Summary

The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.

AVX54746.1
JCVISYN3A_0373

Uncharacterized protein.
M. mycoides homolog: Q6MTH2.
TIGRfam Classification: 1=Unknown.
Category: Essential.

Statistics

Total GO Annotation: 22
Unique PROST Go: 22
Unique BLAST Go: 0
Unique Foldseek Go: 0

Total Homologs: 8
Unique PROST Homologs: 8
Unique BLAST Homologs: 0
Unique Foldseek Homologs: 0

Literature

Danchin and Fang [1]: NA
Yang and Tsui [2]: Exodeoxyribonuclease 7 large subunit
Antczak et al. [3]: Hypothetical protein
Zhang et al. [4]: GO:0005634|nucleus
Bianchi et al. [5]: Unclear

Structures and Sequence Alignment

The best structural homolog that predicted by 5. P was P34514 (Anaphase-promoting complex subunit 2) with a FATCAT P-Value: 0.0204 and RMSD of 7.67 angstrom. The sequence alignment identity is 20.4%.
Structural alignment shown in left. Query protein AVX54746.1 colored as red in alignment, homolog P34514 colored as blue. Query protein AVX54746.1 is also shown in right top, homolog P34514 showed in right bottom. They are colored based on secondary structures. 

  AVX54746.1 -------------------------MPVQES-IYWV-Y------FHDM---VKKIKTD--RF---KKV---D-----ELL------K---KKINEIF--E 40
      P34514 MSIFDRMTTSKEAAMKYRQFCVSKKKEVWDALIYHAKYAKNIEKVYDMTTVLQRVQQECLMFALEKGVGQPDIRDAAELIFPLAMQKVVIKVLRPYFMSH 100

  AVX54746.1 ITHYGLFQYQILKDKPLIN-ID-DSSI-----SEIC-KYIT--N---NYLRFFEYLNYN---NSKTSVYSSKL--T-----K----NELEEISF--IIEN 111
      P34514 FTNYRLAMY--LPHRKIDHGIDLNQELWTPEKKEICGQYVQDFNPFVNELK-TGILNANRHMNAALSVYIRELAATLVMHEKAAFDNELRCSMFQEIME- 196

  AVX54746.1 ISIRYIADNLILTNNNNYN--SDFLTLLLIELSKMHRFDT-NFLARNNDKIVYHSLV--YPL-F---LTM---LV-------IDITNEAQMFNNIK-KIY 191
      P34514 -SLRIWSDQ--VTMQDAFHLISD--T-----IYK----DVFQMLSKN----AYEMIAVDFPVKFRSLITMKYCLLRTNNHGRVDFTN--YLIDQVNTKLL 276

  AVX54746.1 -----TKQNILNA----LKSGRPLSSNEL----------NYFKSHIDILEYDEEWNTFLLNFKQENWTSFSVEKKYKLVFQLAKYTAL------------ 260
      P34514 VASVDTK-DILKAYAACVESLREMDNSCVVMHKVCGVIREYLKRRPDTVQQIISYITS--NKKNE------LEKDMSLQSKTVR-SAMMDEEELKGVNDD 366

  AVX54746.1 FLKDRIKSV-W----------ALSDGE------EIFD---SFYN--------YINLFLINKTSNQTSTIYLTNKIDP-LNKNYDDSDRFLLPFLIKDYNP 331
      P34514 FLPENMETLGWENWMPNPTDATVGDGAPGHQGVDVFNMLVSVYGSKELFVKEYRNL-LAERLS--SS----DNK-DPEFEKRYLD----LLK-LRFQYSE 453

  AVX54746.1 IQIGH-HISSLKD--YSKFVCDKDRIIDFLDAVLLST-NY-INLIDI---LKVDSNYLADFLIQRKKLALVDTLNLYKLNDHNIYKKQYNSINLEDLKFN 423
      P34514 LQ--HCEV-MLRDVIHS---LDIDK--KFEDMSERSAGNYDVPIIPISACI-ISSHYWPK-LETEKTEALMPQ-PLQAAMD--VYQETY----L-DVKRD 535

  AVX54746.1 QDV--LKEI--IKKDFRIEVLKTNNQFVNMLKIISLILALVPSTARRYNYSW---ELIVKY---FIITFGPYKRKKA--LYDKK---TINEI----TYKI 504
      P34514 RKLEWLRSVGCVEVSINIDGVEVDRTIPNMYALL-LFLFLEKET-------WTTAEVVEKMGMSVVVT-----RKRLEWLV-KQGFICMNPIISSDTWTL 621

  AVX54746.1 SK----L---------LSNFKHV---KNKD--D-------YSRTLLIIH------KLENFKN-------------------------------------- 535
      P34514 TRNPSGISIVRPGTPDLEDDEDVEPEENSDMVDALEQYWGYTRNFIANHAPNGEVKAERMHRVYRMFGSPTSAGPTLDHVSAFLQRKVALGLLTCINGSY 721

  AVX54746.1 ---------- 535
      P34514 RIIQEKKDGE 731

Go Annotations

1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.

Source GO Description
5. P GO:0010629 negative regulation of gene expression
5. P GO:0050775 positive regulation of dendrite morphogenesis
5. P GO:0010458 exit from mitosis
5. P GO:0006511 ubiquitin-dependent protein catabolic process
5. P GO:0031915 positive regulation of synaptic plasticity
5. P GO:0044163 host cytoskeleton
5. P GO:0007091 metaphase/anaphase transition of mitotic cell cycle
5. P GO:0039624 viral outer capsid
5. P GO:0031625 ubiquitin protein ligase binding
5. P GO:0051321 meiotic cell cycle
5. P GO:0045773 positive regulation of axon extension
5. P GO:0005680 anaphase-promoting complex
5. P GO:0120151 positive regulation of mitotic actomyosin contractile ring disassembly
5. P GO:0006097 glyoxylate cycle
5. P GO:0006231 dTMP biosynthetic process
5. P GO:0050797 thymidylate synthase (FAD) activity
5. P GO:0016567 protein ubiquitination
5. P GO:0070979 protein K11-linked ubiquitination
5. P GO:0004474 malate synthase activity
5. P GO:0090129 positive regulation of synapse maturation
5. P GO:0051301 cell division
5. P GO:0031145 anaphase-promoting complex-dependent catabolic process

Uniprot GO Annotations

GO Description

Homologs

1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.

Source Homolog Description Fatcat Pvalue PROST Evalue BLAST Evalue Foldseek TMScore
5. P Q8JU58 Microtubule-associated protein VP5 NA 3.80e-02 NA NA
5. P P38338 Uncharacterized protein YBR259W 4.13e-02 1.77e-05 NA NA
5. P Q83048 Protein p59 NA 7.21e-05 NA NA
5. P A0PSI5 Malate synthase G 2.61e-01 1.78e-02 NA NA
5. P Q8BZQ7 Anaphase-promoting complex subunit 2 2.88e-02 1.14e-02 NA NA
5. P Q9Z7F9 UPF0159 protein CPn_0746/CP_1126/CPj0746/CpB0774 4.17e-02 1.63e-04 NA NA
5. P P34514 Anaphase-promoting complex subunit 2 2.04e-02 1.68e-03 NA NA
5. P Q12440 Anaphase-promoting complex subunit 2 1.02e-01 2.11e-02 NA NA