Summary
The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.
AVX54871.1
JCVISYN3A_0609
Chromosome replication initiation protein.
M. mycoides homolog: Q6MST8.
TIGRfam Classification: 3=Putative.
Category: Essential.
Statistics
Total GO Annotation: 14
Unique PROST Go: 12
Unique BLAST Go: 0
Unique Foldseek Go: 0
Total Homologs: 40
Unique PROST Homologs: 37
Unique BLAST Homologs: 0
Unique Foldseek Homologs: 0
Structures and Sequence Alignment
The best structural homolog that predicted by 1. PBF was
P07908
(Replication initiation and membrane attachment protein) with a FATCAT P-Value: 9.3e-10 and RMSD of 2.65 angstrom. The sequence alignment identity is 23.6%.
Structural alignment shown in left. Query protein AVX54871.1 colored as red in alignment, homolog P07908 colored as blue.
Query protein AVX54871.1 is also shown in right top, homolog P07908 showed in right bottom. They are colored based on secondary structures.
AVX54871.1 -------------MLSKNFSYSVSLNFELDQEQYKSLTCLYQPLISAQAISLYLTLIQEVRISNILKEEALES--KRLLNITNFSYKELIKTLDL----L 81 P07908 MADYWKDVLPVDPYVVKSRSM---LQ-DIDR---QIITQLYQPLIGPVAFSLYMTLWGELE-QNRL--WGGESTHRQLMGMTQSN----LKTIHQEQGKL 86 AVX54871.1 NAFKLIKVYVKKSD--YSLIKFEILAPLKSDEFFNHTYLNNLLLNKL-------------------EANDYEITK-F-----MLV-NETKIN-----T-- 146 P07908 EGIGLLKVYMKESERQERLFIYELLPPLRPNEFFEDGMLNVFLYNRVGKTKYQQLKQFFTHPAISEDAKD--ITRPFNHAFESLQPSEWKLTSDMEETVR 184 AVX54871.1 ----NQYQQIVVD----LT-DIYDQSL-IADINIFDTEV------NNF-NTYLKKLNQLINVDYVLNSLKDKDIDLDFIQQSTLKSLYDLLT---IKKLS 226 P07908 LAEGSEYTSVGQSPSYTITEDVFDFDLFLAGLS--ETMIPRKAMTQQVRDT-IKKLSYLYGID----PLQMQNVVMSAIDER------DVITTEALRKAA 271 AVX54871.1 EDQIIYLI-TNSY--DFINKNIDINIFK--------KL---LINLITKKETNFDNKELL-DLINQTTWSEYSKKKYDIDLSSYTTVFENIKQNYCLSNGI 311 P07908 SDW--YQIERNGQLPDLVEKTQPVHLREGEQPAEEDSLDGKLIALL---EA-ISPKKLLQDIADGT---EPSKA--DLKIIEE-IMFEQ-K----LEPGV 354 AVX54871.1 INCLI-------DFSYKKNNGQIIVKYIAKIAKTLFDKNINT---TLKV-----MQFL-----KNIQSKSINY---------NY----ETMFDSNDFN-- 376 P07908 TNVLIYYVMLKTDMKLSKN-------YIQKIASHWARKKVKTVREAMKLAIEENRQYLEWAEGKTKSSKR-NQKVIREEKLPDWMTEKETASDSESGQQK 446 AVX54871.1 LQTEAIFEFSEEELKCLV------------ 394 P07908 LHPQDL----EEQKKKMMEEMQKLKKYSAY 472
Go Annotations
1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.
| Source | GO | Description |
|---|---|---|
| 1. PBF | GO:0006269 | DNA replication, synthesis of RNA primer |
| 1. PBF | GO:1990077 | primosome complex |
| 5. P | GO:0006260 | DNA replication |
| 5. P | GO:0000984 | |
| 5. P | GO:0005509 | calcium ion binding |
| 5. P | GO:0039686 | bidirectional double-stranded viral DNA replication |
| 5. P | GO:0010124 | phenylacetate catabolic process |
| 5. P | GO:0005737 | cytoplasm |
| 5. P | GO:0030261 | chromosome condensation |
| 5. P | GO:0007049 | cell cycle |
| 5. P | GO:2000143 | negative regulation of DNA-templated transcription, initiation |
| 5. P | GO:0051301 | cell division |
| 5. P | GO:0009295 | nucleoid |
| 5. P | GO:0007059 | chromosome segregation |
Uniprot GO Annotations
| GO | Description |
|---|
Homologs
1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.
| Source | Homolog | Description | Fatcat Pvalue | PROST Evalue | BLAST Evalue | Foldseek TMScore |
|---|---|---|---|---|---|---|
| 1. PBF | P47591 | Uncharacterized protein MG349 | 2.57e-10 | 1.03e-38 | 4.58e-04 | 0.3473 |
| 1. PBF | P07908 | Replication initiation and membrane attachment protein | 9.30e-10 | 2.96e-28 | 4.81e-10 | 0.3141 |
| 2. PF | P75253 | Uncharacterized protein MG349 homolog | 7.04e-11 | 4.53e-35 | NA | 0.3667 |
| 5. P | B7VMH0 | Chromosome partition protein MukF | 2.88e-02 | 5.64e-03 | NA | NA |
| 5. P | A7ZYM4 | Chromosome partition protein MukF | 1.49e-02 | 3.31e-02 | NA | NA |
| 5. P | Q32E42 | Chromosome partition protein MukF | 1.50e-02 | 3.62e-02 | NA | NA |
| 5. P | P19654 | Replication protein repL | NA | 6.18e-03 | NA | NA |
| 5. P | B1IW09 | Chromosome partition protein MukF | 2.98e-02 | 3.37e-02 | NA | NA |
| 5. P | P45909 | Uncharacterized protein YqaL | 3.50e-02 | 5.87e-04 | NA | NA |
| 5. P | C4ZQ48 | Chromosome partition protein MukF | 1.32e-02 | 3.62e-02 | NA | NA |
| 5. P | A5F7I0 | Chromosome partition protein MukF | 2.88e-02 | 2.21e-02 | NA | NA |
| 5. P | P17212 | 41 kDa protein | 2.66e-03 | 1.11e-04 | NA | NA |
| 5. P | P60293 | Chromosome partition protein MukF | 1.51e-02 | 3.62e-02 | NA | NA |
| 5. P | P39787 | DNA replication protein DnaD | 2.73e-03 | 1.97e-04 | NA | NA |
| 5. P | P14815 | Replication protein 15 | NA | 1.31e-04 | NA | NA |
| 5. P | O67744 | Uncharacterized protein aq_1909 | 9.71e-03 | 4.12e-02 | NA | NA |
| 5. P | B1X8M6 | Chromosome partition protein MukF | 3.00e-02 | 3.62e-02 | NA | NA |
| 5. P | P76086 | Transcriptional repressor PaaX | 3.24e-02 | 4.15e-04 | NA | NA |
| 5. P | B7LN84 | Chromosome partition protein MukF | 3.08e-02 | 3.81e-02 | NA | NA |
| 5. P | B6I8Z4 | Chromosome partition protein MukF | 1.78e-02 | 3.62e-02 | NA | NA |
| 5. P | A7MEU5 | Chromosome partition protein MukF | 3.16e-02 | 2.80e-02 | NA | NA |
| 5. P | P39781 | Phage-like element PBSX protein XkdB | 1.98e-02 | 5.38e-09 | NA | NA |
| 5. P | B2TUF7 | Chromosome partition protein MukF | 3.18e-02 | 2.11e-02 | NA | NA |
| 5. P | C3LN39 | Chromosome partition protein MukF | 1.06e-02 | 2.90e-02 | NA | NA |
| 5. P | P05684 | Putative replication protein C | 2.21e-03 | 4.83e-07 | NA | NA |
| 5. P | A7ZK12 | Chromosome partition protein MukF | 3.08e-02 | 3.62e-02 | NA | NA |
| 5. P | P60294 | Chromosome partition protein MukF | 3.15e-02 | 3.62e-02 | NA | NA |
| 5. P | Q9KRC6 | Chromosome partition protein MukF | 2.84e-02 | 2.90e-02 | NA | NA |
| 5. P | B7M851 | Chromosome partition protein MukF | 1.75e-02 | 3.62e-02 | NA | NA |
| 5. P | P13962 | Protein RepA | 4.01e-02 | 9.30e-07 | NA | NA |
| 5. P | B7NM52 | Chromosome partition protein MukF | 1.76e-02 | 3.62e-02 | NA | NA |
| 5. P | B7N389 | Chromosome partition protein MukF | 1.85e-02 | 3.62e-02 | NA | NA |
| 5. P | P03688 | Replication protein O | NA | 7.23e-03 | NA | NA |
| 5. P | Q0T6C0 | Chromosome partition protein MukF | 1.69e-02 | 3.62e-02 | NA | NA |
| 5. P | B7LE21 | Chromosome partition protein MukF | 1.80e-02 | 3.62e-02 | NA | NA |
| 5. P | B1LJU1 | Chromosome partition protein MukF | 3.77e-02 | 3.62e-02 | NA | NA |
| 5. P | A9MHW1 | Chromosome partition protein MukF | 3.07e-02 | 4.27e-02 | NA | NA |
| 5. P | Q3Z3J9 | Chromosome partition protein MukF | 1.01e-02 | 3.62e-02 | NA | NA |
| 5. P | Q925X2 | Uncharacterized phage-related protein Lin1244/Lin1753 | 6.63e-03 | 1.24e-08 | NA | NA |
| 5. P | P55391 | Putative replication protein C | 5.27e-03 | 5.08e-08 | NA | NA |