Summary
The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.
AVX54790.1
JCVISYN3A_0428
Phosphate transport system regulatory protein.
M. mycoides homolog: Q6MTC0.
TIGRfam Classification: 5=Equivalog.
Category: Essential.
Statistics
Total GO Annotation: 19
Unique PROST Go: 1
Unique BLAST Go: 2
Unique Foldseek Go: 0
Total Homologs: 52
Unique PROST Homologs: 14
Unique BLAST Homologs: 0
Unique Foldseek Homologs: 1
Structures and Sequence Alignment
The best structural homolog that predicted by 1. PBF was
Q97ID9
(Phosphate-specific transport system accessory protein PhoU homolog) with a FATCAT P-Value: 0 and RMSD of 1.78 angstrom. The sequence alignment identity is 28.6%.
Structural alignment shown in left. Query protein AVX54790.1 colored as red in alignment, homolog Q97ID9 colored as blue.
Query protein AVX54790.1 is also shown in right top, homolog Q97ID9 showed in right bottom. They are colored based on secondary structures.
AVX54790.1 MSSNKILDRDLDQLRS-LIENM--IEETKIQY-ANSYLVIKEENKLIDAQKVIEHDKIINDMQNEF--TSIALWKIS-KQKLVAKDLRLAIGGI-LITRE 92 Q97ID9 M-TRKIFESDLEELHSELL-RMGSMAEKQI-YDCMEALEKQDENM---AEVIIKKDDIIDDMQKEIENKVIRL--IAMQQPIVAEDLRNIFTTVKIVT-D 91 AVX54790.1 IERIADYSKGISKFFIYYKP-N-EKHLLMISELYEL---VVEML-DIFS-DIF--ENLKVDKEQQVLSLEEKINTKFRSFYDQLI----DDIRQKTTKAE 179 Q97ID9 LERLGDHAVDIAKAI---KRLNGEKHHDIVKEIWNMGNKVKSMIKD--SLDAYVERNL--DKAYEVCKRDDDVDSLYKRIFNELLNIMSED------KSK 178 AVX54790.1 AEEIAAVL---KQMFNLERAGDNLLNVQEIINFIKTSKFIEKTEKINK 224 Q97ID9 VNQLTQFLFVCKY---LERIGDRTTNVCESTIYLITGKQVD----LND 219
Go Annotations
1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.
| Source | GO | Description |
|---|---|---|
| 1. PBF | GO:0042803 | protein homodimerization activity |
| 1. PBF | GO:2000186 | negative regulation of phosphate transmembrane transport |
| 1. PBF | GO:0045936 | negative regulation of phosphate metabolic process |
| 1. PBF | GO:0010629 | negative regulation of gene expression |
| 1. PBF | GO:0019220 | regulation of phosphate metabolic process |
| 1. PBF | GO:0006817 | phosphate ion transport |
| 1. PBF | GO:0050928 | negative regulation of positive chemotaxis |
| 1. PBF | GO:0005737 | cytoplasm |
| 1. PBF | GO:0050922 | negative regulation of chemotaxis |
| 1. PBF | GO:0030643 | cellular phosphate ion homeostasis |
| 3. BF | GO:0060326 | cell chemotaxis |
| 4. PB | GO:0016036 | cellular response to phosphate starvation |
| 4. PB | GO:0071467 | cellular response to pH |
| 4. PB | GO:0032413 | negative regulation of ion transmembrane transporter activity |
| 4. PB | GO:0071236 | cellular response to antibiotic |
| 4. PB | GO:0001558 | regulation of cell growth |
| 5. P | GO:0022611 | dormancy process |
| 7. B | GO:0009267 | cellular response to starvation |
| 7. B | GO:0019897 | extrinsic component of plasma membrane |
Uniprot GO Annotations
| GO | Description |
|---|---|
| GO:0045936 | negative regulation of phosphate metabolic process |
| GO:0030643 | cellular phosphate ion homeostasis |
Homologs
1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.
| Source | Homolog | Description | Fatcat Pvalue | PROST Evalue | BLAST Evalue | Foldseek TMScore |
|---|---|---|---|---|---|---|
| 1. PBF | Q52989 | Phosphate-specific transport system accessory protein PhoU homolog | 0.00e+00 | 9.89e-14 | 1.44e-12 | 0.8692 |
| 1. PBF | P0CAV9 | Phosphate-specific transport system accessory protein PhoU homolog | 0.00e+00 | 3.73e-21 | 2.47e-07 | 0.9021 |
| 1. PBF | Q9Z410 | Phosphate-specific transport system accessory protein PhoU homolog | 0.00e+00 | 7.33e-13 | 0.013 | 0.8722 |
| 1. PBF | Q51547 | Phosphate-specific transport system accessory protein PhoU homolog | 0.00e+00 | 8.91e-17 | 0.004 | 0.8925 |
| 1. PBF | Q87C87 | Phosphate-specific transport system accessory protein PhoU homolog | 0.00e+00 | 1.43e-14 | 6.53e-05 | 0.8562 |
| 1. PBF | P72686 | Phosphate-specific transport system accessory protein PhoU homolog | 0.00e+00 | 1.59e-19 | 3.66e-04 | 0.8587 |
| 1. PBF | Q9PBJ9 | Phosphate-specific transport system accessory protein PhoU homolog | 0.00e+00 | 3.39e-14 | 1.65e-04 | 0.8551 |
| 1. PBF | Q9X5E1 | Phosphate-specific transport system accessory protein PhoU homolog | 0.00e+00 | 5.13e-16 | 9.08e-13 | 0.8315 |
| 1. PBF | Q83WB2 | Phosphate-specific transport system accessory protein PhoU | 0.00e+00 | 4.39e-18 | 4.32e-07 | 0.8588 |
| 1. PBF | P0A3Y7 | Phosphate-specific transport system accessory protein PhoU homolog | 0.00e+00 | 1.76e-25 | 0.012 | 0.8659 |
| 1. PBF | Q9RYZ2 | Uncharacterized protein DR_A0161 | 0.00e+00 | 3.37e-27 | 0.023 | 0.8394 |
| 1. PBF | P0A9K8 | Phosphate-specific transport system accessory protein PhoU | 0.00e+00 | 6.57e-16 | 3.48e-07 | 0.8562 |
| 1. PBF | P47649 | Uncharacterized protein MG409 | 0.00e+00 | 1.99e-31 | 2.78e-05 | 0.7993 |
| 1. PBF | O32488 | Phosphate-specific transport system accessory protein PhoU | 0.00e+00 | 1.92e-15 | 3.55e-09 | 0.8595 |
| 1. PBF | Q97ID9 | Phosphate-specific transport system accessory protein PhoU homolog | 0.00e+00 | 1.82e-18 | 0.001 | 0.8934 |
| 1. PBF | P75187 | Uncharacterized protein MG409 homolog | 0.00e+00 | 3.75e-31 | 3.20e-05 | 0.8718 |
| 1. PBF | Q8FBT8 | Phosphate-specific transport system accessory protein PhoU | 0.00e+00 | 2.00e-17 | 3.59e-07 | 0.8708 |
| 1. PBF | O51071 | Phosphate-specific transport system accessory protein PhoU homolog | 0.00e+00 | 1.32e-23 | 3.82e-04 | 0.8913 |
| 1. PBF | Q9X0Y7 | Phosphate-specific transport system accessory protein PhoU homolog 1 | 0.00e+00 | 3.42e-21 | 6.25e-07 | 0.8324 |
| 1. PBF | B8GYG5 | Phosphate-specific transport system accessory protein PhoU homolog | 0.00e+00 | 3.73e-21 | 2.47e-07 | 0.9016 |
| 1. PBF | P0A3Y8 | Phosphate-specific transport system accessory protein PhoU homolog | 0.00e+00 | 1.76e-25 | 0.012 | 0.8635 |
| 2. PF | O27765 | Phosphate-specific transport system accessory protein PhoU homolog 2 | 0.00e+00 | 7.00e-24 | NA | 0.8222 |
| 2. PF | P9WI96 | Phosphate-specific transport system accessory protein PhoU homolog 1 | 0.00e+00 | 6.92e-17 | NA | 0.8585 |
| 2. PF | Q9RS84 | Phosphate-specific transport system accessory protein PhoU homolog | 0.00e+00 | 2.37e-19 | NA | 0.9097 |
| 2. PF | O28911 | Phosphate-specific transport system accessory protein PhoU homolog | 0.00e+00 | 1.90e-24 | NA | 0.7123 |
| 2. PF | Q9XBG0 | Phosphate-specific transport system accessory protein PhoU homolog | 0.00e+00 | 2.34e-19 | NA | 0.8793 |
| 2. PF | O27767 | Phosphate-specific transport system accessory protein PhoU homolog 1 | 0.00e+00 | 1.21e-13 | NA | 0.882 |
| 2. PF | O27724 | UPF0111 protein MTH_1689 | 0.00e+00 | 2.21e-15 | NA | 0.6539 |
| 2. PF | Q9X256 | Phosphate-specific transport system accessory protein PhoU homolog 2 | 0.00e+00 | 1.25e-18 | NA | 0.872 |
| 2. PF | O28133 | UPF0111 protein AF_2149 | 0.00e+00 | 5.02e-12 | NA | 0.684 |
| 2. PF | P9WI94 | Phosphate-specific transport system accessory protein PhoU homolog 2 | 0.00e+00 | 5.59e-14 | NA | 0.8662 |
| 2. PF | Q50047 | Phosphate-specific transport system accessory protein PhoU homolog 1 | 0.00e+00 | 4.04e-17 | NA | 0.8496 |
| 2. PF | P65719 | Phosphate-specific transport system accessory protein PhoU homolog 1 | 0.00e+00 | 6.92e-17 | NA | 0.8582 |
| 2. PF | O67053 | Phosphate-specific transport system accessory protein PhoU homolog | 0.00e+00 | 2.62e-19 | NA | 0.8919 |
| 2. PF | P65721 | Phosphate-specific transport system accessory protein PhoU homolog 2 | 0.00e+00 | 5.59e-14 | NA | 0.8663 |
| 4. PB | B6ZCF1 | Phosphate-specific transport system accessory protein PhoU | NA | 1.70e-17 | 6.89e-08 | NA |
| 4. PB | P0A9K7 | Phosphate-specific transport system accessory protein PhoU | 0.00e+00 | 6.57e-16 | 3.48e-07 | NA |
| 5. P | O30498 | Putative pit accessory protein | 1.97e-12 | 8.94e-08 | NA | NA |
| 5. P | P9WI97 | Phosphate-specific transport system accessory protein PhoU homolog 1 | 0.00e+00 | 6.92e-17 | NA | NA |
| 5. P | O84697 | UPF0111 protein CT_691 | 2.22e-16 | 2.80e-12 | NA | NA |
| 5. P | O58371 | UPF0111 protein PH0637 | 0.00e+00 | 2.13e-09 | NA | NA |
| 5. P | Q58415 | Phosphate-specific transport system accessory protein PhoU homolog | 0.00e+00 | 5.25e-18 | NA | NA |
| 5. P | P44271 | UPF0111 protein HI_1603 | 2.22e-16 | 8.94e-13 | NA | NA |
| 5. P | O34454 | UPF0111 protein YkaA | 2.07e-13 | 1.36e-08 | NA | NA |
| 5. P | O50097 | UPF0111 protein PH1389 | 2.63e-13 | 3.37e-11 | NA | NA |
| 5. P | Q9X016 | UPF0111 protein TM_0914 | 0.00e+00 | 2.27e-12 | NA | NA |
| 5. P | Q58046 | UPF0111 protein MJ0629 | 0.00e+00 | 1.83e-09 | NA | NA |
| 5. P | O28475 | UPF0111 protein AF_1799 | 1.11e-16 | 5.95e-08 | NA | NA |
| 5. P | P9WI95 | Phosphate-specific transport system accessory protein PhoU homolog 2 | 0.00e+00 | 5.59e-14 | NA | NA |
| 5. P | Q9Z7M3 | UPF0111 protein CPn_0681/CP_0066/CPj0681/CpB0708 | 8.88e-16 | 7.98e-11 | NA | NA |
| 5. P | Q9PLN6 | UPF0111 protein TC_0063 | 1.11e-16 | 5.43e-13 | NA | NA |
| 6. F | Q9RSS1 | Uncharacterized protein DR_2053 | 0.00e+00 | NA | NA | 0.7304 |