Summary

The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.

AVX54756.1
JCVISYN3A_0388

Uncharacterized protein.
M. mycoides homolog: Q6MTG0.
TIGRfam Classification: 1=Unknown.
Category: Essential.

Statistics

Total GO Annotation: 20
Unique PROST Go: 20
Unique BLAST Go: 0
Unique Foldseek Go: 0

Total Homologs: 29
Unique PROST Homologs: 29
Unique BLAST Homologs: 0
Unique Foldseek Homologs: 0

Literature

Danchin and Fang [1]: double strand break repair|SMC-like protein, DSB repair is essential for multiplication, may act in concert with JCVISYN3A_0511
Yang and Tsui [2]: Nucleoside diphosphate kinase Ndk
Antczak et al. [3]: Transmembrane protein, likely a cation transporter
Zhang et al. [4]: GO:0046483|heterocycle metabolic process
Bianchi et al. [5]: Unclear

Structures and Sequence Alignment

The best structural homolog that predicted by 5. P was Q9UUA4 (Translocation protein sec66) with a FATCAT P-Value: 0.00145 and RMSD of 1.86 angstrom. The sequence alignment identity is 18.5%.
Structural alignment shown in left. Query protein AVX54756.1 colored as red in alignment, homolog Q9UUA4 colored as blue. Query protein AVX54756.1 is also shown in right top, homolog Q9UUA4 showed in right bottom. They are colored based on secondary structures. 

  AVX54756.1 MQTSTILMI---VLLVFVVGFVIWSTITGKKANKKEKEKRYNQVREKIKEYILKNEHKKNLRIE-FEKVYARKGAEYKYRDVFDVIVQLIEP--KT--QK 92
      Q9UUA4 -------MVSIYVPLIYIT--ILMGSMYG--------VSRF--VR---KS---KNQESKPVSEEWF-------GENYS-RNIFFSLLQQNPPAEDTLLKA 67

  AVX54756.1 VIEIRAYEVEGL----TTKVNKSQYNTEWIVNSQIDLEETKRRIAIGEKTI-KLTKAEKQ---KLKEVEK----IQ----------AKKLAQQEK----- 165
      Q9UUA4 ALVLRA--TEGLRRLMKLKVSRMALNN--LLN----------RGGVGDELIRKFGRLEKETELELMDIAKTANSLQPGWNQFIFQTCNEIIENEKIHSII 153

  AVX54756.1 EQLKK----AKEKQKSQKGSLDIYQ--ERKLNISNKK---FVPSRAKSN 205
      Q9UUA4 DNIPKDIDSISQRWQTEK--I-LYEAADEELRIQAQKELGVL------- 192

Go Annotations

1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.

Source GO Description
5. P GO:0060216 definitive hemopoiesis
5. P GO:0016021 integral component of membrane
5. P GO:0005886 plasma membrane
5. P GO:0001503 ossification
5. P GO:0051087 chaperone binding
5. P GO:0031204 posttranslational protein targeting to membrane, translocation
5. P GO:0030098 lymphocyte differentiation
5. P GO:0000209 protein polyubiquitination
5. P GO:0043130 ubiquitin binding
5. P GO:0016513 core-binding factor complex
5. P GO:0006869 lipid transport
5. P GO:0030099 myeloid cell differentiation
5. P GO:0043378 positive regulation of CD8-positive, alpha-beta T cell differentiation
5. P GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation
5. P GO:0005783 endoplasmic reticulum
5. P GO:0031207 Sec62/Sec63 complex
5. P GO:0030428 cell septum
5. P GO:0048469 cell maturation
5. P GO:0001649 osteoblast differentiation
5. P GO:0051286 cell tip

Uniprot GO Annotations

GO Description
GO:0016020 membrane
GO:0016021 integral component of membrane

Homologs

1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.

Source Homolog Description Fatcat Pvalue PROST Evalue BLAST Evalue Foldseek TMScore
5. P Q65149 Uncharacterized protein EP152R NA 3.07e-04 NA NA
5. P Q6LV37 Co-chaperone protein DjlA 3.13e-02 2.97e-02 NA NA
5. P A0QQF4 Trehalose monomycolate transport factor A 1.28e-02 1.05e-02 NA NA
5. P Q9UUA4 Translocation protein sec66 1.45e-03 2.57e-02 NA NA
5. P O29215 Uncharacterized protein AF_1047 8.55e-03 2.65e-02 NA NA
5. P P44043 Uncharacterized protein HI_0725 6.03e-04 3.05e-02 NA NA
5. P Q91FF1 Uncharacterized protein 373L NA 4.71e-02 NA NA
5. P P0CA62 Uncharacterized protein EP152R NA 2.79e-03 NA NA
5. P Q8DED6 Co-chaperone protein DjlA 3.06e-02 3.59e-02 NA NA
5. P P47604 Uncharacterized protein MG364 1.40e-07 4.25e-11 NA NA
5. P P75236 Uncharacterized protein MG364 homolog 6.47e-07 1.41e-07 NA NA
5. P P0CA83 Membrane protein I177L NA 1.75e-02 NA NA
5. P Q7MP82 Co-chaperone protein DjlA 1.55e-02 4.25e-02 NA NA
5. P Q99X12 Uncharacterized protein SA0203 2.08e-02 4.41e-02 NA NA
5. P P41656 Per os infectivity factor 4 NA 8.21e-06 NA NA
5. P Q56NG7 Protein BptA 1.20e-01 3.83e-02 NA NA
5. P Q08024 Core-binding factor subunit beta 7.30e-03 4.67e-02 NA NA
5. P Q932K6 Uncharacterized protein SAV0210 9.63e-03 2.12e-02 NA NA
5. P P94520 Sigma-w pathway protein YsdB 1.66e-02 7.85e-03 NA NA
5. P P0CA61 Uncharacterized protein EP152R NA 2.39e-03 NA NA
5. P Q91FG7 Uncharacterized protein 357R NA 1.35e-02 NA NA
5. P Q6GCR5 Uncharacterized protein SAS0186 6.61e-03 4.54e-02 NA NA
5. P P27942 Membrane protein I177L NA 3.14e-02 NA NA
5. P Q9CMP7 Uncharacterized protein PM0768 1.59e-03 8.29e-04 NA NA
5. P Q6BKU8 Coupling of ubiquitin conjugation to ER degradation protein 1 2.95e-02 1.75e-02 NA NA
5. P Q28F39 Coiled-coil domain-containing protein 134 3.72e-03 1.26e-02 NA NA
5. P P44607 Co-chaperone protein DjlA 2.61e-02 5.17e-03 NA NA
5. P Q8NYK8 Uncharacterized protein MW0186 1.01e-02 4.54e-02 NA NA
5. P Q87ST2 Co-chaperone protein DjlA 2.30e-02 4.62e-02 NA NA