Summary
The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.
AVX54833.1
JCVISYN3A_0517
Uncharacterized RNA pseudouridine synthase.
M. mycoides homolog: Q6MT30.
TIGRfam Classification: 3=Putative.
Category: Nonessential.
Statistics
Total GO Annotation: 24
Unique PROST Go: 0
Unique BLAST Go: 4
Unique Foldseek Go: 0
Total Homologs: 206
Unique PROST Homologs: 9
Unique BLAST Homologs: 10
Unique Foldseek Homologs: 16
Literature
Danchin and Fang [1]: NA
Yang and Tsui [2]: NA
Antczak et al. [3]: pseudouridine synthase Rlu family protein
Zhang et al. [4]: GO:0000455|enzyme-directed rRNA pseudouridine synthesis
Bianchi et al. [5]: "Pseudouridine synthase RluA family, Ribosomal LSU, RNA binding LYASE, similar PDB: 1V9F"
Structures and Sequence Alignment
The best structural homolog that predicted by 1. PBF was
Q8PHN2
(Ribosomal large subunit pseudouridine synthase D) with a FATCAT P-Value: 0 and RMSD of 1.68 angstrom. The sequence alignment identity is 29.8%.
Structural alignment shown in left. Query protein AVX54833.1 colored as red in alignment, homolog Q8PHN2 colored as blue.
Query protein AVX54833.1 is also shown in right top, homolog Q8PHN2 showed in right bottom. They are colored based on secondary structures.
AVX54833.1 MNKITLNSLNTTL------------RLDKLLVELLTSYDYSRSYIQKLIKE-ECISVNNQIITNNNFVVKPNSQITI----TIK-DPILDPN--LVKNDE 80 Q8PHN2 MSDPSAEPLDPSIRQAIVPDNAAGRRFDAVLAELFP--EFSRSRLSEWIKSGDAL-LDGE-------MARPRD--TLRGGESVQVQVVLETQTHAAPQD- 87 AVX54833.1 IDLDIIYQDDDLLVINKQNNITVHPSLSNTNNTIVNALLASDVELSSINGELRPGIVHRIDKQTTGLLIVAKNDKTHKLLSEMFKNHQIYKEYLAIVSGV 180 Q8PHN2 IPLSVLYEDEQVLVIDKPAGLVVHPGAGNPDRTLVNALLFRDPALASVP---RAGVVHRLDKDTSGVMVVARTVQAQTALVEQLSAREVHRQYLAVVVGA 184 AVX54833.1 IKPNKGLIDAPIGRSQIDRKKMSVTAKNSKQAITTFEVVERFLKNTLVKCQIQTGRTHQIRVHFNYINHPVLNDPVYG---KKHQEFTD--------F-G 268 Q8PHN2 LV-SGGTANAPIDRHPRDRLKMAVR-DDGRDAVTHYRLRERFRAHTALECRLETGRTHQIRVHMAHLKSPIVGDPLYGGALKLPKGATDELVHELRTFKR 282 AVX54833.1 QYLHAYKLRFTHPITKKEIELISPLPKEFDDKIKELRGENND---------- 310 Q8PHN2 QALHAETLEFLHPVSGEPVRASAPVPADLQRLMTVLR-E--DSARAAELARR 331
Go Annotations
1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.
| Source | GO | Description |
|---|---|---|
| 1. PBF | GO:0070131 | positive regulation of mitochondrial translation |
| 1. PBF | GO:0008033 | tRNA processing |
| 1. PBF | GO:0000455 | enzyme-directed rRNA pseudouridine synthesis |
| 1. PBF | GO:0003723 | RNA binding |
| 1. PBF | GO:0001522 | pseudouridine synthesis |
| 1. PBF | GO:0009982 | pseudouridine synthase activity |
| 1. PBF | GO:0000154 | rRNA modification |
| 1. PBF | GO:0009451 | RNA modification |
| 1. PBF | GO:0006364 | rRNA processing |
| 1. PBF | GO:0106029 | tRNA pseudouridine synthase activity |
| 1. PBF | GO:0120159 | rRNA pseudouridine synthase activity |
| 3. BF | GO:0004730 | pseudouridylate synthase activity |
| 4. PB | GO:0031119 | tRNA pseudouridine synthesis |
| 4. PB | GO:0035770 | ribonucleoprotein granule |
| 4. PB | GO:0031118 | rRNA pseudouridine synthesis |
| 4. PB | GO:1990400 | mitochondrial ribosomal large subunit rRNA binding |
| 4. PB | GO:0005739 | mitochondrion |
| 4. PB | GO:0005737 | cytoplasm |
| 4. PB | GO:0070902 | mitochondrial tRNA pseudouridine synthesis |
| 4. PB | GO:0005759 | mitochondrial matrix |
| 7. B | GO:0006399 | tRNA metabolic process |
| 7. B | GO:1990481 | mRNA pseudouridine synthesis |
| 7. B | GO:0043723 | 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity |
| 7. B | GO:0008835 | diaminohydroxyphosphoribosylaminopyrimidine deaminase activity |
Uniprot GO Annotations
| GO | Description |
|---|---|
| GO:0000455 | enzyme-directed rRNA pseudouridine synthesis |
| GO:0003723 | RNA binding |
| GO:0016829 | lyase activity |
| GO:0001522 | pseudouridine synthesis |
| GO:0009982 | pseudouridine synthase activity |
| GO:0016853 | isomerase activity |
| GO:0009451 | RNA modification |
| GO:0120159 | rRNA pseudouridine synthase activity |
Homologs
1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.
| Source | Homolog | Description | Fatcat Pvalue | PROST Evalue | BLAST Evalue | Foldseek TMScore |
|---|---|---|---|---|---|---|
| 1. PBF | P57430 | Ribosomal large subunit pseudouridine synthase C | 1.33e-15 | 5.21e-40 | 1.79e-24 | 0.6509 |
| 1. PBF | P44445 | Ribosomal large subunit pseudouridine synthase D | 1.11e-16 | 1.71e-44 | 1.11e-53 | 0.7233 |
| 1. PBF | Q9PET9 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 1.15e-46 | 3.41e-51 | 0.7345 |
| 1. PBF | Q8DEV0 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 1.74e-45 | 4.94e-59 | 0.7035 |
| 1. PBF | Q9KP71 | Dual-specificity RNA pseudouridine synthase RluA | 6.66e-16 | 6.97e-04 | 1.77e-25 | 0.8887 |
| 1. PBF | Q8P682 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 5.81e-43 | 2.09e-52 | 0.7396 |
| 1. PBF | Q87MD4 | tRNA pseudouridine synthase C | 3.66e-15 | 5.11e-04 | 1.02e-22 | 0.7462 |
| 1. PBF | Q9JVB6 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 8.25e-24 | 1.13e-58 | 0.7309 |
| 1. PBF | P65834 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 7.95e-46 | 2.97e-55 | 0.7011 |
| 1. PBF | Q8K9E9 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 7.20e-52 | 1.82e-48 | 0.7391 |
| 1. PBF | O25610 | Uncharacterized RNA pseudouridine synthase HP_0956 | 1.04e-11 | 1.14e-26 | 1.24e-20 | 0.7048 |
| 1. PBF | P75230 | Uncharacterized RNA pseudouridine synthase MG370 homolog | 1.69e-13 | 5.62e-42 | 7.89e-13 | 0.659 |
| 1. PBF | P0AA38 | Dual-specificity RNA pseudouridine synthase RluA | 0.00e+00 | 4.16e-09 | 3.57e-25 | 0.8527 |
| 1. PBF | Q8Z7J7 | Ribosomal large subunit pseudouridine synthase C | 1.22e-15 | 1.26e-43 | 6.06e-34 | 0.6576 |
| 1. PBF | Q8DCG0 | Dual-specificity RNA pseudouridine synthase RluA | 3.55e-15 | 8.89e-04 | 1.64e-23 | 0.8363 |
| 1. PBF | O25441 | Uncharacterized RNA pseudouridine synthase HP_0745 | 0.00e+00 | 9.58e-40 | 1.33e-37 | 0.8221 |
| 1. PBF | Q89AD9 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 6.35e-53 | 3.87e-51 | 0.79 |
| 1. PBF | P47610 | Uncharacterized RNA pseudouridine synthase MG370 | 3.71e-13 | 2.60e-43 | 6.96e-13 | 0.6601 |
| 1. PBF | P65837 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 2.54e-45 | 1.02e-54 | 0.7009 |
| 1. PBF | Q8XYX8 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 2.73e-30 | 3.15e-53 | 0.706 |
| 1. PBF | P0AA40 | Ribosomal large subunit pseudouridine synthase C | 5.55e-16 | 4.73e-42 | 5.84e-33 | 0.674 |
| 1. PBF | P44433 | Ribosomal large subunit pseudouridine synthase C | 0.00e+00 | 7.46e-44 | 2.25e-30 | 0.6647 |
| 1. PBF | Q82WZ5 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 2.54e-34 | 1.32e-59 | 0.6939 |
| 1. PBF | O25114 | Uncharacterized RNA pseudouridine synthase HP_0347 | 3.43e-11 | 5.45e-28 | 1.09e-16 | 0.6378 |
| 1. PBF | Q8X8J3 | Ribosomal large subunit pseudouridine synthase C | 3.33e-16 | 2.43e-42 | 9.83e-33 | 0.6479 |
| 1. PBF | Q8Z9J5 | Dual-specificity RNA pseudouridine synthase RluA | 0.00e+00 | 5.52e-10 | 1.76e-22 | 0.8437 |
| 1. PBF | Q9K0B0 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 2.52e-23 | 8.85e-59 | 0.7339 |
| 1. PBF | Q9KU20 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 2.04e-43 | 2.97e-61 | 0.7041 |
| 1. PBF | Q87AR7 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 1.64e-47 | 3.77e-52 | 0.744 |
| 1. PBF | Q92IS6 | Ribosomal large subunit pseudouridine synthase C | 1.53e-14 | 1.35e-38 | 2.05e-21 | 0.7061 |
| 1. PBF | Q1RJX7 | Ribosomal large subunit pseudouridine synthase C | 5.55e-16 | 6.56e-41 | 6.49e-20 | 0.6885 |
| 1. PBF | P59840 | tRNA pseudouridine synthase C | 5.55e-15 | 3.78e-03 | 2.26e-30 | 0.7494 |
| 1. PBF | P47451 | Uncharacterized RNA pseudouridine synthase MG209 | 0.00e+00 | 2.19e-49 | 9.89e-42 | 0.734 |
| 1. PBF | P50513 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 1.25e-49 | 1.34e-66 | 0.7364 |
| 1. PBF | Q9KQH0 | Ribosomal large subunit pseudouridine synthase C | 0.00e+00 | 2.28e-44 | 1.55e-33 | 0.6588 |
| 1. PBF | P33640 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 2.15e-47 | 1.37e-55 | 0.7699 |
| 1. PBF | Q8D8G1 | Ribosomal large subunit pseudouridine synthase C | 1.11e-16 | 3.42e-42 | 1.30e-36 | 0.6398 |
| 1. PBF | Q9CKA6 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 1.24e-45 | 2.89e-58 | 0.7453 |
| 1. PBF | Q8FL93 | Dual-specificity RNA pseudouridine synthase RluA | 0.00e+00 | 6.98e-09 | 5.94e-25 | 0.8588 |
| 1. PBF | P59831 | Dual-specificity RNA pseudouridine synthase RluA | 0.00e+00 | 1.68e-08 | 3.49e-16 | 0.8317 |
| 1. PBF | Q8ZQ16 | Ribosomal large subunit pseudouridine synthase C | 2.55e-15 | 1.51e-41 | 3.58e-33 | 0.6538 |
| 1. PBF | Q8FIP7 | Ribosomal large subunit pseudouridine synthase C | 6.66e-16 | 1.72e-42 | 1.20e-32 | 0.6756 |
| 1. PBF | P54604 | Uncharacterized RNA pseudouridine synthase YhcT | 0.00e+00 | 2.19e-48 | 1.41e-38 | 0.7037 |
| 1. PBF | Q45480 | Uncharacterized RNA pseudouridine synthase YlyB | 0.00e+00 | 1.21e-53 | 2.37e-84 | 0.7491 |
| 1. PBF | Q89AH2 | Ribosomal large subunit pseudouridine synthase C | 3.33e-15 | 2.26e-39 | 1.26e-25 | 0.6717 |
| 1. PBF | P65835 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 7.95e-46 | 2.97e-55 | 0.7035 |
| 1. PBF | Q9ZL98 | Uncharacterized RNA pseudouridine synthase jhp_0682 | 0.00e+00 | 1.43e-39 | 7.95e-37 | 0.9022 |
| 1. PBF | Q9HZM9 | Ribosomal large subunit pseudouridine synthase C | 1.11e-16 | 1.87e-44 | 2.08e-24 | 0.6537 |
| 1. PBF | Q87S65 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 5.17e-45 | 2.68e-61 | 0.6978 |
| 1. PBF | Q8ZRV9 | Dual-specificity RNA pseudouridine synthase RluA | 0.00e+00 | 4.09e-10 | 2.32e-22 | 0.8315 |
| 1. PBF | P45614 | Uncharacterized RNA pseudouridine synthase MCAP_0714 | 1.66e-13 | 8.70e-34 | 2.10e-20 | 0.6447 |
| 1. PBF | P59835 | Ribosomal large subunit pseudouridine synthase C | 0.00e+00 | 2.60e-43 | 3.34e-35 | 0.6787 |
| 1. PBF | P59838 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 1.35e-49 | 3.78e-49 | 0.7252 |
| 1. PBF | O50310 | Uncharacterized RNA pseudouridine synthase Cpar_0723 | 0.00e+00 | 7.59e-42 | 1.13e-54 | 0.6977 |
| 1. PBF | Q9CK02 | Dual-specificity RNA pseudouridine synthase RluA | 0.00e+00 | 7.66e-09 | 1.33e-24 | 0.8409 |
| 1. PBF | Q4UKQ3 | Ribosomal large subunit pseudouridine synthase C | 1.72e-14 | 4.40e-40 | 3.78e-24 | 0.683 |
| 1. PBF | Q6CQC4 | 21S rRNA pseudouridine(2819) synthase | 2.92e-07 | 4.90e-03 | 0.042 | 0.667 |
| 1. PBF | Q47417 | tRNA pseudouridine synthase C | 6.65e-07 | 2.46e-17 | 9.00e-21 | 0.6884 |
| 1. PBF | Q8ZFU1 | Ribosomal large subunit pseudouridine synthase C | 4.00e-15 | 2.65e-45 | 1.18e-28 | 0.6767 |
| 1. PBF | Q68XB2 | Ribosomal large subunit pseudouridine synthase C | 2.22e-16 | 1.17e-41 | 1.83e-25 | 0.6935 |
| 1. PBF | Q5E9Z1 | Mitochondrial RNA pseudouridine synthase RPUSD4 | 5.49e-11 | 1.85e-07 | 6.15e-15 | 0.6731 |
| 1. PBF | Q87N15 | Ribosomal large subunit pseudouridine synthase C | 0.00e+00 | 3.76e-43 | 1.62e-31 | 0.6545 |
| 1. PBF | Q9L7A7 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 2.90e-44 | 1.10e-51 | 0.7191 |
| 1. PBF | Q8K9J8 | Ribosomal large subunit pseudouridine synthase C | 5.55e-16 | 5.99e-44 | 4.05e-25 | 0.6661 |
| 1. PBF | Q9ZMA1 | Uncharacterized RNA pseudouridine synthase jhp_0321 | 3.95e-12 | 4.99e-31 | 9.19e-15 | 0.6233 |
| 1. PBF | P0A5T3 | Uncharacterized RNA pseudouridine synthase Mb1567 | 0.00e+00 | 6.05e-49 | 3.10e-54 | 0.7283 |
| 1. PBF | Q9KTL4 | tRNA pseudouridine synthase C | 9.55e-15 | 4.98e-02 | 5.40e-22 | 0.7331 |
| 1. PBF | P65836 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 2.54e-45 | 1.02e-54 | 0.7001 |
| 1. PBF | Q8X9F0 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 4.54e-46 | 5.08e-55 | 0.7012 |
| 1. PBF | P74346 | Uncharacterized RNA pseudouridine synthase slr1629 | 0.00e+00 | 5.91e-40 | 1.07e-60 | 0.7594 |
| 1. PBF | Q8XA10 | Dual-specificity RNA pseudouridine synthase RluA | 0.00e+00 | 8.98e-10 | 9.46e-24 | 0.8738 |
| 1. PBF | P57481 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 3.94e-53 | 3.84e-46 | 0.6944 |
| 1. PBF | Q8PHN2 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 4.53e-42 | 8.68e-52 | 0.7424 |
| 1. PBF | O67638 | Uncharacterized RNA pseudouridine synthase aq_1758 | 0.00e+00 | 8.07e-50 | 1.94e-64 | 0.817 |
| 1. PBF | P9WHQ2 | Uncharacterized RNA pseudouridine synthase MT1592 | 0.00e+00 | 6.05e-49 | 3.10e-54 | 0.7282 |
| 1. PBF | Q9ZDR7 | Ribosomal large subunit pseudouridine synthase C | 6.66e-16 | 2.80e-41 | 6.72e-24 | 0.7089 |
| 1. PBF | Q9ZKP5 | Uncharacterized RNA pseudouridine synthase jhp_0890 | 8.11e-12 | 5.85e-28 | 3.70e-22 | 0.7027 |
| 1. PBF | O31613 | Uncharacterized RNA pseudouridine synthase YjbO | 0.00e+00 | 2.14e-35 | 5.16e-41 | 0.7555 |
| 1. PBF | Q28C59 | Mitochondrial RNA pseudouridine synthase rpusd4 | 2.26e-11 | 2.19e-05 | 4.21e-15 | 0.677 |
| 1. PBF | O66114 | Uncharacterized RNA pseudouridine synthase ZMO0505 | 0.00e+00 | 3.47e-02 | 5.93e-31 | 0.8425 |
| 1. PBF | P75485 | Uncharacterized RNA pseudouridine synthase MG209 homolog | 0.00e+00 | 1.22e-41 | 2.21e-54 | 0.6851 |
| 1. PBF | P44782 | Dual-specificity RNA pseudouridine synthase RluA | 0.00e+00 | 2.94e-09 | 3.34e-23 | 0.846 |
| 1. PBF | Q87LD3 | Dual-specificity RNA pseudouridine synthase RluA | 3.00e-15 | 3.32e-04 | 1.42e-23 | 0.8324 |
| 1. PBF | P72970 | Uncharacterized RNA pseudouridine synthase slr1592 | 2.18e-14 | 2.29e-26 | 9.09e-24 | 0.6429 |
| 1. PBF | Q8ZBV7 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 2.12e-45 | 1.56e-52 | 0.7064 |
| 1. PBF | P70870 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 3.50e-39 | 6.48e-43 | 0.7929 |
| 1. PBF | Q9CM51 | Ribosomal large subunit pseudouridine synthase C | 3.33e-16 | 4.41e-44 | 3.68e-35 | 0.6563 |
| 1. PBF | Q9CNF3 | tRNA pseudouridine synthase C | 7.77e-15 | 2.06e-02 | 1.69e-25 | 0.7578 |
| 1. PBF | Q45826 | Uncharacterized RNA pseudouridine synthase Caur_0901 | 0.00e+00 | 1.75e-44 | 1.50e-64 | 0.7507 |
| 2. PF | O66829 | Uncharacterized RNA pseudouridine synthase aq_554 | 1.28e-06 | 8.26e-07 | NA | 0.4068 |
| 2. PF | Q9CPN4 | Ribosomal small subunit pseudouridine synthase A | 6.44e-06 | 4.33e-07 | NA | 0.4131 |
| 2. PF | Q87QY8 | Ribosomal large subunit pseudouridine synthase E | 2.21e-04 | 1.48e-02 | NA | 0.4945 |
| 2. PF | Q9CKK7 | Ribosomal large subunit pseudouridine synthase E | 1.01e-04 | 1.29e-05 | NA | 0.5053 |
| 2. PF | Q8ZGM2 | Ribosomal small subunit pseudouridine synthase A | 6.56e-06 | 6.48e-07 | NA | 0.4894 |
| 2. PF | Q89AL1 | Ribosomal large subunit pseudouridine synthase B | 3.21e-06 | 1.09e-03 | NA | 0.4769 |
| 2. PF | P65843 | Uncharacterized RNA pseudouridine synthase Mb1738 | 2.79e-06 | 1.58e-09 | NA | 0.4675 |
| 2. PF | Q87QD4 | Ribosomal small subunit pseudouridine synthase A | 4.02e-06 | 2.32e-07 | NA | 0.4592 |
| 2. PF | Q8FHV4 | Ribosomal large subunit pseudouridine synthase B | 9.21e-06 | 4.46e-02 | NA | 0.4096 |
| 2. PF | P45124 | Ribosomal small subunit pseudouridine synthase A | 7.10e-06 | 7.24e-08 | NA | 0.4766 |
| 2. PF | Q8X4Q8 | Ribosomal large subunit pseudouridine synthase B | 7.64e-06 | 2.93e-02 | NA | 0.4112 |
| 2. PF | P0AA45 | Ribosomal small subunit pseudouridine synthase A | 8.72e-07 | 4.08e-06 | NA | 0.4949 |
| 2. PF | Q2TBK7 | Mitochondrial mRNA pseudouridine synthase RPUSD3 | 7.07e-09 | 5.95e-09 | NA | 0.5878 |
| 2. PF | O67444 | Uncharacterized RNA pseudouridine synthase aq_1464 | 1.92e-06 | 1.02e-06 | NA | 0.4558 |
| 2. PF | P9WHQ0 | Uncharacterized RNA pseudouridine synthase MT1751.1 | 2.67e-06 | 1.58e-09 | NA | 0.4685 |
| 2. PF | Q68WJ1 | Uncharacterized RNA pseudouridine synthase RT0532 | 1.73e-06 | 1.22e-05 | NA | 0.4777 |
| 2. PF | P35159 | Ribosomal large subunit pseudouridine synthase B | 2.19e-06 | 8.80e-07 | NA | 0.5064 |
| 2. PF | O05668 | Uncharacterized RNA pseudouridine synthase ML1370 | 3.16e-06 | 4.56e-09 | NA | 0.4502 |
| 2. PF | P44827 | Ribosomal large subunit pseudouridine synthase E | 4.75e-04 | 4.70e-05 | NA | 0.4602 |
| 2. PF | Q92HG4 | Uncharacterized RNA pseudouridine synthase RC0807 | 1.02e-07 | 4.16e-03 | NA | 0.4849 |
| 2. PF | P59815 | Ribosomal large subunit pseudouridine synthase B | 7.60e-06 | 3.89e-02 | NA | 0.4125 |
| 2. PF | Q8Z7D5 | Ribosomal large subunit pseudouridine synthase B | 9.76e-06 | 4.68e-02 | NA | 0.4102 |
| 2. PF | Q9ZJG0 | Uncharacterized RNA pseudouridine synthase jhp_1352 | 2.17e-06 | 1.87e-06 | NA | 0.5278 |
| 2. PF | Q9KRK5 | Ribosomal small subunit pseudouridine synthase A | 5.11e-06 | 1.26e-06 | NA | 0.4713 |
| 2. PF | P0AA44 | Ribosomal small subunit pseudouridine synthase A | 1.02e-06 | 4.08e-06 | NA | 0.4949 |
| 2. PF | Q9I5J6 | Ribosomal small subunit pseudouridine synthase A | 3.60e-07 | 7.51e-07 | NA | 0.4676 |
| 2. PF | Q1RJR2 | Uncharacterized RNA pseudouridine synthase RBE_0321 | 8.14e-08 | 2.30e-03 | NA | 0.4928 |
| 2. PF | P0AA46 | Ribosomal small subunit pseudouridine synthase A | 1.03e-06 | 4.08e-06 | NA | 0.5084 |
| 2. PF | P57369 | Ribosomal large subunit pseudouridine synthase B | 3.43e-06 | 3.23e-03 | NA | 0.4174 |
| 2. PF | Q55578 | Uncharacterized RNA pseudouridine synthase slr0361 | 2.38e-06 | 2.15e-07 | NA | 0.489 |
| 2. PF | O32068 | Uncharacterized RNA pseudouridine synthase YtzG | 7.21e-06 | 3.72e-08 | NA | 0.4744 |
| 2. PF | P55986 | Uncharacterized RNA pseudouridine synthase HP_1459 | 2.20e-06 | 5.64e-06 | NA | 0.5297 |
| 2. PF | Q9ZD06 | Uncharacterized RNA pseudouridine synthase RP544 | 6.09e-07 | 1.80e-04 | NA | 0.4721 |
| 2. PF | P42395 | Ribosomal large subunit pseudouridine synthase B | 4.75e-06 | 7.89e-05 | NA | 0.4515 |
| 2. PF | Q8ZFQ3 | Ribosomal large subunit pseudouridine synthase E | 2.67e-04 | 1.88e-03 | NA | 0.5021 |
| 2. PF | Q8Z7G6 | Ribosomal large subunit pseudouridine synthase E | 2.20e-04 | 5.92e-05 | NA | 0.4785 |
| 2. PF | Q8D8X2 | Ribosomal small subunit pseudouridine synthase A | 6.62e-06 | 2.51e-07 | NA | 0.466 |
| 2. PF | Q8DAS3 | Ribosomal large subunit pseudouridine synthase E | 2.31e-04 | 8.20e-05 | NA | 0.4798 |
| 2. PF | Q4UL59 | Uncharacterized RNA pseudouridine synthase RF_0863 | 7.75e-08 | 1.47e-03 | NA | 0.4883 |
| 2. PF | Q8ZPZ1 | Ribosomal large subunit pseudouridine synthase E | 6.35e-04 | 4.22e-04 | NA | 0.4688 |
| 2. PF | P65841 | Ribosomal small subunit pseudouridine synthase A | 9.73e-07 | 1.38e-06 | NA | 0.489 |
| 2. PF | P65840 | Ribosomal small subunit pseudouridine synthase A | 7.98e-07 | 1.38e-06 | NA | 0.4814 |
| 2. PF | O51155 | Uncharacterized RNA pseudouridine synthase BB_0129 | 6.27e-06 | 4.16e-08 | NA | 0.5033 |
| 3. BF | P0AA42 | tRNA pseudouridine synthase C | 3.15e-14 | NA | 1.28e-20 | 0.73 |
| 3. BF | Q8X6T6 | tRNA pseudouridine synthase C | 3.03e-14 | NA | 1.17e-20 | 0.7363 |
| 3. BF | Q8ZMD5 | tRNA pseudouridine synthase C | 2.52e-14 | NA | 4.71e-18 | 0.7334 |
| 3. BF | P43930 | Uncharacterized RNA pseudouridine synthase HI_0042 | 1.07e-13 | NA | 5.64e-25 | 0.8131 |
| 3. BF | Q8ZH72 | tRNA pseudouridine synthase C | 1.24e-14 | NA | 4.91e-21 | 0.7392 |
| 3. BF | Q8ZIK1 | Dual-specificity RNA pseudouridine synthase RluA | 0.00e+00 | NA | 2.59e-23 | 0.8905 |
| 3. BF | Q6FS81 | 21S rRNA pseudouridine(2819) synthase | 1.08e-12 | NA | 2.91e-07 | 0.7076 |
| 3. BF | Q8Z439 | tRNA pseudouridine synthase C | 2.54e-14 | NA | 9.03e-18 | 0.7261 |
| 3. BF | Q750S3 | 21S rRNA pseudouridine(2819) synthase | 2.30e-10 | NA | 7.56e-06 | 0.6216 |
| 3. BF | Q8FEF9 | tRNA pseudouridine synthase C | 1.81e-14 | NA | 2.65e-21 | 0.7351 |
| 3. BF | Q17QT4 | RNA pseudouridylate synthase domain-containing protein 1 | 5.44e-14 | NA | 3.41e-21 | 0.765 |
| 3. BF | Q8DBG5 | tRNA pseudouridine synthase C | 1.02e-14 | NA | 1.79e-20 | 0.7437 |
| 4. PB | Q0J4D4 | RNA pseudouridine synthase 3, mitochondrial | 2.39e-11 | 3.32e-06 | 2.83e-13 | NA |
| 4. PB | Q9CWX4 | Mitochondrial RNA pseudouridine synthase Rpusd4 | 1.67e-11 | 2.44e-10 | 5.25e-14 | NA |
| 4. PB | P9WHQ3 | Uncharacterized RNA pseudouridine synthase Rv1540 | 0.00e+00 | 6.05e-49 | 3.10e-54 | NA |
| 4. PB | P0AA37 | Dual-specificity RNA pseudouridine synthase RluA | 0.00e+00 | 4.16e-09 | 3.57e-25 | NA |
| 4. PB | P53294 | tRNA pseudouridine(31) synthase | 1.73e-10 | 6.68e-21 | 2.10e-19 | NA |
| 4. PB | P0AA39 | Ribosomal large subunit pseudouridine synthase C | 3.33e-16 | 4.73e-42 | 5.84e-33 | NA |
| 4. PB | Q2QNM3 | RNA pseudouridine synthase 1 | 1.36e-09 | 1.02e-09 | 2.25e-14 | NA |
| 4. PB | Q96CM3 | Mitochondrial RNA pseudouridine synthase RPUSD4 | 1.82e-09 | 1.33e-09 | 1.24e-17 | NA |
| 4. PB | Q4QQT0 | Mitochondrial RNA pseudouridine synthase Rpusd4 | 2.15e-11 | 3.90e-10 | 4.81e-16 | NA |
| 4. PB | P33643 | Ribosomal large subunit pseudouridine synthase D | 0.00e+00 | 4.97e-46 | 6.36e-55 | NA |
| 4. PB | Q14AI6 | Mitochondrial mRNA pseudouridine synthase Rpusd3 | 6.48e-09 | 2.54e-08 | 3.16e-04 | NA |
| 4. PB | Q12069 | tRNA pseudouridine(32) synthase, mitochondrial | 3.06e-11 | 8.82e-08 | 1.38e-22 | NA |
| 4. PB | Q6P087 | Mitochondrial mRNA pseudouridine synthase RPUSD3 | 7.53e-09 | 1.13e-08 | 0.018 | NA |
| 4. PB | Q6DBR0 | Mitochondrial RNA pseudouridine synthase rpusd4 | 3.37e-09 | 6.45e-11 | 8.26e-17 | NA |
| 4. PB | Q5Z8P2 | RNA pseudouridine synthase 2, chloroplastic | 4.70e-14 | 4.94e-12 | 2.04e-50 | NA |
| 4. PB | Q5XET6 | RNA pseudouridine synthase 3, mitochondrial | 8.14e-09 | 3.30e-09 | 9.78e-13 | NA |
| 4. PB | Q0DST9 | RNA pseudouridine synthase 5 | 3.99e-14 | 2.21e-23 | 2.20e-30 | NA |
| 4. PB | P44197 | tRNA pseudouridine synthase C | NA | 3.95e-02 | 1.37e-25 | NA |
| 4. PB | Q5M721 | RNA pseudouridine synthase 5 | 4.01e-14 | 1.43e-27 | 1.83e-22 | NA |
| 4. PB | Q09709 | Uncharacterized protein C18B11.02c | 1.60e-12 | 7.88e-10 | 1.26e-20 | NA |
| 4. PB | Q7XA65 | RNA pseudouridine synthase 1 | 1.11e-09 | 7.27e-14 | 1.61e-13 | NA |
| 4. PB | Q0E0Y3 | RNA pseudouridine synthase 7 | 1.61e-11 | 1.68e-12 | 5.66e-20 | NA |
| 4. PB | Q9LT72 | RNA pseudouridine synthase 4, mitochondrial | 6.24e-10 | 2.27e-08 | 1.06e-11 | NA |
| 4. PB | Q69K07 | RNA pseudouridine synthase 4, mitochondrial | 1.41e-10 | 1.37e-03 | 4.48e-11 | NA |
| 4. PB | Q9LU60 | RNA pseudouridine synthase 7 | 1.55e-11 | 1.19e-14 | 6.71e-25 | NA |
| 4. PB | O16686 | Uncharacterized protein K07E8.7 | 6.19e-09 | 2.07e-09 | 2.26e-19 | NA |
| 4. PB | Q3ECD0 | RNA pseudouridine synthase 2, chloroplastic | 0.00e+00 | 2.56e-09 | 1.20e-51 | NA |
| 5. P | Q8FIB6 | Ribosomal large subunit pseudouridine synthase E | 3.81e-04 | 1.06e-03 | NA | NA |
| 5. P | A3BN26 | RNA pseudouridine synthase 6, chloroplastic | 2.92e-07 | 1.55e-03 | NA | NA |
| 5. P | Q9SVS0 | RNA pseudouridine synthase 6, chloroplastic | 5.48e-07 | 7.98e-04 | NA | NA |
| 5. P | P0AA43 | Ribosomal small subunit pseudouridine synthase A | 8.93e-07 | 4.08e-06 | NA | NA |
| 5. P | Q8X724 | Ribosomal large subunit pseudouridine synthase E | 3.64e-04 | 5.76e-04 | NA | NA |
| 5. P | Q83LF6 | Ribosomal large subunit pseudouridine synthase E | 4.25e-04 | 3.51e-04 | NA | NA |
| 5. P | P9WHQ1 | Uncharacterized RNA pseudouridine synthase Rv1711 | 2.62e-06 | 1.58e-09 | NA | NA |
| 5. P | P72581 | Uncharacterized RNA pseudouridine synthase slr0612 | NA | 1.58e-04 | NA | NA |
| 5. P | P75966 | Ribosomal large subunit pseudouridine synthase E | 3.62e-04 | 4.54e-04 | NA | NA |
| 6. F | Q9HX48 | Ribosomal large subunit pseudouridine synthase E | 4.27e-06 | NA | NA | 0.5429 |
| 6. F | Q9CMY9 | Ribosomal large subunit pseudouridine synthase B | 2.51e-05 | NA | NA | 0.3768 |
| 6. F | Q8P8M6 | Ribosomal large subunit pseudouridine synthase B | 1.20e-04 | NA | NA | 0.379 |
| 6. F | Q9KSS7 | Ribosomal large subunit pseudouridine synthase B | 7.91e-06 | NA | NA | 0.3652 |
| 6. F | Q8ZP51 | Ribosomal large subunit pseudouridine synthase B | 9.02e-06 | NA | NA | 0.4109 |
| 6. F | Q8ZEG0 | Ribosomal large subunit pseudouridine synthase B | 1.22e-05 | NA | NA | 0.3836 |
| 6. F | P45104 | Ribosomal large subunit pseudouridine synthase B | 1.55e-05 | NA | NA | 0.3985 |
| 6. F | Q8PQN3 | Ribosomal large subunit pseudouridine synthase E | 5.18e-06 | NA | NA | 0.5554 |
| 6. F | Q8D8C0 | Ribosomal large subunit pseudouridine synthase B | 7.67e-06 | NA | NA | 0.3522 |
| 6. F | Q8PDR2 | Ribosomal large subunit pseudouridine synthase E | 5.72e-06 | NA | NA | 0.5895 |
| 6. F | Q87BI2 | Ribosomal large subunit pseudouridine synthase B | 8.02e-05 | NA | NA | 0.4206 |
| 6. F | Q8PK58 | Ribosomal large subunit pseudouridine synthase B | 2.60e-04 | NA | NA | 0.4173 |
| 6. F | Q9F855 | Ribosomal large subunit pseudouridine synthase E | 2.02e-03 | NA | NA | 0.4586 |
| 6. F | Q87NB7 | Ribosomal large subunit pseudouridine synthase B | 8.48e-06 | NA | NA | 0.3681 |
| 6. F | Q9HZ55 | Ribosomal large subunit pseudouridine synthase B | 3.27e-05 | NA | NA | 0.396 |
| 6. F | Q9PAP2 | Ribosomal large subunit pseudouridine synthase B | 8.20e-05 | NA | NA | 0.4216 |
| 7. B | Q8IZ73 | RNA pseudouridylate synthase domain-containing protein 2 | 8.18e-08 | NA | 4.90e-22 | NA |
| 7. B | Q149F1 | RNA pseudouridylate synthase domain-containing protein 2 | 1.98e-06 | NA | 7.59e-22 | NA |
| 7. B | Q8VCZ8 | RNA pseudouridylate synthase domain-containing protein 1 | 4.69e-14 | NA | 9.70e-22 | NA |
| 7. B | Q5A0Y2 | 21S rRNA pseudouridine(2819) synthase | 3.38e-11 | NA | 0.001 | NA |
| 7. B | Q12362 | Bifunctional protein RIB2 | 4.56e-10 | NA | 4.12e-25 | NA |
| 7. B | Q08C69 | RNA pseudouridylate synthase domain-containing protein 1 | 1.56e-10 | NA | 8.51e-18 | NA |
| 7. B | Q06244 | 21S rRNA pseudouridine(2819) synthase | 3.75e-10 | NA | 0.001 | NA |
| 7. B | Q8I3Z1 | MATH and LRR domain-containing protein PFE0570w | NA | NA | 4.32e-08 | NA |
| 7. B | P0AA41 | tRNA pseudouridine synthase C | 3.33e-14 | NA | 1.28e-20 | NA |
| 7. B | Q9UJJ7 | RNA pseudouridylate synthase domain-containing protein 1 | 6.01e-14 | NA | 1.89e-20 | NA |