Summary
The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.
AVX54878.1
JCVISYN3A_0616
Fatty acid binding protein.
M. mycoides homolog: Q6MST0.
TIGRfam Classification: 3=Putative.
Category: Essential.
Statistics
Total GO Annotation: 24
Unique PROST Go: 5
Unique BLAST Go: 14
Unique Foldseek Go: 4
Total Homologs: 127
Unique PROST Homologs: 31
Unique BLAST Homologs: 4
Unique Foldseek Homologs: 13
Structures and Sequence Alignment
The best structural homolog that predicted by 1. PBF was
Q97QT7
(DegV domain-containing protein SP_1112) with a FATCAT P-Value: 0 and RMSD of 3.15 angstrom. The sequence alignment identity is 31.1%.
Structural alignment shown in left. Query protein AVX54878.1 colored as red in alignment, homolog Q97QT7 colored as blue.
Query protein AVX54878.1 is also shown in right top, homolog Q97QT7 showed in right bottom. They are colored based on secondary structures.
AVX54878.1 MVNIKIAVLTDSS--FDGRVSDYKDLYVIPL--MIVTQDNQTYYDDENLSKD--KFYNLLN-SQVL-KTSQTTP-GDMLQMWDDLLTKYD--QVIFLPIS 89 Q97QT7 MTKIKI--VTDSSVTIEPELVKQLDITIVPLSVMI---DN-VVYSDADL-KEEGKFLQLMQESKNLPKTSQ-PPVGVFAEIFED-LCK-DGGQILAIHMS 90 AVX54878.1 KGLSGQYNTFKMLQQ-----TEEKYENKVFVCDTSAVSVIMQEVVNKVFDWIKQNKTANEICD---LVSYLA---NDFVTYIIPKNLDTLKQGGRISPAA 178 Q97QT7 HALSG---TVEAARQGASLSTAD-----VTVVDSSFTD---QAL--K-FQVVEAAKLAQEGKDMEAILSHVEEVKNHTELYIGVSTLENLVKGGRISRVT 176 AVX54878.1 AALAKILKITPILKY-DGSID---K-QSTARTFKKALKEALSLLKE-EIKDLKTIDISYSRTDEKTLELIETIIKEEQLEIRLK--SEL-T-NVIASHTG 268 Q97QT7 GLLSSLLNIRAVMQMKDHELQPMVKGRGT-KTFKKWLDELITSLSERAVAE---IGISYSGSDDWAKEMKESL--QAYVE---KPISVLETGSIIQTHTG 267 AVX54878.1 TDTVA-LVGWKK 279 Q97QT7 ENAWAILIRYHS 279
Go Annotations
1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.
| Source | GO | Description |
|---|---|---|
| 1. PBF | GO:0008289 | lipid binding |
| 5. P | GO:0047661 | amino-acid racemase activity |
| 5. P | GO:0009252 | peptidoglycan biosynthetic process |
| 5. P | GO:0071555 | cell wall organization |
| 5. P | GO:0008881 | glutamate racemase activity |
| 5. P | GO:0008360 | regulation of cell shape |
| 6. F | GO:0019563 | glycerol catabolic process |
| 6. F | GO:0047324 | phosphoenolpyruvate-glycerone phosphotransferase activity |
| 6. F | GO:0006071 | glycerol metabolic process |
| 6. F | GO:0004371 | glycerone kinase activity |
| 7. B | GO:0030216 | keratinocyte differentiation |
| 7. B | GO:0031424 | keratinization |
| 7. B | GO:0035315 | hair cell differentiation |
| 7. B | GO:0008544 | epidermis development |
| 7. B | GO:0043588 | skin development |
| 7. B | GO:0005509 | calcium ion binding |
| 7. B | GO:0043163 | cell envelope organization |
| 7. B | GO:0018149 | peptide cross-linking |
| 7. B | GO:0005198 | structural molecule activity |
| 7. B | GO:0003824 | catalytic activity |
| 7. B | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| 7. B | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity |
| 7. B | GO:0001533 | cornified envelope |
| 7. B | GO:0032991 | protein-containing complex |
Uniprot GO Annotations
| GO | Description |
|---|---|
| GO:0008289 | lipid binding |
Homologs
1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.
| Source | Homolog | Description | Fatcat Pvalue | PROST Evalue | BLAST Evalue | Foldseek TMScore |
|---|---|---|---|---|---|---|
| 1. PBF | P0DA55 | DegV domain-containing protein SPs0713 | 0.00e+00 | 2.02e-50 | 2.40e-09 | 0.8213 |
| 1. PBF | Q5XCN8 | DegV domain-containing protein M6_Spy0690 | 0.00e+00 | 4.09e-48 | 4.07e-23 | 0.8706 |
| 1. PBF | Q98QK2 | DegV domain-containing protein MYPU_3590 | 0.00e+00 | 4.03e-40 | 1.55e-24 | 0.8301 |
| 1. PBF | Q97E32 | DegV domain-containing protein CA_C3284 | 0.00e+00 | 5.29e-37 | 1.03e-08 | 0.8504 |
| 1. PBF | Q9CI68 | DegV domain-containing protein YejH | 0.00e+00 | 3.13e-45 | 6.25e-07 | 0.8134 |
| 1. PBF | Q9A0A6 | DegV domain-containing protein SPy_0865/M5005_Spy0672 | 0.00e+00 | 4.50e-49 | 2.26e-22 | 0.8712 |
| 1. PBF | Q5HHS1 | DegV domain-containing protein SACOL0812 | 0.00e+00 | 1.01e-42 | 6.87e-14 | 0.8501 |
| 1. PBF | Q8XKT3 | DegV domain-containing protein CPE1310 | 0.00e+00 | 4.17e-45 | 1.81e-07 | 0.8704 |
| 1. PBF | P0DA58 | DegV domain-containing protein SpyM3_1667 | 0.00e+00 | 7.02e-37 | 6.52e-10 | 0.8577 |
| 1. PBF | Q97QT7 | DegV domain-containing protein SP_1112 | 0.00e+00 | 1.92e-44 | 1.03e-13 | 0.8158 |
| 1. PBF | P0A0N1 | DegV domain-containing protein SA0704 | 0.00e+00 | 1.31e-42 | 6.11e-14 | 0.8651 |
| 1. PBF | Q6GB81 | DegV domain-containing protein SAS0714 | 0.00e+00 | 1.01e-42 | 6.87e-14 | 0.8495 |
| 1. PBF | P75312 | DegV domain-containing protein MG326 homolog | 0.00e+00 | 5.42e-51 | 1.56e-28 | 0.8905 |
| 1. PBF | Q8DP17 | DegV domain-containing protein spr1415 | 0.00e+00 | 1.72e-48 | 2.49e-20 | 0.8527 |
| 1. PBF | P0DA54 | DegV domain-containing protein SpyM3_1149 | 0.00e+00 | 2.02e-50 | 2.40e-09 | 0.8178 |
| 1. PBF | Q9RDL7 | DegV domain-containing protein SCO2569 | 0.00e+00 | 2.65e-41 | 2.51e-05 | 0.8482 |
| 1. PBF | Q6G9D6 | DegV domain-containing protein SAS1368 | 0.00e+00 | 2.08e-40 | 1.61e-19 | 0.856 |
| 1. PBF | Q6GIP2 | DegV domain-containing protein SAR0803 | 0.00e+00 | 1.01e-42 | 6.87e-14 | 0.8502 |
| 1. PBF | P47568 | DegV domain-containing protein MG326 | 0.00e+00 | 2.19e-49 | 2.01e-24 | 0.8821 |
| 1. PBF | Q5X9X0 | DegV domain-containing protein M6_Spy1658 | 0.00e+00 | 4.90e-38 | 2.45e-10 | 0.8615 |
| 1. PBF | Q9CFB9 | DegV domain-containing protein YqaC | 0.00e+00 | 5.42e-51 | 5.74e-17 | 0.8323 |
| 1. PBF | Q9RSY3 | DegV domain-containing protein DR_1986 | 0.00e+00 | 3.65e-44 | 1.26e-08 | 0.8601 |
| 1. PBF | Q9CEH0 | DegV domain-containing protein YteA | 0.00e+00 | 2.63e-38 | 6.75e-13 | 0.8469 |
| 1. PBF | Q6GGY2 | DegV domain-containing protein SAR1438 | 0.00e+00 | 9.16e-41 | 5.77e-19 | 0.8709 |
| 1. PBF | Q97IL6 | DegV domain-containing protein CA_C1624 | 0.00e+00 | 5.34e-52 | 1.54e-20 | 0.8563 |
| 1. PBF | Q9RX15 | DegV domain-containing protein DR_0500 | 0.00e+00 | 5.79e-47 | 3.78e-06 | 0.8278 |
| 1. PBF | Q92AE5 | DegV domain-containing protein lin1977 | 0.00e+00 | 4.63e-50 | 7.30e-09 | 0.8217 |
| 1. PBF | Q5HFZ8 | DegV domain-containing protein SACOL1460 | 0.00e+00 | 2.08e-40 | 1.61e-19 | 0.8615 |
| 1. PBF | P32436 | Protein DegV | 0.00e+00 | 1.81e-42 | 6.82e-14 | 0.8416 |
| 1. PBF | Q8XNM9 | DegV domain-containing protein CPE0304 | 0.00e+00 | 5.76e-43 | 3.21e-12 | 0.8585 |
| 1. PBF | P67373 | DegV domain-containing protein spyM18_1511 | 0.00e+00 | 6.98e-51 | 2.49e-09 | 0.8209 |
| 1. PBF | Q98PF7 | DegV domain-containing protein MYPU_7660 | 0.00e+00 | 5.92e-49 | 5.84e-12 | 0.8774 |
| 1. PBF | P0DA52 | DegV domain-containing protein SpyM3_0586 | 0.00e+00 | 6.53e-48 | 1.32e-22 | 0.8717 |
| 1. PBF | P47688 | DegV domain-containing protein MG450 | 0.00e+00 | 5.02e-46 | 1.42e-10 | 0.8863 |
| 1. PBF | Q97KH1 | DegV domain-containing protein CA_C0948 | 0.00e+00 | 5.38e-50 | 1.45e-15 | 0.8581 |
| 1. PBF | P0DA59 | DegV domain-containing protein SPs1668 | 0.00e+00 | 7.02e-37 | 6.52e-10 | 0.856 |
| 1. PBF | Q5XB32 | DegV domain-containing protein M6_Spy1246 | 0.00e+00 | 6.98e-51 | 2.49e-09 | 0.8172 |
| 1. PBF | P0DA53 | DegV domain-containing protein SPs1267 | 0.00e+00 | 6.53e-48 | 1.32e-22 | 0.8715 |
| 1. PBF | Q9X1H9 | Fatty acid-binding protein TM_1468 | 0.00e+00 | 1.71e-44 | 3.78e-10 | 0.8288 |
| 1. PBF | Q97PP6 | DegV domain-containing protein SP_1557 | 0.00e+00 | 3.73e-47 | 1.53e-20 | 0.8561 |
| 1. PBF | Q8XPD7 | DegV domain-containing protein CPE0026 | 0.00e+00 | 2.68e-40 | 8.48e-21 | 0.836 |
| 1. PBF | P70945 | DegV domain-containing protein YitS | 0.00e+00 | 3.44e-43 | 3.43e-16 | 0.8694 |
| 1. PBF | P75127 | DegV domain-containing protein MG450 homolog | 0.00e+00 | 4.58e-42 | 1.62e-14 | 0.878 |
| 1. PBF | Q8NXM4 | DegV domain-containing protein MW0711 | 0.00e+00 | 1.01e-42 | 6.87e-14 | 0.8507 |
| 1. PBF | Q8DPT4 | DegV domain-containing protein spr1019 | 0.00e+00 | 1.49e-50 | 2.81e-13 | 0.8187 |
| 1. PBF | P0A0N2 | DegV domain-containing protein | 0.00e+00 | 1.31e-42 | 6.11e-14 | 0.8651 |
| 1. PBF | Q8P1E4 | DegV domain-containing protein spyM18_0926 | 0.00e+00 | 4.09e-48 | 4.07e-23 | 0.8708 |
| 1. PBF | Q927X9 | DegV domain-containing protein lin2658 | 0.00e+00 | 1.65e-42 | 2.94e-15 | 0.8609 |
| 1. PBF | P67374 | DegV domain-containing protein SPy_1936/M5005_Spy1650 | 0.00e+00 | 4.90e-38 | 2.45e-10 | 0.8616 |
| 1. PBF | P67372 | DegV domain-containing protein SPy_1493/M5005_Spy1226 | 0.00e+00 | 6.98e-51 | 2.49e-09 | 0.8206 |
| 1. PBF | Q8Y4D5 | DegV domain-containing protein lmo2514 | 0.00e+00 | 2.27e-44 | 1.93e-16 | 0.8699 |
| 1. PBF | Q8XHH5 | DegV domain-containing protein CPE2509 | 0.00e+00 | 5.40e-46 | 2.50e-20 | 0.851 |
| 1. PBF | P67375 | DegV domain-containing protein spyM18_2003 | 0.00e+00 | 4.90e-38 | 2.45e-10 | 0.8594 |
| 1. PBF | P67370 | DegV domain-containing protein SAV1425 | 0.00e+00 | 3.50e-41 | 1.53e-19 | 0.8556 |
| 1. PBF | Q9PPV5 | DegV domain-containing protein UU535 | 0.00e+00 | 1.61e-46 | 1.85e-16 | 0.8807 |
| 1. PBF | Q8Y637 | DegV domain-containing protein lmo1863 | 0.00e+00 | 3.60e-50 | 1.25e-08 | 0.8215 |
| 1. PBF | P0A0N0 | DegV domain-containing protein SAV0749 | 0.00e+00 | 1.31e-42 | 6.11e-14 | 0.865 |
| 1. PBF | Q9K6U8 | DegV domain-containing protein BH3627 | 0.00e+00 | 5.40e-46 | 9.79e-11 | 0.8378 |
| 1. PBF | P67371 | DegV domain-containing protein SA1258 | 0.00e+00 | 3.50e-41 | 1.53e-19 | 0.8642 |
| 1. PBF | Q8NWR0 | DegV domain-containing protein MW1315 | 0.00e+00 | 2.08e-40 | 1.61e-19 | 0.8571 |
| 1. PBF | Q8R9U5 | DegV domain-containing protein TTE1491 | 0.00e+00 | 4.10e-51 | 3.52e-18 | 0.865 |
| 1. PBF | Q97L61 | DegV domain-containing protein CA_C0701 | 0.00e+00 | 8.55e-47 | 3.21e-09 | 0.8453 |
| 2. PF | P67369 | DegV domain-containing protein Mb2440c | 0.00e+00 | 8.37e-43 | NA | 0.8271 |
| 2. PF | Q9RT62 | DegV domain-containing protein DR_1903 | 0.00e+00 | 2.82e-42 | NA | 0.8432 |
| 2. PF | Q8NN60 | DegV domain-containing protein Cgl2349/cg2579 | 0.00e+00 | 9.99e-28 | NA | 0.7347 |
| 2. PF | P0DA57 | DegV domain-containing protein SPs0389 | 0.00e+00 | 3.36e-40 | NA | 0.7971 |
| 2. PF | Q8NZW1 | DegV domain-containing protein spyM18_1709 | 0.00e+00 | 5.05e-40 | NA | 0.7932 |
| 2. PF | Q8DQI6 | DegV domain-containing protein spr0652 | 0.00e+00 | 3.07e-38 | NA | 0.8234 |
| 2. PF | Q97RQ6 | DegV domain-containing protein SP_0742 | 0.00e+00 | 3.07e-38 | NA | 0.8229 |
| 2. PF | P9WP04 | DegV domain-containing protein MT2490 | 0.00e+00 | 8.37e-43 | NA | 0.8177 |
| 2. PF | Q99YH7 | DegV domain-containing protein SPy_1698/M5005_Spy1391 | 0.00e+00 | 4.12e-40 | NA | 0.7979 |
| 2. PF | Q8PGV3 | DegV domain-containing protein XAC3508 | 0.00e+00 | 5.74e-32 | NA | 0.7402 |
| 2. PF | P0DA56 | DegV domain-containing protein SpyM3_1478 | 0.00e+00 | 3.36e-40 | NA | 0.7983 |
| 2. PF | Q4L2X1 | DegV domain-containing protein | 0.00e+00 | 2.06e-34 | NA | 0.8222 |
| 2. PF | Q5XAI8 | DegV domain-containing protein M6_Spy1440 | 0.00e+00 | 3.36e-40 | NA | 0.7967 |
| 2. PF | Q8P5F9 | DegV domain-containing protein XCC3382 | 0.00e+00 | 1.67e-32 | NA | 0.7396 |
| 3. BF | Q9X1U4 | DegV domain-containing protein TM_1608 | 5.18e-14 | NA | 0.003 | 0.7881 |
| 3. BF | P13977 | DegV domain-containing 15.5 kDa protein | 1.89e-10 | NA | 2.16e-04 | 0.8423 |
| 3. BF | Q9PQV3 | DegV domain-containing protein UU190 | 0.00e+00 | NA | 6.54e-16 | 0.8621 |
| 5. P | B7MR95 | Glutamate racemase | 1.41e-01 | 2.87e-02 | NA | NA |
| 5. P | B7LA65 | Glutamate racemase | 1.42e-01 | 3.70e-02 | NA | NA |
| 5. P | P63634 | Glutamate racemase | 1.43e-01 | 3.57e-02 | NA | NA |
| 5. P | A7ZUI7 | Glutamate racemase | 1.31e-01 | 3.70e-02 | NA | NA |
| 5. P | C5A0R6 | Glutamate racemase | 1.29e-01 | 3.57e-02 | NA | NA |
| 5. P | B5QXR2 | Glutamate racemase | 1.30e-01 | 2.63e-02 | NA | NA |
| 5. P | B7M723 | Glutamate racemase | 1.41e-01 | 3.70e-02 | NA | NA |
| 5. P | P40723 | Glutamate racemase | 1.48e-01 | 2.63e-02 | NA | NA |
| 5. P | A1JI42 | Glutamate racemase | 1.46e-01 | 2.11e-02 | NA | NA |
| 5. P | B6I5I5 | Glutamate racemase | 1.37e-01 | 3.70e-02 | NA | NA |
| 5. P | P9WP05 | DegV domain-containing protein Rv2417c | 0.00e+00 | 8.37e-43 | NA | NA |
| 5. P | Q8ZAA2 | Glutamate racemase | 1.45e-01 | 3.19e-02 | NA | NA |
| 5. P | A8A775 | Glutamate racemase | 1.43e-01 | 3.70e-02 | NA | NA |
| 5. P | B1XBX8 | Glutamate racemase | 1.29e-01 | 3.57e-02 | NA | NA |
| 5. P | Q1R3U0 | Glutamate racemase | 1.42e-01 | 3.57e-02 | NA | NA |
| 5. P | P63633 | Glutamate racemase | 1.44e-01 | 3.57e-02 | NA | NA |
| 5. P | Q8Z315 | Glutamate racemase | 1.47e-01 | 2.43e-02 | NA | NA |
| 5. P | P22634 | Glutamate racemase | 1.30e-01 | 3.57e-02 | NA | NA |
| 5. P | Q5PK79 | Glutamate racemase | 1.46e-01 | 2.43e-02 | NA | NA |
| 5. P | B2VGA6 | Glutamate racemase | 1.36e-01 | 2.56e-02 | NA | NA |
| 5. P | A7FD15 | Glutamate racemase | 1.36e-01 | 3.19e-02 | NA | NA |
| 5. P | B1JQ44 | Glutamate racemase | 1.47e-01 | 3.96e-02 | NA | NA |
| 5. P | Q66G56 | Glutamate racemase | 1.38e-01 | 3.57e-02 | NA | NA |
| 5. P | B7LUM6 | Glutamate racemase | 1.38e-01 | 2.20e-02 | NA | NA |
| 5. P | B7MIA7 | Glutamate racemase | 1.44e-01 | 3.57e-02 | NA | NA |
| 5. P | B5BJP1 | Glutamate racemase | 1.47e-01 | 2.43e-02 | NA | NA |
| 5. P | B2JZF9 | Glutamate racemase | 1.48e-01 | 4.03e-02 | NA | NA |
| 5. P | Q8FB89 | Glutamate racemase | 1.37e-01 | 2.87e-02 | NA | NA |
| 5. P | B7NU33 | Glutamate racemase | 1.33e-01 | 3.63e-02 | NA | NA |
| 5. P | Q0SY24 | Glutamate racemase | 1.36e-01 | 3.57e-02 | NA | NA |
| 5. P | Q57H86 | Glutamate racemase | 1.48e-01 | 2.43e-02 | NA | NA |
| 6. F | Q927E6 | PTS-dependent dihydroxyacetone kinase 1, dihydroxyacetone-binding subunit DhaK | 8.69e-11 | NA | NA | 0.4888 |
| 6. F | Q5HGK7 | Uncharacterized protein SACOL1240 | 1.36e-07 | NA | NA | 0.4918 |
| 6. F | Q6GHK9 | Uncharacterized protein SAR1202 | 1.24e-07 | NA | NA | 0.4891 |
| 6. F | P75231 | Uncharacterized protein MG369 homolog | 1.18e-07 | NA | NA | 0.5209 |
| 6. F | Q2FHL2 | Uncharacterized protein SAUSA300_1119 | 1.64e-07 | NA | NA | 0.4991 |
| 6. F | Q6G9Y7 | Uncharacterized protein SAS1160 | 1.62e-07 | NA | NA | 0.4515 |
| 6. F | Q7A5Z4 | Uncharacterized protein SA1069 | 1.20e-07 | NA | NA | 0.4407 |
| 6. F | P47609 | Uncharacterized protein MG369 | 1.91e-07 | NA | NA | 0.5782 |
| 6. F | Q6D8V6 | L-erythrulose kinase | 1.87e-07 | NA | NA | 0.482 |
| 6. F | Q8CSV4 | Uncharacterized protein SE_0901 | 1.71e-07 | NA | NA | 0.4608 |
| 6. F | Q5HPW5 | Uncharacterized protein SERP0792 | 1.58e-07 | NA | NA | 0.4637 |
| 6. F | Q2YXJ0 | Uncharacterized protein SAB1090 | 1.49e-07 | NA | NA | 0.4421 |
| 6. F | Q99UP2 | Uncharacterized protein SAV1226 | 1.22e-07 | NA | NA | 0.4965 |
| 7. B | Q08189 | Protein-glutamine gamma-glutamyltransferase E | 7.97e-01 | NA | 4.48e-04 | NA |
| 7. B | A6QP57 | Protein-glutamine gamma-glutamyltransferase E | 7.98e-01 | NA | 1.24e-04 | NA |
| 7. B | Q96PF1 | Protein-glutamine gamma-glutamyltransferase Z | 8.53e-01 | NA | 0.008 | NA |
| 7. B | D4A5U3 | Protein-glutamine gamma-glutamyltransferase E | 8.91e-01 | NA | 0.007 | NA |