Summary
The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.
AVX54822.1
JCVISYN3A_0500
Maturation protease for ribosomal protein L27.
M. mycoides homolog: Q6MT49.
TIGRfam Classification: 1=Unknown.
Category: Essential.
Statistics
Total GO Annotation: 6
Unique PROST Go: 5
Unique BLAST Go: 0
Unique Foldseek Go: 1
Total Homologs: 39
Unique PROST Homologs: 36
Unique BLAST Homologs: 0
Unique Foldseek Homologs: 0
Literature
Danchin and Fang [1]: L27 N-terminal protease|conserved histidine and cysteine residues
Yang and Tsui [2]: Phage-related ribosomal protease Prp
Antczak et al. [3]: Cysteine protease Prp superfamily
Zhang et al. [4]: GO:0034641|cellular nitrogen compound metabolic process
Bianchi et al. [5]: Prp-like ribosomal protein cysteine processing
Structures and Sequence Alignment
The best structural homolog that predicted by 5. P was
P80242
(Organic hydroperoxide resistance protein OhrB) with a FATCAT P-Value: 0.00628 and RMSD of 1.97 angstrom. The sequence alignment identity is 20.6%.
Structural alignment shown in left. Query protein AVX54822.1 colored as red in alignment, homolog P80242 colored as blue.
Query protein AVX54822.1 is also shown in right top, homolog P80242 showed in right bottom. They are colored based on secondary structures.
AVX54822.1 -----------------------MVDIIINYKNNKIIQFQMK-GHANSDEYGKDLVCAGLTAIVSGAL-------N-AIDSYYKNDVD--IEVLKN---- 62 P80242 MALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAK------KEGQTGTNP--EQLFAAGYAACFGGALEHVAKEQNIEIDS----EIEGQVSLMKDESDG 88 AVX54822.1 --KI--TIIVKQENNNNLQLMLDMLKIQ--IQTI--TIQYPK----NARIK-EVS 104 P80242 GFKIGVTLVV---NTKD----LDREKAQELVNAAHEFCPYSKATRGNVDVKLELK 136
Go Annotations
1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.
| Source | GO | Description |
|---|---|---|
| 5. P | GO:0033194 | response to hydroperoxide |
| 5. P | GO:0006979 | response to oxidative stress |
| 5. P | GO:0006972 | hyperosmotic response |
| 5. P | GO:0051920 | peroxiredoxin activity |
| 5. P | GO:0004601 | peroxidase activity |
| 6. F | GO:0016021 | integral component of membrane |
Uniprot GO Annotations
| GO | Description |
|---|
Homologs
1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.
| Source | Homolog | Description | Fatcat Pvalue | PROST Evalue | BLAST Evalue | Foldseek TMScore |
|---|---|---|---|---|---|---|
| 1. PBF | P47475 | Uncharacterized protein MG233 | 3.23e-12 | 4.04e-36 | 6.35e-06 | 0.8443 |
| 1. PBF | P26942 | Uncharacterized protein YsxB | 4.22e-15 | 3.31e-40 | 2.44e-11 | 0.8999 |
| 2. PF | P75459 | Uncharacterized protein MG233 homolog | 4.00e-11 | 1.85e-33 | NA | 0.8238 |
| 5. P | P0ADX1 | Protein YhfA | 6.49e-03 | 7.37e-09 | NA | NA |
| 5. P | Q4L4R0 | Organic hydroperoxide resistance protein-like | 9.42e-03 | 1.12e-10 | NA | NA |
| 5. P | O31790 | Uncharacterized protein YmaD | 1.01e-02 | 2.80e-08 | NA | NA |
| 5. P | Q8CMV4 | Organic hydroperoxide resistance protein-like 2 | 9.21e-03 | 6.25e-07 | NA | NA |
| 5. P | P0ADX2 | Protein YhfA | 6.57e-03 | 7.37e-09 | NA | NA |
| 5. P | P0A0V5 | Organic hydroperoxide resistance protein | 1.10e-02 | 1.57e-05 | NA | NA |
| 5. P | P75123 | Organic hydroperoxide resistance protein-like | 1.36e-02 | 8.97e-08 | NA | NA |
| 5. P | D4GXC5 | Uncharacterized protein HVO_1289 | 8.64e-03 | 3.70e-08 | NA | NA |
| 5. P | P9WL19 | Uncharacterized protein Rv2923c | 5.67e-03 | 4.34e-07 | NA | NA |
| 5. P | P47666 | Hydroperoxide reductase | 1.50e-02 | 1.08e-10 | NA | NA |
| 5. P | Q99VH8 | Organic hydroperoxide resistance protein-like | 9.39e-03 | 6.32e-10 | NA | NA |
| 5. P | P70736 | Uncharacterized protein ACIAD3023 | 1.14e-02 | 1.83e-04 | NA | NA |
| 5. P | Q6GII8 | Organic hydroperoxide resistance protein-like | 1.23e-02 | 3.48e-10 | NA | NA |
| 5. P | P80242 | Organic hydroperoxide resistance protein OhrB | 6.28e-03 | 5.09e-09 | NA | NA |
| 5. P | P9WL18 | Uncharacterized protein MT2992 | 5.76e-03 | 4.34e-07 | NA | NA |
| 5. P | Q2FIJ2 | Organic hydroperoxide resistance protein-like | 1.24e-02 | 6.32e-10 | NA | NA |
| 5. P | P0ADX3 | Protein YhfA | 7.70e-03 | 7.37e-09 | NA | NA |
| 5. P | P47692 | Organic hydroperoxide resistance protein-like | 2.44e-02 | 4.15e-08 | NA | NA |
| 5. P | Q2G1T3 | Organic hydroperoxide resistance protein-like | 1.37e-02 | 6.32e-10 | NA | NA |
| 5. P | Q5HKS7 | Organic hydroperoxide resistance protein-like 2 | 9.50e-03 | 1.34e-07 | NA | NA |
| 5. P | P75170 | Hydroperoxide reductase | 1.11e-02 | 6.83e-07 | NA | NA |
| 5. P | P0C0L3 | Peroxiredoxin OsmC | 7.15e-03 | 8.98e-07 | NA | NA |
| 5. P | Q49WG0 | Organic hydroperoxide resistance protein-like 2 | 1.26e-02 | 1.55e-07 | NA | NA |
| 5. P | P0A0V4 | Organic hydroperoxide resistance protein | 1.11e-02 | 1.57e-05 | NA | NA |
| 5. P | Q7A6M9 | Organic hydroperoxide resistance protein-like | 1.20e-02 | 6.32e-10 | NA | NA |
| 5. P | Q5HHL3 | Organic hydroperoxide resistance protein-like | 1.22e-02 | 6.32e-10 | NA | NA |
| 5. P | O34762 | Organic hydroperoxide resistance protein OhrA | 8.47e-03 | 3.54e-06 | NA | NA |
| 5. P | Q8NXI1 | Organic hydroperoxide resistance protein-like | 1.22e-02 | 1.01e-09 | NA | NA |
| 5. P | P0C0L2 | Peroxiredoxin OsmC | 7.15e-03 | 8.98e-07 | NA | NA |
| 5. P | Q6GB28 | Organic hydroperoxide resistance protein-like | 1.23e-02 | 1.01e-09 | NA | NA |
| 5. P | Q49W40 | Organic hydroperoxide resistance protein-like 1 | 1.66e-02 | 6.70e-09 | NA | NA |
| 5. P | Q8CTB6 | Organic hydroperoxide resistance protein-like 1 | 1.36e-02 | 5.81e-09 | NA | NA |
| 5. P | P0ADX4 | Protein YhfA | 6.53e-03 | 7.37e-09 | NA | NA |
| 5. P | Q2YWK0 | Organic hydroperoxide resistance protein-like | 1.23e-02 | 2.39e-10 | NA | NA |
| 5. P | Q5HQR8 | Organic hydroperoxide resistance protein-like 1 | 1.09e-02 | 5.81e-09 | NA | NA |
| 5. P | P65056 | Uncharacterized protein Mb2948c | 6.17e-03 | 4.34e-07 | NA | NA |