Summary
The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.
AVX54763.1
JCVISYN3A_0399
Uncharacterized efflux ABC transporter permease.
M. mycoides homolog: Q6MTF1.
TIGRfam Classification: 2=Generic.
Category: Quasiessential.
Statistics
Total GO Annotation: 16
Unique PROST Go: 0
Unique BLAST Go: 0
Unique Foldseek Go: 13
Total Homologs: 82
Unique PROST Homologs: 3
Unique BLAST Homologs: 0
Unique Foldseek Homologs: 77
Structures and Sequence Alignment
The best structural homolog that predicted by 6. F was
P57061
(Lipoprotein-releasing system transmembrane protein LolC) with a FATCAT P-Value: 0.00982 and RMSD of 3.02 angstrom. The sequence alignment identity is 6.4%.
Structural alignment shown in left. Query protein AVX54763.1 colored as red in alignment, homolog P57061 colored as blue.
Query protein AVX54763.1 is also shown in right top, homolog P57061 showed in right bottom. They are colored based on secondary structures.
AVX54763.1 MKRITSFLLLLKQGLKGVFKFKIQFIIILLLSFLASFILSTSLTLTSRINKTYNNIVNNVNKFDYSSTNEIRTYRIDRNNSTTDRSVIALLDLVNNSNSY 100 P57061 ---------------------------------------------------------------------------------------------------- 0 AVX54763.1 YNQSSNNKNTSYLNFILNKKNLTSNFDNKTILTELFENKEFIELFTTINGKDTNWIWENIWLWQLSLYFNKFIYHSYDQFLKNNKDYSYLKNTVIGKYLS 200 P57061 ---------------------------------------------------------------------------------------------------- 0 AVX54763.1 NSFKDKNEFLNDAKVLENLKFENIKNNFNVKEFKNTFNKQIQNKELFSYIYISGMSLFQHIYRNIYLPYFSDFKITNNNKIGNSFYTFLTGNKLNNINDS 300 P57061 ---------------------------------------------------------------------------------------------------- 0 AVX54763.1 QADKWIINDKNKSYLTEFELNKTTIDKNDNSVLIKTESKDDIKKLVLEKGFKGNTDLVLSTIDSNNKVQSISPIINDSSFFKLLFFNGNGTSLTNVVTVL 400 P57061 ---------------------------------------------------------------------------------------------------- 0 AVX54763.1 SDINFIKKDQIIGENQFDNINLFHNIWLAHLKYTAIASGYDINFRTEVFNYDSVTQIRYRLVILNDDHTTNLTILNKNQGARSPSKGEALISEQFARAHK 500 P57061 ---------------------------------------------------------------------------------------------------- 0 AVX54763.1 LKLGQQIIVDGALLTITGFATDTYSFFPTTDPDFPIPQSELGAILYVTRSTINDILGATSQSNTNRVSKGYLSFFLRKRQSNASINLFNSYQMNDISKLY 600 P57061 ---------------------------------------------------------------------------------------------------- 0 AVX54763.1 DSIKYQKDQKNKVTTWLNIKDFDHSIFRFNWTIAPLAINSYKGATLIAALVVSLIAIIALVICIRKTIYFNAKQIGILKALGSSPIQISISYLAYVIVII 700 P57061 ---------------------------------------------------------------------------------------------------- 0 AVX54763.1 LTSVPLGWITGLSTQSVFVKLFVNYFSIPLYSFTIEPFSLLISLLIFGLFGVIVSLLSAIIITKKQLADILAVKQNWSSSKFINRLKRTWFKKAKFTTKF 800 P57061 ---------------------------------------------------------------------------------------------------- 0 AVX54763.1 SLTLASSGKKNIFLLVTVVGISTMFISAGLAIPSIAFTIKNTYYKSIKYANEYNYSKGVSNSPLTKPTINYWSGQDSLDKNILSANLNNEELFYYKDPTA 900 P57061 ---------------------------------------------------------------------------------------------------- 0 AVX54763.1 YASSSYDVNPFPKYLYKVEKFNNNNNEQINKKIAWTLLELIQNKDQTSANHTNGLDLLFTEMFGNNLYNVVGNQFSIGVIDQILGLILNSKNNVVNPKDT 1000 P57061 ---------------------------------------------------------------------------------------------------- 0 AVX54763.1 TTKWTDEQKDLIFKELTNNFTKTGTTAISILVGDLSTSSSDDWKTKIFDAILKAVPPYVSAYIQKPSRKEQFSIGYNVQHYIPDHETLTTITDIKTTINQ 1100 P57061 ---------------------------------------------------------------------------------------------------- 0 AVX54763.1 KNTDLSLTGIANNQSAFIINQKNANNLFIDYKKLLALQEVFLEKKNTDIKLNDQFVLYDSKTNTINVPILPNKQANAFYKLNKNPDISNISTSSKQFFIN 1200 P57061 ---------------------------------------------------------------------------------------------------- 0 AVX54763.1 TKNGYVNIPKHAWIYDDLNFIKSKYYNSLTSEQKNLISKNRTGRNSKTVSDQDIRWLDPYNLDNNKFTLKLLYDNDKFDNDSSYDNKEW-SL--L----N 1293 P57061 ----------------------------------------------------------------------------------MFSLEAWIGLRYLRAKKR 18 AVX54763.1 NSYMFDDFIYNNQFDDLLSSYIRPYYQYKNIQLYIPQSLINTDHIIH-FISSKKTKKELDNSSEHWYKKDIDY-NNVPKSVIKAWDIKNTSEKFLMIRPY 1391 P57061 NGFM--SFI------TMVS--I------AGIALGV-TALIVVLSVMNGF--QKEIRGQLLNVAPH---AEIGYIDNTDTD----W--RN-----L----- 80 AVX54763.1 DLRYSLLVDNVYKSGLSNLTAKPEYWMYQATKTKN---ISGI-TTPIIQKDAK--TNYQNKDLKITIKPVGTLDSYNQKLILADQGLINLVLNL----SI 1481 P57061 -LRFT---EN--RKGI--LAAAP-YVSNQAL-LANAGEIRGVQIRGILPSEERKVVEY--GD-KM---PAGKFED----LI---PGEFDIILGVGLAEAL 157 AVX54763.1 GKKIGIKDNFYNKQTVI-KAGESYN----NIISRFDRYDYNQIINYIDKTKNTKEF-NDLLFSSNKAFDKAQFLWHNAKYSNIEEALD-LTSGISF-IPD 1573 P57061 GAEVG------NKVTVITPEG---NVTPAGVVPRLKQF---TVVGLV-KT-GVYEVDNSLAMTHIQ--D-ARVLYR----------LDKEVAGLRLKLAD 230 AVX54763.1 TAYNGFYILNGHGASSASGDDDMISNIKNQNLLATSKTLINQITFIAISI---GMLLIITVIITSALLVM-LISDIY--VTQYQQFMILMKALGYSN--- 1664 P57061 -PQNA-------PALTAK----LIPEAQRDTVWVRDWTFSNRSYFEAVELEKRMMFIILTLII--AVAAFNLVSSLVMAVTEKQADIAILRTLGLSPGGV 316 AVX54763.1 YKI----SKYA--FGT--AIVFSLIM-WAISTLATW---IL-ITLI---IQIITSLGFAIPYG-FAFWTLIVSFIIIGISFIGSLIVSSNKIRTQKPASL 1747 P57061 MKIFMVQGAFSGFFGTLAGVVCGVLLGWNVGRVVAFFENLLGVHLINSQVYFIDYLPSDVDMGDVA----LIACISLGLSFVATLYPSRRASKTQ-PAEA 411 AVX54763.1 LTVSNE 1753 P57061 LRYE-- 415
Go Annotations
1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.
| Source | GO | Description |
|---|---|---|
| 1. PBF | GO:0022857 | transmembrane transporter activity |
| 1. PBF | GO:0005886 | plasma membrane |
| 1. PBF | GO:0016021 | integral component of membrane |
| 6. F | GO:0005887 | integral component of plasma membrane |
| 6. F | GO:1990281 | efflux pump complex |
| 6. F | GO:0008559 | ABC-type xenobiotic transporter activity |
| 6. F | GO:0046677 | response to antibiotic |
| 6. F | GO:1990961 | xenobiotic detoxification by transmembrane export across the plasma membrane |
| 6. F | GO:0015562 | efflux transmembrane transporter activity |
| 6. F | GO:0098797 | plasma membrane protein complex |
| 6. F | GO:2001070 | starch binding |
| 6. F | GO:0005524 | ATP binding |
| 6. F | GO:0042908 | xenobiotic transport |
| 6. F | GO:0002049 | pyoverdine biosynthetic process |
| 6. F | GO:0042953 | lipoprotein transport |
| 6. F | GO:0015893 |
Uniprot GO Annotations
| GO | Description |
|---|---|
| GO:0005886 | plasma membrane |
| GO:0016020 | membrane |
| GO:0016021 | integral component of membrane |
Homologs
1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.
| Source | Homolog | Description | Fatcat Pvalue | PROST Evalue | BLAST Evalue | Foldseek TMScore |
|---|---|---|---|---|---|---|
| 1. PBF | P75613 | Uncharacterized ABC transporter permease MG064 homolog | 5.50e-06 | 3.88e-14 | 2.08e-05 | 0.4675 |
| 1. PBF | P47310 | Uncharacterized ABC transporter permease MG064 | 5.12e-06 | 1.46e-16 | 1.09e-06 | 0.4936 |
| 5. P | P75109 | Uncharacterized ABC transporter permease MG468 homolog | 5.81e-04 | 2.95e-02 | NA | NA |
| 5. P | O53900 | Uncharacterized ABC transporter permease protein Rv0987 | 3.14e-03 | 2.41e-04 | NA | NA |
| 5. P | P77504 | Uncharacterized ABC transporter permease YbbP | 1.69e-02 | 2.22e-03 | NA | NA |
| 6. F | Q2YRG7 | Macrolide export ATP-binding/permease protein MacB | 5.13e-02 | NA | NA | 0.3953 |
| 6. F | P0C2H3 | Macrolide export ATP-binding/permease protein MacB 2 | 7.89e-02 | NA | NA | 0.3957 |
| 6. F | Q399M3 | Macrolide export ATP-binding/permease protein MacB | 6.24e-02 | NA | NA | 0.3895 |
| 6. F | Q4K9A4 | Macrolide export ATP-binding/permease protein MacB 2 | 3.77e-02 | NA | NA | 0.3879 |
| 6. F | P0ADC4 | Lipoprotein-releasing system transmembrane protein LolC | 3.11e-02 | NA | NA | 0.3756 |
| 6. F | Q6MPX9 | Macrolide export ATP-binding/permease protein MacB | 8.02e-02 | NA | NA | 0.4363 |
| 6. F | Q7CJG3 | Macrolide export ATP-binding/permease protein MacB 2 | 6.08e-02 | NA | NA | 0.4073 |
| 6. F | A1BE50 | Macrolide export ATP-binding/permease protein MacB | 7.19e-02 | NA | NA | 0.4301 |
| 6. F | Q65TH4 | Macrolide export ATP-binding/permease protein MacB | 4.27e-02 | NA | NA | 0.384 |
| 6. F | Q87JM4 | Macrolide export ATP-binding/permease protein MacB | 3.92e-02 | NA | NA | 0.3803 |
| 6. F | P94412 | Uncharacterized ABC transporter permease YclI | 1.87e-02 | NA | NA | 0.3033 |
| 6. F | Q7M8U0 | Macrolide export ATP-binding/permease protein MacB | 5.36e-02 | NA | NA | 0.4014 |
| 6. F | Q63MM6 | Macrolide export ATP-binding/permease protein MacB | 8.76e-02 | NA | NA | 0.4242 |
| 6. F | Q8EIL8 | Macrolide export ATP-binding/permease protein MacB | 1.02e-01 | NA | NA | 0.4204 |
| 6. F | Q7CHI2 | Macrolide export ATP-binding/permease protein MacB 1 | 5.16e-02 | NA | NA | 0.4363 |
| 6. F | Q6D8T5 | Macrolide export ATP-binding/permease protein MacB | 1.54e-01 | NA | NA | 0.4097 |
| 6. F | Q7A040 | Putative hemin transport system permease protein HrtB | 3.01e-02 | NA | NA | 0.4534 |
| 6. F | A0LM36 | Macrolide export ATP-binding/permease protein MacB | 5.21e-02 | NA | NA | 0.3762 |
| 6. F | Q49460 | Uncharacterized ABC transporter permease MG468 | 3.15e-04 | NA | NA | 0.3942 |
| 6. F | Q3SQZ1 | Macrolide export ATP-binding/permease protein MacB | 3.37e-02 | NA | NA | 0.399 |
| 6. F | Q8UKE4 | Macrolide export ATP-binding/permease protein MacB | 9.85e-02 | NA | NA | 0.3863 |
| 6. F | Q5P6D5 | Macrolide export ATP-binding/permease protein MacB | 6.75e-02 | NA | NA | 0.4053 |
| 6. F | Q49ZT7 | Putative hemin transport system permease protein HrtB | 2.59e-02 | NA | NA | 0.4546 |
| 6. F | Q2FED6 | Putative hemin transport system permease protein HrtB | 2.60e-02 | NA | NA | 0.439 |
| 6. F | Q3JGG7 | Macrolide export ATP-binding/permease protein MacB | 1.24e-01 | NA | NA | 0.4175 |
| 6. F | Q4ZT65 | Macrolide export ATP-binding/permease protein MacB 2 | 1.06e-01 | NA | NA | 0.3913 |
| 6. F | Q3B5J7 | Macrolide export ATP-binding/permease protein MacB | 7.39e-02 | NA | NA | 0.415 |
| 6. F | A0B212 | Macrolide export ATP-binding/permease protein MacB | 1.14e-01 | NA | NA | 0.4167 |
| 6. F | Q7A3X2 | Putative hemin transport system permease protein HrtB | 2.75e-02 | NA | NA | 0.4522 |
| 6. F | Q3KF57 | Macrolide export ATP-binding/permease protein MacB 1 | 9.01e-02 | NA | NA | 0.4144 |
| 6. F | P57062 | Lipoprotein-releasing system transmembrane protein LolC | 1.04e-02 | NA | NA | 0.3526 |
| 6. F | Q0PAR0 | Macrolide export ATP-binding/permease protein MacB | 4.79e-02 | NA | NA | 0.4071 |
| 6. F | A0KMJ3 | Macrolide export ATP-binding/permease protein MacB 2 | 1.59e-01 | NA | NA | 0.3536 |
| 6. F | Q4L8L8 | Putative hemin transport system permease protein HrtB | 2.88e-02 | NA | NA | 0.4701 |
| 6. F | Q02MI4 | Macrolide export ATP-binding/permease protein MacB | 6.60e-02 | NA | NA | 0.4107 |
| 6. F | A6QJK2 | Putative hemin transport system permease protein HrtB | 3.18e-02 | NA | NA | 0.4435 |
| 6. F | P46324 | Uncharacterized ABC transporter permease YvrN | 2.86e-02 | NA | NA | 0.3781 |
| 6. F | A0L0V9 | Macrolide export ATP-binding/permease protein MacB | 5.64e-02 | NA | NA | 0.3024 |
| 6. F | Q2KVS6 | Macrolide export ATP-binding/permease protein MacB | 7.04e-02 | NA | NA | 0.3738 |
| 6. F | Q884D4 | Macrolide export ATP-binding/permease protein MacB 1 | 5.83e-02 | NA | NA | 0.3973 |
| 6. F | Q82VK1 | Macrolide export ATP-binding/permease protein MacB | 5.08e-02 | NA | NA | 0.4189 |
| 6. F | Q1CA99 | Macrolide export ATP-binding/permease protein MacB 1 | 6.70e-02 | NA | NA | 0.4362 |
| 6. F | Q99RR7 | Putative hemin transport system permease protein HrtB | 3.01e-02 | NA | NA | 0.4528 |
| 6. F | Q9I190 | Macrolide export ATP-binding/permease protein MacB | 1.12e-01 | NA | NA | 0.409 |
| 6. F | Q6F813 | Macrolide export ATP-binding/permease protein MacB | 6.20e-02 | NA | NA | 0.4373 |
| 6. F | P57061 | Lipoprotein-releasing system transmembrane protein LolC | 9.82e-03 | NA | NA | 0.3589 |
| 6. F | A1BCE9 | Macrolide export ATP-binding/permease protein MacB 3 | 4.23e-02 | NA | NA | 0.4141 |
| 6. F | Q2NSZ1 | Macrolide export ATP-binding/permease protein MacB | 1.51e-01 | NA | NA | 0.4266 |
| 6. F | Q1I7I9 | Macrolide export ATP-binding/permease protein MacB 2 | 3.55e-02 | NA | NA | 0.3985 |
| 6. F | Q2T4B3 | Macrolide export ATP-binding/permease protein MacB | 1.37e-01 | NA | NA | 0.3943 |
| 6. F | Q2RPB4 | Macrolide export ATP-binding/permease protein MacB | 6.81e-02 | NA | NA | 0.4132 |
| 6. F | A1K323 | Macrolide export ATP-binding/permease protein MacB | 7.15e-02 | NA | NA | 0.3868 |
| 6. F | Q2IXX0 | Macrolide export ATP-binding/permease protein MacB | 9.60e-02 | NA | NA | 0.3923 |
| 6. F | Q5HVG3 | Macrolide export ATP-binding/permease protein MacB | 4.67e-02 | NA | NA | 0.3748 |
| 6. F | Q4KES7 | Macrolide export ATP-binding/permease protein MacB 1 | 4.17e-02 | NA | NA | 0.378 |
| 6. F | Q7ULB5 | Macrolide export ATP-binding/permease protein MacB | 4.60e-02 | NA | NA | 0.3913 |
| 6. F | Q48KB2 | Macrolide export ATP-binding/permease protein MacB | 4.92e-02 | NA | NA | 0.3983 |
| 6. F | O35005 | ABC transporter permease YtrF | 7.91e-02 | NA | NA | 0.3322 |
| 6. F | P0C2H2 | Macrolide export ATP-binding/permease protein MacB | 1.40e-01 | NA | NA | 0.4388 |
| 6. F | Q3ATR5 | Macrolide export ATP-binding/permease protein MacB | 1.36e-01 | NA | NA | 0.4191 |
| 6. F | Q1QDA8 | Macrolide export ATP-binding/permease protein MacB | 5.55e-02 | NA | NA | 0.3997 |
| 6. F | Q9K0N7 | Macrolide export ATP-binding/permease protein MacB | 1.06e-01 | NA | NA | 0.3891 |
| 6. F | Q7N6F9 | Macrolide export ATP-binding/permease protein MacB | 5.84e-02 | NA | NA | 0.4283 |
| 6. F | Q4FU75 | Macrolide export ATP-binding/permease protein MacB | 5.41e-02 | NA | NA | 0.398 |
| 6. F | A0KGB3 | Macrolide export ATP-binding/permease protein MacB 1 | 5.08e-02 | NA | NA | 0.4377 |
| 6. F | Q5HLN3 | Putative hemin transport system permease protein HrtB | 3.81e-02 | NA | NA | 0.4369 |
| 6. F | A1VYW8 | Macrolide export ATP-binding/permease protein MacB | 4.35e-02 | NA | NA | 0.403 |
| 6. F | Q9CM47 | Macrolide export ATP-binding/permease protein MacB | 5.23e-02 | NA | NA | 0.4307 |
| 6. F | Q3KE48 | Macrolide export ATP-binding/permease protein MacB 2 | 9.78e-02 | NA | NA | 0.3892 |
| 6. F | A1RG29 | Macrolide export ATP-binding/permease protein MacB | 1.14e-01 | NA | NA | 0.4048 |
| 6. F | Q6GE74 | Putative hemin transport system permease protein HrtB | 2.76e-02 | NA | NA | 0.4213 |
| 6. F | A1B677 | Macrolide export ATP-binding/permease protein MacB 1/2 | 1.95e-01 | NA | NA | 0.4546 |
| 6. F | Q6G1V5 | Macrolide export ATP-binding/permease protein MacB | 5.15e-02 | NA | NA | 0.3449 |
| 6. F | Q9JVR5 | Macrolide export ATP-binding/permease protein MacB | 4.33e-02 | NA | NA | 0.3908 |
| 6. F | O31712 | Uncharacterized ABC transporter permease YknZ | 2.10e-02 | NA | NA | 0.3622 |
| 6. F | Q32DZ9 | Macrolide export ATP-binding/permease protein MacB | 9.87e-02 | NA | NA | 0.3897 |
| 6. F | Q8YIT2 | Macrolide export ATP-binding/permease protein MacB | 5.51e-02 | NA | NA | 0.3854 |