Summary

The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.

AVX54813.1
JCVISYN3A_0478

Uncharacterized protein.
M. mycoides homolog: Q6MT75.
TIGRfam Classification: 1=Unknown.
Category: Essential.

Statistics

Total GO Annotation: 102
Unique PROST Go: 102
Unique BLAST Go: 0
Unique Foldseek Go: 0

Total Homologs: 131
Unique PROST Homologs: 131
Unique BLAST Homologs: 0
Unique Foldseek Homologs: 0

Literature

Danchin and Fang [1]: NA
Yang and Tsui [2]: Holliday junction ATP-dependent DNA helicase RuvA
Antczak et al. [3]: Transmembrane protein, likely a cation transporter from Major Facilitator Superfamily
Zhang et al. [4]: GO:0005886|plasma membrane
Bianchi et al. [5]: "Unclear, membrane ion transport?"

Structures and Sequence Alignment

The best structural homolog that predicted by 5. P was E7FDE0 (Transmembrane protein 138) with a FATCAT P-Value: 3.55e-10 and RMSD of 3.69 angstrom. The sequence alignment identity is 22.1%.
Structural alignment shown in left. Query protein AVX54813.1 colored as red in alignment, homolog E7FDE0 colored as blue. Query protein AVX54813.1 is also shown in right top, homolog E7FDE0 showed in right bottom. They are colored based on secondary structures.

  AVX54813.1 MENKINHKTYKSLKYLLTIS-SVILAICL-LLVFVQFTKAKPLFISLTPFISLLVILLILSFTCLLVYIIYRMKILKTSNYKYIKKEIIYLYTSFSLYIF 98
      E7FDE0 --------------MLQTNNYSLVLLIQLALLTF-------DLFVN--SFSELLRSAPVIQ---LVLFIIQDIGIL--FNV------IIILLMMFNTYVF 66

  AVX54813.1 SFILTVIYLIIALLIKNSESIRIM-----FYVVISIFFICIIL------SSIF---ETLSRL--KEQI--LLYKQQY-QSQQQLKLNKETDNKKQINKEV 179
      E7FDE0 QVGL------VSLLL---ERFRAMLILSALYLTLSICFHCWVMNLRWMESNRFVWTDGLQVLFVFQRIAAVLYYYFYKRTTEYL-----GD--PRLYED- 149

  AVX54813.1 TNNNNNQSKNPFIED------- 194
      E7FDE0 ---------SPWLRDAFARARQ 162

Go Annotations

1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.

Source GO Description
5. P GO:0044214 spanning component of plasma membrane
5. P GO:0043020 NADPH oxidase complex
5. P GO:0001938 positive regulation of endothelial cell proliferation
5. P GO:0010923 negative regulation of phosphatase activity
5. P GO:0001725 stress fiber
5. P GO:1904385 cellular response to angiotensin
5. P GO:0046530 photoreceptor cell differentiation
5. P GO:0009055 electron transfer activity
5. P GO:0015886 heme transport
5. P GO:0001666 response to hypoxia
5. P GO:0070821 tertiary granule membrane
5. P GO:0045087 innate immune response
5. P GO:0150007 clathrin-dependent synaptic vesicle endocytosis
5. P GO:0033864 positive regulation of NAD(P)H oxidase activity
5. P GO:0032760 positive regulation of tumor necrosis factor production
5. P GO:0035212 cell competition in a multicellular organism
5. P GO:1905702 regulation of inhibitory synapse assembly
5. P GO:0014895 smooth muscle hypertrophy
5. P GO:0005774 vacuolar membrane
5. P GO:0060271 cilium assembly
5. P GO:0071333 cellular response to glucose stimulus
5. P GO:0048488 synaptic vesicle endocytosis
5. P GO:1904845 cellular response to L-glutamine
5. P GO:0032930 positive regulation of superoxide anion generation
5. P GO:0005765 lysosomal membrane
5. P GO:0048499 synaptic vesicle membrane organization
5. P GO:0005262 calcium channel activity
5. P GO:0045777 positive regulation of blood pressure
5. P GO:0071310 cellular response to organic substance
5. P GO:0030137 COPI-coated vesicle
5. P GO:0005925 focal adhesion
5. P GO:0006801 superoxide metabolic process
5. P GO:0031594 neuromuscular junction
5. P GO:0042802 identical protein binding
5. P GO:0005794 Golgi apparatus
5. P GO:0070555 response to interleukin-1
5. P GO:0016192 vesicle-mediated transport
5. P GO:0042543 protein N-linked glycosylation via arginine
5. P GO:0032755 positive regulation of interleukin-6 production
5. P GO:0070257 positive regulation of mucus secretion
5. P GO:0005783 endoplasmic reticulum
5. P GO:0031667 response to nutrient levels
5. P GO:0009808 lignin metabolic process
5. P GO:0048038 quinone binding
5. P GO:0017124 SH3 domain binding
5. P GO:0043525 positive regulation of neuron apoptotic process
5. P GO:0072593 reactive oxygen species metabolic process
5. P GO:0017004 cytochrome complex assembly
5. P GO:0034137 positive regulation of toll-like receptor 2 signaling pathway
5. P GO:0050766 positive regulation of phagocytosis
5. P GO:1900426 positive regulation of defense response to bacterium
5. P GO:0050665 hydrogen peroxide biosynthetic process
5. P GO:0070916 inositol phosphoceramide synthase complex
5. P GO:0042554 superoxide anion generation
5. P GO:0048661 positive regulation of smooth muscle cell proliferation
5. P GO:0003106 negative regulation of glomerular filtration by angiotensin
5. P GO:2000009 negative regulation of protein localization to cell surface
5. P GO:0097112 gamma-aminobutyric acid receptor clustering
5. P GO:0005886 plasma membrane
5. P GO:0007605 sensory perception of sound
5. P GO:0016175 superoxide-generating NAD(P)H oxidase activity
5. P GO:0097038 perinuclear endoplasmic reticulum
5. P GO:0046982 protein heterodimerization activity
5. P GO:0050811 GABA receptor binding
5. P GO:0006624 vacuolar protein processing
5. P GO:0030307 positive regulation of cell growth
5. P GO:1904044 response to aldosterone
5. P GO:0002080 acrosomal membrane
5. P GO:0005768 endosome
5. P GO:0015232 heme transmembrane transporter activity
5. P GO:0071260 cellular response to mechanical stimulus
5. P GO:0070917 inositol phosphoceramide synthase regulator activity
5. P GO:0014823 response to activity
5. P GO:0051279 regulation of release of sequestered calcium ion into cytosol
5. P GO:0006673 inositol phosphoceramide metabolic process
5. P GO:0030672 synaptic vesicle membrane
5. P GO:0030285 integral component of synaptic vesicle membrane
5. P GO:0005929 cilium
5. P GO:0045055 regulated exocytosis
5. P GO:0030425 dendrite
5. P GO:0071356 cellular response to tumor necrosis factor
5. P GO:0090114 COPII-coated vesicle budding
5. P GO:0016021 integral component of membrane
5. P GO:0034067 protein localization to Golgi apparatus
5. P GO:0005773 vacuole
5. P GO:0008137 NADH dehydrogenase (ubiquinone) activity
5. P GO:0006865 amino acid transport
5. P GO:0005737 cytoplasm
5. P GO:0071480 cellular response to gamma radiation
5. P GO:1903428 positive regulation of reactive oxygen species biosynthetic process
5. P GO:0004945 angiotensin type II receptor activity
5. P GO:0042493
5. P GO:0099533 positive regulation of presynaptic cytosolic calcium concentration
5. P GO:0071407 cellular response to organic cyclic compound
5. P GO:0060077 inhibitory synapse
5. P GO:0030173 integral component of Golgi membrane
5. P GO:0006954 inflammatory response
5. P GO:0045730 respiratory burst
5. P GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway
5. P GO:0150008 bulk synaptic vesicle endocytosis
5. P GO:0030176 integral component of endoplasmic reticulum membrane
5. P GO:0020037 heme binding

Uniprot GO Annotations

GO Description
GO:0016020 membrane
GO:0016021 integral component of membrane

Homologs

1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.

Source Homolog Description Fatcat Pvalue PROST Evalue BLAST Evalue Foldseek TMScore
5. P Q54T60 Transmembrane protein 50 homolog 4.02e-06 7.98e-05 NA NA
5. P Q1CHQ1 NADH-quinone oxidoreductase subunit A 7.74e-05 9.01e-04 NA NA
5. P Q5R703 Synaptogyrin-1 9.67e-08 4.19e-02 NA NA
5. P P92536 Uncharacterized mitochondrial protein AtMg01020 1.42e-04 7.96e-04 NA NA
5. P Q9N2H0 Cytochrome b-245 light chain 2.73e-03 2.14e-03 NA NA
5. P Q9P7H7 Protein ilm1 3.20e-06 4.52e-06 NA NA
5. P D8ST13 CASP-like protein 2U7 1.36e-08 2.39e-03 NA NA
5. P B2K821 NADH-quinone oxidoreductase subunit A 6.82e-05 8.27e-04 NA NA
5. P O64228 Gene 34.1 protein NA 1.50e-03 NA NA
5. P P75083 Uncharacterized protein MG028 homolog 2.64e-07 5.40e-12 NA NA
5. P Q6L4D2 Membrane protein PM19L 8.68e-08 9.38e-05 NA NA
5. P O95214 Leptin receptor overlapping transcript-like 1 4.28e-07 4.71e-02 NA NA
5. P P55909 Uncharacterized protein YcgB 3.53e-09 1.85e-03 NA NA
5. P B4MXW6 Calcium channel flower 7.05e-04 1.10e-03 NA NA
5. P Q920C4 Membrane-spanning 4-domains subfamily A member 3 6.04e-07 5.51e-03 NA NA
5. P Q8IZ96 CKLF-like MARVEL transmembrane domain-containing protein 1 4.93e-06 2.78e-03 NA NA
5. P P13498 Cytochrome b-245 light chain 4.83e-03 1.01e-02 NA NA
5. P B4GRI8 Calcium channel flower 6.24e-04 2.24e-03 NA NA
5. P A4IIU3 Transmembrane protein 196 4.96e-09 7.42e-03 NA NA
5. P Q9Y826 Meiotic expression up-regulated protein 31 2.71e-06 8.04e-03 NA NA
5. P Q62737 Cytochrome b-245 light chain 3.24e-03 6.07e-05 NA NA
5. P Q55827 Uncharacterized protein sll0481 3.41e-06 2.10e-04 NA NA
5. P B3QY48 NADH-quinone oxidoreductase subunit A 2 1.36e-04 3.84e-02 NA NA
5. P Q8CHQ6 Transmembrane protein 125 1.95e-04 5.11e-05 NA NA
5. P Q9NPI0 Transmembrane protein 138 3.90e-07 5.66e-07 NA NA
5. P Q63ZL3 Heme transporter hrg1-A 1.27e-06 1.90e-02 NA NA
5. P P75439 Uncharacterized protein MG243 homolog 5.60e-04 5.71e-03 NA NA
5. P P34282 Uncharacterized protein C02F5.5 4.15e-05 6.68e-13 NA NA
5. P P0ADJ8 Inner membrane protein YiaA 2.87e-06 6.13e-08 NA NA
5. P P0ADJ9 Inner membrane protein YiaA 2.94e-06 6.13e-08 NA NA
5. P Q57769 Uncharacterized protein MJ0321 4.11e-06 7.03e-04 NA NA
5. P Q55E69 Protein SYS1 homolog 7.19e-06 2.55e-02 NA NA
5. P A9R6M0 NADH-quinone oxidoreductase subunit A 7.58e-05 9.01e-04 NA NA
5. P Q32PD8 Leptin receptor overlapping transcript-like 1 2.01e-07 2.50e-02 NA NA
5. P O31833 Uncharacterized membrane protein YoaS 2.24e-07 4.29e-02 NA NA
5. P O32202 Protein LiaI 1.57e-04 9.77e-05 NA NA
5. P Q295N5 Protein KRTCAP2 homolog 1.66e-05 1.68e-04 NA NA
5. P Q9D7S1 Transmembrane protein 54 5.54e-06 7.38e-04 NA NA
5. P Q750M8 Golgi apparatus membrane protein TVP18 2.75e-04 3.10e-02 NA NA
5. P O29727 Uncharacterized protein AF_0523 1.63e-08 7.22e-08 NA NA
5. P P54946 Uncharacterized protein YxeG 3.70e-06 1.12e-06 NA NA
5. P Q04767 Golgi apparatus membrane protein TVP18 2.12e-04 2.08e-05 NA NA
5. P Q2HJ59 Transmembrane protein 125 1.66e-05 5.17e-04 NA NA
5. P Q66KF2 Transmembrane protein 192 1.72e-09 6.25e-03 NA NA
5. P Q5J8X5 Membrane-spanning 4-domains subfamily A member 13 5.08e-06 1.83e-03 NA NA
5. P B9GHX8 CASP-like protein 2A2 3.36e-06 3.32e-05 NA NA
5. P B4LIH0 Calcium channel flower 7.30e-04 2.88e-03 NA NA
5. P Q9Z1L2 Synaptogyrin-4 2.25e-06 8.49e-03 NA NA
5. P P9WLT4 Uncharacterized protein MT1626 1.05e-04 1.68e-02 NA NA
5. P Q6GV27 Transmembrane protein 225 1.98e-06 7.69e-03 NA NA
5. P P75213 Uncharacterized protein MG384.1 homolog 7.86e-06 1.79e-03 NA NA
5. P Q9D6G5 Transmembrane protein 138 3.71e-07 1.17e-05 NA NA
5. P Q58404 Uncharacterized protein MJ0998 1.31e-05 1.72e-02 NA NA
5. P B1WBM3 Transmembrane protein 138 2.14e-06 5.83e-05 NA NA
5. P O46521 Cytochrome b-245 light chain 4.14e-03 8.41e-06 NA NA
5. P Q5RDE9 Leptin receptor overlapping transcript-like 1 4.53e-07 4.71e-02 NA NA
5. P Q0WDX2 NADH-quinone oxidoreductase subunit A 6.99e-05 9.01e-04 NA NA
5. P Q54UB0 Transmembrane protein 208 homolog 3.69e-06 4.25e-05 NA NA
5. P Q8K071 Transmembrane protein 221 7.22e-06 6.24e-06 NA NA
5. P Q5EB63 Transmembrane protein 196 1.20e-07 8.59e-04 NA NA
5. P Q50325 Uncharacterized protein MG406 homolog 2.99e-05 2.51e-05 NA NA
5. P Q49431 Uncharacterized protein MG406 1.30e-07 3.47e-04 NA NA
5. P C5Y7C7 CASP-like protein 1U3 1.54e-05 1.85e-03 NA NA
5. P Q669A0 NADH-quinone oxidoreductase subunit A 7.38e-05 9.01e-04 NA NA
5. P Q2R0D2 CASP-like protein 1U3 4.40e-06 4.01e-03 NA NA
5. P A7FGQ5 NADH-quinone oxidoreductase subunit A 7.04e-05 9.01e-04 NA NA
5. P B4PD01 Calcium channel flower 3.29e-04 3.53e-03 NA NA
5. P Q58514 Uncharacterized protein MJ1114 6.28e-10 7.66e-07 NA NA
5. P Q5EAL6 Transmembrane protein 192 2.60e-08 3.68e-02 NA NA
5. P P47485 Uncharacterized protein MG243 5.13e-04 2.91e-03 NA NA
5. P P47155 Protein ILM1 1.54e-04 3.46e-03 NA NA
5. P P47274 Uncharacterized protein MG028 8.25e-07 5.47e-16 NA NA
5. P P34363 Uncharacterized protein C48B4.9 3.65e-06 7.89e-04 NA NA
5. P O84009 Uncharacterized protein CT_006 3.46e-04 7.38e-04 NA NA
5. P Q5HYL7 Transmembrane protein 196 1.68e-08 5.26e-05 NA NA
5. P O14223 Golgi apparatus membrane protein tvp15 4.87e-04 1.16e-05 NA NA
5. P A5PJY4 Transmembrane protein 138 6.81e-10 3.12e-05 NA NA
5. P Q95T12 Calcium channel flower 3.85e-04 1.63e-02 NA NA
5. P Q7TSY2 LHFPL tetraspan subfamily member 4 protein 9.40e-07 3.30e-02 NA NA
5. P Q5U4E0 LHFPL tetraspan subfamily member 4 protein 4.98e-06 3.30e-02 NA NA
5. P O14193 SRP-independent targeting protein 2 homolog 2.15e-05 1.07e-03 NA NA
5. P Q92EU0 Putative glycerol transporter Lin0368 6.95e-05 6.31e-03 NA NA
5. P B4HIJ8 Calcium channel flower 7.69e-04 1.91e-02 NA NA
5. P Q1E1E0 Golgi apparatus membrane protein TVP18 6.27e-04 3.38e-02 NA NA
5. P B3NDM7 Calcium channel flower 4.88e-04 2.08e-03 NA NA
5. P O31923 SPbeta prophage-derived uncharacterized protein YoqO 3.12e-06 2.57e-02 NA NA
5. P Q61462 Cytochrome b-245 light chain 2.84e-03 3.68e-05 NA NA
5. P Q12346 Uncharacterized membrane protein YPR071W 4.67e-06 4.71e-02 NA NA
5. P A7TS55 Golgi apparatus membrane protein TVP18 3.68e-04 2.90e-05 NA NA
5. P Q54GE8 Putative uncharacterized transmembrane protein DDB_G0290203 7.12e-05 3.31e-06 NA NA
5. P Q95MN4 Cytochrome b-245 light chain 3.92e-03 1.95e-07 NA NA
5. P Q2GSS4 Golgi apparatus membrane protein TVP18 9.94e-04 1.74e-02 NA NA
5. P Q54U35 Uncharacterized transmembrane protein DDB_G0281339 1.55e-06 3.42e-06 NA NA
5. P Q5RCD5 Transmembrane protein 196 2.98e-08 1.89e-04 NA NA
5. P O13994 Inositol phosphorylceramide synthase regulatory subunit kei1 6.44e-06 1.14e-03 NA NA
5. P P0A5F4 Uncharacterized protein Mb1617 5.23e-05 1.68e-02 NA NA
5. P P9WLT5 Uncharacterized protein Rv1591 1.03e-04 1.68e-02 NA NA
5. P B4QLP9 Calcium channel flower 3.73e-04 2.42e-03 NA NA
5. P O95473 Synaptogyrin-4 6.73e-07 3.30e-02 NA NA
5. P Q8INQ7 Protein KRTCAP2 homolog 1.84e-05 1.63e-04 NA NA
5. P Q5FWC3 Membrane-spanning 4-domains subfamily A member 13 2.92e-08 1.11e-02 NA NA
5. P Q9Y876 Secretory component protein psh3 1.27e-08 8.74e-10 NA NA
5. P P34395 Uncharacterized protein F10E9.1 4.11e-06 9.67e-05 NA NA
5. P Q02774 Secretory component protein SHR3 6.17e-10 1.80e-02 NA NA
5. P Q54L98 Protein KRTCAP2 homolog 6.84e-06 1.74e-05 NA NA
5. P Q197D8 Transmembrane protein 022L NA 8.49e-03 NA NA
5. P B3M9W1 Calcium channel flower 7.45e-04 3.22e-05 NA NA
5. P Q96AQ2 Transmembrane protein 125 2.68e-04 6.66e-03 NA NA
5. P A6ZMD0 Golgi apparatus membrane protein TVP18 1.58e-04 2.08e-05 NA NA
5. P Q7YTM7 Heme transporter hrg-6 7.15e-06 3.83e-03 NA NA
5. P Q74ZU2 Golgi apparatus membrane protein TVP15 2.58e-05 2.14e-02 NA NA
5. P Q494T4 Transmembrane protein 54 2.83e-06 7.22e-03 NA NA
5. P P33250 ATP synthase protein I 3.00e-07 2.50e-15 NA NA
5. P Q9ZB71 Uncharacterized protein MG384.1 1.86e-06 3.69e-03 NA NA
5. P Q32KQ5 Transmembrane protein 225 6.91e-06 3.31e-04 NA NA
5. P B1JGL3 NADH-quinone oxidoreductase subunit A 6.89e-05 9.01e-04 NA NA
5. P Q1C6A9 NADH-quinone oxidoreductase subunit A 7.59e-05 9.01e-04 NA NA
5. P E7FDE0 Transmembrane protein 138 3.55e-10 3.62e-02 NA NA
5. P B4L0H1 Calcium channel flower 3.03e-04 2.40e-02 NA NA
5. P Q03860 Golgi apparatus membrane protein TVP15 7.55e-04 1.37e-03 NA NA
5. P Q642A2 Type-1 angiotensin II receptor-associated protein 1.11e-03 2.20e-02 NA NA
5. P P11022 Membrane protein P8A7 6.27e-04 4.12e-03 NA NA
5. P Q6GV28 Transmembrane protein 225 3.77e-05 4.26e-02 NA NA
5. P O65708 Protein MODIFYING WALL LIGNIN-2 8.36e-09 1.35e-07 NA NA
5. P A5DSM9 Golgi apparatus membrane protein TVP18 8.68e-04 3.56e-02 NA NA
5. P A4TM36 NADH-quinone oxidoreductase subunit A 6.96e-05 9.01e-04 NA NA
5. P Q5ZHU0 Heme transporter HRG1 8.45e-07 9.91e-04 NA NA
5. P P34360 Uncharacterized protein C48B4.6 1.14e-06 1.05e-06 NA NA
5. P Q99382 SRP-independent targeting protein 2 7.72e-05 1.17e-04 NA NA
5. P Q54CL4 Protein transport protein got1 homolog 3.56e-04 1.45e-03 NA NA
5. P Q95L73 Cytochrome b-245 light chain 2.56e-03 2.58e-06 NA NA