Summary

The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.

AVX54880.1
JCVISYN3A_0620

Uncharacterized transcriptional regulator.
M. mycoides homolog: Q6MSS8.
TIGRfam Classification: 2=Generic.
Category: Nonessential.

Statistics

Total GO Annotation: 29
Unique PROST Go: 10
Unique BLAST Go: 0
Unique Foldseek Go: 0

Total Homologs: 171
Unique PROST Homologs: 97
Unique BLAST Homologs: 0
Unique Foldseek Homologs: 0

Literature

Danchin and Fang [1]: control of zinc transport, sensitivity to reactive oxygen species|similar to Zur and PerR
Yang and Tsui [2]: Ferric uptake regulation protein
Antczak et al. [3]: Fur family protein
Zhang et al. [4]: GO:0000035|acyl binding
Bianchi et al. [5]: "Transcriptional Regulator (Fur family, perR-like?)"

Structures and Sequence Alignment

The best structural homolog that predicted by 1. PBF was P54574 (Ferric uptake regulation protein) with a FATCAT P-Value: 1.78e-15 and RMSD of 2.62 angstrom. The sequence alignment identity is 27.4%.
Structural alignment shown in left. Query protein AVX54880.1 colored as red in alignment, homolog P54574 colored as blue. Query protein AVX54880.1 is also shown in right top, homolog P54574 showed in right bottom. They are colored based on secondary structures.

  AVX54880.1 MIHLSKTQQTKYKQIVEKLKLKKI-----RLTDIRSIVIKMLIVS--DHLTIQQI-INNLESEIN-NINVMSVYNTIDLL--LKEHIVFANTFN-GKD-I 87
      P54574 -----------MENRIDRIK-KQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVYL--LVKEKSPEIGLATVYRTLELLTELK--VV--DKINFG-DGV 81

  AVX54880.1 S-YEI----AADKSVHLKCDDCLKVIHLDDKSIENYHFLELL-DLCE------KNGIKLSHFKIEGHGYCLECSSKENK 154
      P54574 SRYDLRKEGAAHFHHHLVCMECGAV---DE--IEE----DLLEDVEEIIERDWKFKIK-DH-RLTFHGICHRCNGKETE 149

Go Annotations

1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.

Source GO Description
1. PBF GO:0000976 transcription cis-regulatory region binding
1. PBF GO:0003677 DNA binding
1. PBF GO:0008270 zinc ion binding
1. PBF GO:0045892 negative regulation of transcription, DNA-templated
1. PBF GO:0003700 DNA-binding transcription factor activity
1. PBF GO:0005737 cytoplasm
1. PBF GO:1900376 regulation of secondary metabolite biosynthetic process
1. PBF GO:0046872 metal ion binding
1. PBF GO:0045893 positive regulation of transcription, DNA-templated
1. PBF GO:0032993 protein-DNA complex
1. PBF GO:0001217 DNA-binding transcription repressor activity
1. PBF GO:1900705 negative regulation of siderophore biosynthetic process
1. PBF GO:0001216 DNA-binding transcription activator activity
2. PF GO:2000374 regulation of oxygen metabolic process
2. PF GO:0071281 cellular response to iron ion
2. PF GO:0051350 negative regulation of lyase activity
2. PF GO:2000470 positive regulation of peroxidase activity
2. PF GO:0019290 siderophore biosynthetic process
2. PF GO:1901668 regulation of superoxide dismutase activity
5. P GO:0006221 pyrimidine nucleotide biosynthetic process
5. P GO:2000144 positive regulation of DNA-templated transcription, initiation
5. P GO:0001113 transcription open complex formation at RNA polymerase II promoter
5. P GO:0009347 aspartate carbamoyltransferase complex
5. P GO:0005886 plasma membrane
5. P GO:0046914 transition metal ion binding
5. P GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
5. P GO:0046677 response to antibiotic
5. P GO:0006367 transcription initiation from RNA polymerase II promoter
5. P GO:0006355 regulation of transcription, DNA-templated

Uniprot GO Annotations

GO Description
GO:0006355 regulation of transcription, DNA-templated
GO:0003700 DNA-binding transcription factor activity

Homologs

1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.

Source Homolog Description Fatcat Pvalue PROST Evalue BLAST Evalue Foldseek TMScore
1. PBF Q2FFN4 Peroxide-responsive repressor PerR 6.55e-11 3.73e-41 1.91e-06 0.6771
1. PBF P44561 Ferric uptake regulation protein 4.43e-09 1.95e-32 2.95e-04 0.5595
1. PBF Q8FZ45 Ferric uptake regulation protein 7.14e-10 9.19e-33 0.025 0.5877
1. PBF Q49YQ6 Peroxide-responsive repressor PerR 1.82e-11 4.06e-39 4.63e-07 0.5673
1. PBF P37736 Ferric uptake regulation protein 5.61e-10 4.74e-23 0.043 0.6165
1. PBF Q6GFJ6 Peroxide-responsive repressor PerR 1.05e-10 3.73e-41 1.91e-06 0.6785
1. PBF Q83S79 Ferric uptake regulation protein 8.48e-10 1.78e-26 3.05e-05 0.5791
1. PBF P0C631 Ferric uptake regulation protein 2.66e-10 3.34e-38 1.26e-07 0.5894
1. PBF Q5HER3 Peroxide-responsive repressor PerR 5.79e-10 3.73e-41 1.91e-06 0.6792
1. PBF P0A9B1 Ferric uptake regulation protein 4.57e-10 8.62e-27 1.04e-04 0.5919
1. PBF Q9ZM26 Ferric uptake regulation protein 2.54e-11 7.79e-49 0.005 0.6338
1. PBF P71086 Peroxide operon regulator 3.71e-11 8.09e-43 4.53e-13 0.6951
1. PBF Q8CNQ7 Peroxide-responsive repressor PerR 6.59e-10 2.17e-43 4.82e-07 0.6737
1. PBF P45599 Ferric uptake regulation protein 8.97e-09 4.43e-20 6.38e-05 0.5869
1. PBF P33086 Ferric uptake regulation protein 6.87e-09 1.63e-24 0.037 0.5982
1. PBF Q5HN74 Peroxide-responsive repressor PerR 8.72e-10 2.17e-43 4.82e-07 0.6748
1. PBF P54574 Ferric uptake regulation protein 1.78e-15 1.73e-41 0.016 0.7791
1. PBF Q7A4T8 Peroxide-responsive repressor PerR 7.47e-11 1.73e-41 1.25e-06 0.6829
1. PBF P0A9B0 Ferric uptake regulation protein 8.80e-10 8.62e-27 1.04e-04 0.5764
1. PBF Q2YU25 Peroxide-responsive repressor PerR 6.83e-11 3.73e-41 1.91e-06 0.6834
1. PBF Q99T18 Peroxide-responsive repressor PerR 6.27e-10 1.73e-41 1.25e-06 0.6831
1. PBF Q7A0J4 Peroxide-responsive repressor PerR 7.52e-11 3.73e-41 1.91e-06 0.6796
1. PBF Q4L7G4 Peroxide-responsive repressor PerR 6.52e-10 1.37e-42 1.68e-08 0.6846
1. PBF A8FKI7 Ferric uptake regulation protein 2.85e-10 3.34e-38 1.26e-07 0.5937
1. PBF Q46463 Ferric uptake regulation protein 2.64e-10 5.63e-40 0.001 0.5796
1. PBF Q6G873 Peroxide-responsive repressor PerR 7.42e-10 3.73e-41 1.91e-06 0.6836
1. PBF O25671 Ferric uptake regulation protein 5.58e-11 1.07e-48 3.56e-04 0.6264
1. PBF Q8YIR8 Ferric uptake regulation protein 1.92e-09 5.19e-33 0.046 0.5619
1. PBF Q9RQL3 Peroxide-responsive repressor PerR 1.12e-10 3.73e-41 1.91e-06 0.6792
2. PF P0A0S9 Ferric uptake regulation protein 2.18e-10 7.33e-38 NA 0.5985
2. PF P9WN84 Zinc uptake regulation protein 2.54e-06 1.42e-22 NA 0.5681
2. PF P0A583 Transcriptional regulator FurA 9.38e-12 4.68e-31 NA 0.7138
2. PF P0C106 Ferric uptake regulation protein 2.16e-08 5.19e-33 NA 0.5753
2. PF Q48835 Ferric uptake regulation protein 1.61e-09 2.16e-34 NA 0.5953
2. PF Q6GGE5 Ferric uptake regulation protein 6.92e-11 4.08e-41 NA 0.6801
2. PF P71333 Ferric uptake regulation protein 8.23e-09 1.38e-32 NA 0.5665
2. PF O28051 Ferric uptake regulation protein homolog 2.22e-11 5.48e-18 NA 0.6872
2. PF P0C0P4 Ferric uptake regulation protein 2.25e-11 2.58e-40 NA 0.6618
2. PF Q97FU2 Transcriptional regulator PerR 6.14e-10 5.64e-38 NA 0.6637
2. PF P0A3E7 Transcriptional regulator ZurR 3.54e-11 4.83e-45 NA 0.632
2. PF P33117 Ferric uptake regulation protein 1.10e-09 1.91e-22 NA 0.6092
2. PF P0A3E6 Transcriptional regulator ZurR 5.69e-11 4.83e-45 NA 0.6383
2. PF P0C6C8 Ferric uptake regulation protein 9.45e-10 2.49e-21 NA 0.6042
2. PF P0A0S7 Ferric uptake regulation protein 2.10e-10 3.81e-38 NA 0.606
2. PF P9WN86 Transcriptional regulator FurA 2.00e-11 4.68e-31 NA 0.6469
2. PF P74739 Ferric uptake regulation protein 1.65e-11 2.52e-23 NA 0.693
2. PF P54479 Zinc-specific metallo-regulatory protein 3.24e-10 9.83e-40 NA 0.5964
2. PF P0A3E4 Ferric uptake regulation protein 3.13e-10 6.48e-34 NA 0.5956
2. PF O68563 Ferric uptake regulation protein (Fragment) 4.04e-08 2.81e-16 NA 0.6156
2. PF P0C1Q1 Ferric uptake regulation protein 6.98e-11 4.08e-41 NA 0.6763
2. PF P0A3E3 Ferric uptake regulation protein 4.00e-10 6.48e-34 NA 0.5873
2. PF P0A034 Ferric uptake regulation protein 2.53e-11 4.08e-41 NA 0.6768
2. PF P0C0P3 Ferric uptake regulation protein 4.39e-11 3.37e-43 NA 0.6649
2. PF P75456 Uncharacterized protein MG236 homolog 5.60e-12 9.20e-17 NA 0.6765
2. PF Q6G912 Ferric uptake regulation protein 7.75e-11 4.08e-41 NA 0.6778
2. PF Q55244 Ferric uptake regulation protein 5.66e-12 4.78e-41 NA 0.6806
2. PF Q5HNZ4 Ferric uptake regulation protein 2.47e-11 2.58e-40 NA 0.6627
2. PF P0AC52 Zinc uptake regulation protein 7.62e-12 3.11e-23 NA 0.5854
2. PF Q51008 Ferric uptake regulation protein 2.54e-10 1.27e-35 NA 0.5976
2. PF O07315 Ferric uptake regulation protein 9.30e-12 5.02e-26 NA 0.6306
2. PF A5F6G4 Ferric uptake regulation protein 1.18e-09 2.11e-23 NA 0.5719
2. PF Q52083 Ferric uptake regulation protein 9.85e-09 8.95e-27 NA 0.6023
2. PF P0A032 Ferric uptake regulation protein 7.66e-11 4.08e-41 NA 0.6775
2. PF Q5HFK6 Ferric uptake regulation protein 6.73e-11 4.08e-41 NA 0.6771
2. PF O30330 Ferric uptake regulation protein 5.09e-09 1.50e-32 NA 0.6086
2. PF P0A033 Ferric uptake regulation protein 2.66e-11 4.08e-41 NA 0.6791
2. PF Q2YRK0 Ferric uptake regulation protein 2.15e-09 5.19e-33 NA 0.5746
2. PF O24755 Ferric uptake regulation protein 9.03e-10 3.29e-20 NA 0.6102
2. PF P0A0S8 Ferric uptake regulation protein 2.17e-08 3.81e-38 NA 0.6265
2. PF P47478 Uncharacterized protein MG236 6.82e-11 1.21e-19 NA 0.6929
2. PF Q03456 Ferric uptake regulation protein 6.64e-09 2.95e-30 NA 0.6138
2. PF P0A3E5 Ferric uptake regulation protein 2.68e-10 6.48e-34 NA 0.5832
4. PB Q2G282 Peroxide-responsive repressor PerR 7.27e-10 3.73e-41 1.91e-06 NA
4. PB P0A9A9 Ferric uptake regulation protein 3.70e-10 8.62e-27 1.04e-04 NA
5. P P9WN85 Zinc uptake regulation protein 2.53e-06 1.42e-22 NA NA
5. P Q8ZYH0 Transcription factor E 7.29e-04 2.20e-08 NA NA
5. P Q0W8N8 Transcription factor E 3.44e-03 2.21e-03 NA NA
5. P Q8TY11 Transcription factor E 1.13e-03 1.11e-07 NA NA
5. P P9WN87 Transcriptional regulator FurA 1.73e-11 4.68e-31 NA NA
5. P Q5V3R0 Transcription factor E 6.63e-03 6.97e-07 NA NA
5. P O29501 Transcription factor E 2.83e-03 1.01e-05 NA NA
5. P Q81EN2 Uncharacterized HTH-type transcriptional regulator BC_1936 1.97e-04 4.84e-03 NA NA
5. P O34709 HTH-type transcriptional repressor OpcR 8.87e-04 2.16e-02 NA NA
5. P C3MRF5 Transcription factor E 7.12e-04 8.40e-03 NA NA
5. P C0SPB8 Putative HTH-type transcriptional regulator YvaV 6.67e-04 1.18e-04 NA NA
5. P P9WMJ5 Transcriptional regulator BlaI 1.44e-04 1.37e-04 NA NA
5. P A0B8L2 Aspartate carbamoyltransferase regulatory chain 3.99e-01 1.39e-02 NA NA
5. P A4YJ15 Transcription factor E 3.31e-04 1.01e-02 NA NA
5. P C3N7L2 Transcription factor E 5.17e-04 8.40e-03 NA NA
5. P Q9YBD5 Aspartate carbamoyltransferase regulatory chain 2.15e-01 4.27e-02 NA NA
5. P A4SHP7 Aspartate carbamoyltransferase regulatory chain 2.87e-01 8.40e-03 NA NA
5. P Q74MZ3 Transcription factor E 8.37e-05 1.45e-11 NA NA
5. P P96705 Uncharacterized HTH-type transcriptional regulator YdgG 1.24e-03 1.88e-02 NA NA
5. P A8ABJ9 Transcription factor E 5.92e-04 1.35e-03 NA NA
5. P P9WMJ4 Transcriptional regulator BlaI 1.72e-04 1.37e-04 NA NA
5. P P9WMG2 Uncharacterized HTH-type transcriptional regulator MT3179 2.01e-03 7.90e-04 NA NA
5. P Q46DA7 Aspartate carbamoyltransferase regulatory chain 4.75e-01 8.55e-03 NA NA
5. P A0B9P3 Transcription factor E 1.18e-02 5.24e-05 NA NA
5. P Q63CL4 Uncharacterized HTH-type transcriptional regulator BCE33L1758 1.98e-04 3.92e-02 NA NA
5. P Q18HD8 Transcription factor E 1.46e-02 1.94e-05 NA NA
5. P A5UKV8 Transcription factor E 9.74e-03 2.02e-06 NA NA
5. P A4G0F7 Transcription factor E 7.08e-04 1.64e-05 NA NA
5. P Q0W5I3 Aspartate carbamoyltransferase regulatory chain 4.54e-01 2.20e-02 NA NA
5. P P0DPR8 HTH-type transcriptional regulator FarR 2.00e-04 9.38e-04 NA NA
5. P A0KQG1 Aspartate carbamoyltransferase regulatory chain 2.82e-01 9.52e-03 NA NA
5. P O31949 SPbeta prophage-derived uncharacterized protein YonI 3.38e-03 1.37e-03 NA NA
5. P O31672 HTH-type transcriptional regulator MhqR 4.32e-04 2.91e-04 NA NA
5. P Q2FT22 Transcription factor E 6.89e-03 1.60e-09 NA NA
5. P A8M8Z5 Transcription factor E 1.43e-04 2.42e-08 NA NA
5. P Q2FY19 Ferric uptake regulation protein 5.44e-11 4.08e-41 NA NA
5. P P68263 Methicillin resistance regulatory protein MecI 1.54e-05 2.36e-03 NA NA
5. P P0A041 Penicillinase repressor 2.04e-05 1.22e-07 NA NA
5. P O31472 Uncharacterized HTH-type transcriptional regulator YcgE 3.29e-04 8.47e-03 NA NA
5. P O93774 HTH-type transcriptional regulator lrs14 5.79e-04 8.40e-03 NA NA
5. P A3MY45 Transcription factor E 6.59e-04 5.03e-08 NA NA
5. P P0AC51 Zinc uptake regulation protein 8.54e-12 3.11e-23 NA NA
5. P Q58187 Transcription factor E 7.81e-04 8.82e-07 NA NA
5. P Q8X7U4 Transcriptional regulator MntR 1.40e-03 2.40e-03 NA NA
5. P B2RL77 Aspartate carbamoyltransferase regulatory chain 1.69e-01 2.50e-02 NA NA
5. P P0A649 Uncharacterized HTH-type transcriptional regulator Mb3122 2.74e-03 4.93e-04 NA NA
5. P A2SQM6 Transcription factor E 8.29e-03 5.16e-09 NA NA
5. P C3MY51 Transcription factor E 7.69e-04 8.40e-03 NA NA
5. P P0C7L5 Uncharacterized HTH-type transcriptional regulator B-115 NA 2.01e-03 NA NA
5. P A0RCV1 Uncharacterized HTH-type transcriptional regulator BALH_1720 2.99e-04 3.92e-02 NA NA
5. P A7I7T6 Transcription factor E 6.52e-03 2.72e-09 NA NA
5. P Q3IP08 Transcription factor E 6.21e-03 4.81e-07 NA NA
5. P Q46G12 Transcription factor E 7.49e-03 3.33e-08 NA NA
5. P P68262 Methicillin resistance regulatory protein MecI 1.55e-05 2.36e-03 NA NA
5. P A3DN07 Transcription factor E 1.41e-03 3.90e-04 NA NA
5. P A6VI24 Transcription factor E 7.16e-04 8.89e-06 NA NA
5. P A0RYF4 Transcription factor E 2.05e-03 3.93e-06 NA NA
5. P O26938 Aspartate carbamoyltransferase regulatory chain 2.57e-01 1.85e-02 NA NA
5. P P0A042 Penicillinase repressor 2.06e-05 1.22e-07 NA NA
5. P A6UW55 Transcription factor E 1.39e-03 1.51e-05 NA NA
5. P Q975T8 Transcription factor E 6.69e-04 1.80e-05 NA NA
5. P Q739W8 Uncharacterized HTH-type transcriptional regulator BCE_2019 2.00e-04 3.88e-02 NA NA
5. P C3MZJ0 Transcription factor E 7.33e-04 8.40e-03 NA NA
5. P O69451 Ferric uptake regulation protein 2 NA 4.57e-41 NA NA
5. P A1RTG5 Transcription factor E 5.05e-04 4.86e-08 NA NA
5. P Q6HK19 Uncharacterized HTH-type transcriptional regulator BT9727_1775 3.14e-04 3.92e-02 NA NA
5. P A6UR14 Transcription factor E 6.94e-04 8.62e-07 NA NA
5. P I6Y8F7 HTH-type transcriptional regulator MmpR5 1.47e-04 8.21e-04 NA NA
5. P Q9YAD5 Transcription factor E 4.51e-04 2.25e-10 NA NA
5. P A3CVQ3 Transcription factor E 6.18e-03 1.28e-09 NA NA
5. P Q8PZ06 Transcription factor E 6.35e-03 1.56e-07 NA NA
5. P P0A9F2 Transcriptional regulator MntR 1.47e-03 1.03e-03 NA NA
5. P O54281 Methicillin resistance regulatory protein MecI 9.47e-06 2.98e-03 NA NA
5. P Q9UYS6 Transcription factor E 5.00e-04 4.18e-03 NA NA
5. P Q932L5 Methicillin resistance regulatory protein MecI 1.22e-04 2.09e-03 NA NA
5. P Q47839 Transcriptional repressor CopY 2.82e-05 2.93e-09 NA NA
5. P Q12YV9 Transcription factor E 1.03e-02 3.67e-07 NA NA
5. P O27705 Transcription factor E 1.93e-03 3.68e-06 NA NA
5. P Q7MX57 Aspartate carbamoyltransferase regulatory chain 1.62e-01 2.50e-02 NA NA
5. P Q58958 Putative HTH-type transcriptional regulator MJ1563 2.33e-04 2.12e-04 NA NA
5. P O07127 Uncharacterized 16.5 kDa protein in ptsI 3'region 5.55e-04 2.25e-03 NA NA
5. P B1YA16 Transcription factor E 6.56e-04 1.15e-08 NA NA
5. P Q6M181 Transcription factor E 7.01e-04 1.86e-05 NA NA
5. P A4WGY5 Transcription factor E 4.34e-04 2.06e-10 NA NA
5. P C3NFW2 Transcription factor E 6.80e-04 3.58e-03 NA NA
5. P Q8TJB7 Transcription factor E 8.86e-03 3.98e-08 NA NA
5. P Q9HRC7 Transcription factor E 1.22e-02 2.12e-07 NA NA
5. P P06555 Penicillinase repressor 8.95e-05 3.09e-04 NA NA
5. P A1RY32 Transcription factor E 1.51e-04 8.03e-03 NA NA
5. P Q2NEV4 Transcription factor E 1.59e-03 5.89e-12 NA NA
5. P P68261 Methicillin resistance regulatory protein MecI 1.65e-05 2.36e-03 NA NA
5. P Q980M5 Transcription factor E 7.51e-04 6.41e-03 NA NA
5. P C4KIS0 Transcription factor E 7.15e-04 8.40e-03 NA NA
5. P O69450 Ferric uptake regulation protein 1 (Fragment) NA 1.57e-16 NA NA
5. P P9WMG3 Uncharacterized HTH-type transcriptional regulator Rv3095 2.72e-03 4.93e-04 NA NA
5. P Q895A7 UPF0251 protein CTC_01373 6.47e-02 2.18e-02 NA NA
5. P P0A9F1 Transcriptional regulator MntR 1.50e-03 1.03e-03 NA NA