 0.00e+00 3.20e-18 6.31e-28 0.9633
1. PBF P13998 Inorganic pyrophosphatase 3.07e-11 8.18e-13 6.58e-07 0.7535
1. PBF Q9ZLL5 Inorganic pyrophosphatase 0.00e+00 1.54e-24 1.76e-28 0.9487
1. PBF O26363 Inorganic pyrophosphatase 0.00e+00 6.67e-20 8.34e-40 0.9718
1. PBF Q8KA31 Inorganic pyrophosphatase 0.00e+00 1.15e-22 4.22e-23 0.9338
1. PBF Q8XWX1 Inorganic pyrophosphatase 0.00e+00 3.12e-23 6.66e-27 0.9367
1. PBF P50308 Inorganic pyrophosphatase 0.00e+00 4.81e-25 7.68e-34 0.9462
1. PBF O13505 Inorganic pyrophosphatase 3.29e-11 4.22e-12 9.76e-05 0.7469
1. PBF P65751 Inorganic pyrophosphatase 0.00e+00 3.41e-22 9.80e-24 0.9374
1. PBF P57190 Inorganic pyrophosphatase 0.00e+00 6.74e-23 8.07e-22 0.9269
1. PBF Q6FRB7 Inorganic pyrophosphatase 2.37e-11 2.27e-14 1.54e-05 0.7572
1. PBF Q72MG4 Inorganic pyrophosphatase 0.00e+00 9.14e-21 5.33e-27 0.9776
1. PBF O34955 Inorganic pyrophosphatase 0.00e+00 4.13e-25 1.97e-30 0.9258
1. PBF Q6BWA5 Inorganic pyrophosphatase 2.80e-11 2.12e-11 9.44e-05 0.7522
1. PBF Q98Q96 Inorganic pyrophosphatase 0.00e+00 3.28e-47 1.93e-36 0.9126
1. PBF Q9C0T9 Inorganic pyrophosphatase 1.48e-11 1.91e-12 9.71e-05 0.75
1. PBF P9WI54 Inorganic pyrophosphatase 0.00e+00 1.15e-30 5.27e-36 0.9433
1. PBF Q8P5M4 Inorganic pyrophosphatase 0.00e+00 3.69e-24 1.41e-19 0.9382
1. PBF P44529 Inorganic pyrophosphatase 0.00e+00 6.31e-23 1.10e-25 0.9467
1. PBF P51064 Inorganic pyrophosphatase 0.00e+00 8.93e-22 9.75e-21 0.9375
1. PBF Q4UKW0 Inorganic pyrophosphatase 0.00e+00 6.80e-22 3.12e-20 0.9327
1. PBF P65744 Inorganic pyrophosphatase 0.00e+00 4.17e-21 6.47e-23 0.9359
1. PBF Q8U438 Inorganic pyrophosphatase 0.00e+00 1.51e-25 3.15e-40 0.9793
1. PBF Q5B912 Inorganic pyrophosphatase 5.83e-13 1.14e-14 6.91e-05 0.75
1. PBF Q8GQS5 Inorganic pyrophosphatase 0.00e+00 1.50e-26 1.69e-31 0.9417
1. PBF P56153 Inorganic pyrophosphatase 0.00e+00 1.12e-24 1.87e-28 0.95
1. PBF Q3KKS0 Inorganic pyrophosphatase 0.00e+00 9.95e-10 1.93e-13 0.7831
1. PBF P75250 Inorganic pyrophosphatase 0.00e+00 6.32e-48 3.06e-49 0.9204
1. PBF Q68WE9 Inorganic pyrophosphatase 0.00e+00 1.17e-26 1.59e-23 0.9258
1. PBF Q97W51 Inorganic pyrophosphatase 0.00e+00 5.36e-23 8.50e-34 0.9455
1. PBF P19514 Inorganic pyrophosphatase 0.00e+00 4.57e-27 4.13e-49 0.9673
1. PBF Q979E6 Inorganic pyrophosphatase 0.00e+00 1.85e-22 5.25e-25 0.9363
1. PBF Q9AC20 Inorganic pyrophosphatase 0.00e+00 6.47e-21 7.49e-27 0.932
1. PBF Q8EZ21 Inorganic pyrophosphatase 0.00e+00 9.14e-21 5.33e-27 0.9775
1. PBF P80507 Inorganic pyrophosphatase 0.00e+00 1.39e-18 6.37e-40 0.9729
1. PBF Q8TMI3 Inorganic pyrophosphatase 0.00e+00 1.61e-21 1.89e-35 0.9675
1. PBF O05545 Inorganic pyrophosphatase 0.00e+00 1.76e-22 3.62e-28 0.9565
1. PBF Q7MPD2 Inorganic pyrophosphatase 0.00e+00 1.76e-20 2.15e-25 0.9367
1. PBF Q1RIN6 Inorganic pyrophosphatase 0.00e+00 5.72e-23 3.13e-22 0.9304
1. PBF Q6KZB3 Inorganic pyrophosphatase 0.00e+00 1.04e-17 5.91e-38 0.9667
1. PBF P38576 Inorganic pyrophosphatase 0.00e+00 8.89e-27 2.85e-42 0.9496
1. PBF P80562 Inorganic pyrophosphatase 0.00e+00 3.03e-17 3.17e-38 0.9733
1. PBF Q7VPC0 Inorganic pyrophosphatase 0.00e+00 1.62e-19 3.11e-28 0.9331
1. PBF Q9X8I9 Inorganic pyrophosphatase 0.00e+00 3.52e-29 4.49e-35 0.9472
1. PBF Q9RGQ1 Inorganic pyrophosphatase 0.00e+00 1.27e-22 7.22e-19 0.9292
1. PBF P59417 Inorganic pyrophosphatase 0.00e+00 4.30e-19 2.71e-17 0.9414
1. PBF Q757J8 Inorganic pyrophosphatase 1.16e-11 4.56e-13 2.63e-06 0.7518
1. PBF B0B8Z8 Inorganic pyrophosphatase 0.00e+00 9.95e-10 1.93e-13 0.7827
1. PBF O69540 Inorganic pyrophosphatase 0.00e+00 6.95e-31 2.06e-34 0.9506
1. PBF Q43187 Soluble inorganic pyrophosphatase PPA1 0.00e+00 7.18e-04 1.12e-34 0.9599
1. PBF Q9ZCW5 Inorganic pyrophosphatase 0.00e+00 4.65e-21 1.11e-22 0.9279
1. PBF Q8PWY5 Inorganic pyrophosphatase 0.00e+00 6.51e-29 1.51e-34 0.9566
1. PBF Q9JVG3 Inorganic pyrophosphatase 0.00e+00 2.68e-24 1.17e-25 0.9498
1. PBF Q9Z6Y8 Inorganic pyrophosphatase 0.00e+00 2.20e-12 2.28e-16 0.8158
1. PBF Q88QF6 Inorganic pyrophosphatase 0.00e+00 2.07e-22 1.10e-24 0.9374
1. PBF Q9PQH6 Inorganic pyrophosphatase 0.00e+00 1.25e-51 1.91e-43 0.9188
1. PBF Q8DHR2 Inorganic pyrophosphatase 0.00e+00 4.61e-17 1.35e-40 0.9776
1. PBF Q9KCG7 Inorganic pyrophosphatase 0.00e+00 1.26e-24 1.47e-48 0.9843
1. PBF Q9KP34 Inorganic pyrophosphatase 0.00e+00 2.60e-20 1.76e-24 0.9348
1. PBF P65750 Inorganic pyrophosphatase 0.00e+00 3.41e-22 9.80e-24 0.9359
1. PBF Q9UY24 Inorganic pyrophosphatase 0.00e+00 1.76e-25 1.11e-39 0.9795
1. PBF P57918 Inorganic pyrophosphatase 0.00e+00 1.16e-18 4.83e-28 0.9332
1. PBF P47593 Inorganic pyrophosphatase 0.00e+00 4.21e-49 4.51e-45 0.929
1. PBF Q8NM79 Inorganic pyrophosphatase 0.00e+00 3.58e-28 4.89e-35 0.9456
1. PBF P58733 Inorganic pyrophosphatase 0.00e+00 4.14e-24 7.75e-32 0.9295
1. PBF Q74MY6 Inorganic pyrophosphatase 0.00e+00 5.34e-29 6.59e-23 0.9235
1. PBF Q8UC37 Inorganic pyrophosphatase 0.00e+00 2.16e-20 3.93e-24 0.9275
1. PBF Q9PHM9 Inorganic pyrophosphatase 0.00e+00 1.50e-22 2.38e-31 0.9467
1. PBF A2X8Q3 Soluble inorganic pyrophosphatase 0.00e+00 5.17e-03 2.62e-35 0.9589
1. PBF Q92LH1 Inorganic pyrophosphatase 0.00e+00 3.85e-21 2.64e-23 0.934
1. PBF Q9HWZ6 Inorganic pyrophosphatase 0.00e+00 1.65e-22 8.64e-28 0.9355
1. PBF Q9PLF1 Inorganic pyrophosphatase 0.00e+00 2.28e-09 1.58e-15 0.774
1. PBF Q98ER2 Inorganic pyrophosphatase 0.00e+00 3.94e-24 5.20e-21 0.9333
1. PBF Q6C1T4 Inorganic pyrophosphatase 1.11e-15 7.17e-12 3.19e-05 0.7516
1. PBF P37981 Inorganic pyrophosphatase 0.00e+00 4.33e-23 4.45e-42 0.9804
1. PBF Q92H74 Inorganic pyrophosphatase 0.00e+00 5.70e-22 8.78e-21 0.9293
1. PBF Q5R8T6 Inorganic pyrophosphatase 5.99e-11 1.19e-12 3.27e-10 0.7359
1. PBF O59570 Inorganic pyrophosphatase 0.00e+00 4.70e-26 3.62e-39 0.977
1. PBF P0A7B0 Inorganic pyrophosphatase 0.00e+00 4.83e-20 1.75e-25 0.9305
1. PBF Q6MVH7 Inorganic pyrophosphatase 4.33e-14 5.15e-10 0.001 0.7823
1. PBF Q89WY0 Inorganic pyrophosphatase 0.00e+00 5.35e-22 5.93e-22 0.9293
1. PBF Q8D274 Inorganic pyrophosphatase 0.00e+00 4.86e-22 5.25e-19 0.9308
1. PBF Q8FMF8 Inorganic pyrophosphatase 0.00e+00 7.43e-28 9.57e-35 0.9453
1. PBF Q8EVW9 Inorganic pyrophosphatase 0.00e+00 2.98e-49 6.19e-43 0.9229
1. PBF Q8ZB98 Inorganic pyrophosphatase 0.00e+00 2.49e-19 4.14e-26 0.9339
1. PBF O67501 Inorganic pyrophosphatase 0.00e+00 5.06e-29 2.36e-32 0.9377
1. PBF Q8TVE2 Inorganic pyrophosphatase 0.00e+00 9.73e-21 6.94e-41 0.9744
1. PBF Q9HSF3 Inorganic pyrophosphatase 0.00e+00 1.33e-18 1.10e-27 0.9641
3. BF Q93Y52 Soluble inorganic pyrophosphatase 1, chloroplastic 2.45e-12 NA 1.83e-09 0.7553
3. BF O23979 Soluble inorganic pyrophosphatase 0.00e+00 NA 8.23e-28 0.8946
4. PB O82793 Soluble inorganic pyrophosphatase 3 0.00e+00 3.99e-02 1.58e-35 NA
4. PB P9WI55 Inorganic pyrophosphatase 0.00e+00 1.15e-30 5.27e-36 NA
4. PB Q9D819 Inorganic pyrophosphatase 5.37e-11 1.68e-12 3.79e-10 NA
4. PB P21216 Soluble inorganic pyrophosphatase 2 0.00e+00 3.01e-03 1.39e-32 NA
4. PB O48556 Soluble inorganic pyrophosphatase 0.00e+00 6.78e-03 7.66e-34 NA
4. PB P83777 Inorganic pyrophosphatase 3.35e-11 6.22e-10 1.22e-04 NA
4. PB Q15181 Inorganic pyrophosphatase 4.19e-11 2.29e-12 3.50e-10 NA
4. PB P0A7A9 Inorganic pyrophosphatase 0.00e+00 4.83e-20 1.75e-25 NA
4. PB O82597 Soluble inorganic pyrophosphatase 5 0.00e+00 7.31e-03 2.80e-35 NA
4. PB Q0DYB1 Soluble inorganic pyrophosphatase 0.00e+00 5.17e-03 2.62e-35 NA
4. PB Q9LFF9 Soluble inorganic pyrophosphatase 4 0.00e+00 4.96e-03 5.42e-33 NA
4. PB P87118 Putative inorganic pyrophosphatase C3A12.02 4.22e-11 6.92e-09 4.34e-06 NA
4. PB P19117 Inorganic pyrophosphatase 4.93e-11 2.50e-13 5.75e-05 NA
4. PB P00817 Inorganic pyrophosphatase 1.37e-11 2.78e-14 4.65e-06 NA
4. PB Q93V56 Soluble inorganic pyrophosphatase 1 0.00e+00 1.07e-02 1.12e-36 NA
5. P Q06FM8 50S ribosomal protein L14, chloroplastic 5.87e-01 2.85e-02 NA NA
5. P A6MMY1 50S ribosomal protein L14, chloroplastic 5.89e-01 4.79e-02 NA NA
7. B Q91VM9 Inorganic pyrophosphatase 2, mitochondrial 1.13e-10 NA 7.53e-09 NA
7. B O77460 Inorganic pyrophosphatase 2.33e-10 NA 5.48e-07 NA
7. B O77392 Probable inorganic pyrophosphatase 1.20e-10 NA 3.27e-06 NA
7. B Q18680 Inorganic pyrophosphatase 1 6.39e-09 NA 7.68e-05 NA
7. B P28239 Inorganic pyrophosphatase, mitochondrial 4.38e-13 NA 6.66e-05 NA
7. B Q54PV8 Inorganic pyrophosphatase 4.36e-13 NA 3.26e-09 NA
7. B Q9LXC9 Soluble inorganic pyrophosphatase 6, chloroplastic 8.80e-14 NA 5.63e-08 NA
7. B Q9H2U2 Inorganic pyrophosphatase 2, mitochondrial 6.91e-11 NA 1.46e-09 NA