Summary
The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.
AVX54861.1
JCVISYN3A_0592
Uncharacterized protein.
M. mycoides homolog: Q6MSW5.
TIGRfam Classification: NA.
Category: Quasiessential.
Statistics
Total GO Annotation: 35
Unique PROST Go: 1
Unique BLAST Go: 34
Unique Foldseek Go: 0
Total Homologs: 29
Unique PROST Homologs: 23
Unique BLAST Homologs: 4
Unique Foldseek Homologs: 0
Structures and Sequence Alignment
The best structural homolog that predicted by 5. P was
Q4UMY2
(DNA recombination protein RmuC homolog) with a FATCAT P-Value: 2.06e-11 and RMSD of 2.80 angstrom. The sequence alignment identity is 25.1%.
Structural alignment shown in left. Query protein AVX54861.1 colored as red in alignment, homolog Q4UMY2 colored as blue.
Query protein AVX54861.1 is also shown in right top, homolog Q4UMY2 showed in right bottom. They are colored based on secondary structures.
AVX54861.1 MSD-LKAT-NKILIEKLENNKKEFLKDLDNNKKIW---ETSSDKKIQELKTELLKNNKKEFEQLISQKLELESNIKLLNEQ----LNKQEELIKLQLENQ 91 Q4UMY2 MPYLLPITAAALLI--L-------LALI-----IWFYVKTKT------FKTQL------QF--LSEQNLEISNNNQLLNQEKIGCLQKIEQL-KCKVEYQ 71 AVX54861.1 YIALLNKQK---ENF---EQQINQL-KDELTKNTYEL---ENNNWKHKTELTE-IITTKNNKIN-----------ELEKDLEIVKREKLTKNIKLVGEEL 169 Q4UMY2 EQTIKDSEKIREESFSSAKAALFDLGKD-LSKQLIEIHKMENN---AARELAEKNIATASGKFNSEFERLITMVGALNKDIE---QSKGT--VDLIKQSL 162 AVX54861.1 ENYCLNQFNEASMFAFKTSTLIKDNIVIKNEDDLKGTKG--DFIFKVY----AEENK---QNLL-L---SVMC-EMK------SEQLNSHNKKKNSD-HY 248 Q4UMY2 ----LSPIG-AGLLA-EI-TL--ENI-LKS----SGLRPNLDFIMQ-YGLTTTDSGKLRPDALIFLPSGNLMVIDSKASKFLVDEQDNSGNLSKTMNYHL 247 AVX54861.1 KKLDDDRNKKNLDYA--LLVSELEYDTNDSLIYRVNDYKDM-F--VIRPMYFISFLGVLE-TIALKYKDLK-LNKLQQEIMFKE-KQDILN--EFEEFKN 338 Q4UMY2 KSL---ANK---DYAENIL-------TN------LNK-KDQNFNNVITLM-FLPTEQAVEKVIA---ADPEFLQKAWSCNIFPVGPAGLMNMLSFAKF-- 321 AVX54861.1 NLLDNALKHIDTKVNEINKSAENIK---KEANKILET--T------ELVINKHLNTVKN--K----IN-NF----K-IEKV-LES--------------- 399 Q4UMY2 QITD----H---------RRSENYKVIIEEVRKLLSSIGTMADYSQKIGNNLH-NMVTNYDKFAASFNRNFMSRVKNIHKLGIDSGNKAMPAALERYQIV 407 AVX54861.1 --------------------- 399 Q4UMY2 SSKSEIIEVEAENPPQIEEKL 428
Go Annotations
1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.
| Source | GO | Description |
|---|---|---|
| 5. P | GO:0006310 | DNA recombination |
| 7. B | GO:0009888 | tissue development |
| 7. B | GO:0003682 | chromatin binding |
| 7. B | GO:0043197 | dendritic spine |
| 7. B | GO:0050775 | positive regulation of dendrite morphogenesis |
| 7. B | GO:1990837 | sequence-specific double-stranded DNA binding |
| 7. B | GO:0009887 | animal organ morphogenesis |
| 7. B | GO:0042491 | inner ear auditory receptor cell differentiation |
| 7. B | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| 7. B | GO:0006357 | regulation of transcription by RNA polymerase II |
| 7. B | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| 7. B | GO:0014037 | Schwann cell differentiation |
| 7. B | GO:0005201 | extracellular matrix structural constituent |
| 7. B | GO:0007517 | muscle organ development |
| 7. B | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| 7. B | GO:0030334 | regulation of cell migration |
| 7. B | GO:0062023 | collagen-containing extracellular matrix |
| 7. B | GO:0000301 | retrograde transport, vesicle recycling within Golgi |
| 7. B | GO:0007275 | multicellular organism development |
| 7. B | GO:0043005 | neuron projection |
| 7. B | GO:0000139 | Golgi membrane |
| 7. B | GO:0042383 | sarcolemma |
| 7. B | GO:0032224 | positive regulation of synaptic transmission, cholinergic |
| 7. B | GO:0045995 | regulation of embryonic development |
| 7. B | GO:0035633 | maintenance of blood-brain barrier |
| 7. B | GO:0031594 | neuromuscular junction |
| 7. B | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| 7. B | GO:0043565 | sequence-specific DNA binding |
| 7. B | GO:0005604 | basement membrane |
| 7. B | GO:0001822 | kidney development |
| 7. B | GO:0030674 | protein-macromolecule adaptor activity |
| 7. B | GO:0030155 | regulation of cell adhesion |
| 7. B | GO:0007411 | axon guidance |
| 7. B | GO:0043083 | synaptic cleft |
| 7. B | GO:0030324 | lung development |
Uniprot GO Annotations
| GO | Description |
|---|---|
| GO:0016020 | membrane |
| GO:0016021 | integral component of membrane |
Homologs
1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.
| Source | Homolog | Description | Fatcat Pvalue | PROST Evalue | BLAST Evalue | Foldseek TMScore |
|---|---|---|---|---|---|---|
| 1. PBF | P47394 | Uncharacterized protein MG148 | 2.22e-16 | 7.62e-46 | 6.77e-24 | 0.4572 |
| 1. PBF | P75584 | Uncharacterized protein MG148 homolog | 0.00e+00 | 3.56e-27 | 5.43e-17 | 0.363 |
| 5. P | Q9REQ3 | DNA recombination protein RmuC homolog | 2.51e-09 | 3.79e-15 | NA | NA |
| 5. P | Q8ZAL8 | DNA recombination protein RmuC homolog | 1.29e-07 | 5.34e-16 | NA | NA |
| 5. P | Q87AZ9 | DNA recombination protein RmuC homolog | 1.36e-09 | 4.68e-12 | NA | NA |
| 5. P | Q9CLG7 | DNA recombination protein RmuC homolog | 5.49e-08 | 3.92e-22 | NA | NA |
| 5. P | Q9I4U3 | DNA recombination protein RmuC homolog | 7.29e-10 | 5.67e-18 | NA | NA |
| 5. P | P44733 | DNA recombination protein RmuC homolog | 2.33e-08 | 7.41e-20 | NA | NA |
| 5. P | Q9PG89 | DNA recombination protein RmuC homolog | 1.62e-09 | 3.22e-12 | NA | NA |
| 5. P | Q9PL95 | DNA recombination protein RmuC homolog | 1.80e-08 | 5.48e-07 | NA | NA |
| 5. P | Q92GR5 | DNA recombination protein RmuC homolog | 2.50e-09 | 4.47e-14 | NA | NA |
| 5. P | Q4UMY2 | DNA recombination protein RmuC homolog | 2.06e-11 | 1.09e-14 | NA | NA |
| 5. P | O84832 | DNA recombination protein RmuC homolog | 6.64e-08 | 8.81e-07 | NA | NA |
| 5. P | Q1RJ81 | DNA recombination protein RmuC homolog | 8.08e-08 | 4.33e-14 | NA | NA |
| 5. P | Q9Z6S7 | DNA recombination protein RmuC homolog | 4.72e-10 | 2.20e-07 | NA | NA |
| 5. P | P0AG71 | DNA recombination protein RmuC | 4.81e-08 | 4.27e-16 | NA | NA |
| 5. P | P0A2B7 | DNA recombination protein RmuC | 1.32e-07 | 2.49e-17 | NA | NA |
| 5. P | P0AG72 | DNA recombination protein RmuC | 8.09e-08 | 4.27e-16 | NA | NA |
| 5. P | P0AG73 | DNA recombination protein RmuC | 6.61e-08 | 4.27e-16 | NA | NA |
| 5. P | Q9KVQ7 | DNA recombination protein RmuC homolog | 3.31e-08 | 4.68e-14 | NA | NA |
| 5. P | Q9JXH2 | DNA recombination protein RmuC homolog | 1.56e-08 | 3.87e-05 | NA | NA |
| 5. P | Q68W48 | DNA recombination protein RmuC homolog | 1.16e-07 | 6.03e-13 | NA | NA |
| 5. P | Q9ZCN3 | DNA recombination protein RmuC homolog | 1.07e-10 | 2.52e-12 | NA | NA |
| 5. P | P0A2B8 | DNA recombination protein RmuC | 4.97e-08 | 2.49e-17 | NA | NA |
| 5. P | Q9JWG3 | DNA recombination protein RmuC homolog | 7.02e-08 | 3.75e-05 | NA | NA |
| 7. B | P24043 | Laminin subunit alpha-2 | NA | NA | 0.029 | NA |
| 7. B | P53565 | Homeobox protein cut-like 1 | 1.14e-02 | NA | 0.026 | NA |
| 7. B | P39880 | Homeobox protein cut-like 1 | 4.66e-03 | NA | 0.020 | NA |
| 7. B | P53564 | Homeobox protein cut-like 1 | 5.39e-03 | NA | 0.026 | NA |