Summary

The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.

AVX54832.1
JCVISYN3A_0516

Uncharacterized protein.
M. mycoides homolog: Q6MT31.
TIGRfam Classification: 1=Unknown.
Category: Quasiessential.

Statistics

Total GO Annotation: 31
Unique PROST Go: 30
Unique BLAST Go: 0
Unique Foldseek Go: 0

Total Homologs: 70
Unique PROST Homologs: 69
Unique BLAST Homologs: 0
Unique Foldseek Homologs: 0

Literature

Danchin and Fang [1]: membrane endopeptidase|rhomboid endopeptidase
Yang and Tsui [2]: Cell division protein FtsZ
Antczak et al. [3]: Transmembrane protein, likely cation transporter or protease
Zhang et al. [4]: GO:0019239|deaminase activity
Bianchi et al. [5]: gplG-yqgP Membrane Protease

Structures and Sequence Alignment

The best structural homolog that predicted by 2. PF was P54493 (Rhomboid protease GluP) with a FATCAT P-Value: 1.53e-08 and RMSD of 3.11 angstrom. The sequence alignment identity is 21.4%.
Structural alignment shown in left. Query protein AVX54832.1 colored as red in alignment, homolog P54493 colored as blue. Query protein AVX54832.1 is also shown in right top, homolog P54493 showed in right bottom. They are colored based on secondary structures.

  AVX54832.1 MTNSSTSDKKTLENFFIKNFKY-KLLKSKVNSSVSYLYS--SNE-------K--HQVIILNFDNNISFEKE--KEYI------IKKVEKQI----KKPVN 76
      P54493 --------------MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLVRL-YKHDLDFRQEMVRD-IEEQAERVERVRHQLGRRRMKLLN 84

  AVX54832.1 VFHIV---IDND-NQLTTKS---NLIVLHSSI--QT-LATDLE---PYFKNTNLLVFNH-TIDNE-----------LK-DDKQPSEEANNKLFTSFLENV 150
      P54493 VFFSTEAPVD-DWEEIAKKTFEKGTVSVEPAIVRGTMLRDDLQAVFPSFR-TEDCSEEHASFENAQMARERFLSLVLKQEEQRKTEAA---VF------- 172

  AVX54832.1 KNNKITFSWAVLLILILIPSMLQIVGYFILETNPNSKNV-LILAFGGT-NWNLTIVGKQWWRIFTYGIAPIKQN-G---LIVDILSLLILGTSFFSISKI 244
      P54493 QNGKPTFTY--LFI------ALQILMFFLLEINGGSTNTETLVAFGAKEN-SLIAQG-EWWRLLT----PIVLHIGIAHLAFNTLALWSVGTA------- 251

  AVX54832.1 TEIQLANTKKLILATILSYLILGLFSS--SVL--PTIY--TG--GLISTMGIFIGVLLIDVSGSTTPMAKFSQAKT----VVYILIL-IGFSFFLG--D- 328
      P54493 VE-RMYGSGRFLL--I--YLAAGITGSIASFVFSP--YPSAGASGAI--FG-CLGALLY-VALSNRKM--F--LRTIGTNIIVIIIINLGFGFAVSNIDN 336

  AVX54832.1 -GWTGLLITG--TAVILG----SAFWGILKVNIKEWAWIQYVHIFLILAILAISLTFIF--LPHLTPALDQHILITLST-YYKKGWFSINSLNKIVNNIG 418
      P54493 SGHIGGLIGGFFAAAALGLPKAGAF-G--K---------RLLSAVLLIA-LAVG--FLYYGL-H-SPSHQESALIQQASELYQEGKY--EEVTELLN--G 415

  AVX54832.1 ----WDGQFNQFGKF--ITNF------------------------------------------------------------------------ 433
      P54493 EAAQKDASADLL-KILAVSDIQIGEYDQAVSLLERAVKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES 507

Go Annotations

1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.

Source GO Description
2. PF GO:0004252 serine-type endopeptidase activity
5. P GO:0031969 chloroplast membrane
5. P GO:0035311 wing cell fate specification
5. P GO:0060352 cell adhesion molecule production
5. P GO:0043703 photoreceptor cell fate determination
5. P GO:0006465 signal peptide processing
5. P GO:0016021 integral component of membrane
5. P GO:0005886 plasma membrane
5. P GO:0061331 epithelial cell proliferation involved in Malpighian tubule morphogenesis
5. P GO:0042749 regulation of circadian sleep/wake cycle
5. P GO:0048149 behavioral response to ethanol
5. P GO:0006654 phosphatidic acid biosynthetic process
5. P GO:0007479 leg disc proximal/distal pattern formation
5. P GO:0007474 imaginal disc-derived wing vein specification
5. P GO:0007436 larval salivary gland morphogenesis
5. P GO:0035202 tracheal pit formation in open tracheal system
5. P GO:0019374 galactolipid metabolic process
5. P GO:0001752 compound eye photoreceptor fate commitment
5. P GO:0007391 dorsal closure
5. P GO:0035225 determination of genital disc primordium
5. P GO:0001742 oenocyte differentiation
5. P GO:0042327 positive regulation of phosphorylation
5. P GO:0007438 oenocyte development
5. P GO:0040026 positive regulation of vulval development
5. P GO:0048865 stem cell fate commitment
5. P GO:0090317 negative regulation of intracellular protein transport
5. P GO:0008586 imaginal disc-derived wing vein morphogenesis
5. P GO:0007476 imaginal disc-derived wing morphogenesis
5. P GO:0042058 regulation of epidermal growth factor receptor signaling pathway
5. P GO:0035160 maintenance of epithelial integrity, open tracheal system
5. P GO:0038004 epidermal growth factor receptor ligand maturation

Uniprot GO Annotations

GO Description
GO:0016020 membrane
GO:0016021 integral component of membrane

Homologs

1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.

Source Homolog Description Fatcat Pvalue PROST Evalue BLAST Evalue Foldseek TMScore
2. PF P54493 Rhomboid protease GluP 1.53e-08 6.31e-10 NA 0.4241
5. P B4TKV0 Rhomboid protease GlpG 1.59e-04 6.97e-08 NA NA
5. P Q57IV1 Rhomboid protease GlpG 2.89e-04 6.54e-08 NA NA
5. P Q32AN6 Rhomboid protease GlpG 1.67e-04 9.14e-08 NA NA
5. P Q695T8 Rhomboid-like protease 4 5.37e-04 1.33e-03 NA NA
5. P Q1R5L1 Rhomboid protease GlpG 1.58e-04 9.25e-08 NA NA
5. P B7NE28 Rhomboid protease GlpG 1.87e-04 9.25e-08 NA NA
5. P Q3YWA4 Rhomboid protease GlpG 1.57e-04 9.14e-08 NA NA
5. P A8A5N2 Rhomboid protease GlpG 1.58e-04 9.25e-08 NA NA
5. P B4TY77 Rhomboid protease GlpG 3.60e-04 1.11e-07 NA NA
5. P Q7CFX8 Rhomboid protease GlpG 1.63e-04 2.21e-09 NA NA
5. P B7LSC6 Rhomboid protease GlpG 1.79e-04 6.13e-08 NA NA
5. P Q8Z229 Rhomboid protease GlpG 1.59e-04 6.97e-08 NA NA
5. P B5BHH5 Rhomboid protease GlpG 1.59e-04 7.83e-08 NA NA
5. P Q1CCK6 Rhomboid protease GlpG 1.74e-04 2.21e-09 NA NA
5. P A8AQX4 Rhomboid protease GlpG 3.08e-04 1.53e-08 NA NA
5. P Q0SZP2 Rhomboid protease GlpG 1.55e-04 7.44e-08 NA NA
5. P B5FKE3 Rhomboid protease GlpG 1.28e-04 6.97e-08 NA NA
5. P B7M2I4 Rhomboid protease GlpG 2.95e-04 1.09e-07 NA NA
5. P A1AGU7 Rhomboid protease GlpG 1.61e-04 9.25e-08 NA NA
5. P A4WFK8 Rhomboid protease GlpG 1.02e-04 1.14e-07 NA NA
5. P Q0TC44 Rhomboid protease GlpG 1.56e-04 9.25e-08 NA NA
5. P B1IP42 Rhomboid protease GlpG 1.56e-04 9.25e-08 NA NA
5. P B7N156 Rhomboid protease GlpG 3.73e-04 8.14e-08 NA NA
5. P Q31VK9 Rhomboid protease GlpG 1.59e-04 9.25e-08 NA NA
5. P Q9FFX0 RHOMBOID-like protein 9, chloroplastic 1.77e-05 9.71e-05 NA NA
5. P B7NMI8 Rhomboid protease GlpG 1.58e-04 8.35e-08 NA NA
5. P P58873 Rhomboid-related protein 3 9.71e-05 9.29e-03 NA NA
5. P A1JSF0 Rhomboid protease GlpG 7.13e-04 1.03e-09 NA NA
5. P P20350 Protein rhomboid 5.98e-06 1.47e-03 NA NA
5. P A4TGR2 Rhomboid protease GlpG 8.73e-04 2.21e-09 NA NA
5. P B1JHY8 Rhomboid protease GlpG 1.84e-04 2.21e-09 NA NA
5. P Q8VC82 Rhomboid-related protein 1 1.73e-05 7.37e-09 NA NA
5. P B7MDQ0 Rhomboid protease GlpG 1.63e-04 9.25e-08 NA NA
5. P P09391 Rhomboid protease GlpG 1.50e-04 9.25e-08 NA NA
5. P A7ZSV4 Rhomboid protease GlpG 1.51e-04 1.09e-07 NA NA
5. P A8GKU2 Rhomboid protease GlpG 1.21e-04 2.09e-07 NA NA
5. P F4ICF4 RHOMBOID-like protein 10, chloroplastic 2.36e-04 1.86e-02 NA NA
5. P Q8FCS5 Rhomboid protease GlpG 1.60e-04 9.25e-08 NA NA
5. P B2K5W4 Rhomboid protease GlpG 8.76e-04 2.21e-09 NA NA
5. P Q1C2L2 Rhomboid protease GlpG 1.75e-04 2.21e-09 NA NA
5. P A9MMA7 Rhomboid protease GlpG 1.69e-04 1.73e-07 NA NA
5. P A7MGE5 Rhomboid protease GlpG homolog 2.39e-04 1.23e-09 NA NA
5. P B1X769 Rhomboid protease GlpG 1.87e-04 9.25e-08 NA NA
5. P Q664J1 Rhomboid protease GlpG 1.64e-04 1.85e-09 NA NA
5. P A7FNW6 Rhomboid protease GlpG 1.78e-04 2.21e-09 NA NA
5. P Q2NQH3 Rhomboid protease GlpG 2.57e-04 2.17e-10 NA NA
5. P B5R383 Rhomboid protease GlpG 1.52e-04 6.97e-08 NA NA
5. P Q83PV6 Rhomboid protease GlpG 1.62e-04 8.03e-08 NA NA
5. P B5XTR5 Rhomboid protease GlpG 2.12e-04 8.57e-08 NA NA
5. P B1LI84 Rhomboid protease GlpG 2.06e-04 9.25e-08 NA NA
5. P A6TF43 Rhomboid protease GlpG 1.79e-04 7.93e-08 NA NA
5. P Q8X6Z6 Rhomboid protease GlpG 1.55e-04 9.14e-08 NA NA
5. P Q5PLZ8 Rhomboid protease GlpG 3.07e-04 7.83e-08 NA NA
5. P C4ZVX5 Rhomboid protease GlpG 1.70e-04 9.25e-08 NA NA
5. P B5YTX6 Rhomboid protease GlpG 1.67e-04 9.14e-08 NA NA
5. P B6I2Y7 Rhomboid protease GlpG 1.62e-04 1.09e-07 NA NA
5. P Q58EK4 Presenilins-associated rhomboid-like protein, mitochondrial 2.60e-03 6.70e-03 NA NA
5. P B2U3N2 Rhomboid protease GlpG 1.61e-04 2.09e-07 NA NA
5. P Q19821 Rhomboid-related protein 1 3.34e-05 4.61e-12 NA NA
5. P B4SVM1 Rhomboid protease GlpG 1.68e-04 6.97e-08 NA NA
5. P Q84WG3 Rhomboid-like protein 16, chloroplastic 4.35e-04 4.89e-02 NA NA
5. P B5R7J1 Rhomboid protease GlpG 1.59e-04 6.97e-08 NA NA
5. P Q8ZLH5 Rhomboid protease GlpG 1.59e-04 6.97e-08 NA NA
5. P B7UKC8 Rhomboid protease GlpG 1.63e-04 9.25e-08 NA NA
5. P P58872 Rhomboid-related protein 3 6.90e-05 1.05e-02 NA NA
5. P B7L4V0 Rhomboid protease GlpG 1.53e-04 1.09e-07 NA NA
5. P B5F8P0 Rhomboid protease GlpG 1.69e-04 1.11e-07 NA NA
5. P Q6CZL3 Rhomboid protease GlpG 2.88e-04 5.72e-10 NA NA
5. P Q7N9W4 Rhomboid protease GlpG 8.47e-04 3.20e-09 NA NA