Summary
The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.
AVX54799.1
JCVISYN3A_0438
Uncharacterized protein.
M. mycoides homolog: Q6MTB0.
TIGRfam Classification: 2=Generic.
Category: Nonessential.
Statistics
Total GO Annotation: 44
Unique PROST Go: 2
Unique BLAST Go: 11
Unique Foldseek Go: 0
Total Homologs: 74
Unique PROST Homologs: 1
Unique BLAST Homologs: 14
Unique Foldseek Homologs: 1
Literature
Danchin and Fang [1]: hydrolase|carry out dinucleotidyl hydrolase, nucleotidyltransferase and phosphoramidite hydrolase activities; possibly involved in Zn homeostasis
Yang and Tsui [2]: Histidine triad protein
Antczak et al. [3]: Histidine triad HIT hydrolaselike protein
Zhang et al. [4]: GO:0009166|nucleotide catabolic process
Bianchi et al. [5]: Histidine triad protein
Structures and Sequence Alignment
The best structural homolog that predicted by 1. PBF was
O07513
(Protein hit) with a FATCAT P-Value: 0 and RMSD of 1.88 angstrom. The sequence alignment identity is 38.7%.
Structural alignment shown in left. Query protein AVX54799.1 colored as red in alignment, homolog O07513 colored as blue.
Query protein AVX54799.1 is also shown in right top, homolog O07513 showed in right bottom. They are colored based on secondary structures.
AVX54799.1 M----DCLFCKIINQEIPSYKIYENEYVYSFLDVRPVSNGHLLVITKKHFEN-FSACDDKYLQEVILAKKY------LVNLLKEKLNPAGFNYLSN--EQ 87 O07513 MHCAENCIFCKIIAGDIPSAKVYEDEHVLAFLDISQVTKGHTLVIPKTHIENVYEFTDE-------LAKQYFHAVPKIARAIRDEFEPIGLNTLNNNGEK 93 AVX54799.1 AISGQTVLHYHEHIMPKYEK-DKGF--LLKAEIVDI--DELENTFNKIVK----- 132 O07513 A--GQSVFHYHMHIIPRYGKGD-GFGAVWKTHADDYKPEDLQNISSSIAKRLASS 145
Go Annotations
1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.
| Source | GO | Description |
|---|---|---|
| 1. PBF | GO:0009117 | nucleotide metabolic process |
| 1. PBF | GO:0006163 | purine nucleotide metabolic process |
| 1. PBF | GO:0006790 | sulfur compound metabolic process |
| 1. PBF | GO:0055130 | D-alanine catabolic process |
| 1. PBF | GO:0047627 | adenylylsulfatase activity |
| 1. PBF | GO:0047710 | bis(5'-adenosyl)-triphosphatase activity |
| 1. PBF | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
| 1. PBF | GO:0005634 | nucleus |
| 1. PBF | GO:0042802 | identical protein binding |
| 1. PBF | GO:0043530 | adenosine 5'-monophosphoramidase activity |
| 1. PBF | GO:0001650 | fibrillar center |
| 1. PBF | GO:0015964 | diadenosine triphosphate catabolic process |
| 1. PBF | GO:0003824 | catalytic activity |
| 1. PBF | GO:0016787 | hydrolase activity |
| 1. PBF | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator |
| 1. PBF | GO:0009150 | purine ribonucleotide metabolic process |
| 1. PBF | GO:0000166 | nucleotide binding |
| 3. BF | GO:0009154 | purine ribonucleotide catabolic process |
| 3. BF | GO:0006694 | steroid biosynthetic process |
| 3. BF | GO:0005739 | mitochondrion |
| 3. BF | GO:0003877 | ATP adenylyltransferase activity |
| 3. BF | GO:0000118 | histone deacetylase complex |
| 3. BF | GO:2000757 | negative regulation of peptidyl-lysine acetylation |
| 3. BF | GO:0006355 | regulation of transcription, DNA-templated |
| 4. PB | GO:0090305 | nucleic acid phosphodiester bond hydrolysis |
| 4. PB | GO:0005829 | cytosol |
| 4. PB | GO:0004081 | bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity |
| 4. PB | GO:0004780 | sulfate adenylyltransferase (ADP) activity |
| 4. PB | GO:0031625 | ubiquitin protein ligase binding |
| 4. PB | GO:0006259 | DNA metabolic process |
| 4. PB | GO:0005777 | peroxisome |
| 5. P | GO:0010043 | response to zinc ion |
| 5. P | GO:0016151 | nickel cation binding |
| 7. B | GO:0015967 | diadenosine tetraphosphate catabolic process |
| 7. B | GO:0099503 | secretory vesicle |
| 7. B | GO:0043605 | cellular amide catabolic process |
| 7. B | GO:0016042 | lipid catabolic process |
| 7. B | GO:0005737 | cytoplasm |
| 7. B | GO:0050850 | positive regulation of calcium-mediated signaling |
| 7. B | GO:0006139 | nucleobase-containing compound metabolic process |
| 7. B | GO:0006915 | apoptotic process |
| 7. B | GO:0008796 | bis(5'-nucleosyl)-tetraphosphatase activity |
| 7. B | GO:0009164 | nucleoside catabolic process |
| 7. B | GO:0110050 | deaminated glutathione amidase activity |
Uniprot GO Annotations
| GO | Description |
|---|---|
| GO:0003824 | catalytic activity |
Homologs
1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.
| Source | Homolog | Description | Fatcat Pvalue | PROST Evalue | BLAST Evalue | Foldseek TMScore |
|---|---|---|---|---|---|---|
| 1. PBF | P94252 | Uncharacterized HIT-like protein BB_0379 | 0.00e+00 | 8.92e-49 | 9.50e-27 | 0.874 |
| 1. PBF | C4LYI2 | Histidine triad nucleotide-binding protein | 1.06e-13 | 5.71e-10 | 5.86e-16 | 0.7945 |
| 1. PBF | P75504 | Uncharacterized 16.1 kDa HIT-like protein | 0.00e+00 | 1.13e-36 | 1.69e-34 | 0.9653 |
| 1. PBF | P47378 | Uncharacterized HIT-like protein MG132 | 0.00e+00 | 1.80e-44 | 6.29e-37 | 0.9702 |
| 1. PBF | Q89AG5 | Uncharacterized HIT-like protein bbp_327 | 1.83e-13 | 4.46e-06 | 0.043 | 0.8252 |
| 1. PBF | P0A5B6 | Uncharacterized HIT-like protein Mb0782c | 1.57e-08 | 8.27e-32 | 4.70e-10 | 0.8723 |
| 1. PBF | P26724 | Uncharacterized 13.2 kDa HIT-like protein in hisE 3'region | 7.00e-13 | 1.47e-08 | 4.88e-06 | 0.7812 |
| 1. PBF | O66536 | Uncharacterized HIT-like protein aq_141 | 1.43e-11 | 7.70e-10 | 2.11e-13 | 0.7957 |
| 1. PBF | P64382 | Uncharacterized HIT-like protein HP_0404 | 4.47e-13 | 3.79e-08 | 9.11e-10 | 0.8858 |
| 1. PBF | O07817 | Protein HitA | 7.44e-15 | 2.88e-06 | 6.20e-13 | 0.8532 |
| 1. PBF | P95937 | Uncharacterized HIT-like protein SSO2163 | 0.00e+00 | 9.02e-39 | 2.12e-17 | 0.9403 |
| 1. PBF | Q8K9I9 | Uncharacterized HIT-like protein BUsg_345 | 2.93e-12 | 1.89e-07 | 0.010 | 0.7516 |
| 1. PBF | P49774 | Uncharacterized HIT-like protein ML2237 | 1.79e-08 | 1.05e-31 | 7.02e-10 | 0.8695 |
| 1. PBF | P0ACE9 | Purine nucleoside phosphoramidase | 2.85e-12 | 4.36e-11 | 2.46e-05 | 0.7448 |
| 1. PBF | P9WML2 | Uncharacterized HIT-like protein MT0784 | 1.54e-08 | 8.27e-32 | 4.70e-10 | 0.846 |
| 1. PBF | P9WML0 | Uncharacterized HIT-like protein MT1300 | 1.31e-11 | 5.85e-28 | 1.14e-16 | 0.9337 |
| 1. PBF | P32083 | Uncharacterized 13.1 kDa HIT-like protein in P37 5'region | 0.00e+00 | 1.08e-05 | 1.50e-13 | 0.9511 |
| 1. PBF | Q9ZDL1 | Uncharacterized HIT-like protein RP317 | 5.57e-13 | 4.92e-11 | 3.38e-09 | 0.7292 |
| 1. PBF | Q9Z863 | HIT-like protein CPn_0488/CP_0266/CPj0488/CpB0508 | 1.73e-13 | 7.94e-11 | 2.96e-05 | 0.8035 |
| 1. PBF | P42855 | 14 kDa zinc-binding protein (Fragment) | 9.71e-13 | 3.26e-07 | 5.75e-07 | 0.7883 |
| 1. PBF | O07513 | Protein hit | 0.00e+00 | 7.47e-37 | 2.75e-28 | 0.884 |
| 1. PBF | P57438 | Uncharacterized HIT-like protein BU357 | 1.46e-12 | 5.35e-08 | 0.002 | 0.7629 |
| 1. PBF | P32084 | Uncharacterized HIT-like protein Synpcc7942_1390 | 2.89e-14 | 2.08e-07 | 2.81e-10 | 0.8492 |
| 1. PBF | P64383 | Uncharacterized HIT-like protein jhp_0977 | 4.79e-13 | 3.79e-08 | 9.11e-10 | 0.8874 |
| 1. PBF | P73481 | Uncharacterized HIT-like protein slr1234 | 8.43e-13 | 3.55e-07 | 8.59e-11 | 0.834 |
| 1. PBF | Q28BZ2 | Adenosine 5'-monophosphoramidase HINT3 | 2.27e-08 | 4.69e-11 | 0.001 | 0.7502 |
| 1. PBF | P44956 | Purine nucleoside phosphoramidase | 9.69e-13 | 1.12e-08 | 3.80e-08 | 0.8032 |
| 1. PBF | Q1KZG4 | Bis(5'-adenosyl)-triphosphatase | 2.76e-07 | 5.51e-22 | 1.93e-05 | 0.9197 |
| 1. PBF | P0ACE8 | Purine nucleoside phosphoramidase | 2.99e-12 | 4.36e-11 | 2.46e-05 | 0.7392 |
| 2. PF | O84390 | Uncharacterized HIT-like protein CT_385 | 1.25e-13 | 4.60e-08 | NA | 0.8078 |
| 3. BF | C8Z5L6 | Bis(5'-adenosyl)-triphosphatase | 1.11e-07 | NA | 7.91e-04 | 0.7474 |
| 3. BF | Q2YDJ4 | Adenosine 5'-monophosphoramidase HINT3 | 3.63e-07 | NA | 3.11e-05 | 0.6687 |
| 3. BF | Q5R9L4 | Adenosine 5'-monophosphoramidase HINT3 | 3.90e-07 | NA | 3.24e-04 | 0.6709 |
| 3. BF | C7GQV5 | Bis(5'-adenosyl)-triphosphatase | 6.58e-08 | NA | 7.91e-04 | 0.746 |
| 3. BF | A6ZYQ3 | Bis(5'-adenosyl)-triphosphatase | 1.48e-07 | NA | 7.91e-04 | 0.749 |
| 3. BF | Q8SQ21 | Adenosine 5'-monophosphoramidase HINT2 | 6.47e-12 | NA | 7.63e-07 | 0.8377 |
| 3. BF | P80912 | Adenosine 5'-monophosphoramidase HINT1 | 3.23e-12 | NA | 1.78e-13 | 0.8646 |
| 3. BF | P62958 | Adenosine 5'-monophosphoramidase HINT1 | 4.50e-13 | NA | 4.81e-13 | 0.8539 |
| 3. BF | P9WMK8 | AP-4-A phosphorylase | 1.49e-08 | NA | 3.93e-05 | 0.8417 |
| 3. BF | B5VGI4 | Bis(5'-adenosyl)-triphosphatase | 1.63e-07 | NA | 7.91e-04 | 0.7482 |
| 3. BF | Q5RF69 | Adenosine 5'-monophosphoramidase HINT1 | 5.98e-13 | NA | 2.20e-12 | 0.8614 |
| 3. BF | B3LFZ1 | Bis(5'-adenosyl)-triphosphatase | 1.04e-07 | NA | 7.91e-04 | 0.7475 |
| 4. PB | Q9JIX3 | Bis(5'-adenosyl)-triphosphatase | 2.93e-07 | 4.57e-22 | 6.18e-04 | NA |
| 4. PB | P49789 | Bis(5'-adenosyl)-triphosphatase | 1.65e-07 | 7.87e-24 | 5.08e-04 | NA |
| 4. PB | P49776 | Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] | 5.03e-11 | 1.00e-04 | 2.15e-04 | NA |
| 4. PB | Q23921 | Protein pkiA | 3.12e-12 | 9.78e-04 | 2.06e-06 | NA |
| 4. PB | P0ACE7 | Purine nucleoside phosphoramidase | 2.99e-12 | 4.36e-11 | 2.46e-05 | NA |
| 4. PB | O89106 | Bis(5'-adenosyl)-triphosphatase | 3.42e-07 | 1.15e-21 | 5.36e-04 | NA |
| 4. PB | F4K1R2 | Adenylylsulfatase HINT3 | 1.74e-10 | 1.04e-04 | 1.07e-18 | NA |
| 4. PB | P9WML3 | Uncharacterized HIT-like protein Rv0759c | 1.67e-08 | 8.27e-32 | 4.70e-10 | NA |
| 4. PB | Q59WG0 | Adenosine 5'-monophosphoramidase HNT1 | 5.55e-16 | 9.99e-29 | 6.52e-23 | NA |
| 4. PB | Q58276 | Uncharacterized HIT-like protein MJ0866 | 0.00e+00 | 1.41e-50 | 3.50e-28 | NA |
| 4. PB | Q86KK2 | Bis(5'-adenosyl)-triphosphatase | 1.41e-08 | 3.55e-20 | 1.49e-05 | NA |
| 4. PB | O94586 | Adenosine 5'-monophosphoramidase hnt1 | 0.00e+00 | 9.02e-39 | 1.53e-17 | NA |
| 4. PB | F4KEV7 | Bifunctional bis(5'-adenosyl)-triphosphatase/adenylylsulfatase FHIT | 3.48e-07 | 1.16e-09 | 7.82e-04 | NA |
| 4. PB | Q84VV6 | Bifunctional adenosine 5'-phosphosulfate phosphorylase/adenylylsulfatase HINT4 | 3.83e-08 | 1.70e-19 | 0.001 | NA |
| 4. PB | P9WML1 | Uncharacterized HIT-like protein Rv1262c | 7.73e-12 | 5.85e-28 | 1.14e-16 | NA |
| 4. PB | Q04344 | Adenosine 5'-monophosphoramidase HNT1 | 0.00e+00 | 6.21e-20 | 1.81e-21 | NA |
| 5. P | Q5PNN8 | Adenosine 5'-monophosphoramidase HINT3 | 2.96e-08 | 3.56e-14 | NA | NA |
| 6. F | Q9PK09 | Uncharacterized HIT-like protein TC_0664 | 2.42e-12 | NA | NA | 0.7729 |
| 7. B | O76464 | Nitrilase and fragile histidine triad fusion protein NitFhit | 2.25e-04 | NA | 3.02e-06 | NA |
| 7. B | Q9BX68 | Adenosine 5'-monophosphoramidase HINT2 | 1.43e-12 | NA | 2.51e-06 | NA |
| 7. B | P62959 | Adenosine 5'-monophosphoramidase HINT1 | 3.38e-12 | NA | 1.03e-13 | NA |
| 7. B | P70349 | Adenosine 5'-monophosphoramidase HINT1 | 4.16e-13 | NA | 1.03e-13 | NA |
| 7. B | O76463 | Nitrilase and fragile histidine triad fusion protein NitFhit | 1.32e-04 | NA | 3.60e-06 | NA |
| 7. B | P9WMK9 | AP-4-A phosphorylase | 1.22e-08 | NA | 3.93e-05 | NA |
| 7. B | P49773 | Adenosine 5'-monophosphoramidase HINT1 | 3.27e-13 | NA | 1.21e-12 | NA |
| 7. B | Q8GUN2 | Adenylylsulfatase HINT1 | 4.51e-12 | NA | 2.57e-06 | NA |
| 7. B | P42856 | 14 kDa zinc-binding protein | 4.67e-12 | NA | 7.99e-07 | NA |
| 7. B | P49775 | Bis(5'-adenosyl)-triphosphatase | 1.38e-07 | NA | 7.91e-04 | NA |
| 7. B | Q9D0S9 | Adenosine 5'-monophosphoramidase HINT2 | 8.00e-12 | NA | 1.79e-06 | NA |
| 7. B | P53795 | Histidine triad nucleotide-binding protein 1 | 4.49e-13 | NA | 2.28e-08 | NA |
| 7. B | Q9CPS6 | Adenosine 5'-monophosphoramidase HINT3 | 7.35e-08 | NA | 0.012 | NA |
| 7. B | Q9NQE9 | Adenosine 5'-monophosphoramidase HINT3 | 4.11e-07 | NA | 3.40e-04 | NA |