Summary
The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.
AVX54888.1
JCVISYN3A_0639
Uncharacterized efflux ABC transporter permease.
M. mycoides homolog: Q6MSQ5.
TIGRfam Classification: 2=Generic.
Category: Essential.
Statistics
Total GO Annotation: 15
Unique PROST Go: 0
Unique BLAST Go: 0
Unique Foldseek Go: 8
Total Homologs: 88
Unique PROST Homologs: 2
Unique BLAST Homologs: 1
Unique Foldseek Homologs: 81
Structures and Sequence Alignment
The best structural homolog that predicted by 6. F was
Q4L8L8
(Putative hemin transport system permease protein HrtB) with a FATCAT P-Value: 9.8e-05 and RMSD of 2.98 angstrom. The sequence alignment identity is 9.5%.
Structural alignment shown in left. Query protein AVX54888.1 colored as red in alignment, homolog Q4L8L8 colored as blue.
Query protein AVX54888.1 is also shown in right top, homolog Q4L8L8 showed in right bottom. They are colored based on secondary structures.
AVX54888.1 MKTKNKKNKWLGLILKNSLKNSFKYKSQLFGLVLLVMIMSLIMSLISAINSRVLDKYDDLITNSNQHNLVLKLDPYENVSTSLITSNNQIQAQQQFINRL 100 Q4L8L8 ---------------------------------------------------------------------------------------------------- 0 AVX54888.1 NEKLYSRYNFKFDWSRTESREFKQVKSLNNLQTLKAVSKQYLTDNKVDQLVIVKGRNINSNKEVLIDPIYAKKHNIKINDIIRFQKDVLGDQLLVNSLEN 200 Q4L8L8 ---------------------------------------------------------------------------------------------------- 0 AVX54888.1 KTTTKQQFEDINKITKQGLTDNNGIYQIKYASSFDWYQVVGFANSADFIFPTINAYSPIPNRLNEGIIYVDPLRFGLIKQTDGFYKYDSTSSKLVVSSNN 300 Q4L8L8 ---------------------------------------------------------------------------------------------------- 0 AVX54888.1 EWESFYSLKTKQKLSDEIVDWMNQYFSQLINKKAQDKWIYKLEDPNYRFNSRTSVIKKTISAYNIYSFIVLLAVISVVLYTTFLITKKQILNSRGQIGTM 400 Q4L8L8 ---------------------------------------------------------------------------------------------------- 0 AVX54888.1 RAIGYKKRQMVLNYVMMPFFTSIVGGILGYILSCLISIIIINRFSNYFSLDYGVFSFDWIGLLNNLIFMWLIISSISFLIGYLIMKKGAINLLENRNAKK 500 Q4L8L8 ---------------------------------------------------------------------------------------------------- 0 AVX54888.1 ISKLGSLIKSLSNKRKFNHRLRAALLVNSGSKLTGVGFVVLIATILFTISFVSPNLLKNNKIYAYNGVKYNQIVEYSQPTYNNPFSFIRVFNPDKKSDDK 600 Q4L8L8 ---------------------------------------------------------------------------------------------------- 0 AVX54888.1 YNIIKNNNRYLATSLPTKNNQYDLQTIINDYLNQTYNNAYYSLAIDLQDKQEVQAINLALSNMKLLQAQDIALTKQYFKYISSLSITPSSIHHILLKNWP 700 Q4L8L8 ---------------------------------------------------------------------------------------------------- 0 AVX54888.1 DYDNLINKLKEIKENEFETLLNQFKYLQQFYATYTNSIGLAINRSYINSFDLKDKKDLRIQKFNNNSSDQNNLKTKAYDDILNSDLLALSKSSFSAKDFK 800 Q4L8L8 ---------------------------------------------------------------------------------------------------- 0 AVX54888.1 NKIIDQFKLTNSDSSLGMYHILDNKWNKSNSISDQFLDISAFDFINKKYKLDDLKDLVIKLSLWFSVMFYKRDDQALIQAAYSRAPYFVKQNL--K-IS- 896 Q4L8L8 ------------------------------------------------------------------------------------------MNLAWKEIKF 10 AVX54888.1 YNSNKDYTLGFNLTTFNKNYEQLGT-LLNVKTL------DNKHTFKI-YGILNN----HDYIDLYDQNK-TDL-IKKLFDSEQNSI--II--N------Q 972 Q4L8L8 YRFR--YTL-IMLIIF-----LLGSMVLFISGLAQGLAREN-----ISY--LNNMPAEH-YI-VED-NKEPKLESSQLNQSQQNKIEKIIHENATQMGTQ 92 AVX54888.1 TIAKRLNLKPNDKISLNVLQNELQHIKNNKTTIFKTSDWSMKQDTSYDSFIQRSDISTNNLKVKTNNSVLELNNGFSDVNSYYQSYLNNELKLGTKIQNK 1072 Q4L8L8 TL--KINQQDQDVITLNT----PKHL----TPKLVSGNYPKKQN---EIAI--SE------KL-T---------G-------------NDLKVGDTV--- 145 AVX54888.1 TFKIVGIHDGY------NENMAWIKESDAQEILNYKQNKSIWWKDIFAPQWNK---TFSSIQAKQVLNDTLDLNNKSLTDYSYEQFVNEFINNKNHKNHK 1163 Q4L8L8 TFK--GHHHNYKISGIMNESM-Y---SHSSMIL---MNKEA-FKSL-----NKQVSTFYPVD-K--INK--D-NKESL---------------KQIKGIK 209 AVX54888.1 IA-KKVLQIFDNQFPIFNYKYSKSNDIGNLDTIVSTY--SKI---ADYNPVSLNGQHLENKTSYDGIGQ-GVIQTITPIQITKQILDQISNLVMLALVLA 1256 Q4L8L8 VVNEKALT--DN---IASYQ-AEQMPL-NL-MIISLFVITAIVLSAFFYVMTI------QK-----IPQIGILKAI-GIK-TKHLL--------TALLLQ 280 AVX54888.1 IITILMIAFVIILLTTSLIISDNTRFI-ATLKV-LGYSNKYITENILGMYFIVIANMLVIGFVSGWFIFDSTIKSLYSII-VLPIIFPIWLPFAVILAVS 1353 Q4L8L8 IILTTMVG-VILAFSVILIL--NA-FMPVTMPFYLSYS------QVLLM--IVV--FLIVGLI-G---------ALLSFIKVLK-VDP-------IEAIG 348 AVX54888.1 GIYLITLIVGFNSIYKTDATLTLKDNDV 1381 Q4L8L8 GME------------------------- 351
Go Annotations
1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.
| Source | GO | Description |
|---|---|---|
| 1. PBF | GO:0022857 | transmembrane transporter activity |
| 1. PBF | GO:0005886 | plasma membrane |
| 1. PBF | GO:0016021 | integral component of membrane |
| 3. BF | GO:0015562 | efflux transmembrane transporter activity |
| 3. BF | GO:0008559 | ABC-type xenobiotic transporter activity |
| 3. BF | GO:1990961 | xenobiotic detoxification by transmembrane export across the plasma membrane |
| 3. BF | GO:0046677 | response to antibiotic |
| 6. F | GO:0005887 | integral component of plasma membrane |
| 6. F | GO:2001070 | starch binding |
| 6. F | GO:1990281 | efflux pump complex |
| 6. F | GO:0005524 | ATP binding |
| 6. F | GO:0042908 | xenobiotic transport |
| 6. F | GO:0002049 | pyoverdine biosynthetic process |
| 6. F | GO:0042953 | lipoprotein transport |
| 6. F | GO:0015893 |
Uniprot GO Annotations
| GO | Description |
|---|---|
| GO:0005886 | plasma membrane |
| GO:0016020 | membrane |
| GO:0016021 | integral component of membrane |
Homologs
1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.
| Source | Homolog | Description | Fatcat Pvalue | PROST Evalue | BLAST Evalue | Foldseek TMScore |
|---|---|---|---|---|---|---|
| 1. PBF | P75613 | Uncharacterized ABC transporter permease MG064 homolog | 1.48e-08 | 6.12e-06 | 4.78e-18 | 0.529 |
| 1. PBF | P47310 | Uncharacterized ABC transporter permease MG064 | 5.74e-08 | 2.03e-08 | 7.73e-20 | 0.5085 |
| 3. BF | P75109 | Uncharacterized ABC transporter permease MG468 homolog | 1.04e-04 | NA | 5.78e-07 | 0.4314 |
| 3. BF | Q2EHL8 | Macrolide export ATP-binding/permease protein MacB | 1.76e-03 | NA | 0.009 | 0.3402 |
| 5. P | O53900 | Uncharacterized ABC transporter permease protein Rv0987 | 1.71e-03 | 7.21e-03 | NA | NA |
| 5. P | P77504 | Uncharacterized ABC transporter permease YbbP | 6.32e-04 | 7.02e-03 | NA | NA |
| 6. F | P0C2H3 | Macrolide export ATP-binding/permease protein MacB 2 | 1.04e-03 | NA | NA | 0.4491 |
| 6. F | Q0TJH0 | Macrolide export ATP-binding/permease protein MacB | 2.20e-03 | NA | NA | 0.453 |
| 6. F | Q4K9A4 | Macrolide export ATP-binding/permease protein MacB 2 | 4.55e-04 | NA | NA | 0.4135 |
| 6. F | P0ADC4 | Lipoprotein-releasing system transmembrane protein LolC | 3.95e-03 | NA | NA | 0.4245 |
| 6. F | Q6MPX9 | Macrolide export ATP-binding/permease protein MacB | 3.76e-04 | NA | NA | 0.4295 |
| 6. F | Q2YZ25 | Putative hemin transport system permease protein HrtB | 1.64e-04 | NA | NA | 0.5436 |
| 6. F | Q8Z824 | Macrolide export ATP-binding/permease protein MacB | 9.02e-03 | NA | NA | 0.4529 |
| 6. F | Q7CJG3 | Macrolide export ATP-binding/permease protein MacB 2 | 1.36e-03 | NA | NA | 0.4522 |
| 6. F | Q0C1N8 | Macrolide export ATP-binding/permease protein MacB | 8.05e-04 | NA | NA | 0.4117 |
| 6. F | A1BE50 | Macrolide export ATP-binding/permease protein MacB | 9.00e-04 | NA | NA | 0.4459 |
| 6. F | P94412 | Uncharacterized ABC transporter permease YclI | 4.63e-03 | NA | NA | 0.3975 |
| 6. F | Q8K9N7 | Uncharacterized membrane protein BUsg_286 | 1.44e-02 | NA | NA | 0.4012 |
| 6. F | Q7M8U0 | Macrolide export ATP-binding/permease protein MacB | 6.05e-04 | NA | NA | 0.4149 |
| 6. F | P9WG16 | Uncharacterized ABC transporter permease MT0078 | 4.87e-04 | NA | NA | 0.5862 |
| 6. F | Q6D8T5 | Macrolide export ATP-binding/permease protein MacB | 1.33e-03 | NA | NA | 0.4656 |
| 6. F | A1U0A9 | Macrolide export ATP-binding/permease protein MacB | 1.07e-03 | NA | NA | 0.4244 |
| 6. F | Q7VMF9 | Macrolide export ATP-binding/permease protein MacB | 2.59e-04 | NA | NA | 0.4205 |
| 6. F | Q7A040 | Putative hemin transport system permease protein HrtB | 1.59e-04 | NA | NA | 0.5637 |
| 6. F | A0LM36 | Macrolide export ATP-binding/permease protein MacB | 2.08e-02 | NA | NA | 0.3762 |
| 6. F | Q49ZT7 | Putative hemin transport system permease protein HrtB | 1.37e-04 | NA | NA | 0.5694 |
| 6. F | Q5P6D5 | Macrolide export ATP-binding/permease protein MacB | 1.35e-03 | NA | NA | 0.3986 |
| 6. F | Q2FED6 | Putative hemin transport system permease protein HrtB | 1.26e-04 | NA | NA | 0.5741 |
| 6. F | Q4ZT65 | Macrolide export ATP-binding/permease protein MacB 2 | 1.82e-03 | NA | NA | 0.4398 |
| 6. F | Q1C5W7 | Macrolide export ATP-binding/permease protein MacB 2 | 1.78e-03 | NA | NA | 0.4545 |
| 6. F | Q3B5J7 | Macrolide export ATP-binding/permease protein MacB | 1.17e-03 | NA | NA | 0.417 |
| 6. F | Q57R58 | Macrolide export ATP-binding/permease protein MacB | 1.00e-02 | NA | NA | 0.4513 |
| 6. F | Q7A3X2 | Putative hemin transport system permease protein HrtB | 1.31e-04 | NA | NA | 0.5723 |
| 6. F | P65008 | Uncharacterized ABC transporter permease Mb2592 | 3.81e-04 | NA | NA | 0.5527 |
| 6. F | Q3KF57 | Macrolide export ATP-binding/permease protein MacB 1 | 7.04e-04 | NA | NA | 0.4125 |
| 6. F | Q8CRA9 | Putative hemin transport system permease protein HrtB | 1.30e-04 | NA | NA | 0.559 |
| 6. F | Q0PAR0 | Macrolide export ATP-binding/permease protein MacB | 9.16e-03 | NA | NA | 0.4086 |
| 6. F | Q4L8L8 | Putative hemin transport system permease protein HrtB | 9.80e-05 | NA | NA | 0.5664 |
| 6. F | Q6G6W0 | Putative hemin transport system permease protein HrtB | 1.80e-04 | NA | NA | 0.5495 |
| 6. F | Q5PGK9 | Macrolide export ATP-binding/permease protein MacB | 1.87e-03 | NA | NA | 0.4585 |
| 6. F | Q1CJW8 | Macrolide export ATP-binding/permease protein MacB 1 | 1.47e-03 | NA | NA | 0.4497 |
| 6. F | A6QJK2 | Putative hemin transport system permease protein HrtB | 1.28e-04 | NA | NA | 0.5728 |
| 6. F | Q02MI4 | Macrolide export ATP-binding/permease protein MacB | 1.66e-03 | NA | NA | 0.4071 |
| 6. F | P46324 | Uncharacterized ABC transporter permease YvrN | 4.84e-03 | NA | NA | 0.4077 |
| 6. F | A0L0V9 | Macrolide export ATP-binding/permease protein MacB | 6.69e-03 | NA | NA | 0.4779 |
| 6. F | Q217L2 | Macrolide export ATP-binding/permease protein MacB | 1.62e-03 | NA | NA | 0.4421 |
| 6. F | Q4ZV10 | Macrolide export ATP-binding/permease protein MacB 1 | 6.40e-04 | NA | NA | 0.3977 |
| 6. F | Q884D4 | Macrolide export ATP-binding/permease protein MacB 1 | 5.07e-04 | NA | NA | 0.4214 |
| 6. F | Q99RR7 | Putative hemin transport system permease protein HrtB | 1.48e-04 | NA | NA | 0.5585 |
| 6. F | Q5HDJ5 | Putative hemin transport system permease protein HrtB | 2.16e-04 | NA | NA | 0.5215 |
| 6. F | Q88F88 | Macrolide export ATP-binding/permease protein MacB | 9.44e-04 | NA | NA | 0.4461 |
| 6. F | Q9I190 | Macrolide export ATP-binding/permease protein MacB | 1.43e-03 | NA | NA | 0.4292 |
| 6. F | Q1RE44 | Macrolide export ATP-binding/permease protein MacB | 1.94e-03 | NA | NA | 0.4521 |
| 6. F | A1BCE9 | Macrolide export ATP-binding/permease protein MacB 3 | 8.58e-04 | NA | NA | 0.4152 |
| 6. F | Q2NSZ1 | Macrolide export ATP-binding/permease protein MacB | 8.94e-04 | NA | NA | 0.4533 |
| 6. F | Q5F6V6 | Macrolide export ATP-binding/permease protein MacB | 1.74e-03 | NA | NA | 0.4446 |
| 6. F | Q1I7I9 | Macrolide export ATP-binding/permease protein MacB 2 | 4.43e-04 | NA | NA | 0.4679 |
| 6. F | A1K323 | Macrolide export ATP-binding/permease protein MacB | 1.48e-03 | NA | NA | 0.4053 |
| 6. F | Q5HVG3 | Macrolide export ATP-binding/permease protein MacB | 9.27e-03 | NA | NA | 0.3985 |
| 6. F | Q668L6 | Macrolide export ATP-binding/permease protein MacB 2 | 1.45e-03 | NA | NA | 0.446 |
| 6. F | Q8KFE9 | Macrolide export ATP-binding/permease protein MacB | 1.93e-03 | NA | NA | 0.4553 |
| 6. F | Q83LR7 | Macrolide export ATP-binding/permease protein MacB | 2.36e-03 | NA | NA | 0.4501 |
| 6. F | Q4KES7 | Macrolide export ATP-binding/permease protein MacB 1 | 3.96e-03 | NA | NA | 0.4092 |
| 6. F | Q7ULB5 | Macrolide export ATP-binding/permease protein MacB | 8.84e-03 | NA | NA | 0.4099 |
| 6. F | Q48KB2 | Macrolide export ATP-binding/permease protein MacB | 7.32e-04 | NA | NA | 0.3931 |
| 6. F | P9WG14 | Uncharacterized ABC transporter permease MT2639 | 4.07e-04 | NA | NA | 0.5494 |
| 6. F | P0ADC5 | Lipoprotein-releasing system transmembrane protein LolC | 3.95e-03 | NA | NA | 0.4282 |
| 6. F | P0C2H2 | Macrolide export ATP-binding/permease protein MacB | 9.15e-04 | NA | NA | 0.4481 |
| 6. F | A0RP01 | Macrolide export ATP-binding/permease protein MacB | 1.70e-03 | NA | NA | 0.383 |
| 6. F | Q0VT01 | Macrolide export ATP-binding/permease protein MacB | 2.92e-04 | NA | NA | 0.4039 |
| 6. F | Q3ATR5 | Macrolide export ATP-binding/permease protein MacB | 2.31e-03 | NA | NA | 0.4354 |
| 6. F | Q1QDA8 | Macrolide export ATP-binding/permease protein MacB | 4.12e-04 | NA | NA | 0.468 |
| 6. F | A1A9B7 | Macrolide export ATP-binding/permease protein MacB 1 | 1.85e-03 | NA | NA | 0.4541 |
| 6. F | Q9K0N7 | Macrolide export ATP-binding/permease protein MacB | 1.61e-03 | NA | NA | 0.4199 |
| 6. F | Q7N6F9 | Macrolide export ATP-binding/permease protein MacB | 1.55e-03 | NA | NA | 0.4456 |
| 6. F | Q4FU75 | Macrolide export ATP-binding/permease protein MacB | 4.45e-04 | NA | NA | 0.4492 |
| 6. F | A0KGB3 | Macrolide export ATP-binding/permease protein MacB 1 | 1.01e-03 | NA | NA | 0.4194 |
| 6. F | Q5HLN3 | Putative hemin transport system permease protein HrtB | 1.17e-04 | NA | NA | 0.5263 |
| 6. F | A1VYW8 | Macrolide export ATP-binding/permease protein MacB | 1.06e-02 | NA | NA | 0.412 |
| 6. F | Q9CM47 | Macrolide export ATP-binding/permease protein MacB | 1.62e-03 | NA | NA | 0.4566 |
| 6. F | A1RG29 | Macrolide export ATP-binding/permease protein MacB | 1.38e-03 | NA | NA | 0.4681 |
| 6. F | Q6GE74 | Putative hemin transport system permease protein HrtB | 1.86e-04 | NA | NA | 0.5448 |
| 6. F | Q9JVR5 | Macrolide export ATP-binding/permease protein MacB | 1.57e-03 | NA | NA | 0.4215 |
| 6. F | O31712 | Uncharacterized ABC transporter permease YknZ | 4.86e-04 | NA | NA | 0.4505 |
| 6. F | Q32DZ9 | Macrolide export ATP-binding/permease protein MacB | 5.32e-03 | NA | NA | 0.444 |
| 6. F | P42424 | ABC transporter permease protein YxdM | 8.31e-03 | NA | NA | 0.322 |
| 6. F | Q92NU9 | Macrolide export ATP-binding/permease protein MacB | 1.19e-02 | NA | NA | 0.4286 |
| 7. B | Q49460 | Uncharacterized ABC transporter permease MG468 | 6.40e-06 | NA | 0.011 | NA |