Summary

The literature section presents previous knowledge about this protein. There have been five different efforts to annotate minimal organism genome. The annotations from those efforts are given in the Literature section for completeness.

AVX54989.1
JCVISYN3A_0827

Uncharacterized protein.
M. mycoides homolog: Q6MS36.
TIGRfam Classification: 1=Unknown.
Category: Quasiessential.

Statistics

Total GO Annotation: 32
Unique PROST Go: 32
Unique BLAST Go: 0
Unique Foldseek Go: 0

Total Homologs: 35
Unique PROST Homologs: 33
Unique BLAST Homologs: 0
Unique Foldseek Homologs: 0

Literature

Danchin and Fang [1]: NA
Yang and Tsui [2]: Adenylosuccinate lyase
Antczak et al. [3]: Transmembrane protein, likely an ion transporter
Zhang et al. [4]: GO:0000055|ribosomal large subunit export from nucleus
Bianchi et al. [5]: Unclear

Structures and Sequence Alignment

The best structural homolog that predicted by 5. P was B0CG09 (Proton extrusion protein PcxA) with a FATCAT P-Value: 0.00238 and RMSD of 5.81 angstrom. The sequence alignment identity is 18.4%.
Structural alignment shown in left. Query protein AVX54989.1 colored as red in alignment, homolog B0CG09 colored as blue. Query protein AVX54989.1 is also shown in right top, homolog B0CG09 showed in right bottom. They are colored based on secondary structures. 

  AVX54989.1 -------------------------------------MKEL---YLKLLNLSLNILKTDKL--KYF---ILKNEEF---KLKYLNLINDILTLETNHNQS 52
      B0CG09 MSSSSPNPFRRSLKFVEQWYRETPQRALDGAYEAARAIEEIEKKHFKGQPVPLRI-RTESVMTNYFQSEVQKNLQFIQTRLREFK--SSSLVVE------ 91

  AVX54989.1 LDDKVFAKTFAKA-FILITKTTKQRFEANDE--ITIEQIENNY-KQLVSYIVKEFKVVKSKLVSENEQISEEIINQNAIL---TDQSISK-IESRLSKQE 144
      B0CG09 VADKLKPPSIPPAPTPLDTPNT---IDFTDEYDVTSEE----YSSELVSPSID----AQGSL----DKLA--FI--DAVLKRYRSASIQREAAAAASKAA 172

  AVX54989.1 QLKEQKTSENSQKTATIISEEPILENQVNDQNQSNQQADFLN---SFNPNMFANLNNAD-LP--VLPSQDPRF----YPYKG-KPKFM-PYLKIALCVLA 232
      B0CG09 RASAPKSGSEMKK--NI--PQPL---PIQSAQNSLYESEFISDDITEDP---SKLDSSSFIPRSILRTA-TRFRKELNPDPGTEDDILNDFRNSRVRTRA 261

  AVX54989.1 VISTILLASSLLYLSYTTIDISSSTYAG-IIESNKNWDQV-IK-NG--DKEILKSWPLGISQIALMFKR-AF-GL--PILIYMIPAILICTYTKKTLSNP 323
      B0CG09 AVSFVL---GLMIVPLLTQQVSKNLVIGPFVDKLKGPEQIEIRINPEIENEVL-------TELARFEERLKFESLTSPIPLS--PA-EIQFQLKAKAEDL 348

  AVX54989.1 REKY----RIPLFPIIFFIMFFIGLTINLYEFTSIEKFKASWKVFLIGLTNKTDLDINK-FFDELLKEHGL--KFKLASALVITSLIITILT-----LIL 411
      B0CG09 KEEYQWDLRQPLKNAISDLFSLVALAI--Y--------------FVL---NRQKIAVLKSFFDEII--YGLSDSAKAFIIILFTDVFVGFHSPHGWEVIV 427

  AVX54989.1 AVVLIIVN-PKLDREKIVK---ATLEHQKAVM--AVMQGQKY-------EMDPS---LYEE-DEIEIKHPSKLKLFFLKLKNKKKKEDNKESND 488
      B0CG09 ESVLSHFGLPQ-DR-NFINMFIATF----PVMLDTVF---KYWIFRYLNQISPSAVATYRNMNE------------------------------ 482

Go Annotations

1. PBF indicates the go terms that are found by both PROST and BLAST and Foldseek.
2. PF indicates the go terms that are found by only PROST and Foldseek.
3. BF indicates the go terms that are found by only BLAST and Foldseek.
4. PB indicates the go terms that are found by both PROST and BLAST.
5. P indicates the go terms that are found by only PROST.
6. F indicates the go terms that are found by only Foldseek.
7. B indicates the go terms that are found by only BLAST.

Source GO Description
5. P GO:0015078 proton transmembrane transporter activity
5. P GO:0055036 virion membrane
5. P GO:0005886 plasma membrane
5. P GO:0030111 regulation of Wnt signaling pathway
5. P GO:0055038 recycling endosome membrane
5. P GO:0015031 protein transport
5. P GO:0097658 Asi complex
5. P GO:0075513 caveolin-mediated endocytosis of virus by host cell
5. P GO:0002079 inner acrosomal membrane
5. P GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization
5. P GO:0019062 virion attachment to host cell
5. P GO:0002081 outer acrosomal membrane
5. P GO:0060271 cilium assembly
5. P GO:0030658 transport vesicle membrane
5. P GO:0039663 membrane fusion involved in viral entry into host cell
5. P GO:0016021 integral component of membrane
5. P GO:0032588 trans-Golgi network membrane
5. P GO:0019375 galactolipid biosynthetic process
5. P GO:0031154 culmination involved in sorocarp development
5. P GO:0060478 acrosomal vesicle exocytosis
5. P GO:0005769 early endosome
5. P GO:0072583 clathrin-dependent endocytosis
5. P GO:0035869 ciliary transition zone
5. P GO:0030136 clathrin-coated vesicle
5. P GO:0005637 nuclear inner membrane
5. P GO:0050665 hydrogen peroxide biosynthetic process
5. P GO:0071230 cellular response to amino acid stimulus
5. P GO:0036369 transcription factor catabolic process
5. P GO:0005741 mitochondrial outer membrane
5. P GO:0030587 sorocarp development
5. P GO:0032050 clathrin heavy chain binding
5. P GO:0031160 spore wall

Uniprot GO Annotations

GO Description
GO:0016020 membrane
GO:0016021 integral component of membrane

Homologs

1. PBF indicates the homologs that are found by both PROST and BLAST and Foldseek.
2. PF indicates the homologs that are found by only PROST and Foldseek.
3. BF indicates the homologs that are found by only BLAST and Foldseek.
4. PB indicates the homologs that are found by both PROST and BLAST.
5. P indicates the homologs that are found by only PROST.
6. F indicates the homologs that are found by only Foldseek.
7. B indicates the homologs that are found by only BLAST.

Source Homolog Description Fatcat Pvalue PROST Evalue BLAST Evalue Foldseek TMScore
2. PF Q49415 Uncharacterized protein MG314 1.18e-05 6.38e-22 NA 0.2591
2. PF Q50363 Uncharacterized protein MG314 homolog 5.40e-05 4.28e-22 NA 0.2873
5. P A2YMP7 Putative secretory carrier-associated membrane protein 1 1.21e-02 2.21e-02 NA NA
5. P P30029 Large envelope protein NA 2.78e-02 NA NA
5. P B0JI44 Proton extrusion protein PcxA 8.00e-03 2.39e-02 NA NA
5. P Q02465 Prespore protein Dd31 7.73e-03 6.11e-04 NA NA
5. P Q1ZXE4 Frizzled and smoothened-like protein Q 7.23e-03 4.91e-02 NA NA
5. P Q3MDY0 Proton extrusion protein PcxA 1.04e-02 2.18e-03 NA NA
5. P Q86283 Uncharacterized protein S9 NA 1.13e-02 NA NA
5. P B7KHV5 Proton extrusion protein PcxA 3.70e-03 1.59e-02 NA NA
5. P F1NVK6 Transmembrane protein 237 2.92e-02 3.42e-03 NA NA
5. P Q753J1 Nuclear control of ATPase protein 2 6.64e-03 4.47e-02 NA NA
5. P Q8H5X5 Secretory carrier-associated membrane protein 1 1.14e-02 1.93e-02 NA NA
5. P Q54N94 Putative uncharacterized transmembrane protein DDB_G0285385 1.41e-02 7.59e-03 NA NA
5. P Q8BUV8 Protein GPR107 9.20e-03 3.15e-02 NA NA
5. P A5GTC7 Proton extrusion protein PcxA 9.59e-03 3.88e-02 NA NA
5. P Q2LCV6 Equatorin 2.57e-01 4.64e-02 NA NA
5. P P53895 Protein ASI2 1.02e-02 2.70e-02 NA NA
5. P Q6PE13 Proline-rich transmembrane protein 3 2.19e-01 4.83e-03 NA NA
5. P Q8GUK1 Protein DGS1, mitochondrial 6.90e-03 3.40e-02 NA NA
5. P P72771 CemA-like protein sll1685 1.43e-02 1.94e-05 NA NA
5. P Q2JRR7 Proton extrusion protein PcxA 1.37e-02 6.15e-03 NA NA
5. P O28640 Uncharacterized protein AF_1633 6.11e-02 8.72e-03 NA NA
5. P P59112 Proton extrusion protein PcxA 4.39e-03 4.64e-02 NA NA
5. P Q8YWE0 Proton extrusion protein PcxA 5.12e-03 1.08e-03 NA NA
5. P A9ULX8 Transmembrane protein 237 2.17e-02 4.88e-04 NA NA
5. P Q31PJ8 Proton extrusion protein PcxA 1.30e-02 1.41e-02 NA NA
5. P B1X0Z7 Proton extrusion protein PcxA 3.38e-03 3.10e-04 NA NA
5. P Q91C35 Large envelope protein NA 1.13e-02 NA NA
5. P B0CG09 Proton extrusion protein PcxA 2.38e-03 1.55e-03 NA NA
5. P Q5N4M6 Proton extrusion protein PcxA 1.43e-02 1.41e-02 NA NA
5. P F6UF99 Transmembrane protein 237 3.17e-02 2.54e-03 NA NA
5. P E1BN97 Transmembrane protein 237 7.90e-02 7.51e-03 NA NA
5. P Q9ZCN2 Uncharacterized protein RP691 3.42e-03 7.44e-03 NA NA
5. P Q10YZ5 Proton extrusion protein PcxA 1.15e-02 8.22e-03 NA NA