Summary

The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.

AVX54784.1
JCVISYN3A_0421

Uncharacterized protein.
M. mycoides homolog: Q6MTC6.
TIGRfam Classification: 1=Unknown.
Category: Quasiessential.

Statistics

Total GO Annotation: 30
Unique PROST Go: 30
Unique BLAST Go: 0
Unique Foldseek Go: 0

Total Homologs: 76
Unique PROST Homologs: 53
Unique BLAST Homologs: 0
Unique Foldseek Homologs: 7

Literature

Danchin and Fang [1]: tRNA modification protein; may methylate U54, possiblly with YloV|similarity to yeast S-adenosylmethioninedependent tRNA (uracil-5-)-methyltransferase suggests tRNA target
Yang and Tsui [2]: Molybdopterin synthase catalytic subunit
Antczak et al. [3]: Alkaline shock protein Asp23 family protein
Zhang et al. [4]: GO:0044249|cellular biosynthetic process
Bianchi et al. [5]: Asp23 Family Lipid Regulator (yloU-like)

Structures and Sequence Alignment

The best structural homolog that predicted by 2. PF was Q8CNG0 (Alkaline shock protein 23) with a FATCAT P-Value: 9.73e-08 and RMSD of 3.01 angstrom. The sequence alignment identity is 18.5%.
Structural alignment shown in left. Query protein AVX54784.1 colored as red in alignment, homolog Q8CNG0 colored as blue. Query protein AVX54784.1 is also shown in right top, homolog Q8CNG0 showed in right bottom. They are colored based on secondary structures. 

  AVX54784.1 ---------------------------------------MSTIDEFVVQTI-----REAVITVPGVV---G-----LAN-FS-ANNKKDLSTNDIHKAIE 46
      Q8CNG0 MAVDNNKAKQAYDNQTGVNEQERKEQQQAQNNQPQFENKLTFSDE-VVEKIAGIAARE----VKGILDMKGGFTDSFTNAFSNGNN---VTTG-V--SVE 89

  AVX54784.1 FVIDKNIQHFKIHVILLYG-----V--NILDILKEIQIRIKY--ELEKNFKNNIEHKVDVIVEDLI----------------------- 103
      Q8CNG0 -VGEKQ-AAVDLKVILEYGESAPKIFRKVTDLVKE---QVKYITGLEV-----VE--VNMQVDDVMTKKEWQQKNEKDNKENNEREGLK 166

Go Annotations

1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.

Source GO Description
5. P GO:0033739 preQ1 synthase activity
5. P GO:0001055 RNA polymerase II activity
5. P GO:0046983 protein dimerization activity
5. P GO:0099001 viral genome ejection through host cell envelope, long flexible tail mechanism
5. P GO:0030234 enzyme regulator activity
5. P GO:0030275 LRR domain binding
5. P GO:0006366 transcription by RNA polymerase II
5. P GO:0043024 ribosomal small subunit binding
5. P GO:0006360 transcription by RNA polymerase I
5. P GO:0006808 regulation of nitrogen utilization
5. P GO:0098003 viral tail assembly
5. P GO:0005737 cytoplasm
5. P GO:0042304 regulation of fatty acid biosynthetic process
5. P GO:0005665 RNA polymerase II, core complex
5. P GO:0008616 queuosine biosynthetic process
5. P GO:0005759 mitochondrial matrix
5. P GO:0050790 regulation of catalytic activity
5. P GO:0036094 small molecule binding
5. P GO:0000166 nucleotide binding
5. P GO:0005666 RNA polymerase III complex
5. P GO:0044572 [4Fe-4S] cluster assembly
5. P GO:0046857 oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor
5. P GO:0039503 suppression by virus of host innate immune response
5. P GO:0030490 maturation of SSU-rRNA
5. P GO:0005736 RNA polymerase I complex
5. P GO:0003899 DNA-directed 5'-3' RNA polymerase activity
5. P GO:0042797 tRNA transcription by RNA polymerase III
5. P GO:0008704 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity
5. P GO:0098015 virus tail
5. P GO:0106035 protein maturation by [4Fe-4S] cluster transfer

Uniprot GO Annotations

GO Description

Homologs

1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.

Source Homolog Description Fatcat Pvalue PROST Evalue BLAST Evalue Foldseek TMScore
2. PF Q5HM47 Alkaline shock protein 23 1.41e-07 2.87e-03 NA 0.7471
2. PF P0A0P7 Alkaline shock protein 23 2.31e-07 6.61e-03 NA 0.7295
2. PF P0A0P6 Alkaline shock protein 23 2.31e-07 6.61e-03 NA 0.7296
2. PF Q6GEP7 Alkaline shock protein 23 1.42e-07 6.61e-03 NA 0.722
2. PF Q5HE23 Alkaline shock protein 23 1.60e-07 6.61e-03 NA 0.7318
2. PF O34318 Uncharacterized protein YloU 1.11e-11 9.93e-18 NA 0.7736
2. PF Q5XA93 Uncharacterized protein Spy1535 5.37e-08 2.59e-13 NA 0.7347
2. PF Q5XA14 Uncharacterized protein Spy1614 2.54e-11 6.05e-17 NA 0.8307
2. PF Q2YYG3 Alkaline shock protein 23 1.56e-07 6.61e-03 NA 0.7307
2. PF Q6G7D2 Alkaline shock protein 23 2.28e-07 6.61e-03 NA 0.7283
2. PF Q49ZC7 Alkaline shock protein 23 1.30e-05 2.57e-02 NA 0.7272
2. PF P54519 Uncharacterized protein YqhY 1.70e-08 1.33e-17 NA 0.7352
2. PF P99157 Alkaline shock protein 23 2.07e-07 6.61e-03 NA 0.7317
2. PF Q8CNG0 Alkaline shock protein 23 9.73e-08 2.87e-03 NA 0.7237
2. PF P0A0P8 Alkaline shock protein 23 2.49e-07 6.61e-03 NA 0.7294
2. PF Q2FEV0 Alkaline shock protein 23 2.44e-07 6.61e-03 NA 0.7304
5. P O30794 Nitrogen regulatory protein P-II 6.38e-03 1.78e-03 NA NA
5. P B1IA81 Ribosome-binding factor A 7.29e-05 4.37e-02 NA NA
5. P Q97S56 Ribosome-binding factor A 9.47e-05 2.47e-02 NA NA
5. P P0A3F4 Nitrogen regulatory protein P-II 6.13e-03 5.96e-03 NA NA
5. P Q32P79 DNA-directed RNA polymerase II subunit RPB11 6.07e-04 3.67e-02 NA NA
5. P P52435 DNA-directed RNA polymerase II subunit RPB11-a 6.63e-04 3.67e-02 NA NA
5. P Q1RH48 Ribosome-binding factor A 1.76e-04 2.57e-02 NA NA
5. P Q04RM8 NADPH-dependent 7-cyano-7-deazaguanine reductase 7.36e-02 4.42e-03 NA NA
5. P Q9VIZ0 Probable DNA-directed RNA polymerases I and III subunit RPAC2 1.42e-03 3.90e-02 NA NA
5. P Q3E793 BolA-like protein 1 6.59e-04 1.15e-02 NA NA
5. P Q07428 Nitrogen regulatory PII-like protein 1.50e-02 4.24e-02 NA NA
5. P P0A9Z6 Nitrogen regulatory protein P-II 1 5.50e-03 2.83e-02 NA NA
5. P P0A9Z5 Nitrogen regulatory protein P-II 1 5.38e-03 2.83e-02 NA NA
5. P C1C5S9 Ribosome-binding factor A 9.01e-05 3.65e-02 NA NA
5. P P0A3F5 Nitrogen regulatory protein P-II 6.38e-03 5.96e-03 NA NA
5. P Q9XVH6 Probable DNA-directed RNA polymerase II subunit RPB11 3.61e-03 1.97e-02 NA NA
5. P P33762 Uncharacterized protein BB_0439 2.67e-02 9.24e-03 NA NA
5. P Q8DQV1 Ribosome-binding factor A 1.02e-04 3.15e-02 NA NA
5. P P03241 Early 4 ORF3 protein NA 1.56e-02 NA NA
5. P C1CQ49 Ribosome-binding factor A 1.04e-04 3.65e-02 NA NA
5. P Q82WC9 Ribosome-binding factor A 7.87e-05 1.39e-02 NA NA
5. P Q051Z3 NADPH-dependent 7-cyano-7-deazaguanine reductase 6.55e-02 4.42e-03 NA NA
5. P B8ZM94 Ribosome-binding factor A 9.64e-05 3.65e-02 NA NA
5. P P0A9Z2 Nitrogen regulatory protein P-II 1 5.26e-03 2.83e-02 NA NA
5. P Q12W27 DNA-directed RNA polymerase subunit Rpo11 2.40e-03 8.88e-03 NA NA
5. P Q9K333 Ribosome-binding factor A 4.11e-05 4.54e-02 NA NA
5. P Q12238 UV-induced protein uvi31 7.32e-03 2.15e-02 NA NA
5. P Q05354 5-carboxymethyl-2-hydroxymuconate Delta-isomerase 5.12e-04 3.46e-02 NA NA
5. P Q8U3S2 Uncharacterized protein PF0383 1.20e-04 1.93e-02 NA NA
5. P P65970 Ribosome-binding factor A 1.21e-04 9.16e-03 NA NA
5. P P03732 Tail tube terminator protein NA 4.24e-02 NA NA
5. P A8GUU4 Ribosome-binding factor A 1.62e-04 2.57e-02 NA NA
5. P P0A9Z3 Nitrogen regulatory protein P-II 1 5.46e-03 2.83e-02 NA NA
5. P A8AVQ3 Ribosome-binding factor A 1.56e-04 1.96e-02 NA NA
5. P P0A9Z4 Nitrogen regulatory protein P-II 1 5.51e-03 2.83e-02 NA NA
5. P Q5SJV1 Ribosome-binding factor A 2.24e-05 2.20e-04 NA NA
5. P Q55247 Nitrogen regulatory protein P-II 6.71e-03 4.18e-03 NA NA
5. P A1AVA0 Ribosome-binding factor A 8.79e-05 4.52e-04 NA NA
5. P Q30UP6 NADPH-dependent 7-cyano-7-deazaguanine reductase 8.47e-02 4.54e-02 NA NA
5. P Q2FW66 Alkaline shock protein 23 2.01e-07 6.61e-03 NA NA
5. P Q60SM4 Probable DNA-directed RNA polymerase II subunit RPB11 3.70e-03 2.67e-03 NA NA
5. P P0A9Z1 Nitrogen regulatory protein P-II 1 5.55e-03 2.83e-02 NA NA
5. P Q04LV9 Ribosome-binding factor A 9.64e-05 3.15e-02 NA NA
5. P A5IZH0 Ribosome-binding factor A 3.92e-05 1.68e-02 NA NA
5. P C1CJ40 Ribosome-binding factor A 9.32e-05 3.65e-02 NA NA
5. P Q3K301 Ribosome-binding factor A 7.51e-05 4.54e-02 NA NA
5. P P65969 Ribosome-binding factor A 1.21e-04 9.16e-03 NA NA
5. P P21193 Nitrogen regulatory protein P-II 6.53e-03 4.51e-02 NA NA
5. P B5E267 Ribosome-binding factor A 9.11e-05 3.65e-02 NA NA
5. P Q47894 Nitrogen regulatory protein P-II 6.77e-03 2.67e-03 NA NA
5. P Q9X765 Ribosome-binding factor A 3.77e-05 1.34e-03 NA NA
5. P P44072 Uncharacterized protein HI_0907 2.19e-02 3.08e-02 NA NA
5. P C1CCT9 Ribosome-binding factor A 7.97e-05 4.37e-02 NA NA
6. F Q48TA2 Stress response regulator gls24 homolog 1.55e-06 NA NA 0.7045
6. F P0CZ87 Stress response regulator gls24 homolog 1.54e-06 NA NA 0.713
6. F P0CZ86 Stress response regulator gls24 homolog 1.64e-06 NA NA 0.7116
6. F Q5XBW6 Stress response regulator gls24 homolog 1.31e-06 NA NA 0.689
6. F Q4L860 Alkaline shock protein 23 1.33e-07 NA NA 0.7492
6. F Q7CN70 Stress response regulator gls24 homolog 1.58e-06 NA NA 0.7116
6. F Q99ZE5 Stress response regulator gls24 homolog 1.56e-06 NA NA 0.6969