Summary

The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.

AVX54929.1
JCVISYN3A_0691

Uncharacterized protein.
M. mycoides homolog: Q6MSK7.
TIGRfam Classification: 2=Generic.
Category: Essential.

Statistics

Total GO Annotation: 62
Unique PROST Go: 39
Unique BLAST Go: 0
Unique Foldseek Go: 2

Total Homologs: 135
Unique PROST Homologs: 71
Unique BLAST Homologs: 0
Unique Foldseek Homologs: 28

Literature

Danchin and Fang [1]: NA
Yang and Tsui [2]: Chaperone protein HtpG
Antczak et al. [3]: Transmembrane transporter, likely transporting cations, drugs or toxins
Zhang et al. [4]: GO:0015893|drug transport
Bianchi et al. [5]: "Unclear Membrane Protein, Transport"

Structures and Sequence Alignment

The best structural homolog that predicted by 2. PF was O34674 (Lipid II flippase MurJ) with a FATCAT P-Value: 0 and RMSD of 3.15 angstrom. The sequence alignment identity is 19.4%.
Structural alignment shown in left. Query protein AVX54929.1 colored as red in alignment, homolog O34674 colored as blue. Query protein AVX54929.1 is also shown in right top, homolog O34674 showed in right bottom. They are colored based on secondary structures.

  AVX54929.1 MQVNVESTTANMPINDSKKTTSAK--SGVFSALLGV-VSSITNMIIQFLLIYWV-LQSFGTEI--SGFIRISMSLSIIGGTAEG-ALALSTVLMLTEPLS 93
      O34674 --------------------MSSKLLRGTFVLTLGTYISRILGMV--YLIPFSIMVGATGGALFQYGYNQYTLFLNI--ATM-GFPAAVSK--FVSKYNS 73

  AVX54929.1 KKDWITVNEIFSTAKRNYNNKIVSGFILVFLLSILYPLQIAISPLITSGESIKWGIDFTTPLSKTTSTLKFWELSAVFLILGTKQTLLAGLF-GVHENIM 192
      O34674 KGDYETSRKML---KAGMSVMLVTGMIAFFILYLSAPMFAEIS-L--GGKDNN-GL--T--IDHVVYVIRM--VSLALLVVPI-MSLVRGFFQG-H-QMM 157

  AVX54929.1 ------Q-ADQ--K-----NAS----K----KLVV-----LFCDVL--FYGIFFVLLNSYIYWNDKHTPVLLFLPFLFYPVIRGLLITSYVKK------K 257
      O34674 GPTAVSQVVEQIVRIIFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGL--VVL--YIYWNKRKGSLLAMMPNT-GPTA-NL---SY-KKMFFELFS 247

  AVX54929.1 Y--P------AIKFYN--DFNNLN--LIRRSTKIYWSSIGQSIL------VNSDLIIIFLALGS-IGLKVSSLI-SL--------YMVVAINLRI--IMT 327
      O34674 YAAPYVFVGLAIPLYNYIDTNTFNKAMIEAGHQ----AISQDMLAILTLYVQK-LVMIPVSLATAFGL---TLIPTITESFTSGNYKL--LNQQINQTMQ 337

  AVX54929.1 SLVTSFKEYFSSVIIKK--G--RLDWETYSNYEFYS--YI---VGVFSFLITSIMTPYIVTGLFSKIILNDVDTTGLTKKTIEFIIFSPFFSGIFGATTG 418
      O34674 TIL--F------LIIPAVVGISLLSGPTYT-F-FYGSESLHPELGA-NILLW--YSPVAI--LFSLFTVNAAILQGINKQ--KFAVVSL----VIGVVIK 416

  AVX54929.1 LIV---LLESKITLIHAKGMHRTIAKPLNLIAFSFFISSFIITLLLNRFIGNVESKISWVIIVFYSSKILFLIIAYIY---LWIFSWDKLVYNARFNRII 512
      O34674 LVLNVPLI--K--LMQADGA--ILATALGYIA-S-LLYGFI---MIKRHAG-----YSYKILV--KRTVLMLVLSAIMGIAVKIVQW--VL---GF---- 489

  AVX54929.1 PNILFVT-----LSAC--LVIAFSLSADDIYILLKFDTNKKVPVDILHIILGLIIIFIASFF-----IGILTFVYNKIVKNTSVTRLIFYSLPFIKRLNK 600
      O34674 ----FISYQDGQMQAAIVVVIAAAVGG-AVYLYCGY------RLGFLQKILGR---RLPGFFRKGRHAG------------------------------- 544

  AVX54929.1 EKQEKAKRDLFEKENINIDKFLLKQEDLLKAMYGFKEKKVIDQDEFEKYSKYKPKPKVYILKASDMNKDESEY 673
      O34674 ------------------------------------------------------------------------- 544

Go Annotations

1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.

Source GO Description
2. PF GO:0042910 xenobiotic transmembrane transporter activity
2. PF GO:0022857 transmembrane transporter activity
2. PF GO:0005887 integral component of plasma membrane
2. PF GO:0016021 integral component of membrane
2. PF GO:0009252 peptidoglycan biosynthetic process
2. PF GO:0005886 plasma membrane
2. PF GO:0045232 S-layer organization
2. PF GO:0006811 ion transport
2. PF GO:0071555 cell wall organization
2. PF GO:0015648 lipid-linked peptidoglycan transporter activity
2. PF GO:0034204 lipid translocation
2. PF GO:0006855 xenobiotic transmembrane transport
2. PF GO:0015297 antiporter activity
2. PF GO:0046677 response to antibiotic
2. PF GO:0000271 polysaccharide biosynthetic process
2. PF GO:0015836 lipid-linked peptidoglycan transport
2. PF GO:0009243 O antigen biosynthetic process
2. PF GO:0034203 glycolipid translocation
2. PF GO:0098567 periplasmic side of plasma membrane
2. PF GO:0008360 regulation of cell shape
2. PF GO:0006488 dolichol-linked oligosaccharide biosynthetic process
5. P GO:0006119 oxidative phosphorylation
5. P GO:0030504 inorganic diphosphate transmembrane transporter activity
5. P GO:0015231 5-formyltetrahydrofolate transmembrane transporter activity
5. P GO:0098655 cation transmembrane transport
5. P GO:0015179 L-amino acid transmembrane transporter activity
5. P GO:0050845 teichuronic acid biosynthetic process
5. P GO:0005507 copper ion binding
5. P GO:0008517 folic acid transmembrane transporter activity
5. P GO:0004129 cytochrome-c oxidase activity
5. P GO:0015114 phosphate ion transmembrane transporter activity
5. P GO:0034202 glycolipid floppase activity
5. P GO:0070469 respirasome
5. P GO:0097638 L-arginine import across plasma membrane
5. P GO:0009060 aerobic respiration
5. P GO:0009486 cytochrome bo3 ubiquinol oxidase activity
5. P GO:0015884 folic acid transport
5. P GO:0015453 oxidoreduction-driven active transmembrane transporter activity
5. P GO:0089718 amino acid import across plasma membrane
5. P GO:0008643 carbohydrate transport
5. P GO:0000935 division septum
5. P GO:0015990 electron transport coupled proton transport
5. P GO:0015885 5-formyltetrahydrofolate transport
5. P GO:0016682 oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
5. P GO:0042887 amide transmembrane transporter activity
5. P GO:0031982 vesicle
5. P GO:0005789 endoplasmic reticulum membrane
5. P GO:0009246 enterobacterial common antigen biosynthetic process
5. P GO:0009319 cytochrome o ubiquinol oxidase complex
5. P GO:0020037 heme binding
5. P GO:0022904 respiratory electron transport chain
5. P GO:0016020 membrane
5. P GO:0061459 L-arginine transmembrane transporter activity
5. P GO:0051958 methotrexate transport
5. P GO:0015350 methotrexate transmembrane transporter activity
5. P GO:0042908 xenobiotic transport
5. P GO:1902475 L-alpha-amino acid transmembrane transport
5. P GO:0015695 organic cation transport
5. P GO:1901612 cardiolipin binding
5. P GO:0009242 colanic acid biosynthetic process
6. F GO:0015774 polysaccharide transport
6. F GO:0006814 sodium ion transport

Uniprot GO Annotations

GO Description
GO:0016020 membrane
GO:0016021 integral component of membrane

Homologs

1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.

Source Homolog Description Fatcat Pvalue PROST Evalue BLAST Evalue Foldseek TMScore
2. PF P33699 Succinoglycan biosynthesis transport protein ExoT 1.22e-15 1.33e-10 NA 0.6838
2. PF B4E9G3 Lipid II flippase MurJ 5.77e-11 4.59e-13 NA 0.5781
2. PF P26400 Putative O-antigen transporter 9.21e-13 9.15e-03 NA 0.7374
2. PF Q89AI1 Probable lipid II flippase MurJ 1.38e-13 8.41e-11 NA 0.641
2. PF Q8K9L3 Probable lipid II flippase MurJ 0.00e+00 2.26e-10 NA 0.6658
2. PF O34238 Probable lipid II flippase MurJ 7.09e-14 6.99e-09 NA 0.664
2. PF P75130 Uncharacterized protein MG447 homolog 1.86e-10 9.92e-03 NA 0.4897
2. PF Q05347 Putative O-antigen export protein 0.00e+00 1.25e-02 NA 0.6982
2. PF Q9ZCW4 Probable lipid II flippase MurJ 0.00e+00 3.20e-09 NA 0.6786
2. PF O34674 Lipid II flippase MurJ 0.00e+00 9.11e-17 NA 0.6591
2. PF P37555 Uncharacterized membrane protein YabM 4.96e-13 1.19e-12 NA 0.6226
2. PF P56882 Probable lipid II flippase MurJ 5.55e-13 4.57e-14 NA 0.6239
2. PF Q4L8N9 Multidrug export protein MepA 2.78e-15 7.81e-04 NA 0.5924
2. PF Q8VNZ2 Probable lipid II flippase MurJ 2.96e-14 3.34e-09 NA 0.6805
2. PF Q7N1G0 Probable multidrug resistance protein NorM 2.71e-13 1.26e-03 NA 0.6355
2. PF P37169 Probable lipid II flippase MurJ 1.23e-13 8.68e-10 NA 0.6614
2. PF Q8UDF5 Probable multidrug resistance protein NorM 3.78e-11 5.14e-03 NA 0.5438
2. PF O67658 Probable lipid II flippase MurJ 4.00e-11 3.87e-11 NA 0.6728
2. PF P71060 Uncharacterized membrane protein EpsK 0.00e+00 9.05e-14 NA 0.6732
2. PF P53660 Uncharacterized protein MG447 homolog MYCGA2290 2.75e-05 4.22e-04 NA 0.4848
2. PF Q00758 Stage V sporulation protein B 5.05e-14 6.41e-17 NA 0.5803
2. PF O05467 Probable lipid II flippase MurJ 0.00e+00 1.14e-13 NA 0.6098
2. PF P0AF17 Probable lipid II flippase MurJ 7.48e-14 1.40e-13 NA 0.6658
2. PF D4GYG8 Probable flippase AglR 5.56e-11 2.29e-11 NA 0.6336
2. PF Q9HTR0 Probable multidrug resistance protein NorM 6.33e-10 1.14e-02 NA 0.4721
2. PF P44958 Probable lipid II flippase MurJ 3.68e-10 8.62e-14 NA 0.6768
2. PF P57415 Probable lipid II flippase MurJ 0.00e+00 9.61e-12 NA 0.6038
2. PF B7IE18 Lipid II flippase MurJ 3.08e-10 2.47e-11 NA 0.6235
2. PF D4GU68 Probable low-salt glycan biosynthesis flippase Agl15 2.23e-11 6.26e-05 NA 0.646
2. PF O07940 Uncharacterized transporter YisQ 1.18e-12 1.32e-03 NA 0.4877
2. PF Q9WXU1 Probable lipid II flippase MurJ 4.97e-13 2.64e-06 NA 0.5869
2. PF Q48457 Uncharacterized membrane protein in cps region 3.33e-16 3.95e-09 NA 0.6192
2. PF Q55179 Probable lipid II flippase MurJ 1.66e-09 9.51e-14 NA 0.6732
2. PF Q49VC5 Multidrug export protein MepA 2.44e-15 1.25e-03 NA 0.5996
2. PF Q2YVH4 Multidrug export protein MepA 1.33e-15 4.49e-02 NA 0.5694
2. PF O51750 Probable lipid II flippase MurJ 7.13e-12 3.69e-18 NA 0.6229
5. P Q0D2E8 Protein RFT1 homolog 2.80e-09 2.25e-04 NA NA
5. P Q5RFD2 Multidrug and toxin extrusion protein 1 2.13e-09 3.52e-02 NA NA
5. P O32273 Teichuronic acid biosynthesis protein TuaB 1.11e-16 1.65e-09 NA NA
5. P Q9ZKW7 Probable lipid II flippase MurJ 9.04e-11 8.96e-03 NA NA
5. P P34956 Quinol oxidase subunit 1 3.24e-04 2.28e-05 NA NA
5. P Q49WI3 Probable quinol oxidase subunit 1 6.43e-05 6.63e-04 NA NA
5. P Q89AA4 Cytochrome bo(3) ubiquinol oxidase subunit 1 5.48e-05 1.00e-04 NA NA
5. P P0ABI9 Cytochrome bo(3) ubiquinol oxidase subunit 1 4.97e-05 3.09e-04 NA NA
5. P O83529 Probable lipid II flippase MurJ 5.44e-14 3.48e-12 NA NA
5. P Q8K994 Cytochrome bo(3) ubiquinol oxidase subunit 1 1.92e-04 9.59e-06 NA NA
5. P Q92AG2 Probable multidrug resistance protein NorM 1.40e-11 3.66e-02 NA NA
5. P Q754Q7 Oligosaccharide translocation protein RFT1 3.51e-09 2.28e-09 NA NA
5. P Q96FL8 Multidrug and toxin extrusion protein 1 2.26e-09 6.20e-03 NA NA
5. P P45272 Multidrug resistance protein HmrM 1.78e-15 5.09e-03 NA NA
5. P Q3V050 Multidrug and toxin extrusion protein 2 1.01e-08 6.49e-04 NA NA
5. P P98057 Probable cytochrome c oxidase subunit 1 3.17e-05 9.72e-04 NA NA
5. P P58368 Progressive ankylosis protein homolog B 4.36e-09 4.20e-02 NA NA
5. P P0AAA7 Lipid III flippase 0.00e+00 1.41e-02 NA NA
5. P P47685 Uncharacterized protein MG447 2.98e-14 7.80e-06 NA NA
5. P Q9WWR2 Cytochrome bo(3) ubiquinol oxidase subunit 1 1.59e-04 3.38e-04 NA NA
5. P Q2YX15 Probable quinol oxidase subunit 1 6.60e-05 2.70e-04 NA NA
5. P Q4L564 Probable quinol oxidase subunit 1 6.89e-05 4.17e-04 NA NA
5. P Q71YH0 Probable multidrug resistance protein NorM 1.58e-11 4.49e-02 NA NA
5. P P0ABJ0 Cytochrome bo(3) ubiquinol oxidase subunit 1 4.71e-05 3.09e-04 NA NA
5. P Q5HH24 Probable quinol oxidase subunit 1 6.47e-05 3.49e-04 NA NA
5. P P42726 Trifolitoxin-processing protein TfxD 1.13e-08 7.08e-03 NA NA
5. P Q23444 Protein RFT1 homolog 5.70e-09 8.08e-07 NA NA
5. P Q6FPE8 Oligosaccharide translocation protein RFT1 1.92e-08 3.74e-09 NA NA
5. P A4IIS8 Multidrug and toxin extrusion protein 1 5.24e-08 9.43e-03 NA NA
5. P Q9Z7H5 Probable lipid II flippase MurJ 1.57e-09 1.06e-21 NA NA
5. P P98009 Ubiquinol oxidase subunit 1 1.82e-04 6.59e-03 NA NA
5. P Q9LE20 Protein DETOXIFICATION 54 7.43e-09 3.81e-02 NA NA
5. P P0AF16 Lipid II flippase MurJ 2.22e-16 1.40e-13 NA NA
5. P P0ABI8 Cytochrome bo(3) ubiquinol oxidase subunit 1 4.82e-05 3.09e-04 NA NA
5. P Q58467 Uncharacterized membrane protein MJ1068 5.66e-14 4.10e-13 NA NA
5. P P24010 Cytochrome c oxidase subunit 1 1.25e-04 6.32e-03 NA NA
5. P Q6GI24 Probable quinol oxidase subunit 1 6.48e-05 3.05e-04 NA NA
5. P Q7N3V2 Multidrug resistance protein MdtK 3.88e-09 4.28e-02 NA NA
5. P Q5I0E9 Multidrug and toxin extrusion protein 1 1.82e-08 8.09e-03 NA NA
5. P O31695 Uncharacterized MFS-type transporter YkuC 2.89e-05 3.59e-02 NA NA
5. P P0AAA8 Lipid III flippase 0.00e+00 1.41e-02 NA NA
5. P Q55721 Folate-biopterin transporter 1.05e-04 5.88e-03 NA NA
5. P Q46378 Probable lipid II flippase MurJ 4.30e-09 9.42e-19 NA NA
5. P P40913 Oligosaccharide translocation protein RFT1 1.75e-08 1.41e-11 NA NA
5. P Q8Y654 Probable multidrug resistance protein NorM 1.37e-11 1.44e-02 NA NA
5. P Q5HQB0 Probable quinol oxidase subunit 1 6.17e-05 2.55e-04 NA NA
5. P Q96AA3 Protein RFT1 homolog 9.90e-10 1.17e-04 NA NA
5. P Q54IV7 Protein RFT1 homolog 6.28e-07 1.02e-04 NA NA
5. P Q58119 Uncharacterized transporter MJ0709 9.91e-11 1.17e-02 NA NA
5. P Q9I426 Cytochrome bo(3) ubiquinol oxidase subunit 1 2.05e-04 3.86e-04 NA NA
5. P Q6GAF3 Probable quinol oxidase subunit 1 6.40e-05 2.70e-04 NA NA
5. P Q99V37 Probable quinol oxidase subunit 1 6.45e-05 2.70e-04 NA NA
5. P Q7A699 Probable quinol oxidase subunit 1 6.40e-05 2.70e-04 NA NA
5. P P57543 Cytochrome bo(3) ubiquinol oxidase subunit 1 2.10e-04 3.27e-04 NA NA
5. P Q5QWR6 Probable multidrug resistance protein NorM 5.11e-10 1.52e-02 NA NA
5. P Q8CPP7 Probable quinol oxidase subunit 1 6.32e-05 2.55e-04 NA NA
5. P P38206 Oligosaccharide translocation protein RFT1 8.71e-09 5.65e-07 NA NA
5. P O25551 Probable lipid II flippase MurJ 9.28e-11 3.61e-04 NA NA
5. P Q9WZS2 Probable multidrug resistance protein NorM 5.12e-13 5.65e-03 NA NA
5. P Q5R7E4 Multidrug and toxin extrusion protein 2 1.78e-08 2.15e-03 NA NA
5. P P77377 Lipopolysaccharide biosynthesis protein WzxC 1.11e-16 2.39e-11 NA NA
5. P E0TW66 Quinol oxidase subunit 1 6.89e-05 2.53e-05 NA NA
5. P Q8VYL8 Protein DETOXIFICATION 10 7.24e-09 3.01e-02 NA NA
5. P Q7A182 Probable quinol oxidase subunit 1 6.74e-05 2.70e-04 NA NA
5. P Q9PJB9 Probable lipid II flippase MurJ 4.88e-10 1.66e-18 NA NA
5. P Q8C3B8 Protein RFT1 homolog 5.14e-09 2.34e-03 NA NA
5. P O94302 Oligosaccharide translocation protein rft1 1.98e-09 4.61e-09 NA NA
5. P Q5A6N8 Oligosaccharide translocation protein RFT1 4.71e-09 2.19e-11 NA NA
5. P Q2FI18 Probable quinol oxidase subunit 1 6.62e-05 2.70e-04 NA NA
5. P Q9CMZ9 Probable multidrug resistance protein NorM 3.98e-13 1.91e-02 NA NA
5. P Q2FZK0 Probable quinol oxidase subunit 1 6.41e-05 2.70e-04 NA NA
6. F Q5HIW0 Multidrug export protein MepA 2.00e-15 NA NA 0.5984
6. F P9WLW0 Uncharacterized protein MT1558/MT1560 2.93e-11 NA NA 0.5442
6. F Q6NB79 Probable multidrug resistance protein NorM 2.78e-10 NA NA 0.5445
6. F Q88CB9 Probable multidrug resistance protein NorM 5.46e-09 NA NA 0.566
6. F Q6GJY2 Multidrug export protein MepA 2.33e-15 NA NA 0.55
6. F Q99191 Putative O-antigen transporter 3.33e-16 NA NA 0.6988
6. F P37781 Putative O-antigen transporter 0.00e+00 NA NA 0.729
6. F Q8NYB0 Multidrug export protein MepA 2.89e-15 NA NA 0.584
6. F Q7A7N0 Multidrug export protein MepA 2.11e-15 NA NA 0.596
6. F Q9KRU4 Multidrug resistance protein NorM 3.37e-10 NA NA 0.4962
6. F Q7WJR0 Probable multidrug resistance protein NorM 1.23e-10 NA NA 0.5023
6. F Q45411 EPS I polysaccharide export inner membrane protein EpsE 0.00e+00 NA NA 0.6092
6. F Q03583 Putative O-antigen transporter 0.00e+00 NA NA 0.7025
6. F Q98D15 Probable multidrug resistance protein NorM 2.86e-10 NA NA 0.5182
6. F P59985 Uncharacterized protein Mb3654 1.49e-10 NA NA 0.6706
6. F Q6C6S3 Oligosaccharide translocation protein RFT1 2.93e-09 NA NA 0.4892
6. F Q9F5N7 Multidrug resistance protein NorM 8.91e-10 NA NA 0.5185
6. F Q99WP2 Multidrug export protein MepA 2.22e-15 NA NA 0.5935
6. F P9WJK2 Probable peptidoglycan biosynthesis protein MviN 7.45e-08 NA NA 0.564
6. F Q9CNC5 Uncharacterized membrane protein PM0507 1.33e-13 NA NA 0.6366
6. F Q55364 Probable multidrug resistance protein NorM 3.90e-10 NA NA 0.5573
6. F Q8YFD7 Probable multidrug resistance protein NorM 2.20e-10 NA NA 0.4794
6. F A7KAU2 Multidrug and toxin extrusion protein 1 7.44e-10 NA NA 0.4851
6. F Q6GCD7 Multidrug export protein MepA 2.78e-15 NA NA 0.5993
6. F P9WKX8 Uncharacterized protein MT3732 1.60e-10 NA NA 0.6794
6. F Q92PZ0 Probable multidrug resistance protein NorM 8.48e-10 NA NA 0.5659
6. F Q2FJS9 Multidrug export protein MepA 2.11e-15 NA NA 0.5606
6. F Q7NXN3 Probable multidrug resistance protein NorM 6.23e-10 NA NA 0.5332