Summary
The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.
AVX54773.1
JCVISYN3A_0409
Uncharacterized protein.
M. mycoides homolog: Q6MTE0.
TIGRfam Classification: 2=Generic.
Category: Quasiessential.
Statistics
Total GO Annotation: 16
Unique PROST Go: 3
Unique BLAST Go: 1
Unique Foldseek Go: 0
Total Homologs: 69
Unique PROST Homologs: 3
Unique BLAST Homologs: 0
Unique Foldseek Homologs: 0
Structures and Sequence Alignment
The best structural homolog that predicted by 1. PBF was
Q9JXG9
(GTP cyclohydrolase 1 type 2 homolog) with a FATCAT P-Value: 0 and RMSD of 2.68 angstrom. The sequence alignment identity is 22.1%.
Structural alignment shown in left. Query protein AVX54773.1 colored as red in alignment, homolog Q9JXG9 colored as blue.
Query protein AVX54773.1 is also shown in right top, homolog Q9JXG9 showed in right bottom. They are colored based on secondary structures.
AVX54773.1 MLL--DNIISYLNQ-----LFNPKKASNWDHV--GFQF---DYKKLNNINISKVLVCLDLTNDCLEFAISNQIQLIITRHPFIF-NELKLEKKNPN---- 83 Q9JXG9 MVLCRD-FLTWCNETLQTALF--K-----DYAPNGLQVEGREY-------IGKIVTSVTASRAAIDFAVEQKADLLLVHHGMFWKNEL------PTVTGW 79 AVX54773.1 KKQMIKKLNKHKILVFSIHTNYDS--SIKQNLLEILNKKLKINSFKKYGKDKESNLFYLDQKISVNDLINDLKEVFSLNKIRLNSNIN--LNSK---I-- 174 Q9JXG9 KKERIAALLRHDINMAGYHLPLDAHPTLGNN--AQLADRLGFATEKRFG---EQNL--------LNS--GSLKQAKTLGA--LAAHIETVLQRKPVVIGN 162 AVX54773.1 --KDF----YLTSGS-G-ASTMIENMLKNCTFITGEVKWDQWIYANSNNVNLIEIGHYA-ENHFIDDL-KNKLQIKFKDIKIFNYDIKNQFIEK 258 Q9JXG9 PEREIRRVAWCSGGAQGFFQTAIDEGVD--LYLTGEISEAQYHLANETGTAFISAGHHATERYGVRALAESAAEV-F-GLEVCHFDENNPA--- 249
Go Annotations
1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.
| Source | GO | Description |
|---|---|---|
| 1. PBF | GO:0003934 | GTP cyclohydrolase I activity |
| 1. PBF | GO:0005737 | cytoplasm |
| 1. PBF | GO:0046872 | metal ion binding |
| 1. PBF | GO:1903507 | negative regulation of nucleic acid-templated transcription |
| 1. PBF | GO:0035998 | 7,8-dihydroneopterin 3'-triphosphate biosynthetic process |
| 1. PBF | GO:0030182 | neuron differentiation |
| 2. PF | GO:0006281 | DNA repair |
| 4. PB | GO:0008134 | transcription factor binding |
| 4. PB | GO:0005739 | mitochondrion |
| 4. PB | GO:0042802 | identical protein binding |
| 4. PB | GO:0003933 | GTP cyclohydrolase activity |
| 4. PB | GO:0045893 | positive regulation of transcription, DNA-templated |
| 5. P | GO:0060187 | cell pole |
| 5. P | GO:0034214 | protein hexamerization |
| 5. P | GO:0010212 | response to ionizing radiation |
| 7. B | GO:0005634 | nucleus |
Uniprot GO Annotations
| GO | Description |
|---|
Homologs
1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.
| Source | Homolog | Description | Fatcat Pvalue | PROST Evalue | BLAST Evalue | Foldseek TMScore |
|---|---|---|---|---|---|---|
| 1. PBF | P53434 | GTP cyclohydrolase 1 type 2 homolog | 1.11e-16 | 2.92e-08 | 2.72e-08 | 0.7589 |
| 1. PBF | Q97JI0 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 4.80e-37 | 1.32e-07 | 0.825 |
| 1. PBF | Q6G907 | GTP cyclohydrolase 1 type 2 homolog | 3.00e-15 | 2.24e-07 | 3.60e-05 | 0.8232 |
| 1. PBF | P67273 | GTP cyclohydrolase 1 type 2 homolog | 3.00e-15 | 3.45e-07 | 3.47e-05 | 0.7936 |
| 1. PBF | Q9L012 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 3.78e-29 | 6.81e-08 | 0.7789 |
| 1. PBF | Q9JWG6 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 1.63e-26 | 3.25e-04 | 0.8519 |
| 1. PBF | Q5XCH0 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 2.93e-37 | 6.14e-13 | 0.8596 |
| 1. PBF | Q8CSD9 | GTP cyclohydrolase 1 type 2 homolog | 4.77e-15 | 1.50e-07 | 4.57e-05 | 0.7855 |
| 1. PBF | Q92BQ8 | GTP cyclohydrolase 1 type 2 homolog | 1.11e-16 | 3.97e-08 | 7.36e-09 | 0.7717 |
| 1. PBF | Q9PPK2 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 2.20e-45 | 1.79e-13 | 0.844 |
| 1. PBF | Q9KD39 | GTP cyclohydrolase 1 type 2 homolog | 3.33e-16 | 6.11e-07 | 5.60e-06 | 0.8212 |
| 1. PBF | P67276 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 3.79e-37 | 6.20e-13 | 0.8606 |
| 1. PBF | Q05B89 | NIF3-like protein 1 | 8.81e-11 | 9.53e-07 | 2.36e-06 | 0.8162 |
| 1. PBF | Q9CGM3 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 1.52e-40 | 1.89e-13 | 0.8769 |
| 1. PBF | Q8YS75 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 3.48e-37 | 4.62e-17 | 0.811 |
| 1. PBF | Q9JXG9 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 3.11e-26 | 6.56e-05 | 0.8533 |
| 1. PBF | Q5HFK1 | GTP cyclohydrolase 1 type 2 homolog | 2.78e-15 | 1.77e-07 | 3.51e-05 | 0.8263 |
| 1. PBF | O25613 | GTP cyclohydrolase 1 type 2 | 0.00e+00 | 6.63e-46 | 1.13e-12 | 0.8559 |
| 1. PBF | Q9ZKP2 | GTP cyclohydrolase 1 type 2 | 0.00e+00 | 1.24e-46 | 6.35e-13 | 0.8525 |
| 1. PBF | P54472 | GTP cyclohydrolase 1 type 2 homolog | 4.44e-16 | 1.87e-07 | 3.80e-08 | 0.8469 |
| 1. PBF | O58361 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 7.54e-29 | 3.48e-04 | 0.8241 |
| 1. PBF | Q8XIV9 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 2.07e-40 | 1.16e-08 | 0.8415 |
| 1. PBF | P67274 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 3.79e-37 | 6.20e-13 | 0.8606 |
| 1. PBF | Q98QB0 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 6.25e-42 | 2.70e-22 | 0.8618 |
| 1. PBF | Q97PK0 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 3.37e-35 | 5.04e-10 | 0.8547 |
| 1. PBF | Q6GGE0 | GTP cyclohydrolase 1 type 2 homolog | 2.66e-15 | 4.31e-08 | 1.61e-05 | 0.8067 |
| 1. PBF | P67272 | GTP cyclohydrolase 1 type 2 homolog | 2.66e-15 | 3.45e-07 | 3.47e-05 | 0.7938 |
| 1. PBF | Q5HNY9 | GTP cyclohydrolase 1 type 2 homolog | 5.44e-15 | 1.40e-07 | 4.65e-05 | 0.7917 |
| 1. PBF | P0DG85 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 3.79e-37 | 6.20e-13 | 0.8611 |
| 1. PBF | Q9PQE0 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 3.45e-40 | 3.88e-14 | 0.8211 |
| 1. PBF | Q8NWB9 | GTP cyclohydrolase 1 type 2 homolog | 2.78e-15 | 2.24e-07 | 3.60e-05 | 0.8268 |
| 1. PBF | P0DG84 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 3.79e-37 | 6.20e-13 | 0.8608 |
| 2. PF | Q9UYT3 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 1.28e-30 | NA | 0.8277 |
| 2. PF | Q8K9N4 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 2.46e-28 | NA | 0.8493 |
| 2. PF | Q89AJ8 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 1.50e-24 | NA | 0.8416 |
| 2. PF | P0AFP8 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 3.12e-29 | NA | 0.8302 |
| 2. PF | O69481 | GTP cyclohydrolase 1 type 2 homolog | 1.64e-13 | 8.80e-05 | NA | 0.7479 |
| 2. PF | Q9HP80 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 5.08e-31 | NA | 0.8169 |
| 2. PF | P0A657 | GTP cyclohydrolase 1 type 2 homolog | 5.17e-13 | 5.48e-06 | NA | 0.7126 |
| 2. PF | P67270 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 6.63e-30 | NA | 0.8278 |
| 2. PF | P57387 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 1.01e-26 | NA | 0.8368 |
| 2. PF | Q9PKS8 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 3.03e-31 | NA | 0.8411 |
| 2. PF | Q9Z946 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 2.25e-31 | NA | 0.8329 |
| 2. PF | P0AFP7 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 3.12e-29 | NA | 0.8272 |
| 2. PF | P45371 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 8.24e-27 | NA | 0.8036 |
| 2. PF | Q57354 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 1.27e-25 | NA | 0.8059 |
| 2. PF | O51424 | GTP cyclohydrolase 1 type 2 homolog | 2.22e-16 | 4.23e-30 | NA | 0.7769 |
| 2. PF | O28497 | GTP cyclohydrolase 1 type 2 homolog | 1.11e-16 | 2.97e-33 | NA | 0.8198 |
| 2. PF | P67271 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 6.63e-30 | NA | 0.8276 |
| 2. PF | P9WFM0 | GTP cyclohydrolase 1 type 2 homolog | 1.07e-13 | 5.48e-06 | NA | 0.7128 |
| 2. PF | Q8ZD91 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 2.00e-28 | NA | 0.8348 |
| 2. PF | Q9KQA7 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 8.39e-27 | NA | 0.8371 |
| 2. PF | Q8XVA0 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 1.86e-33 | NA | 0.839 |
| 2. PF | O84110 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 1.45e-32 | NA | 0.8434 |
| 2. PF | O83942 | GTP cyclohydrolase 1 type 2 homolog | 1.11e-15 | 2.00e-32 | NA | 0.7393 |
| 2. PF | Q9HVX2 | GTP cyclohydrolase 1 type 2 homolog | 1.11e-16 | 6.60e-26 | NA | 0.7974 |
| 2. PF | Q9CP72 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 6.85e-29 | NA | 0.8125 |
| 2. PF | Q9RY41 | GTP cyclohydrolase 1 type 2 homolog | 1.11e-16 | 1.26e-30 | NA | 0.7859 |
| 2. PF | O27214 | GTP cyclohydrolase 1 type 2 homolog | 8.88e-16 | 2.19e-25 | NA | 0.8001 |
| 4. PB | O94404 | Protein NIF3 homolog | 0.00e+00 | 2.15e-25 | 1.22e-16 | NA |
| 4. PB | Q9NK57 | NIF3-like protein 1 | 0.00e+00 | 1.53e-25 | 1.40e-07 | NA |
| 4. PB | Q9GZT8 | NIF3-like protein 1 | 1.31e-10 | 5.25e-06 | 1.88e-06 | NA |
| 4. PB | Q4V7D6 | NIF3-like protein 1 | 2.93e-10 | 2.70e-06 | 8.45e-07 | NA |
| 4. PB | Q55E83 | NIF3-like protein 1 | 8.17e-10 | 1.52e-09 | 1.26e-06 | NA |
| 4. PB | Q9EQ80 | NIF3-like protein 1 | 7.55e-11 | 7.81e-07 | 5.99e-05 | NA |
| 4. PB | P53081 | NGG1-interacting factor 3 | 0.00e+00 | 7.56e-24 | 3.64e-05 | NA |
| 5. P | Q58337 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 2.26e-39 | NA | NA |
| 5. P | P0AFP6 | GTP cyclohydrolase 1 type 2 homolog | 0.00e+00 | 3.12e-29 | NA | NA |
| 5. P | P9WFM1 | GTP cyclohydrolase 1 type 2 homolog | 5.58e-13 | 5.48e-06 | NA | NA |