Summary
The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.
AVX54775.1
JCVISYN3A_0411
Uncharacterized protein.
M. mycoides homolog: Q6MTD7.
TIGRfam Classification: 1=Unknown.
Category: Nonessential.
Statistics
Total GO Annotation: 5
Unique PROST Go: 3
Unique BLAST Go: 0
Unique Foldseek Go: 0
Total Homologs: 19
Unique PROST Homologs: 7
Unique BLAST Homologs: 0
Unique Foldseek Homologs: 1
Literature
Danchin and Fang [1]: NA
Yang and Tsui [2]: Glutamine--fructose-6-phosphate aminotransferase
Antczak et al. [3]: Transmembrane protein, ABC-transporter permease, likely metal ion transporter
Zhang et al. [4]: GO:0008144|drug binding
Bianchi et al. [5]: "Unclear membrane protein, possible flippase spoVB-murJ-like"
Structures and Sequence Alignment
The best structural homolog that predicted by 5. P was
P69986
(Yop proteins translocation protein U) with a FATCAT P-Value: 0.00358 and RMSD of 5.50 angstrom. The sequence alignment identity is 15.3%.
Structural alignment shown in left. Query protein AVX54775.1 colored as red in alignment, homolog P69986 colored as blue.
Query protein AVX54775.1 is also shown in right top, homolog P69986 showed in right bottom. They are colored based on secondary structures.
AVX54775.1 MQIPIIKPKKAPPLTIEEINEIKQHSSYEKSYLKTFNKYKKKVEHRIYFKTSFWWDIFIIALAALANTITTDYFILATGDTGLFPGGTATI--ARFLSIV 98 P69986 MS----GEKTEQP-TPKKIRDARKKGQVAKS---------KEV-----VSTA-----LIVALSAMLMGL-SDYYFEHFSKLMLIPAEQSYLPFSQALSYV 75 AVX54775.1 LNKHITSISTSSSFFIFL-F-IVNLPFFV--------FGFI-----------KV----GIK--FTLTSLLYILLSIGWNQIITRLPIINPNEWSLIINYK 171 P69986 VDNVLL------EFF-YLCFPLLTVAALMAIASHVVQYGFLISGEAIKPDIKKINPIEGAKRIFSIKSLVEFLKSI-LKVVLLSI-LI----W-IIIKGN 161 AVX54775.1 LIS--SLPT---EWSSKL------WLFVFSIFGGFFLGIT---YSL-TYR-VGSSTAGTDFI-SAY--------V-SKK--YNKQIGSINMKINF---TL 240 P69986 LVTLLQLPTCGIECITPLLGQILRQLMVICTVG--FVVISIADYAFEYYQYIKELKMSKDEIKREYKEMEGSPEIKSKRRQFHQEIQSRNMRENVKRSSV 259 AVX54775.1 LLIFVVLN-T--VIMPIYKIDSTAKLSVLNTL--TDEQF-TEIYNK-AKDSGKFIL-----------DFNSHHHFYLPS-NWSVSDQQI-WT-RQQI--- 316 P69986 ----VVANPTHIAIGILYKRGET-PLPLV-TFKYTDAQVQT--VRKIAEEEGVPILQRIPLARALYWDALVDH--YIPAEQIEATAEVLRWLERQNIEKQ 349 AVX54775.1 -AQIIASNTNFTNYDNLTTIIKLKFVFGPSLFASFICFVIQGVVIDRIYPKNKLFTVLISTTKPREVKNYLFESGYRNNIHFLENQTAKKENGYIAQSVI 415 P69986 HSEML----------------------------------------------------------------------------------------------- 354 AVX54775.1 MIHIGLMNWKPLQAGANNIDPDMMISFIRTKQVKGPWSYSLDTQKRELSLYKKVITDRRLMARIEKESILLTKQKITNDKKLKSKSKTF 504 P69986 ----------------------------------------------------------------------------------------- 354
Go Annotations
1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.
| Source | GO | Description |
|---|---|---|
| 1. PBF | GO:0005886 | plasma membrane |
| 1. PBF | GO:0016021 | integral component of membrane |
| 5. P | GO:0044781 | bacterial-type flagellum organization |
| 5. P | GO:0044780 | bacterial-type flagellum assembly |
| 5. P | GO:0009306 | protein secretion |
Uniprot GO Annotations
| GO | Description |
|---|---|
| GO:0016020 | membrane |
| GO:0016021 | integral component of membrane |
Homologs
1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.
| Source | Homolog | Description | Fatcat Pvalue | PROST Evalue | BLAST Evalue | Foldseek TMScore |
|---|---|---|---|---|---|---|
| 1. PBF | P47681 | Uncharacterized protein MG443 | 3.82e-13 | 2.76e-16 | 1.66e-07 | 0.6763 |
| 1. PBF | Q49432 | Uncharacterized protein MG432 | 0.00e+00 | 1.03e-22 | 6.91e-09 | 0.6791 |
| 1. PBF | P39803 | UPF0750 membrane protein YitT | 3.11e-09 | 4.18e-08 | 6.94e-05 | 0.8453 |
| 1. PBF | P75134 | Uncharacterized protein MG443 homolog | 2.85e-13 | 2.57e-13 | 3.33e-07 | 0.6941 |
| 1. PBF | P75166 | Uncharacterized protein MG432 homolog | 0.00e+00 | 1.94e-18 | 0.002 | 0.6648 |
| 2. PF | P54478 | UPF0750 membrane protein YqfU | 5.22e-05 | 1.66e-12 | NA | 0.5702 |
| 2. PF | P42978 | UPF0750 membrane protein YpjC | 2.03e-07 | 2.90e-13 | NA | 0.5903 |
| 2. PF | P96672 | UPF0750 membrane protein YdeO | 1.51e-08 | 1.10e-12 | NA | 0.5954 |
| 2. PF | O34792 | UPF0750 membrane protein YvjA | 1.13e-08 | 4.69e-08 | NA | 0.5469 |
| 2. PF | P94357 | UPF0750 membrane protein YxkD | 6.68e-08 | 7.48e-10 | NA | 0.6006 |
| 3. BF | P27712 | Uncharacterized protein in fibril gene 3'region (Fragment) | 1.07e-09 | NA | 2.28e-43 | 0.6742 |
| 5. P | Q8K9S1 | Flagellar biosynthetic protein FlhB | 7.23e-03 | 2.91e-02 | NA | NA |
| 5. P | Q89AN6 | Flagellar biosynthetic protein FlhB | 1.65e-02 | 3.91e-02 | NA | NA |
| 5. P | P69986 | Yop proteins translocation protein U | 3.58e-03 | 3.84e-02 | NA | NA |
| 5. P | P76299 | Flagellar biosynthetic protein FlhB | 4.67e-03 | 3.34e-02 | NA | NA |
| 5. P | O54243 | Flagellar biosynthetic protein FlhB | 1.62e-02 | 1.63e-02 | NA | NA |
| 5. P | P69987 | Yop proteins translocation protein U | 3.65e-03 | 3.84e-02 | NA | NA |
| 5. P | O83710 | Flagellar biosynthetic protein FlhB | 4.69e-03 | 8.03e-03 | NA | NA |
| 6. F | O06740 | UPF0750 membrane protein YitE | 8.32e-06 | NA | NA | 0.7394 |