Summary

The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.

AVX54828.1
JCVISYN3A_0511

Uncharacterized protein.
M. mycoides homolog: Q6MT37.
TIGRfam Classification: 1=Unknown.
Category: Essential.

Statistics

Total GO Annotation: 43
Unique PROST Go: 43
Unique BLAST Go: 0
Unique Foldseek Go: 0

Total Homologs: 46
Unique PROST Homologs: 46
Unique BLAST Homologs: 0
Unique Foldseek Homologs: 0

Literature

Danchin and Fang [1]: double strand break repair|similar to DNA double strand break repair protein of M. jannaschii, likely phage origin, controls the balance between DNA end bridging and DNA resection
Yang and Tsui [2]: 3-isopropylmalate dehydratase small subunit
Antczak et al. [3]: Hypothetical protein
Zhang et al. [4]: GO:0046474|glycerophospholipid biosynthetic process
Bianchi et al. [5]: "Unclear, possibly pfpI-like"

Structures and Sequence Alignment

The best structural homolog that predicted by 5. P was O06636 (Putative flagella-related protein C) with a FATCAT P-Value: 8.69e-05 and RMSD of 3.51 angstrom. The sequence alignment identity is 21.7%.
Structural alignment shown in left. Query protein AVX54828.1 colored as red in alignment, homolog O06636 colored as blue. Query protein AVX54828.1 is also shown in right top, homolog O06636 showed in right bottom. They are colored based on secondary structures. 

  AVX54828.1 MKLNDKLKNFFNNIKSYFTTKEKII--IKNKPKAIETKTENNNNNLDNNSQSYHDISNNKEY---IDKRATLDSQNEFILKVISNKAELLEQL--VDIK- 92
      O06636 ----------MPNIS-------EIIDDIKQKIK-LGKK--NDTTPLEDDSE---D-----EFSFVLDEETTAESDND--L-VAAN-EELLAKMGELESKF 68

  AVX54828.1 --------NTFKHCEDCL--DIY--KKNLDDMKLKILRLKKHIDNNYG-FLGDEKEYQNYV-FIDDVQTYSQTDESAGLKLVHKLEDHFNKYSNYDIDYF 178
      O06636 PKIEMMVTNLRKENEN-LRSDIHNINENFQDM-MALYEV---VSNQINPFIGISKVTATSMEKVEKIE-----HESTNLK--KRVEE----LQN---DVV 149

  AVX54828.1 IPCNKHKDLIDKHKILSIKIKDLDKIISN-------------------- 207
      O06636 ILANVY---LQEHDI------DLDGVI-NEILAEEEFSKAILGEDSDDW 188

Go Annotations

1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.

Source GO Description
5. P GO:0042632 cholesterol homeostasis
5. P GO:0039502 suppression by virus of host type I interferon-mediated signaling pathway
5. P GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
5. P GO:0051225 spindle assembly
5. P GO:0010874 regulation of cholesterol efflux
5. P GO:0043410 positive regulation of MAPK cascade
5. P GO:0001919 regulation of receptor recycling
5. P GO:0007040 lysosome organization
5. P GO:0007098 centrosome cycle
5. P GO:0005880 nuclear microtubule
5. P GO:0097589 archaeal-type flagellum
5. P GO:0034080 CENP-A containing chromatin assembly
5. P GO:0071986 Ragulator complex
5. P GO:0034613 cellular protein localization
5. P GO:0032509 endosome transport via multivesicular body sorting pathway
5. P GO:1904669 ATP export
5. P GO:1990498 mitotic spindle microtubule
5. P GO:0039563 suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity
5. P GO:0060620 regulation of cholesterol import
5. P GO:0005765 lysosomal membrane
5. P GO:0000922 spindle pole
5. P GO:0051020 GTPase binding
5. P GO:0007032 endosome organization
5. P GO:0032008 positive regulation of TOR signaling
5. P GO:0032418 lysosome localization
5. P GO:0060090 molecular adaptor activity
5. P GO:0008017 microtubule binding
5. P GO:0045121 membrane raft
5. P GO:0031902 late endosome membrane
5. P GO:0039686 bidirectional double-stranded viral DNA replication
5. P GO:0016197 endosomal transport
5. P GO:0050790 regulation of catalytic activity
5. P GO:0005813 centrosome
5. P GO:0000813 ESCRT I complex
5. P GO:0070652 HAUS complex
5. P GO:0039564 suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity
5. P GO:0033645 host cell endomembrane system
5. P GO:0006623 protein targeting to vacuole
5. P GO:0071230 cellular response to amino acid stimulus
5. P GO:0006612 protein targeting to membrane
5. P GO:0005764 lysosome
5. P GO:0001558 regulation of cell growth
5. P GO:0010872 regulation of cholesterol esterification

Uniprot GO Annotations

GO Description

Homologs

1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.

Source Homolog Description Fatcat Pvalue PROST Evalue BLAST Evalue Foldseek TMScore
5. P Q9CQ22 Ragulator complex protein LAMTOR1 1.12e-02 1.45e-02 NA NA
5. P B7UFV2 UPF0304 protein YfbU 1.56e-02 9.57e-03 NA NA
5. P Q8Y9T5 Listeria nuclear targeted protein A 4.03e-04 4.74e-04 NA NA
5. P Q7SYW7 Ragulator complex protein LAMTOR1 2.65e-02 4.99e-02 NA NA
5. P O06636 Putative flagella-related protein C 8.69e-05 2.45e-07 NA NA
5. P Q99L00 HAUS augmin-like complex subunit 8 3.11e-02 6.08e-03 NA NA
5. P P06164 Protein C NA 1.18e-06 NA NA
5. P B1X905 UPF0304 protein YfbU 1.68e-02 3.84e-03 NA NA
5. P Q83QS1 UPF0304 protein YfbU 1.57e-02 3.69e-02 NA NA
5. P P32534 Protein C NA 4.27e-04 NA NA
5. P B7M5X3 UPF0304 protein YfbU 1.64e-02 3.84e-03 NA NA
5. P B1LLP8 UPF0304 protein YfbU 1.80e-02 3.84e-03 NA NA
5. P B5FG97 UPF0304 protein VFMJ11_1926 2.22e-02 5.01e-03 NA NA
5. P Q4PDA7 Mediator of RNA polymerase II transcription subunit 10 3.24e-03 2.76e-09 NA NA
5. P P06165 Protein C NA 1.74e-05 NA NA
5. P Q96EN9 Required for excision 1-B domain-containing protein 1.72e-04 2.60e-02 NA NA
5. P Q8XCV1 UPF0304 protein YfbU 1.73e-02 3.84e-03 NA NA
5. P B1IXP8 UPF0304 protein YfbU 2.33e-02 3.84e-03 NA NA
5. P Q0TFF2 UPF0304 protein YfbU 1.65e-02 3.84e-03 NA NA
5. P B7LBE8 UPF0304 protein YfbU 1.63e-02 3.84e-03 NA NA
5. P P32533 Protein C NA 4.59e-04 NA NA
5. P B7N5Q6 UPF0304 protein YfbU 1.72e-02 3.84e-03 NA NA
5. P O29833 Uncharacterized protein AF_0414 7.56e-02 1.51e-02 NA NA
5. P Q1T763 Centromere protein R 6.27e-03 2.16e-02 NA NA
5. P B7NNX3 UPF0304 protein YfbU 1.65e-02 3.84e-03 NA NA
5. P Q0T2J3 UPF0304 protein YfbU 1.57e-02 1.15e-02 NA NA
5. P B6I7L6 UPF0304 protein YfbU 1.69e-02 3.84e-03 NA NA
5. P P32535 Protein C NA 1.96e-03 NA NA
5. P P0A8W8 UPF0304 protein YfbU 1.46e-02 3.84e-03 NA NA
5. P Q6P2W7 Ragulator complex protein LAMTOR1 8.32e-03 2.55e-02 NA NA
5. P B7MXH3 UPF0304 protein YfbU 1.62e-02 3.84e-03 NA NA
5. P B7MG58 UPF0304 protein YfbU 1.66e-02 3.84e-03 NA NA
5. P P0A8W9 UPF0304 protein YfbU 1.64e-02 3.84e-03 NA NA
5. P Q5UNZ7 Uncharacterized protein R741 NA 4.90e-02 NA NA
5. P C4ZVI7 UPF0304 protein YfbU 1.72e-02 3.84e-03 NA NA
5. P P28055 Protein C NA 5.36e-04 NA NA
5. P Q57M20 UPF0304 protein YfbU 1.75e-02 4.20e-02 NA NA
5. P P13342 DNA helicase assembly protein NA 4.20e-02 NA NA
5. P Q9WS38 Protein C NA 9.35e-04 NA NA
5. P Q96BQ5 Coiled-coil domain-containing protein 127 3.71e-04 9.12e-03 NA NA
5. P B2TW75 UPF0304 protein YfbU 1.62e-02 3.84e-03 NA NA
5. P Q17Q97 Required for excision 1-B domain-containing protein 2.01e-04 2.16e-03 NA NA
5. P Q99176 Protein SRN2 7.32e-04 4.63e-03 NA NA
5. P Q5BK57 HAUS augmin-like complex subunit 8 1.17e-02 5.91e-03 NA NA
5. P Q9E785 Matrix protein NA 3.40e-02 NA NA
5. P B5YXT4 UPF0304 protein YfbU 1.42e-02 3.84e-03 NA NA