Summary

The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.

AVX54846.1
JCVISYN3A_0530

Uncharacterized protein.
M. mycoides homolog: Q6MT16.
TIGRfam Classification: 1=Unknown.
Category: Quasiessential.

Statistics

Total GO Annotation: 44
Unique PROST Go: 44
Unique BLAST Go: 0
Unique Foldseek Go: 0

Total Homologs: 103
Unique PROST Homologs: 103
Unique BLAST Homologs: 0
Unique Foldseek Homologs: 0

Literature

Danchin and Fang [1]: promiscuous phosphatase|similar to RibZ phosphatase family
Yang and Tsui [2]: Endonuclease III
Antczak et al. [3]: Hypothetical protein
Zhang et al. [4]: GO:0016070|RNA metabolic process
Bianchi et al. [5]: "Unclear, yshE-like? "

Structures and Sequence Alignment

The best structural homolog that predicted by 5. P was P23862 (Primosomal replication protein N'') with a FATCAT P-Value: 3.36e-06 and RMSD of 1.83 angstrom. The sequence alignment identity is 16.3%.
Structural alignment shown in left. Query protein AVX54846.1 colored as red in alignment, homolog P23862 colored as blue. Query protein AVX54846.1 is also shown in right top, homolog P23862 showed in right bottom. They are colored based on secondary structures. 

  AVX54846.1 MTDFILIRNSFFKNNVSKIQKTKYLNMTINWSFSDFEDILNK--PNFITYLQNSSKL-NFSYL--MIDAIENKINQIRNLFK-KTNT--ACIDYLLKTNN 92
      P23862 -------------------MKTA-L-------------LLEKLEGQLATLRQRCAPVSQFATLSARFD---------RHLFQTRATTLQACLD---EAGD 55

  AVX54846.1 TNFIEINYKKFLLTSYTLLRDFI--NQI-FINWIFN------DAL---NNHW-IEFNKAYDN---NLMFNYQFERLE-LDFQKNLFNII---KAINKKIN 172
      P23862 -N----------LAA---LRHAVEQQQLPQVAWLAEHLAAQLEAIAREASAWSL---REWDSAPPKI-ARWQRKRIQHQDFERRLREMVAERRARLARVT 137

  AVX54846.1 DPVI--RIL---ISAY----------IEDINNKQTYLNQIHKNLK 202
      P23862 D-LVEQQTLHREVEAYEARLARCRHALEKIENRLARLTR------ 175

Go Annotations

1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.

Source GO Description
5. P GO:0006312 mitotic recombination
5. P GO:0085034 suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade
5. P GO:0009535 chloroplast thylakoid membrane
5. P GO:0106363 protein-cysteine methyltransferase activity
5. P GO:0050618 phycoerythrobilin:ferredoxin oxidoreductase activity
5. P GO:0000217 DNA secondary structure binding
5. P GO:0043065 positive regulation of apoptotic process
5. P GO:0007130 synaptonemal complex assembly
5. P GO:0070402 NADPH binding
5. P GO:0042025 host cell nucleus
5. P GO:0050868 negative regulation of T cell activation
5. P GO:0030089 phycobilisome
5. P GO:0045087 innate immune response
5. P GO:0000939 inner kinetochore
5. P GO:0009968 negative regulation of signal transduction
5. P GO:0018298 protein-chromophore linkage
5. P GO:0010024 phytochromobilin biosynthetic process
5. P GO:0050797 thymidylate synthase (FAD) activity
5. P GO:0030430 host cell cytoplasm
5. P GO:0000779 condensed chromosome, centromeric region
5. P GO:0006235 dTTP biosynthetic process
5. P GO:0050660 flavin adenine dinucleotide binding
5. P GO:0050897 cobalt ion binding
5. P GO:0031676 plasma membrane-derived thylakoid membrane
5. P GO:0050728 negative regulation of inflammatory response
5. P GO:0000818 nuclear MIS12/MIND complex
5. P GO:0031929 TOR signaling
5. P GO:0039644 suppression by virus of host NF-kappaB cascade
5. P GO:0042981 regulation of apoptotic process
5. P GO:0031617 NMS complex
5. P GO:0000444 MIS12/MIND type complex
5. P GO:0010520 regulation of reciprocal meiotic recombination
5. P GO:0039686 bidirectional double-stranded viral DNA replication
5. P GO:0032259 methylation
5. P GO:0030437 ascospore formation
5. P GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
5. P GO:0006231 dTMP biosynthetic process
5. P GO:0032007 negative regulation of TOR signaling
5. P GO:0015979 photosynthesis
5. P GO:0010207 photosystem II assembly
5. P GO:0033235 positive regulation of protein sumoylation
5. P GO:0004799 thymidylate synthase activity
5. P GO:0043666 regulation of phosphoprotein phosphatase activity
5. P GO:0050620 phycocyanobilin:ferredoxin oxidoreductase activity

Uniprot GO Annotations

GO Description

Homologs

1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.

Source Homolog Description Fatcat Pvalue PROST Evalue BLAST Evalue Foldseek TMScore
5. P Q9USK5 Type 2A phosphatase activator tip41 7.35e-01 2.68e-02 NA NA
5. P Q77D96 Matrix protein NA 9.31e-03 NA NA
5. P B1L944 Flavin-dependent thymidylate synthase 2.76e-02 1.53e-03 NA NA
5. P Q5HP81 UPF0302 protein SERP1032 6.10e-03 7.21e-04 NA NA
5. P Q01808 Nucleoprotein NA 1.86e-02 NA NA
5. P Q6P589 Tumor necrosis factor alpha-induced protein 8-like protein 2 9.43e-05 6.32e-07 NA NA
5. P A6U1T1 UPF0302 protein SaurJH1_1550 4.57e-03 1.58e-02 NA NA
5. P Q6P7I6 Tumor necrosis factor alpha-induced protein 8-like protein 2 1.54e-03 4.78e-07 NA NA
5. P P21036 Protein C1 NA 2.03e-02 NA NA
5. P Q93TL5 Phycocyanobilin:ferredoxin oxidoreductase 5.76e-02 5.11e-04 NA NA
5. P B2KI57 Tumor necrosis factor alpha-induced protein 8-like protein 2 5.78e-05 3.04e-06 NA NA
5. P Q9Z7A3 Protein CPn_0803/CP_1068/CPj0803/CpB0832 1.88e-03 8.44e-03 NA NA
5. P P67761 UPF0302 protein MW1352 4.53e-03 1.58e-02 NA NA
5. P P67759 UPF0302 protein SAV1462 4.90e-03 1.58e-02 NA NA
5. P A7X2G1 UPF0302 protein SAHV_1450 4.60e-03 1.58e-02 NA NA
5. P Q6GGU7 UPF0302 protein SAR1473 4.48e-03 3.40e-02 NA NA
5. P A1UEV1 Flavin-dependent thymidylate synthase 1.22e-02 6.01e-03 NA NA
5. P P17368 Protein C1 NA 8.91e-03 NA NA
5. P Q9PJF6 Uncharacterized protein TC_0873 2.18e-03 3.64e-02 NA NA
5. P Q6GQ44 Tumor necrosis factor alpha-induced protein 8 1.36e-04 2.07e-05 NA NA
5. P Q47CW9 Perchlorate reductase assembly chaperone protein 1.01e-03 3.77e-02 NA NA
5. P Q9PR96 Uncharacterized protein UU049 3.65e-02 6.06e-05 NA NA
5. P Q7VC23 Protein Thf1 3.36e-04 4.39e-02 NA NA
5. P O59052 UPF0128 protein PH1314 2.51e-01 2.80e-02 NA NA
5. P P17122 Sporulation-specific protein 16 2.44e-02 8.98e-04 NA NA
5. P Q8CSI3 UPF0302 protein SE_1151 6.07e-03 7.21e-04 NA NA
5. P A8Z442 UPF0302 protein USA300HOU_1400 4.80e-03 1.80e-02 NA NA
5. P Q5UR57 Uncharacterized protein L805 NA 1.86e-02 NA NA
5. P Q9P6M3 Kinetochore protein mis14 3.92e-04 2.91e-04 NA NA
5. P B0UWD5 UPF0304 protein HSM_1818 1.21e-02 8.22e-03 NA NA
5. P B7NZC7 Tumor necrosis factor alpha-induced protein 8-like protein 2 8.94e-05 9.87e-04 NA NA
5. P Q5BKH4 Tumor necrosis factor alpha-induced protein 8-like protein 2 1.69e-03 1.33e-06 NA NA
5. P A5ISZ2 UPF0302 protein SaurJH9_1521 4.53e-03 1.58e-02 NA NA
5. P A3PYB1 Flavin-dependent thymidylate synthase 1.20e-02 2.11e-03 NA NA
5. P P33859 Protein C1 NA 3.40e-02 NA NA
5. P O95379 Tumor necrosis factor alpha-induced protein 8 1.13e-04 1.40e-03 NA NA
5. P Q6G9A0 UPF0302 protein SAS1405 4.32e-03 1.58e-02 NA NA
5. P A5IJX2 Flavin-dependent thymidylate synthase 2.77e-02 1.46e-03 NA NA
5. P Q5ZI78 Tumor necrosis factor alpha-induced protein 8 1.06e-04 4.64e-04 NA NA
5. P O66629 Uncharacterized protein aq_272 2.01e-03 9.41e-04 NA NA
5. P P0A1U5 Uncharacterized protein YjaG 4.29e-03 1.23e-03 NA NA
5. P A5PK29 Tumor necrosis factor alpha-induced protein 8-like protein 1 9.72e-05 5.42e-05 NA NA
5. P Q54714 C-phycocyanin beta subunit 2.01e-04 2.52e-02 NA NA
5. P P0CA86 Uncharacterized protein S183L NA 2.70e-02 NA NA
5. P P13342 DNA helicase assembly protein NA 3.53e-08 NA NA
5. P P31037 Protein A49R NA 2.99e-02 NA NA
5. P Q3V4V3 Uncharacterized protein ORF220 NA 3.37e-02 NA NA
5. P P23862 Primosomal replication protein N'' 3.36e-06 6.07e-04 NA NA
5. P Q60310 UPF0304 protein MJECS11 1.82e-02 4.67e-03 NA NA
5. P O19896 Allophycocyanin subunit beta-18 1.68e-04 4.86e-02 NA NA
5. P P00312 C-phycocyanin-1 beta subunit 4.17e-04 1.83e-02 NA NA
5. P P51215 Allophycocyanin subunit beta-18 2.02e-04 3.59e-03 NA NA
5. P P05097 C-phycoerythrin beta chain 5.58e-04 9.65e-03 NA NA
5. P O26061 Flavin-dependent thymidylate synthase 2.63e-02 1.35e-02 NA NA
5. P P06539 C-phycocyanin beta subunit 4.14e-04 1.83e-02 NA NA
5. P Q58675 Uncharacterized protein MJ1279 1.52e-02 2.83e-03 NA NA
5. P Q1ECV8 Tumor necrosis factor, alpha-induced protein 8-like protein 2 A 1.23e-04 9.16e-05 NA NA
5. P Q5UQ02 Uncharacterized protein R793 NA 8.15e-03 NA NA
5. P Q7SZE8 Tumor necrosis factor alpha-induced protein 8-like protein 1 6.41e-05 6.64e-05 NA NA
5. P Q1BA61 Flavin-dependent thymidylate synthase 1.22e-02 6.01e-03 NA NA
5. P A9X192 Tumor necrosis factor alpha-induced protein 8-like protein 2 1.69e-04 2.12e-07 NA NA
5. P A0A3Z7J6R4 Cysteine S-methyltransferase OspZ 1.49e-02 2.80e-03 NA NA
5. P Q0BSB1 UPF0262 protein GbCGDNIH1_1393 1.59e-03 4.28e-02 NA NA
5. P Q28ZG0 Tumor necrosis factor alpha-induced protein 8-like protein 1.12e-03 1.73e-03 NA NA
5. P B0KWC3 Tumor necrosis factor alpha-induced protein 8-like protein 2 8.58e-05 5.91e-08 NA NA
5. P Q7SIF9 R-phycoerythrin beta chain 5.03e-04 8.15e-03 NA NA
5. P P73053 Flavin-dependent thymidylate synthase 5.84e-02 8.37e-03 NA NA
5. P Q7T364 Tumor necrosis factor, alpha-induced protein 8-like protein 2 B 9.33e-05 1.33e-04 NA NA
5. P Q9P799 Uncharacterized protein P35G2.04c 3.76e-04 1.68e-05 NA NA
5. P A5WBY3 Chaperone protein TorD 1.77e-03 3.37e-02 NA NA
5. P Q5ZJU8 Tumor necrosis factor alpha-induced protein 8-like protein 1 2.54e-04 7.51e-09 NA NA
5. P P67760 UPF0302 protein SA1295 6.47e-03 1.58e-02 NA NA
5. P B9KBK3 Flavin-dependent thymidylate synthase 2.52e-02 1.02e-02 NA NA
5. P A8F7Q7 Flavin-dependent thymidylate synthase 1.53e-02 1.10e-04 NA NA
5. P P0CA85 Uncharacterized protein S183L NA 4.07e-02 NA NA
5. P Q65183 Uncharacterized protein S183L NA 1.97e-03 NA NA
5. P P0DSQ7 Protein A49 NA 1.72e-02 NA NA
5. P Q5RF18 Tumor necrosis factor alpha-induced protein 8 1.68e-04 3.23e-02 NA NA
5. P Q5UNY3 Uncharacterized protein L729 NA 6.94e-03 NA NA
5. P O68966 Allophycocyanin subunit alpha-B 5.74e-04 3.58e-02 NA NA
5. P Q6CQ02 Increased recombination centers protein 19 2.09e-03 2.29e-03 NA NA
5. P Q3ZBK5 Tumor necrosis factor alpha-induced protein 8-like protein 2 7.90e-05 3.95e-07 NA NA
5. P Q1XDS1 Allophycocyanin subunit beta-18 2.98e-04 1.20e-02 NA NA
5. P P21068 Protein A49 NA 4.78e-02 NA NA
5. P Q2FGX8 UPF0302 protein SAUSA300_1353 4.71e-03 1.80e-02 NA NA
5. P Q5UQ05 Uncharacterized protein R790 NA 3.67e-02 NA NA
5. P Q9WYT0 Flavin-dependent thymidylate synthase 2.64e-02 1.01e-03 NA NA
5. P P0A227 Protein MxiK 3.56e-02 2.87e-02 NA NA
5. P Q10012 Uncharacterized protein T19C3.6 9.82e-06 3.69e-03 NA NA
5. P B4UT01 Tumor necrosis factor alpha-induced protein 8-like protein 2 1.99e-04 1.52e-03 NA NA
5. P Q5UPY9 Uncharacterized protein R304 NA 3.18e-02 NA NA
5. P P0A1U4 Uncharacterized protein YjaG 4.72e-03 1.23e-03 NA NA
5. P P0A228 Protein MxiK 7.68e-03 2.87e-02 NA NA
5. P A0A3T2V133 Cysteine S-methyltransferase OspZ 1.48e-02 1.73e-03 NA NA
5. P A0E513 Ubiquinone biosynthesis protein COQ4 homolog 2, mitochondrial 9.69e-03 3.72e-03 NA NA
5. P A6QH13 UPF0302 protein NWMN_1373 4.78e-03 1.80e-02 NA NA
5. P Q5HFW1 UPF0302 protein SACOL1502 4.95e-03 1.80e-02 NA NA
5. P Q8WVP5 Tumor necrosis factor alpha-induced protein 8-like protein 1 6.38e-05 4.62e-07 NA NA
5. P Q93TM8 Phycoerythrobilin:ferredoxin oxidoreductase 1.07e-02 1.48e-04 NA NA
5. P Q2FYH3 UPF0302 protein SAOUHSC_01479 4.66e-03 3.21e-02 NA NA
5. P Q6AYJ8 Tumor necrosis factor alpha-induced protein 8-like protein 2 1.69e-04 3.02e-02 NA NA
5. P P0DSQ8 Protein A49 NA 1.72e-02 NA NA
5. P O67553 Uncharacterized protein aq_1631 9.61e-06 1.48e-04 NA NA