Summary
The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.
AVX54832.1
JCVISYN3A_0516
Uncharacterized protein.
M. mycoides homolog: Q6MT31.
TIGRfam Classification: 1=Unknown.
Category: Quasiessential.
Statistics
Total GO Annotation: 31
Unique PROST Go: 30
Unique BLAST Go: 0
Unique Foldseek Go: 0
Total Homologs: 70
Unique PROST Homologs: 69
Unique BLAST Homologs: 0
Unique Foldseek Homologs: 0
Literature
Danchin and Fang [1]: membrane endopeptidase|rhomboid endopeptidase
Yang and Tsui [2]: Cell division protein FtsZ
Antczak et al. [3]: Transmembrane protein, likely cation transporter or protease
Zhang et al. [4]: GO:0019239|deaminase activity
Bianchi et al. [5]: gplG-yqgP Membrane Protease
Structures and Sequence Alignment
The best structural homolog that predicted by 2. PF was
P54493
(Rhomboid protease GluP) with a FATCAT P-Value: 1.53e-08 and RMSD of 3.11 angstrom. The sequence alignment identity is 21.4%.
Structural alignment shown in left. Query protein AVX54832.1 colored as red in alignment, homolog P54493 colored as blue.
Query protein AVX54832.1 is also shown in right top, homolog P54493 showed in right bottom. They are colored based on secondary structures.
AVX54832.1 MTNSSTSDKKTLENFFIKNFKY-KLLKSKVNSSVSYLYS--SNE-------K--HQVIILNFDNNISFEKE--KEYI------IKKVEKQI----KKPVN 76 P54493 --------------MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLVRL-YKHDLDFRQEMVRD-IEEQAERVERVRHQLGRRRMKLLN 84 AVX54832.1 VFHIV---IDND-NQLTTKS---NLIVLHSSI--QT-LATDLE---PYFKNTNLLVFNH-TIDNE-----------LK-DDKQPSEEANNKLFTSFLENV 150 P54493 VFFSTEAPVD-DWEEIAKKTFEKGTVSVEPAIVRGTMLRDDLQAVFPSFR-TEDCSEEHASFENAQMARERFLSLVLKQEEQRKTEAA---VF------- 172 AVX54832.1 KNNKITFSWAVLLILILIPSMLQIVGYFILETNPNSKNV-LILAFGGT-NWNLTIVGKQWWRIFTYGIAPIKQN-G---LIVDILSLLILGTSFFSISKI 244 P54493 QNGKPTFTY--LFI------ALQILMFFLLEINGGSTNTETLVAFGAKEN-SLIAQG-EWWRLLT----PIVLHIGIAHLAFNTLALWSVGTA------- 251 AVX54832.1 TEIQLANTKKLILATILSYLILGLFSS--SVL--PTIY--TG--GLISTMGIFIGVLLIDVSGSTTPMAKFSQAKT----VVYILIL-IGFSFFLG--D- 328 P54493 VE-RMYGSGRFLL--I--YLAAGITGSIASFVFSP--YPSAGASGAI--FG-CLGALLY-VALSNRKM--F--LRTIGTNIIVIIIINLGFGFAVSNIDN 336 AVX54832.1 -GWTGLLITG--TAVILG----SAFWGILKVNIKEWAWIQYVHIFLILAILAISLTFIF--LPHLTPALDQHILITLST-YYKKGWFSINSLNKIVNNIG 418 P54493 SGHIGGLIGGFFAAAALGLPKAGAF-G--K---------RLLSAVLLIA-LAVG--FLYYGL-H-SPSHQESALIQQASELYQEGKY--EEVTELLN--G 415 AVX54832.1 ----WDGQFNQFGKF--ITNF------------------------------------------------------------------------ 433 P54493 EAAQKDASADLL-KILAVSDIQIGEYDQAVSLLERAVKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES 507
Go Annotations
1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.
Source | GO | Description |
---|---|---|
2. PF | GO:0004252 | serine-type endopeptidase activity |
5. P | GO:0031969 | chloroplast membrane |
5. P | GO:0035311 | wing cell fate specification |
5. P | GO:0060352 | cell adhesion molecule production |
5. P | GO:0043703 | photoreceptor cell fate determination |
5. P | GO:0006465 | signal peptide processing |
5. P | GO:0016021 | integral component of membrane |
5. P | GO:0005886 | plasma membrane |
5. P | GO:0061331 | epithelial cell proliferation involved in Malpighian tubule morphogenesis |
5. P | GO:0042749 | regulation of circadian sleep/wake cycle |
5. P | GO:0048149 | behavioral response to ethanol |
5. P | GO:0006654 | phosphatidic acid biosynthetic process |
5. P | GO:0007479 | leg disc proximal/distal pattern formation |
5. P | GO:0007474 | imaginal disc-derived wing vein specification |
5. P | GO:0007436 | larval salivary gland morphogenesis |
5. P | GO:0035202 | tracheal pit formation in open tracheal system |
5. P | GO:0019374 | galactolipid metabolic process |
5. P | GO:0001752 | compound eye photoreceptor fate commitment |
5. P | GO:0007391 | dorsal closure |
5. P | GO:0035225 | determination of genital disc primordium |
5. P | GO:0001742 | oenocyte differentiation |
5. P | GO:0042327 | positive regulation of phosphorylation |
5. P | GO:0007438 | oenocyte development |
5. P | GO:0040026 | positive regulation of vulval development |
5. P | GO:0048865 | stem cell fate commitment |
5. P | GO:0090317 | negative regulation of intracellular protein transport |
5. P | GO:0008586 | imaginal disc-derived wing vein morphogenesis |
5. P | GO:0007476 | imaginal disc-derived wing morphogenesis |
5. P | GO:0042058 | regulation of epidermal growth factor receptor signaling pathway |
5. P | GO:0035160 | maintenance of epithelial integrity, open tracheal system |
5. P | GO:0038004 | epidermal growth factor receptor ligand maturation |
Uniprot GO Annotations
GO | Description |
---|---|
GO:0016020 | membrane |
GO:0016021 | integral component of membrane |
Homologs
1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.
Source | Homolog | Description | Fatcat Pvalue | PROST Evalue | BLAST Evalue | Foldseek TMScore |
---|---|---|---|---|---|---|
2. PF | P54493 | Rhomboid protease GluP | 1.53e-08 | 6.31e-10 | NA | 0.4241 |
5. P | B4TKV0 | Rhomboid protease GlpG | 1.59e-04 | 6.97e-08 | NA | NA |
5. P | Q57IV1 | Rhomboid protease GlpG | 2.89e-04 | 6.54e-08 | NA | NA |
5. P | Q32AN6 | Rhomboid protease GlpG | 1.67e-04 | 9.14e-08 | NA | NA |
5. P | Q695T8 | Rhomboid-like protease 4 | 5.37e-04 | 1.33e-03 | NA | NA |
5. P | Q1R5L1 | Rhomboid protease GlpG | 1.58e-04 | 9.25e-08 | NA | NA |
5. P | B7NE28 | Rhomboid protease GlpG | 1.87e-04 | 9.25e-08 | NA | NA |
5. P | Q3YWA4 | Rhomboid protease GlpG | 1.57e-04 | 9.14e-08 | NA | NA |
5. P | A8A5N2 | Rhomboid protease GlpG | 1.58e-04 | 9.25e-08 | NA | NA |
5. P | B4TY77 | Rhomboid protease GlpG | 3.60e-04 | 1.11e-07 | NA | NA |
5. P | Q7CFX8 | Rhomboid protease GlpG | 1.63e-04 | 2.21e-09 | NA | NA |
5. P | B7LSC6 | Rhomboid protease GlpG | 1.79e-04 | 6.13e-08 | NA | NA |
5. P | Q8Z229 | Rhomboid protease GlpG | 1.59e-04 | 6.97e-08 | NA | NA |
5. P | B5BHH5 | Rhomboid protease GlpG | 1.59e-04 | 7.83e-08 | NA | NA |
5. P | Q1CCK6 | Rhomboid protease GlpG | 1.74e-04 | 2.21e-09 | NA | NA |
5. P | A8AQX4 | Rhomboid protease GlpG | 3.08e-04 | 1.53e-08 | NA | NA |
5. P | Q0SZP2 | Rhomboid protease GlpG | 1.55e-04 | 7.44e-08 | NA | NA |
5. P | B5FKE3 | Rhomboid protease GlpG | 1.28e-04 | 6.97e-08 | NA | NA |
5. P | B7M2I4 | Rhomboid protease GlpG | 2.95e-04 | 1.09e-07 | NA | NA |
5. P | A1AGU7 | Rhomboid protease GlpG | 1.61e-04 | 9.25e-08 | NA | NA |
5. P | A4WFK8 | Rhomboid protease GlpG | 1.02e-04 | 1.14e-07 | NA | NA |
5. P | Q0TC44 | Rhomboid protease GlpG | 1.56e-04 | 9.25e-08 | NA | NA |
5. P | B1IP42 | Rhomboid protease GlpG | 1.56e-04 | 9.25e-08 | NA | NA |
5. P | B7N156 | Rhomboid protease GlpG | 3.73e-04 | 8.14e-08 | NA | NA |
5. P | Q31VK9 | Rhomboid protease GlpG | 1.59e-04 | 9.25e-08 | NA | NA |
5. P | Q9FFX0 | RHOMBOID-like protein 9, chloroplastic | 1.77e-05 | 9.71e-05 | NA | NA |
5. P | B7NMI8 | Rhomboid protease GlpG | 1.58e-04 | 8.35e-08 | NA | NA |
5. P | P58873 | Rhomboid-related protein 3 | 9.71e-05 | 9.29e-03 | NA | NA |
5. P | A1JSF0 | Rhomboid protease GlpG | 7.13e-04 | 1.03e-09 | NA | NA |
5. P | P20350 | Protein rhomboid | 5.98e-06 | 1.47e-03 | NA | NA |
5. P | A4TGR2 | Rhomboid protease GlpG | 8.73e-04 | 2.21e-09 | NA | NA |
5. P | B1JHY8 | Rhomboid protease GlpG | 1.84e-04 | 2.21e-09 | NA | NA |
5. P | Q8VC82 | Rhomboid-related protein 1 | 1.73e-05 | 7.37e-09 | NA | NA |
5. P | B7MDQ0 | Rhomboid protease GlpG | 1.63e-04 | 9.25e-08 | NA | NA |
5. P | P09391 | Rhomboid protease GlpG | 1.50e-04 | 9.25e-08 | NA | NA |
5. P | A7ZSV4 | Rhomboid protease GlpG | 1.51e-04 | 1.09e-07 | NA | NA |
5. P | A8GKU2 | Rhomboid protease GlpG | 1.21e-04 | 2.09e-07 | NA | NA |
5. P | F4ICF4 | RHOMBOID-like protein 10, chloroplastic | 2.36e-04 | 1.86e-02 | NA | NA |
5. P | Q8FCS5 | Rhomboid protease GlpG | 1.60e-04 | 9.25e-08 | NA | NA |
5. P | B2K5W4 | Rhomboid protease GlpG | 8.76e-04 | 2.21e-09 | NA | NA |
5. P | Q1C2L2 | Rhomboid protease GlpG | 1.75e-04 | 2.21e-09 | NA | NA |
5. P | A9MMA7 | Rhomboid protease GlpG | 1.69e-04 | 1.73e-07 | NA | NA |
5. P | A7MGE5 | Rhomboid protease GlpG homolog | 2.39e-04 | 1.23e-09 | NA | NA |
5. P | B1X769 | Rhomboid protease GlpG | 1.87e-04 | 9.25e-08 | NA | NA |
5. P | Q664J1 | Rhomboid protease GlpG | 1.64e-04 | 1.85e-09 | NA | NA |
5. P | A7FNW6 | Rhomboid protease GlpG | 1.78e-04 | 2.21e-09 | NA | NA |
5. P | Q2NQH3 | Rhomboid protease GlpG | 2.57e-04 | 2.17e-10 | NA | NA |
5. P | B5R383 | Rhomboid protease GlpG | 1.52e-04 | 6.97e-08 | NA | NA |
5. P | Q83PV6 | Rhomboid protease GlpG | 1.62e-04 | 8.03e-08 | NA | NA |
5. P | B5XTR5 | Rhomboid protease GlpG | 2.12e-04 | 8.57e-08 | NA | NA |
5. P | B1LI84 | Rhomboid protease GlpG | 2.06e-04 | 9.25e-08 | NA | NA |
5. P | A6TF43 | Rhomboid protease GlpG | 1.79e-04 | 7.93e-08 | NA | NA |
5. P | Q8X6Z6 | Rhomboid protease GlpG | 1.55e-04 | 9.14e-08 | NA | NA |
5. P | Q5PLZ8 | Rhomboid protease GlpG | 3.07e-04 | 7.83e-08 | NA | NA |
5. P | C4ZVX5 | Rhomboid protease GlpG | 1.70e-04 | 9.25e-08 | NA | NA |
5. P | B5YTX6 | Rhomboid protease GlpG | 1.67e-04 | 9.14e-08 | NA | NA |
5. P | B6I2Y7 | Rhomboid protease GlpG | 1.62e-04 | 1.09e-07 | NA | NA |
5. P | Q58EK4 | Presenilins-associated rhomboid-like protein, mitochondrial | 2.60e-03 | 6.70e-03 | NA | NA |
5. P | B2U3N2 | Rhomboid protease GlpG | 1.61e-04 | 2.09e-07 | NA | NA |
5. P | Q19821 | Rhomboid-related protein 1 | 3.34e-05 | 4.61e-12 | NA | NA |
5. P | B4SVM1 | Rhomboid protease GlpG | 1.68e-04 | 6.97e-08 | NA | NA |
5. P | Q84WG3 | Rhomboid-like protein 16, chloroplastic | 4.35e-04 | 4.89e-02 | NA | NA |
5. P | B5R7J1 | Rhomboid protease GlpG | 1.59e-04 | 6.97e-08 | NA | NA |
5. P | Q8ZLH5 | Rhomboid protease GlpG | 1.59e-04 | 6.97e-08 | NA | NA |
5. P | B7UKC8 | Rhomboid protease GlpG | 1.63e-04 | 9.25e-08 | NA | NA |
5. P | P58872 | Rhomboid-related protein 3 | 6.90e-05 | 1.05e-02 | NA | NA |
5. P | B7L4V0 | Rhomboid protease GlpG | 1.53e-04 | 1.09e-07 | NA | NA |
5. P | B5F8P0 | Rhomboid protease GlpG | 1.69e-04 | 1.11e-07 | NA | NA |
5. P | Q6CZL3 | Rhomboid protease GlpG | 2.88e-04 | 5.72e-10 | NA | NA |
5. P | Q7N9W4 | Rhomboid protease GlpG | 8.47e-04 | 3.20e-09 | NA | NA |